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The map label for this gene is tipA [H]

Identifier: 38232732

GI number: 38232732

Start: 83969

End: 84745

Strand: Reverse

Name: tipA [H]

Synonym: DIP0102

Alternate gene names: 38232732

Gene position: 84745-83969 (Counterclockwise)

Preceding gene: 38232733

Following gene: 38232730

Centisome position: 3.41

GC content: 55.34

Gene sequence:

>777_bases
ATGGTAACTCCCATGGAAGAACACAATCTTCGCACTGTTGGTGAAGTAGCAGACCTCGTCGGTGTAAGCGTGCGCACTCT
TCACCATTGGGATGACATCGGACTAGTCAGCCCCCAATGGCGTAGTTGGGCCGATTACCGCCTCTACAGCGAGGAGGATG
TTGCCCAGATTTACCAGGTCTTGCTGTACCGCGAAACTGGCATGCCGCTAAAAACCATCCGCGACATGCTCGAAGGCAAC
AGCTCTCCCGCGGACCATCTCCAACGACAGCTGGAACTTCTGCAACAGCGGAAACATCGTGTGACTTCCATGATCGAATC
TGTACATCAACTTTTGGAGGACACCATGAACCACAACGAACCGCTCTCTGCAGACCACACCGCGAAGGTCCTTGGCCGCG
AATGGAGCAAGTGGGAGAAGGAAGCCGAGGAGCGATGGGGTGACACCGAAGACTGGGCAATCTTCCAACAGCGCGCAGCA
CAGATGGGCAAGGACGACTTTGCTGCTCGGCAGATGGTCATGCACAAGCTAGACCAGCGACTTGCCCAAGCTTTCGAATC
GGGTATGGCCCCTGATTCCCCAGACGCACATGCACTCGCAGAGGAACACCGGGCATGTTTATCGCAATGGTTTCCGGTTT
CACACAGCAAGCATGCGCTGATTGCTCAGGGCTACACTGCCGATCCGCGCTTTACCGCGCATTATGACAAGTACGCGAAA
GGCTTGGCGGTCTGGTTGGAGAAGGCTATTCAGAGCAACGCTCAACGCCACACCTAA

Upstream 100 bases:

>100_bases
GGTAGACCAAGTACAAGAAGCCGTAAAGAAGAAGATCGACGAGCAGTAGTCGAATCTAATAAAAATCGGCCCACTTGACC
CTCACACCGCGTCAGGGTGA

Downstream 100 bases:

>100_bases
TAAAAATCGGCCAGGTGGGTTGGACAGCAACATTGTGCCCAACTCATCTGGCCGTTTTTCATATGCGGCTTAGCCGAAGG
TTAGCGAGTAGAAGCTCACG

Product: transcriptional activator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MVTPMEEHNLRTVGEVADLVGVSVRTLHHWDDIGLVSPQWRSWADYRLYSEEDVAQIYQVLLYRETGMPLKTIRDMLEGN
SSPADHLQRQLELLQQRKHRVTSMIESVHQLLEDTMNHNEPLSADHTAKVLGREWSKWEKEAEERWGDTEDWAIFQQRAA
QMGKDDFAARQMVMHKLDQRLAQAFESGMAPDSPDAHALAEEHRACLSQWFPVSHSKHALIAQGYTADPRFTAHYDKYAK
GLAVWLEKAIQSNAQRHT

Sequences:

>Translated_258_residues
MVTPMEEHNLRTVGEVADLVGVSVRTLHHWDDIGLVSPQWRSWADYRLYSEEDVAQIYQVLLYRETGMPLKTIRDMLEGN
SSPADHLQRQLELLQQRKHRVTSMIESVHQLLEDTMNHNEPLSADHTAKVLGREWSKWEKEAEERWGDTEDWAIFQQRAA
QMGKDDFAARQMVMHKLDQRLAQAFESGMAPDSPDAHALAEEHRACLSQWFPVSHSKHALIAQGYTADPRFTAHYDKYAK
GLAVWLEKAIQSNAQRHT
>Mature_258_residues
MVTPMEEHNLRTVGEVADLVGVSVRTLHHWDDIGLVSPQWRSWADYRLYSEEDVAQIYQVLLYRETGMPLKTIRDMLEGN
SSPADHLQRQLELLQQRKHRVTSMIESVHQLLEDTMNHNEPLSADHTAKVLGREWSKWEKEAEERWGDTEDWAIFQQRAA
QMGKDDFAARQMVMHKLDQRLAQAFESGMAPDSPDAHALAEEHRACLSQWFPVSHSKHALIAQGYTADPRFTAHYDKYAK
GLAVWLEKAIQSNAQRHT

Specific function: Transcriptional activator. Is activated when bound to the antibiotic thiostrepton [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR012925
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind; PF07739 TipAS [H]

EC number: NA

Molecular weight: Translated: 29792; Mature: 29792

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTPMEEHNLRTVGEVADLVGVSVRTLHHWDDIGLVSPQWRSWADYRLYSEEDVAQIYQV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCHHHHHCCCHHHHHHHHHH
LLYRETGMPLKTIRDMLEGNSSPADHLQRQLELLQQRKHRVTSMIESVHQLLEDTMNHNE
HHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PLSADHTAKVLGREWSKWEKEAEERWGDTEDWAIFQQRAAQMGKDDFAARQMVMHKLDQR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LAQAFESGMAPDSPDAHALAEEHRACLSQWFPVSHSKHALIAQGYTADPRFTAHYDKYAK
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCHHHHHHHHHH
GLAVWLEKAIQSNAQRHT
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVTPMEEHNLRTVGEVADLVGVSVRTLHHWDDIGLVSPQWRSWADYRLYSEEDVAQIYQV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCHHHHHCCCHHHHHHHHHH
LLYRETGMPLKTIRDMLEGNSSPADHLQRQLELLQQRKHRVTSMIESVHQLLEDTMNHNE
HHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PLSADHTAKVLGREWSKWEKEAEERWGDTEDWAIFQQRAAQMGKDDFAARQMVMHKLDQR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LAQAFESGMAPDSPDAHALAEEHRACLSQWFPVSHSKHALIAQGYTADPRFTAHYDKYAK
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCHHHHHHHHHH
GLAVWLEKAIQSNAQRHT
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]