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The map label for this gene is dprE1 [H]

Identifier: 38232787

GI number: 38232787

Start: 136124

End: 137590

Strand: Reverse

Name: dprE1 [H]

Synonym: DIP0162

Alternate gene names: 38232787

Gene position: 137590-136124 (Counterclockwise)

Preceding gene: 38232788

Following gene: 38232786

Centisome position: 5.53

GC content: 59.44

Gene sequence:

>1467_bases
ATGACGACCGACAAGGGCACGTCCAGCACCGCAGCTTCGAACGGTGCCTCCGGAGCCCTATACACAGAAGCCAAGAAACT
CACAGGTTGGGGCCGTACCGCACCAACCACCGCCGAGGTTCTGTCCACCCCAGATCTCGACGTAATCGTTGATGCAGTCC
GCCAGGTGGCCGAGCAGAATGATTCCAAGCCAGCGCACCTCAAGCGCGGCGTGATCGCTCGTGGCATGGGCCGCTCCTAC
GGTGACCCCGCCCAGAACTCCGGTGGCCTCGTCGTAGACATGCAAGCCCTGAACAAGATCCACTCCATCGACCCAGAATC
GGCGATTGTCGACGTCGACGGTGGCGTGACCTTGGACCAGCTCATGAAAGCCGCACTGCCTTATGGCCTGTGGGTTCCCG
TTCTACCAGGTACCCGCCAAGTAACCATCGGCGGCGCAATTGGCCCTGATATCCACGGCAAGAACCACCACTCCGCAGGT
TCCTTCGGCGACCACGTTGCCTCCATGGAACTGCTCGTTGCCGACGGCCGTATCCTGCACCTTGAGCCAGAAGGCTCCGC
AGACGACCCCACCGGCGAACTATTCTGGGCAACCGTCGGCGGCATGGGCCTGACCGGCATTATCGTGCGCGCACGCATCC
GCATGACCAAGACGGAAACCGCGTACTTCATTGCCGACGGCGACCTGACCGCCAACCTCGACGAAACCATCGAGTTCCAC
TCCGATGGCTCCGAGCACAACTACACCTACTCGTCTGCATGGTTCGACGCCATCTCCCCTGAGCCAAAGCTCGGCCGTGC
CGCCATCTCCCGCGGTTCGCTGGCCACCTTGGCACAGCTGGAGGAGATCGCGCCGAAGCTGGCTAAGGATCCACTGAAGT
TCAATGCTCCGCAGCTGGTCACTGTGCCGGATATCTTCCCAAGCTTCACCATGAACAAGCTCTCCATGATCGCCATCGGC
GAGCTGTGGTGGCTCAAGTCCGGAACCTACAAGAACAAGGTGCAAAACCTCACGCAGTTCTACCAGCCACTAGACCTCAT
CGGTGAGTGGAACCGCGGCTACGGCTCCAAGGGCTTCTTGCAGTACCAGTTCGTGGTGCCACGCGAGGCAGTCGAGCCAT
TCAAGGACATTGTCAAGGACATTCAGAAGTCCGGCCACTACTCTGCACTGAACGTGTTCAAGCTGTTCGGTGAGGGTAAC
AAGGCACCATTGTCCTACCCAATGCCTGGTTGGAACGTCTGCGTTGACTTCCCCATCAAGCCTGGTCTTGGCGCTTTCTT
GGATGATCTGGATAAGCGCGTGATGGAATTCGGTGGCCGCCTGTACTTGGCTAAGGAGTCCCGTACCTCTGCGGAGAACT
TCCACAAGATGTACCCAGGTATGGAAGGCTGGTTGAAGACCCGCAACGCTATCGACCCCACGGGTGTCTTTGCGTCCGAT
ATGTCCCGCCGCCTCGAGCTGCACTAA

Upstream 100 bases:

>100_bases
GAAAATGTTTGTTCCCACATCAGAACGTGAGAAAAACCACCCGCTCGGACACGCCCAGTCATAGTCACATGTCACGTGAA
GCGGGTACCGTTGTAAAACG

Downstream 100 bases:

>100_bases
AAGAAAGGACTACTTCCTCATGCTGAATGCAGTAGGCCAAGCACAAAATATTCTTCTGTTGGGCGGCACGTCCGAAATCG
GTCTTTCCATCGTCGCCGAG

Product: putative oxidoreductase, FAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MTTDKGTSSTAASNGASGALYTEAKKLTGWGRTAPTTAEVLSTPDLDVIVDAVRQVAEQNDSKPAHLKRGVIARGMGRSY
GDPAQNSGGLVVDMQALNKIHSIDPESAIVDVDGGVTLDQLMKAALPYGLWVPVLPGTRQVTIGGAIGPDIHGKNHHSAG
SFGDHVASMELLVADGRILHLEPEGSADDPTGELFWATVGGMGLTGIIVRARIRMTKTETAYFIADGDLTANLDETIEFH
SDGSEHNYTYSSAWFDAISPEPKLGRAAISRGSLATLAQLEEIAPKLAKDPLKFNAPQLVTVPDIFPSFTMNKLSMIAIG
ELWWLKSGTYKNKVQNLTQFYQPLDLIGEWNRGYGSKGFLQYQFVVPREAVEPFKDIVKDIQKSGHYSALNVFKLFGEGN
KAPLSYPMPGWNVCVDFPIKPGLGAFLDDLDKRVMEFGGRLYLAKESRTSAENFHKMYPGMEGWLKTRNAIDPTGVFASD
MSRRLELH

Sequences:

>Translated_488_residues
MTTDKGTSSTAASNGASGALYTEAKKLTGWGRTAPTTAEVLSTPDLDVIVDAVRQVAEQNDSKPAHLKRGVIARGMGRSY
GDPAQNSGGLVVDMQALNKIHSIDPESAIVDVDGGVTLDQLMKAALPYGLWVPVLPGTRQVTIGGAIGPDIHGKNHHSAG
SFGDHVASMELLVADGRILHLEPEGSADDPTGELFWATVGGMGLTGIIVRARIRMTKTETAYFIADGDLTANLDETIEFH
SDGSEHNYTYSSAWFDAISPEPKLGRAAISRGSLATLAQLEEIAPKLAKDPLKFNAPQLVTVPDIFPSFTMNKLSMIAIG
ELWWLKSGTYKNKVQNLTQFYQPLDLIGEWNRGYGSKGFLQYQFVVPREAVEPFKDIVKDIQKSGHYSALNVFKLFGEGN
KAPLSYPMPGWNVCVDFPIKPGLGAFLDDLDKRVMEFGGRLYLAKESRTSAENFHKMYPGMEGWLKTRNAIDPTGVFASD
MSRRLELH
>Mature_487_residues
TTDKGTSSTAASNGASGALYTEAKKLTGWGRTAPTTAEVLSTPDLDVIVDAVRQVAEQNDSKPAHLKRGVIARGMGRSYG
DPAQNSGGLVVDMQALNKIHSIDPESAIVDVDGGVTLDQLMKAALPYGLWVPVLPGTRQVTIGGAIGPDIHGKNHHSAGS
FGDHVASMELLVADGRILHLEPEGSADDPTGELFWATVGGMGLTGIIVRARIRMTKTETAYFIADGDLTANLDETIEFHS
DGSEHNYTYSSAWFDAISPEPKLGRAAISRGSLATLAQLEEIAPKLAKDPLKFNAPQLVTVPDIFPSFTMNKLSMIAIGE
LWWLKSGTYKNKVQNLTQFYQPLDLIGEWNRGYGSKGFLQYQFVVPREAVEPFKDIVKDIQKSGHYSALNVFKLFGEGNK
APLSYPMPGWNVCVDFPIKPGLGAFLDDLDKRVMEFGGRLYLAKESRTSAENFHKMYPGMEGWLKTRNAIDPTGVFASDM
SRRLELH

Specific function: Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007173
- InterPro:   IPR016166
- InterPro:   IPR016168
- InterPro:   IPR006094 [H]

Pfam domain/function: PF04030 ALO; PF01565 FAD_binding_4 [H]

EC number: NA

Molecular weight: Translated: 53075; Mature: 52944

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDKGTSSTAASNGASGALYTEAKKLTGWGRTAPTTAEVLSTPDLDVIVDAVRQVAEQN
CCCCCCCCCCCCCCCCCCCEEHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCC
DSKPAHLKRGVIARGMGRSYGDPAQNSGGLVVDMQALNKIHSIDPESAIVDVDGGVTLDQ
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCCCCEEEECCCCCCHHH
LMKAALPYGLWVPVLPGTRQVTIGGAIGPDIHGKNHHSAGSFGDHVASMELLVADGRILH
HHHHHCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHEEEEEECCEEEE
LEPEGSADDPTGELFWATVGGMGLTGIIVRARIRMTKTETAYFIADGDLTANLDETIEFH
ECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHEEEEECCEEEEEECCCEECCHHHHEEEC
SDGSEHNYTYSSAWFDAISPEPKLGRAAISRGSLATLAQLEEIAPKLAKDPLKFNAPQLV
CCCCCCCEEEHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEE
TVPDIFPSFTMNKLSMIAIGELWWLKSGTYKNKVQNLTQFYQPLDLIGEWNRGYGSKGFL
ECCCCCCCCHHHHEEEEEEEHEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
QYQFVVPREAVEPFKDIVKDIQKSGHYSALNVFKLFGEGNKAPLSYPMPGWNVCVDFPIK
EEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCC
PGLGAFLDDLDKRVMEFGGRLYLAKESRTSAENFHKMYPGMEGWLKTRNAIDPTGVFASD
CCCHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHCCCHHHHHHHCCCCCCCCHHHHH
MSRRLELH
HHHHCCCC
>Mature Secondary Structure 
TTDKGTSSTAASNGASGALYTEAKKLTGWGRTAPTTAEVLSTPDLDVIVDAVRQVAEQN
CCCCCCCCCCCCCCCCCCEEHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCC
DSKPAHLKRGVIARGMGRSYGDPAQNSGGLVVDMQALNKIHSIDPESAIVDVDGGVTLDQ
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCCCCEEEECCCCCCHHH
LMKAALPYGLWVPVLPGTRQVTIGGAIGPDIHGKNHHSAGSFGDHVASMELLVADGRILH
HHHHHCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHEEEEEECCEEEE
LEPEGSADDPTGELFWATVGGMGLTGIIVRARIRMTKTETAYFIADGDLTANLDETIEFH
ECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHEEEEECCEEEEEECCCEECCHHHHEEEC
SDGSEHNYTYSSAWFDAISPEPKLGRAAISRGSLATLAQLEEIAPKLAKDPLKFNAPQLV
CCCCCCCEEEHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEE
TVPDIFPSFTMNKLSMIAIGELWWLKSGTYKNKVQNLTQFYQPLDLIGEWNRGYGSKGFL
ECCCCCCCCHHHHEEEEEEEHEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEE
QYQFVVPREAVEPFKDIVKDIQKSGHYSALNVFKLFGEGNKAPLSYPMPGWNVCVDFPIK
EEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCC
PGLGAFLDDLDKRVMEFGGRLYLAKESRTSAENFHKMYPGMEGWLKTRNAIDPTGVFASD
CCCHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHCCCHHHHHHHCCCCCCCCHHHHH
MSRRLELH
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]