Click here to switch to the map view.

The map label for this gene is manC [H]

Identifier: 21674968

GI number: 21674968

Start: 2047201

End: 2048325

Strand: Reverse

Name: manC [H]

Synonym: CT2159

Alternate gene names: 21674968

Gene position: 2048325-2047201 (Counterclockwise)

Preceding gene: 21674970

Following gene: 21674966

Centisome position: 95.05

GC content: 54.76

Gene sequence:

>1125_bases
ATGAAGCAGATTGCCGACAAACATGTCTATGCGGTGGTTATGGCCGGAGGTATAGGCAGCAAGCTCTGGCCTCTTTCGAG
AAAGAAATCCCCAAAGCAGTTTCTCCATTTCTTCGACGGCGGAACGATGATCCGGAAAACGGTCGAAAGAATTGCCGGTG
CCGTCCGGAGAGAGAACATTCTCATCATCACCGGCAAGCAGCATAGGCGCCTGGTCAACGACTCGCTTCCCGATTTCGAT
GTCGATAACATCATTATCGAACCCACCATCAAGGATACGGCCACCTGCATCGCGCTGGCCACGACCTTCATTCGCAAGCG
CGATCCCGACGCTGTCACTATCGTACTGCCTGCCGACCATCTCGTGCTTGACGAAGAGCATTTCCTGAAGACGGTCTCCA
AGGGCGTCAGACTTGCGCGGAAACAGAGAGGGCTGATCACGGTCGGCATCCATCCTGACAGGCCTGAGACGCGATATGGA
TATATCCAGGTCGAACCATCGGTTATGATCGGGGAGGAAAACGACGATCCGGATGACGATGACATTGCACTCTTCCGGGT
GAAAACCTTTGCCGAGAAACCCGATCTGGCTACTGCCGAGCATTTTTTGCAAAGCCAGGACTTCTGGTGGAACAGTGGCG
TGTTCATCTGGCACGTCGATGACATTAGCCGGGAGTACAGCCGCTCGTTGCCCGATCTGTATGAAGATATGCAGAACGTT
CACGCCTTTATCGGTACCGAGCGGCAGGAGTCGGTCATCGAGGATGTCTATAGCTGGGTTCACCCTGTTTCGATTGCCTA
CGGCATCATGGAAAAGGCTGAGAAGGTCTATATGCTTGCCGGGAATTTTGGCTGGACCGATCTTGGATGCTGGGACGAGG
TGATCAAGATTGGTCTTGGCCTCGAAGGACGCGACATGGATGGCAGCGAGTCGATCATGATCGACTCGAAAAACGTCTTT
GTCCGGAAGCCCCATGGCAAGGCGGTGGTGAGCATCGGCGTGGATGACATTATCGTGGTCGATACGCCCGACGCGCTGCT
TATCTGCAAGGCGGGCGAGTCGCAAAAGGTGGTCAAAGCGGTTGAGATGATGAGGCGGGAGCCGGGGTTGGAGGGGTTCC
TGTAG

Upstream 100 bases:

>100_bases
TGCCCCGGGGAAATGCCCGTCGGCACTGGTGGAAAATGTCGTACATTAACAAAAAAGGATTTTTGGTGAAAGCGTTGTAA
GATCAGCAAGATTATGAAGT

Downstream 100 bases:

>100_bases
GATGATGTGGGGTGGTCAGAGAAAAAAAGAAAGCCGGAGCACAACCTCCGGCTTTCTTTTTTTCAGGCTTTTTTCTTTGA
CCACGTTGCGCCTTCCCTGG

Product: mannose-1-phosphate guanylyltransferase, putative

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MKQIADKHVYAVVMAGGIGSKLWPLSRKKSPKQFLHFFDGGTMIRKTVERIAGAVRRENILIITGKQHRRLVNDSLPDFD
VDNIIIEPTIKDTATCIALATTFIRKRDPDAVTIVLPADHLVLDEEHFLKTVSKGVRLARKQRGLITVGIHPDRPETRYG
YIQVEPSVMIGEENDDPDDDDIALFRVKTFAEKPDLATAEHFLQSQDFWWNSGVFIWHVDDISREYSRSLPDLYEDMQNV
HAFIGTERQESVIEDVYSWVHPVSIAYGIMEKAEKVYMLAGNFGWTDLGCWDEVIKIGLGLEGRDMDGSESIMIDSKNVF
VRKPHGKAVVSIGVDDIIVVDTPDALLICKAGESQKVVKAVEMMRREPGLEGFL

Sequences:

>Translated_374_residues
MKQIADKHVYAVVMAGGIGSKLWPLSRKKSPKQFLHFFDGGTMIRKTVERIAGAVRRENILIITGKQHRRLVNDSLPDFD
VDNIIIEPTIKDTATCIALATTFIRKRDPDAVTIVLPADHLVLDEEHFLKTVSKGVRLARKQRGLITVGIHPDRPETRYG
YIQVEPSVMIGEENDDPDDDDIALFRVKTFAEKPDLATAEHFLQSQDFWWNSGVFIWHVDDISREYSRSLPDLYEDMQNV
HAFIGTERQESVIEDVYSWVHPVSIAYGIMEKAEKVYMLAGNFGWTDLGCWDEVIKIGLGLEGRDMDGSESIMIDSKNVF
VRKPHGKAVVSIGVDDIIVVDTPDALLICKAGESQKVVKAVEMMRREPGLEGFL
>Mature_374_residues
MKQIADKHVYAVVMAGGIGSKLWPLSRKKSPKQFLHFFDGGTMIRKTVERIAGAVRRENILIITGKQHRRLVNDSLPDFD
VDNIIIEPTIKDTATCIALATTFIRKRDPDAVTIVLPADHLVLDEEHFLKTVSKGVRLARKQRGLITVGIHPDRPETRYG
YIQVEPSVMIGEENDDPDDDDIALFRVKTFAEKPDLATAEHFLQSQDFWWNSGVFIWHVDDISREYSRSLPDLYEDMQNV
HAFIGTERQESVIEDVYSWVHPVSIAYGIMEKAEKVYMLAGNFGWTDLGCWDEVIKIGLGLEGRDMDGSESIMIDSKNVF
VRKPHGKAVVSIGVDDIIVVDTPDALLICKAGESQKVVKAVEMMRREPGLEGFL

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=367, Percent_Identity=33.7874659400545, Blast_Score=187, Evalue=7e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 42192; Mature: 42192

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQIADKHVYAVVMAGGIGSKLWPLSRKKSPKQFLHFFDGGTMIRKTVERIAGAVRRENI
CCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCE
LIITGKQHRRLVNDSLPDFDVDNIIIEPTIKDTATCIALATTFIRKRDPDAVTIVLPADH
EEEECCHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCC
LVLDEEHFLKTVSKGVRLARKQRGLITVGIHPDRPETRYGYIQVEPSVMIGEENDDPDDD
EEECHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEEEEECCEEEECCCCCCCCCC
DIALFRVKTFAEKPDLATAEHFLQSQDFWWNSGVFIWHVDDISREYSRSLPDLYEDMQNV
CEEEEEEEECCCCCCHHHHHHHHCCCCCEEECCEEEEEEHHHHHHHHHCCHHHHHHHHHH
HAFIGTERQESVIEDVYSWVHPVSIAYGIMEKAEKVYMLAGNFGWTDLGCWDEVIKIGLG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHCCC
LEGRDMDGSESIMIDSKNVFVRKPHGKAVVSIGVDDIIVVDTPDALLICKAGESQKVVKA
CCCCCCCCCCEEEEECCCEEEECCCCCEEEEECCCCEEEEECCCEEEEEECCCCHHHHHH
VEMMRREPGLEGFL
HHHHHHCCCCCCCC
>Mature Secondary Structure
MKQIADKHVYAVVMAGGIGSKLWPLSRKKSPKQFLHFFDGGTMIRKTVERIAGAVRRENI
CCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCE
LIITGKQHRRLVNDSLPDFDVDNIIIEPTIKDTATCIALATTFIRKRDPDAVTIVLPADH
EEEECCHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCC
LVLDEEHFLKTVSKGVRLARKQRGLITVGIHPDRPETRYGYIQVEPSVMIGEENDDPDDD
EEECHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCEEEEEEECCEEEECCCCCCCCCC
DIALFRVKTFAEKPDLATAEHFLQSQDFWWNSGVFIWHVDDISREYSRSLPDLYEDMQNV
CEEEEEEEECCCCCCHHHHHHHHCCCCCEEECCEEEEEEHHHHHHHHHCCHHHHHHHHHH
HAFIGTERQESVIEDVYSWVHPVSIAYGIMEKAEKVYMLAGNFGWTDLGCWDEVIKIGLG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHCCC
LEGRDMDGSESIMIDSKNVFVRKPHGKAVVSIGVDDIIVVDTPDALLICKAGESQKVVKA
CCCCCCCCCCEEEEECCCEEEECCCCCEEEEECCCCEEEEECCCEEEEEECCCCHHHHHH
VEMMRREPGLEGFL
HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]