BacMap

Definition	Corynebacterium diphtheriae NCTC 13129 chromosome, complete genome.
Accession	NC_002935
Length	2,488,635

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The map label for this gene is ppiA [H]

Identifier: 38232667

GI number: 38232667

Start: 24888

End: 25430

Strand: Direct

Name: ppiA [H]

Synonym: DIP0025

Alternate gene names: 38232667

Gene position: 24888-25430 (Clockwise)

Preceding gene: 38232665

Following gene: 38232669

Centisome position: 1.0

GC content: 54.33

Gene sequence:

>543_bases
ATGCTTATGATGAATGGCATGACTTTGAAGACCGCTACTGCGATTTTGCACACCAACCGTGGTGACGTTTCCATCGAGTT
GTTTGGCAACCATGCGCCAAAGACCGTCGAAAACTTTGTCACCTTGGCAAACGGTACCGCTGAGTACAAGACCGAAAACG
CTTCCGGCACCAACGAGGGCCCCTTCTACGATGGCGCAGTGTTCCACCGCGTTATCGACGGCTTCATGATCCAGGGTGGC
GATCCAACCGGCACCGGTCGTGGCGGCCCAGGCTACATGTTTGCTGATGAGTTCCACCCTGAGCTCCAGTTCGATCGCCC
ATTCCTTCTGGCTATGGCGAATGCCGGCCCAGGAACCAATGGCTCCCAGTTCTTTATCACCGTGGTACCAACCCCACACT
TGAACAACCACCACACCATCTTCGGTGAGGTCACCGATGCAGCTTCTCAGAAGGTTGTTCTTGACATCGCTCAGACTGCA
ACCGATCGTATGGATCGCCCAGTTGAGCCAGTGGTTATCGAGTCCGTCGAAATCACCGAATAA

Upstream 100 bases:

>100_bases
GTTAGTACAACTGCGCCACGGATGGTGGTTGGGTTCATCCTTTATCGTCCTTCCCAGTTGTGGTTACTTATCCATCAAGC
GTAGCGAGGTTGCGGGTTTC

Downstream 100 bases:

>100_bases
AAAGCTTACGCTGAGCGCTTTAACGCTTAACGACGCCCCTGCTAGCACTTTTTACTGAACTAGCCCCAGAGGTTGGACTG
GTTTAATTCTAGGTGGTTAG

Product: peptidyl-prolyl cis-trans isomerase A

Products: NA

Alternate protein names: PPIase A; Rotamase A [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MLMMNGMTLKTATAILHTNRGDVSIELFGNHAPKTVENFVTLANGTAEYKTENASGTNEGPFYDGAVFHRVIDGFMIQGG
DPTGTGRGGPGYMFADEFHPELQFDRPFLLAMANAGPGTNGSQFFITVVPTPHLNNHHTIFGEVTDAASQKVVLDIAQTA
TDRMDRPVEPVVIESVEITE

Sequences:

>Translated_180_residues
MLMMNGMTLKTATAILHTNRGDVSIELFGNHAPKTVENFVTLANGTAEYKTENASGTNEGPFYDGAVFHRVIDGFMIQGG
DPTGTGRGGPGYMFADEFHPELQFDRPFLLAMANAGPGTNGSQFFITVVPTPHLNNHHTIFGEVTDAASQKVVLDIAQTA
TDRMDRPVEPVVIESVEITE
>Mature_180_residues
MLMMNGMTLKTATAILHTNRGDVSIELFGNHAPKTVENFVTLANGTAEYKTENASGTNEGPFYDGAVFHRVIDGFMIQGG
DPTGTGRGGPGYMFADEFHPELQFDRPFLLAMANAGPGTNGSQFFITVVPTPHLNNHHTIFGEVTDAASQKVVLDIAQTA
TDRMDRPVEPVVIESVEITE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=171, Percent_Identity=47.953216374269, Blast_Score=147, Evalue=3e-36,
Organism=Homo sapiens, GI7706339, Length=161, Percent_Identity=47.2049689440994, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI64276486, Length=167, Percent_Identity=43.7125748502994, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI19557636, Length=169, Percent_Identity=41.4201183431953, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI42560244, Length=168, Percent_Identity=44.047619047619, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI6631100, Length=159, Percent_Identity=42.7672955974843, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI4758950, Length=157, Percent_Identity=43.9490445859873, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI4826932, Length=168, Percent_Identity=42.8571428571429, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI4505991, Length=152, Percent_Identity=45.3947368421053, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI22547212, Length=167, Percent_Identity=41.3173652694611, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI7657473, Length=167, Percent_Identity=41.3173652694611, Blast_Score=100, Evalue=7e-22,
Organism=Homo sapiens, GI22547215, Length=173, Percent_Identity=40.4624277456647, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI10863927, Length=130, Percent_Identity=42.3076923076923, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI5454154, Length=163, Percent_Identity=41.7177914110429, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI256017253, Length=129, Percent_Identity=39.5348837209302, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI221139811, Length=129, Percent_Identity=39.5348837209302, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI256017251, Length=129, Percent_Identity=39.5348837209302, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI209417936, Length=129, Percent_Identity=38.7596899224806, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI30102944, Length=129, Percent_Identity=38.7596899224806, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI219842199, Length=129, Percent_Identity=38.7596899224806, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI178057341, Length=129, Percent_Identity=38.7596899224806, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI310129267, Length=130, Percent_Identity=39.2307692307692, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI310120620, Length=130, Percent_Identity=39.2307692307692, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI169164185, Length=129, Percent_Identity=39.5348837209302, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI169163623, Length=129, Percent_Identity=39.5348837209302, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI169163387, Length=129, Percent_Identity=39.5348837209302, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI310127646, Length=129, Percent_Identity=38.7596899224806, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI310114371, Length=129, Percent_Identity=38.7596899224806, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI310119221, Length=129, Percent_Identity=38.7596899224806, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI310110104, Length=129, Percent_Identity=38.7596899224806, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI5031987, Length=130, Percent_Identity=43.0769230769231, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI150418007, Length=130, Percent_Identity=37.6923076923077, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI5174637, Length=157, Percent_Identity=35.6687898089172, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI169214050, Length=129, Percent_Identity=38.7596899224806, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI239751853, Length=130, Percent_Identity=38.4615384615385, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI113428306, Length=130, Percent_Identity=38.4615384615385, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI303305009, Length=130, Percent_Identity=39.2307692307692, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI45439316, Length=130, Percent_Identity=39.2307692307692, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI310132444, Length=130, Percent_Identity=37.6923076923077, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI310113152, Length=130, Percent_Identity=37.6923076923077, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI20911035, Length=171, Percent_Identity=30.9941520467836, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI310127745, Length=127, Percent_Identity=37.7952755905512, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI310119290, Length=127, Percent_Identity=37.7952755905512, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI310114540, Length=128, Percent_Identity=37.5, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI27735045, Length=147, Percent_Identity=31.9727891156463, Blast_Score=71, Evalue=5e-13,
Organism=Escherichia coli, GI1786736, Length=179, Percent_Identity=35.195530726257, Blast_Score=78, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=170, Percent_Identity=48.8235294117647, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17539496, Length=156, Percent_Identity=48.7179487179487, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17552784, Length=160, Percent_Identity=43.125, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71997782, Length=140, Percent_Identity=43.5714285714286, Blast_Score=113, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17551282, Length=159, Percent_Identity=44.6540880503145, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17551284, Length=159, Percent_Identity=44.6540880503145, Blast_Score=111, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17532641, Length=174, Percent_Identity=40.2298850574713, Blast_Score=111, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71980594, Length=168, Percent_Identity=35.7142857142857, Blast_Score=111, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71980590, Length=163, Percent_Identity=36.8098159509202, Blast_Score=109, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17552780, Length=157, Percent_Identity=46.4968152866242, Blast_Score=107, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17506307, Length=159, Percent_Identity=44.0251572327044, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17565860, Length=156, Percent_Identity=41.025641025641, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17532643, Length=157, Percent_Identity=42.6751592356688, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17559074, Length=158, Percent_Identity=39.2405063291139, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17566266, Length=132, Percent_Identity=43.9393939393939, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17539498, Length=162, Percent_Identity=37.6543209876543, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17552782, Length=157, Percent_Identity=36.9426751592357, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI32563659, Length=171, Percent_Identity=28.6549707602339, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323246, Length=162, Percent_Identity=40.7407407407407, Blast_Score=115, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6323562, Length=165, Percent_Identity=43.030303030303, Blast_Score=105, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320359, Length=131, Percent_Identity=48.8549618320611, Blast_Score=101, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320510, Length=162, Percent_Identity=41.358024691358, Blast_Score=99, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6321848, Length=158, Percent_Identity=41.1392405063291, Blast_Score=95, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6322492, Length=187, Percent_Identity=35.2941176470588, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17986117, Length=168, Percent_Identity=44.6428571428571, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI19922912, Length=170, Percent_Identity=48.2352941176471, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI19922376, Length=173, Percent_Identity=38.728323699422, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21357249, Length=171, Percent_Identity=38.5964912280702, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24650807, Length=159, Percent_Identity=44.6540880503145, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI20130249, Length=157, Percent_Identity=45.2229299363057, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24652460, Length=137, Percent_Identity=40.1459854014599, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17136360, Length=161, Percent_Identity=38.5093167701863, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45549139, Length=130, Percent_Identity=44.6153846153846, Blast_Score=93, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24586038, Length=166, Percent_Identity=37.9518072289157, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24664125, Length=160, Percent_Identity=37.5, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21357783, Length=160, Percent_Identity=37.5, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17647301, Length=159, Percent_Identity=35.2201257861635, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24661775, Length=162, Percent_Identity=33.9506172839506, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355237, Length=162, Percent_Identity=33.9506172839506, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24661771, Length=162, Percent_Identity=33.9506172839506, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355677, Length=179, Percent_Identity=26.2569832402235, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 19442; Mature: 19442

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2 ; PS00284 SERPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMMNGMTLKTATAILHTNRGDVSIELFGNHAPKTVENFVTLANGTAEYKTENASGTNEG
CEEECCEEEHEEEEEEECCCCCEEEEEECCCCCHHHHHEEEECCCCCEEEECCCCCCCCC
PFYDGAVFHRVIDGFMIQGGDPTGTGRGGPGYMFADEFHPELQFDRPFLLAMANAGPGTN
CCCCHHHHHHHHCCEEEECCCCCCCCCCCCCCEECCCCCCCCCCCCCEEEEEECCCCCCC
GSQFFITVVPTPHLNNHHTIFGEVTDAASQKVVLDIAQTATDRMDRPVEPVVIESVEITE
CCEEEEEEECCCCCCCCEEEEEEECCCCCCEEEEEHHHHHHHHCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MLMMNGMTLKTATAILHTNRGDVSIELFGNHAPKTVENFVTLANGTAEYKTENASGTNEG
CEEECCEEEHEEEEEEECCCCCEEEEEECCCCCHHHHHEEEECCCCCEEEECCCCCCCCC
PFYDGAVFHRVIDGFMIQGGDPTGTGRGGPGYMFADEFHPELQFDRPFLLAMANAGPGTN
CCCCHHHHHHHHCCEEEECCCCCCCCCCCCCCEECCCCCCCCCCCCCEEEEEECCCCCCC
GSQFFITVVPTPHLNNHHTIFGEVTDAASQKVVLDIAQTATDRMDRPVEPVVIESVEITE
CCEEEEEEECCCCCCCCEEEEEEECCCCCCEEEEEHHHHHHHHCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]