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The map label for this gene is sdhA [H]

Identifier: 21675074

GI number: 21675074

Start: 2134348

End: 2136288

Strand: Reverse

Name: sdhA [H]

Synonym: CT2267

Alternate gene names: 21675074

Gene position: 2136288-2134348 (Counterclockwise)

Preceding gene: 21675075

Following gene: 21675073

Centisome position: 99.13

GC content: 62.39

Gene sequence:

>1941_bases
ATGATACAACTGAACGCCAACGCGCCGGGCGTGCCGCTTGCCGACCAGTGGGACGCCTACAAGGCCGGTTGCAAGCTGGT
CAGCCCGAACAACAAGCGCAAGCTCGACATCATCGTGGTCGGTACGGGGCTTGCGGGTGCTTCGGCGGCGACGACGCTCG
GACAGCTCGGCTACAATGTTAAGTCGTTCTGCTATCAGGACACGCCGCGCCGCGCGCACAGTATCGCCGCGCAGGGGGGT
ATCAACGCCGCCAAGAACTACCAGAACGATGGCGACAACGTTTTCCGGCTCTTTTACGATACCATCAAGGGAGGGGACTA
CCGGTCGCGCGAATCGAACGTCTATCGGCTCGCTTCGATCAGCCCGGAGATCATTGACATTTGCGTGGCGCAAGGCGTGC
CCTTCGCCCGCGAATACGGCGGCCTGCTCGCCAACCGCTCCTTCGGCGGTGCCCAGGTGTCGCGCACATTCTACGCGCGG
GGGCAGACTGGCCAGCAGCTCCTGATCGGTGCGTACAGCGCGATGAGCCGCCAGATTGCCGCGGGCACGGTGCAGCTCTA
CAGCCGTCGCGACGTGCTTGACATCGTCGTCGTCGATGGCAAGGCGCGGGGCATCATCGCGAGGAATCTCGTCACCGGCG
AAATCGAGCGCCACTCGGCTCACGCCGTGGTGCTGGCCACGGGCGGCTACAGCAACGTTTTCTACCTCTCGACCAACGCG
ATGGGCTCGAACGCCACGCCAGCGTGGAGCGCCTATAAAAAGGGGGCGCTCTTCGCCAACCCCTGCTTCACGCAGATTCA
CCCCACCTGTATTCCGGTGCATGGCGAGTTCCAGTCGAAGCTCACGTTGATGAGCGAGAGCCTGCGCAACGACGGGCGCA
TCTGGGTGCCGAAGGAAAAGTCGGACGCCGAACTGATCCGGCAGAAAAAGCTGCGTCCGGAGCAGATTCACGAGTCGAAG
CGTGACTACTACCTCGAACGGCGCTACCCGGCCTTCGGCAACCTCGTGCCGCGCGATGTTGCTTCGCGGGCGGCCAAAGA
GCGCTGCGACGCGGGCTTCGGCGTCGGCTCGACCGGGCTGGCGGTCTATCTCGACTTCGGCGACGCCATCGAGCGGCTGG
GCCGAGCCGAAATCTCAGCCCGCTACGGCAACCTGTTCCAGATGTACCAGCGCATCGTCGATGACAATCCCTACCGCACG
CCGATGATGATCTACCCGGCGGTGCACTACACGATGGGCGGTTTGTGGGTCGATTACGAGCTGATGACCACCGTGCCGGG
CCTCTACTCAATCGGTGAATGCAACTTCTCCGACCACGGCGCGAATCGCCTCGGCGCCTCGGCCCTGATGCAAGGGCTCG
CCGACGGCTACTTCGTTTTGCCTTACACCATCTCGAACTACCTCTCGCACGAGATCAATACGCCGCCCATTCCGACCACG
CTGCCGGAGTTTCATCTTGCTGCCCGCGACGTAACCGACCGGCTCGACCGGCTCAAAAAGAGCAACGGCAAGGAGTCTGT
CGATCACTTCCACCGCAAGCTCGGCAAAATCATGTGGGAGTACTGCGGCATGTCACGCAACGAGGCTGGCTTGACGAAAG
CTCTCGGTCTGATAGAGGAACTGAAGGCGGAGTTCGCTTCGGGCGTGAATATCCCGGGCGGGCTGAAGGAGTACAATCCT
GAACTGGAAAAGGCGTGCCGCGTCGAGGATTTCATCGAACTCGGCGACCTCATGGTGCGCGACGCCTTGCACCGCAAGGA
GTCGTGCGGCGGCCACTTCCGCGAGGAGTACCAGACCCCCGACCACGAAGCGCTGCGCAACGATGATGAGTTCGCCTACG
TCGCTGCCTGGGAGTACAAGGGGCGCAACGACGAGCCGGAGATGCACCGCGAAGAGCTTCGCTTCGAGACGGTGACGCCA
TCGCAACGATCCTACAAATAA

Upstream 100 bases:

>100_bases
AGCACCGTTTACGCCATCGTCATCGCGGGCGGGTTTATGGCGATTCCGCTGCGCTTCACTTTGTTCAACTAATGCCGCGC
CGCATGGAGACCTGTCGCCA

Downstream 100 bases:

>100_bases
CCGTCGATCATGAAGTTCACTCTCAAAATCTGGCGGCAGAAAAACGCCGACGACAAAGGCCGGATGGTCAGCTACAAGGT
CGATGATATTTCGCCCGACA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MIQLNANAPGVPLADQWDAYKAGCKLVSPNNKRKLDIIVVGTGLAGASAATTLGQLGYNVKSFCYQDTPRRAHSIAAQGG
INAAKNYQNDGDNVFRLFYDTIKGGDYRSRESNVYRLASISPEIIDICVAQGVPFAREYGGLLANRSFGGAQVSRTFYAR
GQTGQQLLIGAYSAMSRQIAAGTVQLYSRRDVLDIVVVDGKARGIIARNLVTGEIERHSAHAVVLATGGYSNVFYLSTNA
MGSNATPAWSAYKKGALFANPCFTQIHPTCIPVHGEFQSKLTLMSESLRNDGRIWVPKEKSDAELIRQKKLRPEQIHESK
RDYYLERRYPAFGNLVPRDVASRAAKERCDAGFGVGSTGLAVYLDFGDAIERLGRAEISARYGNLFQMYQRIVDDNPYRT
PMMIYPAVHYTMGGLWVDYELMTTVPGLYSIGECNFSDHGANRLGASALMQGLADGYFVLPYTISNYLSHEINTPPIPTT
LPEFHLAARDVTDRLDRLKKSNGKESVDHFHRKLGKIMWEYCGMSRNEAGLTKALGLIEELKAEFASGVNIPGGLKEYNP
ELEKACRVEDFIELGDLMVRDALHRKESCGGHFREEYQTPDHEALRNDDEFAYVAAWEYKGRNDEPEMHREELRFETVTP
SQRSYK

Sequences:

>Translated_646_residues
MIQLNANAPGVPLADQWDAYKAGCKLVSPNNKRKLDIIVVGTGLAGASAATTLGQLGYNVKSFCYQDTPRRAHSIAAQGG
INAAKNYQNDGDNVFRLFYDTIKGGDYRSRESNVYRLASISPEIIDICVAQGVPFAREYGGLLANRSFGGAQVSRTFYAR
GQTGQQLLIGAYSAMSRQIAAGTVQLYSRRDVLDIVVVDGKARGIIARNLVTGEIERHSAHAVVLATGGYSNVFYLSTNA
MGSNATPAWSAYKKGALFANPCFTQIHPTCIPVHGEFQSKLTLMSESLRNDGRIWVPKEKSDAELIRQKKLRPEQIHESK
RDYYLERRYPAFGNLVPRDVASRAAKERCDAGFGVGSTGLAVYLDFGDAIERLGRAEISARYGNLFQMYQRIVDDNPYRT
PMMIYPAVHYTMGGLWVDYELMTTVPGLYSIGECNFSDHGANRLGASALMQGLADGYFVLPYTISNYLSHEINTPPIPTT
LPEFHLAARDVTDRLDRLKKSNGKESVDHFHRKLGKIMWEYCGMSRNEAGLTKALGLIEELKAEFASGVNIPGGLKEYNP
ELEKACRVEDFIELGDLMVRDALHRKESCGGHFREEYQTPDHEALRNDDEFAYVAAWEYKGRNDEPEMHREELRFETVTP
SQRSYK
>Mature_646_residues
MIQLNANAPGVPLADQWDAYKAGCKLVSPNNKRKLDIIVVGTGLAGASAATTLGQLGYNVKSFCYQDTPRRAHSIAAQGG
INAAKNYQNDGDNVFRLFYDTIKGGDYRSRESNVYRLASISPEIIDICVAQGVPFAREYGGLLANRSFGGAQVSRTFYAR
GQTGQQLLIGAYSAMSRQIAAGTVQLYSRRDVLDIVVVDGKARGIIARNLVTGEIERHSAHAVVLATGGYSNVFYLSTNA
MGSNATPAWSAYKKGALFANPCFTQIHPTCIPVHGEFQSKLTLMSESLRNDGRIWVPKEKSDAELIRQKKLRPEQIHESK
RDYYLERRYPAFGNLVPRDVASRAAKERCDAGFGVGSTGLAVYLDFGDAIERLGRAEISARYGNLFQMYQRIVDDNPYRT
PMMIYPAVHYTMGGLWVDYELMTTVPGLYSIGECNFSDHGANRLGASALMQGLADGYFVLPYTISNYLSHEINTPPIPTT
LPEFHLAARDVTDRLDRLKKSNGKESVDHFHRKLGKIMWEYCGMSRNEAGLTKALGLIEELKAEFASGVNIPGGLKEYNP
ELEKACRVEDFIELGDLMVRDALHRKESCGGHFREEYQTPDHEALRNDDEFAYVAAWEYKGRNDEPEMHREELRFETVTP
SQRSYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=565, Percent_Identity=26.5486725663717, Blast_Score=167, Evalue=3e-41,
Organism=Escherichia coli, GI1790597, Length=579, Percent_Identity=26.9430051813472, Blast_Score=191, Evalue=2e-49,
Organism=Escherichia coli, GI1788928, Length=595, Percent_Identity=25.7142857142857, Blast_Score=129, Evalue=7e-31,
Organism=Escherichia coli, GI1786942, Length=438, Percent_Identity=28.9954337899543, Blast_Score=124, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17505833, Length=556, Percent_Identity=28.0575539568345, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17550100, Length=552, Percent_Identity=26.8115942028986, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322701, Length=595, Percent_Identity=28.4033613445378, Blast_Score=180, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6322416, Length=593, Percent_Identity=26.8128161888702, Blast_Score=161, Evalue=3e-40,
Organism=Drosophila melanogaster, GI17137288, Length=555, Percent_Identity=27.2072072072072, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24655642, Length=555, Percent_Identity=27.2072072072072, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24655647, Length=555, Percent_Identity=27.2072072072072, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24663005, Length=600, Percent_Identity=26, Blast_Score=142, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 71942; Mature: 71942

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQLNANAPGVPLADQWDAYKAGCKLVSPNNKRKLDIIVVGTGLAGASAATTLGQLGYNV
CEEECCCCCCCCCCCCCCHHHCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCH
KSFCYQDTPRRAHSIAAQGGINAAKNYQNDGDNVFRLFYDTIKGGDYRSRESNVYRLASI
HHHHHCCCCHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECC
SPEIIDICVAQGVPFAREYGGLLANRSFGGAQVSRTFYARGQTGQQLLIGAYSAMSRQIA
CHHHHHHHHHCCCCHHHHHCCHHCCCCCCCHHHHHEEEECCCCCCHHHHHHHHHHHHHHH
AGTVQLYSRRDVLDIVVVDGKARGIIARNLVTGEIERHSAHAVVLATGGYSNVFYLSTNA
HHHHHHHCCCCEEEEEEECCCCCCEEEHHHEECCHHCCCCCEEEEEECCCCEEEEEEECC
MGSNATPAWSAYKKGALFANPCFTQIHPTCIPVHGEFQSKLTLMSESLRNDGRIWVPKEK
CCCCCCCCHHHHHCCCEEECCCHHCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCC
SDAELIRQKKLRPEQIHESKRDYYLERRYPAFGNLVPRDVASRAAKERCDAGFGVGSTGL
CHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCE
AVYLDFGDAIERLGRAEISARYGNLFQMYQRIVDDNPYRTPMMIYPAVHYTMGGLWVDYE
EEEEECHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHCCEEEEEE
LMTTVPGLYSIGECNFSDHGANRLGASALMQGLADGYFVLPYTISNYLSHEINTPPIPTT
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHCCCCCCCCCCC
LPEFHLAARDVTDRLDRLKKSNGKESVDHFHRKLGKIMWEYCGMSRNEAGLTKALGLIEE
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LKAEFASGVNIPGGLKEYNPELEKACRVEDFIELGDLMVRDALHRKESCGGHFREEYQTP
HHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCC
DHEALRNDDEFAYVAAWEYKGRNDEPEMHREELRFETVTPSQRSYK
CHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHCEEECCCCCCCCC
>Mature Secondary Structure
MIQLNANAPGVPLADQWDAYKAGCKLVSPNNKRKLDIIVVGTGLAGASAATTLGQLGYNV
CEEECCCCCCCCCCCCCCHHHCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCH
KSFCYQDTPRRAHSIAAQGGINAAKNYQNDGDNVFRLFYDTIKGGDYRSRESNVYRLASI
HHHHHCCCCHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECC
SPEIIDICVAQGVPFAREYGGLLANRSFGGAQVSRTFYARGQTGQQLLIGAYSAMSRQIA
CHHHHHHHHHCCCCHHHHHCCHHCCCCCCCHHHHHEEEECCCCCCHHHHHHHHHHHHHHH
AGTVQLYSRRDVLDIVVVDGKARGIIARNLVTGEIERHSAHAVVLATGGYSNVFYLSTNA
HHHHHHHCCCCEEEEEEECCCCCCEEEHHHEECCHHCCCCCEEEEEECCCCEEEEEEECC
MGSNATPAWSAYKKGALFANPCFTQIHPTCIPVHGEFQSKLTLMSESLRNDGRIWVPKEK
CCCCCCCCHHHHHCCCEEECCCHHCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCC
SDAELIRQKKLRPEQIHESKRDYYLERRYPAFGNLVPRDVASRAAKERCDAGFGVGSTGL
CHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCE
AVYLDFGDAIERLGRAEISARYGNLFQMYQRIVDDNPYRTPMMIYPAVHYTMGGLWVDYE
EEEEECHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHCCEEEEEE
LMTTVPGLYSIGECNFSDHGANRLGASALMQGLADGYFVLPYTISNYLSHEINTPPIPTT
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHCCCCCCCCCCC
LPEFHLAARDVTDRLDRLKKSNGKESVDHFHRKLGKIMWEYCGMSRNEAGLTKALGLIEE
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LKAEFASGVNIPGGLKEYNPELEKACRVEDFIELGDLMVRDALHRKESCGGHFREEYQTP
HHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCC
DHEALRNDDEFAYVAAWEYKGRNDEPEMHREELRFETVTPSQRSYK
CHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]