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The map label for this gene is lysC [H]

Identifier: 38232898

GI number: 38232898

Start: 240889

End: 242154

Strand: Direct

Name: lysC [H]

Synonym: DIP0277

Alternate gene names: 38232898

Gene position: 240889-242154 (Clockwise)

Preceding gene: 38232896

Following gene: 38232899

Centisome position: 9.68

GC content: 58.21

Gene sequence:

>1266_bases
GTGGCACTTGTAGTACAGAAATATGGAGGTTCTTCGCTAGAAAGCGCGGAACGGATCCGACGTGTCGCTGAACGGATCGT
GGCCACTAAGAAGCAGGGGCACGACGTAGTCGTCGTGTGCTCTGCCATGGGGGATACCACCGATGAGCTGCTCGACCTTG
CAGCACAGGTGAATCCAGTTCCGCCAGCACGCGAGATGGATATGTTGTTGACGGCTGGCGAGCGTATCTCGAATGCGTTG
GTGGCCATGGCCATTGAGTCCTTCGGGGCGAAAGCGCAGTCGTTTACAGGTTCACAAGCTGGTGTAATCACCACGGAGCG
CCACGGAAACGCGCGCATCGTGGACGTCACCCCAGGGCGTGTACGTGAAGCCTTGGACGAGGGCAAGATCTGTCTCGTCG
CCGGATTCCAAGGCGTGAACCGCGAATCAAAGGACGTGACCACGCTGGGTCGTGGCGGTTCCGATACCACCGCAGTGGCG
TTGGCAGCGGCGCTTAATGCTGATGTGTGCGAGATCTACTCGGACGTAGATGGCGTGTACACGGCGGACCCCCGCATTGT
TCCTAACGCACAGAAGTTGGAAAAGCTGTGTTTCGAGGAAATGCTGGAGCTTGCCGCAAGCGGTTCCAAGATTTTGGTAT
TGCGCAGTGTTGAGTACGCCCGCGCGTTTGGCGTGCCGCTGCGTGTTCGTTCGTCTTATAGCAATGATCCCGGCACATTG
GTCGCCGGCTCGATGGAGGATATCCCTGTGGAAGAAGCAGTACTAACTGGTGTAGCGACCGACAACTCTGAAGCTAAGAT
CACGGTTCTGGGTATCCCAGATTCCCCAGGCAGCGCATCGGCAGTGTTCCGCGCGCTTGCCGACGCCGAAATCAACATCG
ACACGGTGCTGCAAAACATCTCCTCCCTCGAGGACAACCGCACCGACATTACCTTCACCTGCCCGCGTGCCGACGGTCCC
CACGCCATGGAACTGCTCCGCAACCTGCAGGCAAAGAACGACTGGCAGAACGTGCTTTACGACGACCAGATCGGCAAGGT
TTCCCTCGTGGGCGCCGGTATGAAATCCCACCCAGGGGTCACCGCAGAGTTCTGCGAAGCACTGCGCGACGCCGGTGTGA
ACATCGAATTGATCTCCACCTCCGAAATCCGCATCTCAGTACTGATCCGCGAATCGGACGTCGATGTGGCAGCCCGTGCC
ATCCACGAGAAGTTCGAGCTCGGTGGCGAAACCGAAGCAATTGTCTACGCTGGTACCGGACGGTAA

Upstream 100 bases:

>100_bases
ATTGACTGTAGTATAGAAATTCGTAATTTCATGGTCTTGAACGAGGGACGCACACGCTGGTTAACGCAGCGTTGTGGCGT
TCCGGGAAGGGCGTAGCCCC

Downstream 100 bases:

>100_bases
GCGAGGAGTTTTAAGAAAACCGTGTGATAAAAGACCTCTCGCTAATAGTGTGCAAGAGGTCTTTTGATGTGATTGTGTAA
TTTTGCATGGGTCTCACCCT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MALVVQKYGGSSLESAERIRRVAERIVATKKQGHDVVVVCSAMGDTTDELLDLAAQVNPVPPAREMDMLLTAGERISNAL
VAMAIESFGAKAQSFTGSQAGVITTERHGNARIVDVTPGRVREALDEGKICLVAGFQGVNRESKDVTTLGRGGSDTTAVA
LAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLCFEEMLELAASGSKILVLRSVEYARAFGVPLRVRSSYSNDPGTL
VAGSMEDIPVEEAVLTGVATDNSEAKITVLGIPDSPGSASAVFRALADAEINIDTVLQNISSLEDNRTDITFTCPRADGP
HAMELLRNLQAKNDWQNVLYDDQIGKVSLVGAGMKSHPGVTAEFCEALRDAGVNIELISTSEIRISVLIRESDVDVAARA
IHEKFELGGETEAIVYAGTGR

Sequences:

>Translated_421_residues
MALVVQKYGGSSLESAERIRRVAERIVATKKQGHDVVVVCSAMGDTTDELLDLAAQVNPVPPAREMDMLLTAGERISNAL
VAMAIESFGAKAQSFTGSQAGVITTERHGNARIVDVTPGRVREALDEGKICLVAGFQGVNRESKDVTTLGRGGSDTTAVA
LAAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLCFEEMLELAASGSKILVLRSVEYARAFGVPLRVRSSYSNDPGTL
VAGSMEDIPVEEAVLTGVATDNSEAKITVLGIPDSPGSASAVFRALADAEINIDTVLQNISSLEDNRTDITFTCPRADGP
HAMELLRNLQAKNDWQNVLYDDQIGKVSLVGAGMKSHPGVTAEFCEALRDAGVNIELISTSEIRISVLIRESDVDVAARA
IHEKFELGGETEAIVYAGTGR
>Mature_420_residues
ALVVQKYGGSSLESAERIRRVAERIVATKKQGHDVVVVCSAMGDTTDELLDLAAQVNPVPPAREMDMLLTAGERISNALV
AMAIESFGAKAQSFTGSQAGVITTERHGNARIVDVTPGRVREALDEGKICLVAGFQGVNRESKDVTTLGRGGSDTTAVAL
AAALNADVCEIYSDVDGVYTADPRIVPNAQKLEKLCFEEMLELAASGSKILVLRSVEYARAFGVPLRVRSSYSNDPGTLV
AGSMEDIPVEEAVLTGVATDNSEAKITVLGIPDSPGSASAVFRALADAEINIDTVLQNISSLEDNRTDITFTCPRADGPH
AMELLRNLQAKNDWQNVLYDDQIGKVSLVGAGMKSHPGVTAEFCEALRDAGVNIELISTSEIRISVLIRESDVDVAARAI
HEKFELGGETEAIVYAGTGR

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=467, Percent_Identity=28.4796573875803, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1790455, Length=238, Percent_Identity=31.9327731092437, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790376, Length=476, Percent_Identity=24.7899159663866, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320893, Length=376, Percent_Identity=26.063829787234, Blast_Score=94, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44733; Mature: 44602

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVVQKYGGSSLESAERIRRVAERIVATKKQGHDVVVVCSAMGDTTDELLDLAAQVNPV
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCC
PPAREMDMLLTAGERISNALVAMAIESFGAKAQSFTGSQAGVITTERHGNARIVDVTPGR
CCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEEECCCCEEEEECCCHH
VREALDEGKICLVAGFQGVNRESKDVTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVY
HHHHHCCCCEEEEECCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCEE
TADPRIVPNAQKLEKLCFEEMLELAASGSKILVLRSVEYARAFGVPLRVRSSYSNDPGTL
ECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHCCCEEEECCCCCCCCCE
VAGSMEDIPVEEAVLTGVATDNSEAKITVLGIPDSPGSASAVFRALADAEINIDTVLQNI
EECCCCCCCHHHHHHEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHH
SSLEDNRTDITFTCPRADGPHAMELLRNLQAKNDWQNVLYDDQIGKVSLVGAGMKSHPGV
HHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEEECCCCCCCCC
TAEFCEALRDAGVNIELISTSEIRISVLIRESDVDVAARAIHEKFELGGETEAIVYAGTG
CHHHHHHHHHCCCEEEEEECCCEEEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCC
R
C
>Mature Secondary Structure 
ALVVQKYGGSSLESAERIRRVAERIVATKKQGHDVVVVCSAMGDTTDELLDLAAQVNPV
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCC
PPAREMDMLLTAGERISNALVAMAIESFGAKAQSFTGSQAGVITTERHGNARIVDVTPGR
CCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEEECCCCEEEEECCCHH
VREALDEGKICLVAGFQGVNRESKDVTTLGRGGSDTTAVALAAALNADVCEIYSDVDGVY
HHHHHCCCCEEEEECCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCEE
TADPRIVPNAQKLEKLCFEEMLELAASGSKILVLRSVEYARAFGVPLRVRSSYSNDPGTL
ECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHCCCEEEECCCCCCCCCE
VAGSMEDIPVEEAVLTGVATDNSEAKITVLGIPDSPGSASAVFRALADAEINIDTVLQNI
EECCCCCCCHHHHHHEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHH
SSLEDNRTDITFTCPRADGPHAMELLRNLQAKNDWQNVLYDDQIGKVSLVGAGMKSHPGV
HHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEEECCCCCCCCC
TAEFCEALRDAGVNIELISTSEIRISVLIRESDVDVAARAIHEKFELGGETEAIVYAGTG
CHHHHHHHHHCCCEEEEEECCCEEEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]