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The map label for this gene is pcoA [H]

Identifier: 38232701

GI number: 38232701

Start: 59436

End: 60917

Strand: Direct

Name: pcoA [H]

Synonym: DIP0067

Alternate gene names: 38232701

Gene position: 59436-60917 (Clockwise)

Preceding gene: 38232700

Following gene: 38232707

Centisome position: 2.39

GC content: 64.17

Gene sequence:

>1482_bases
ATGACGAACGCGTTTTCCCGACGACAGTTTCTGCTCGGCGGGCTCGTCCTCGCCGGTACCGGGGCCGTGGCCGCCTGCAC
CAGCGACCCTGGACCCGCTGCCTCGGCACCAGGTTCCTCCCTTCGCCCCACTCCCACCCCCACTGCGCTCGGTGAGCCGA
CGGTGCGCCGGACACTGACCGCCCGGCCCCTCTCCCTGGATATCGGCGGCATCGAAGCCAAGACGTGGGGATACGTCTCT
GACACCGGGGATGCGGCCATTGAGGCCACCGCCGGCGACGTCCTCCAGGTCGATATCACCAATGAACTGCCTGAGAGCAC
CTCCATCCACTGGCATGGCATCGCACTCCACAACGCAGCCGACGGTGTGCCCGGCATGACCCAGGACCCCATTGAACCTG
GCGAGTCTTTCTCCTATGTTTTTGAAGTCCCCCACGGTGGCACCTACTTCTACCATTCCCACACCGGCCTGCAGCTTGAT
CGCGGCCTCCACGCCCCACTGATCATCCGTGACCCGCAAGATGCTGAGGACCAGGACGTCGAGTGGACCATCGTGCTCGA
CGACTGGGTCGATGGTATTCAGGGCACTCCCGACGATGAGCTCGATAAGCTCACCGGAATGGGTTCAGGCGACCATAACG
GGAAGAAGGGGATGGGAGGTCACGGCCATATGATGCACGGCACCCCGGACCGGGTACTGGGCGGGGATGCCGGCGATGTG
ATGTATCCGCACTACCTCATCAACGGACGTATCCCCCGTGCTCACCGGACCTTCGAGGCTCGCCCGGGCGATAAGGCCCG
CCTGCGGTTTATCAACTCCGGCGGTGACACCATCTTCAAGGTGGCCCTCGGTGGTCACCGCATGACCGTCACCCACACCG
ACGGCTTCCCTGTCCAGCCCTGGGAGACCGAATCGATCTACCTGTCGATGGGCGAACGTGTCGACGTCGAGGTCATCCTC
GGCGACGGCATCTTCCCGCTCACGGCTTTGGCGGTGGGTAAGGACGACCGCGCCTTCGCCGTCATCCGCACCGCCGGCGG
CCAGGCCCCCCACCCCGATGTCGACTTCCCCGAGTTGTCGTCCACCGGACTGCTTCTGTCCTCCCTGAAGCCAGCAGACC
GTGCACTCCTGCCCGAGGGCACACCAGACCGAGAAGTCAGCATCGACCTGGGCGGGCAGATGATGCCATATGAATGGCGC
ATTCTCACCGACGGCCAATCCTCCTCCGCGACCGTGCAGGAGGGCCAGCGCCTGCGGATGGTCATGCGCAACAGGACCAT
GATGCCCCATCCCATGCACATCCACGGCCATACGTGGGCGCTGCCCGGCAGCGGCGGGCTACGCAAGGACACCGTCCTTC
TCCGCCACGGTGAAACCATGATCGCCGACCTGATCGCTGACAACCCCGGTGAGTGGGCATTTCACTGCCATAACGCCTAT
CACATGGAAACCGGGATGCTCAGCTCGCTTCGCTACGAGTAA

Upstream 100 bases:

>100_bases
ACCTGTGTCACAGACCTGCGCCTGACGTGATGGCTCAGCAGGGTCCTCACCTGCGCCTGTCTCCCGTGTCACTGAATTCT
TACACCAGAAAGGTTAAATC

Downstream 100 bases:

>100_bases
CCCCCACAGCAGGGTTGAGCGCCGAGGTGGGCGGGGGTGTCCCCCGAGTAGTGGACACGGCGTTGGTGTCAGGGTTGAGC
AGTGCGTGCCAAGAGTCGAC

Product: putative exported multicopper oxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MTNAFSRRQFLLGGLVLAGTGAVAACTSDPGPAASAPGSSLRPTPTPTALGEPTVRRTLTARPLSLDIGGIEAKTWGYVS
DTGDAAIEATAGDVLQVDITNELPESTSIHWHGIALHNAADGVPGMTQDPIEPGESFSYVFEVPHGGTYFYHSHTGLQLD
RGLHAPLIIRDPQDAEDQDVEWTIVLDDWVDGIQGTPDDELDKLTGMGSGDHNGKKGMGGHGHMMHGTPDRVLGGDAGDV
MYPHYLINGRIPRAHRTFEARPGDKARLRFINSGGDTIFKVALGGHRMTVTHTDGFPVQPWETESIYLSMGERVDVEVIL
GDGIFPLTALAVGKDDRAFAVIRTAGGQAPHPDVDFPELSSTGLLLSSLKPADRALLPEGTPDREVSIDLGGQMMPYEWR
ILTDGQSSSATVQEGQRLRMVMRNRTMMPHPMHIHGHTWALPGSGGLRKDTVLLRHGETMIADLIADNPGEWAFHCHNAY
HMETGMLSSLRYE

Sequences:

>Translated_493_residues
MTNAFSRRQFLLGGLVLAGTGAVAACTSDPGPAASAPGSSLRPTPTPTALGEPTVRRTLTARPLSLDIGGIEAKTWGYVS
DTGDAAIEATAGDVLQVDITNELPESTSIHWHGIALHNAADGVPGMTQDPIEPGESFSYVFEVPHGGTYFYHSHTGLQLD
RGLHAPLIIRDPQDAEDQDVEWTIVLDDWVDGIQGTPDDELDKLTGMGSGDHNGKKGMGGHGHMMHGTPDRVLGGDAGDV
MYPHYLINGRIPRAHRTFEARPGDKARLRFINSGGDTIFKVALGGHRMTVTHTDGFPVQPWETESIYLSMGERVDVEVIL
GDGIFPLTALAVGKDDRAFAVIRTAGGQAPHPDVDFPELSSTGLLLSSLKPADRALLPEGTPDREVSIDLGGQMMPYEWR
ILTDGQSSSATVQEGQRLRMVMRNRTMMPHPMHIHGHTWALPGSGGLRKDTVLLRHGETMIADLIADNPGEWAFHCHNAY
HMETGMLSSLRYE
>Mature_492_residues
TNAFSRRQFLLGGLVLAGTGAVAACTSDPGPAASAPGSSLRPTPTPTALGEPTVRRTLTARPLSLDIGGIEAKTWGYVSD
TGDAAIEATAGDVLQVDITNELPESTSIHWHGIALHNAADGVPGMTQDPIEPGESFSYVFEVPHGGTYFYHSHTGLQLDR
GLHAPLIIRDPQDAEDQDVEWTIVLDDWVDGIQGTPDDELDKLTGMGSGDHNGKKGMGGHGHMMHGTPDRVLGGDAGDVM
YPHYLINGRIPRAHRTFEARPGDKARLRFINSGGDTIFKVALGGHRMTVTHTDGFPVQPWETESIYLSMGERVDVEVILG
DGIFPLTALAVGKDDRAFAVIRTAGGQAPHPDVDFPELSSTGLLLSSLKPADRALLPEGTPDREVSIDLGGQMMPYEWRI
LTDGQSSSATVQEGQRLRMVMRNRTMMPHPMHIHGHTWALPGSGGLRKDTVLLRHGETMIADLIADNPGEWAFHCHNAYH
METGMLSSLRYE

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=550, Percent_Identity=26, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323703, Length=465, Percent_Identity=23.8709677419355, Blast_Score=112, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6321067, Length=492, Percent_Identity=23.5772357723577, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI18859919, Length=240, Percent_Identity=32.0833333333333, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574104, Length=280, Percent_Identity=30, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585842, Length=246, Percent_Identity=29.2682926829268, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281360167, Length=246, Percent_Identity=29.2682926829268, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221330000, Length=246, Percent_Identity=29.2682926829268, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221329998, Length=246, Percent_Identity=29.2682926829268, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24650186, Length=240, Percent_Identity=28.3333333333333, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 53197; Mature: 53066

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNAFSRRQFLLGGLVLAGTGAVAACTSDPGPAASAPGSSLRPTPTPTALGEPTVRRTLT
CCCCHHHHHHHHCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEE
ARPLSLDIGGIEAKTWGYVSDTGDAAIEATAGDVLQVDITNELPESTSIHWHGIALHNAA
CCCEEEECCCEEECCCCEEECCCCCEEEECCCCEEEEEECCCCCCCCCEEEEEEEEECCC
DGVPGMTQDPIEPGESFSYVFEVPHGGTYFYHSHTGLQLDRGLHAPLIIRDPQDAEDQDV
CCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCEEECCCCCCCEEEECCCCCCCCCC
EWTIVLDDWVDGIQGTPDDELDKLTGMGSGDHNGKKGMGGHGHMMHGTPDRVLGGDAGDV
EEEEEEHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
MYPHYLINGRIPRAHRTFEARPGDKARLRFINSGGDTIFKVALGGHRMTVTHTDGFPVQP
ECCEEEECCCCCCCCCCEECCCCCCEEEEEEECCCCEEEEEEECCCEEEEEECCCCCCCC
WETESIYLSMGERVDVEVILGDGIFPLTALAVGKDDRAFAVIRTAGGQAPHPDVDFPELS
CCCCEEEEECCCEEEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCC
STGLLLSSLKPADRALLPEGTPDREVSIDLGGQMMPYEWRILTDGQSSSATVQEGQRLRM
CCCEEEECCCCCHHCCCCCCCCCCEEEEECCCEECCEEEEEEECCCCCCCHHHHHHHHHH
VMRNRTMMPHPMHIHGHTWALPGSGGLRKDTVLLRHGETMIADLIADNPGEWAFHCHNAY
HHHCCCCCCCCEEECCCEEECCCCCCCCCCEEEEECCCCEEHHHHCCCCCCEEEEECCEE
HMETGMLSSLRYE
EECCCCHHHHCCC
>Mature Secondary Structure 
TNAFSRRQFLLGGLVLAGTGAVAACTSDPGPAASAPGSSLRPTPTPTALGEPTVRRTLT
CCCHHHHHHHHCCEEEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHEEE
ARPLSLDIGGIEAKTWGYVSDTGDAAIEATAGDVLQVDITNELPESTSIHWHGIALHNAA
CCCEEEECCCEEECCCCEEECCCCCEEEECCCCEEEEEECCCCCCCCCEEEEEEEEECCC
DGVPGMTQDPIEPGESFSYVFEVPHGGTYFYHSHTGLQLDRGLHAPLIIRDPQDAEDQDV
CCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCEEECCCCCCCEEEECCCCCCCCCC
EWTIVLDDWVDGIQGTPDDELDKLTGMGSGDHNGKKGMGGHGHMMHGTPDRVLGGDAGDV
EEEEEEHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
MYPHYLINGRIPRAHRTFEARPGDKARLRFINSGGDTIFKVALGGHRMTVTHTDGFPVQP
ECCEEEECCCCCCCCCCEECCCCCCEEEEEEECCCCEEEEEEECCCEEEEEECCCCCCCC
WETESIYLSMGERVDVEVILGDGIFPLTALAVGKDDRAFAVIRTAGGQAPHPDVDFPELS
CCCCEEEEECCCEEEEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCC
STGLLLSSLKPADRALLPEGTPDREVSIDLGGQMMPYEWRILTDGQSSSATVQEGQRLRM
CCCEEEECCCCCHHCCCCCCCCCCEEEEECCCEECCEEEEEEECCCCCCCHHHHHHHHHH
VMRNRTMMPHPMHIHGHTWALPGSGGLRKDTVLLRHGETMIADLIADNPGEWAFHCHNAY
HHHCCCCCCCCEEECCCEEECCCCCCCCCCEEEEECCCCEEHHHHCCCCCCEEEEECCEE
HMETGMLSSLRYE
EECCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]