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The map label for this gene is etfA [H]

Identifier: 21674950

GI number: 21674950

Start: 2024388

End: 2025296

Strand: Reverse

Name: etfA [H]

Synonym: CT2141

Alternate gene names: 21674950

Gene position: 2025296-2024388 (Counterclockwise)

Preceding gene: 21674951

Following gene: 21674949

Centisome position: 93.98

GC content: 66.23

Gene sequence:

>909_bases
ATGAAGCTGCTGCTTGTTGGCGAAGTTCGCGACGGTCGCGTCACCGCCGAAACCGCCGAGTTGTTCGGATTCGCAGCTTG
TTTTTCTGCGGAGGTTTCGATGGTGCTGGCTGGATCGACTGACGATTTGCCCTCATTCGAGGGAAAGCTCTATCGCGCGG
ATGGCGTGAACGCGTTCGATCTTGCCTGTCACAAACGGCTTGTGCTGGCCGCCGTCGAGCGTGAGCAGCCGGACGCCGTG
GTGTTTCTGCACTCCTCGCATGGCTGGGAACTCGCGCCGCGCGTGGCGTTTGCGATGCAGTCGGCTCAGGTGTCCGGGGT
TGTGGGACTCGACGACGGCGGCTACGTGGTCGAAAGCTGCAACGGCAAGATGCGCCGCACCGTCAAGCCGCTGACCGACC
GCGTTGTGCTGACGCTTCAGCTGGGCGCGTTCGATGCTCCGGCGATGGCGGGGATTCCCGAAGTGACCGCTCTCGATGTC
GAACCGGATTCGACCATCGAGTTTCTCGATTGCGTCCAGCCTGAGCGGGGTATCGATCTGACTCGCGCAGGGGTGATTGT
CAGTGCCGGGCGCGGCGTCGGGAGCGCGGAGCGCGTCGAGCTGGTGCGGGCGCTCGCCGATGCGCTCGGCGGCGAAGTCG
GCGCGAGCCGCCCGGTGGTCGATGCCGGATGGCTCGAACGGGCGCGGCAGGTGGGGTCGAGCGGCCAGAGCGTTTCGCCC
GCGCTCTACGTGGCGTGCGGCATCTCCGGTGCGATCCAGCATCTTGCCGGAATGAAAGGCTCCGGCTTTGTGCTCGCCAT
CAACACCGACCGCGACACGCCCATCACGAGCGTGGCCGACGTGCTCGCCGTCGCCGACGTGGCCGAGTTCCTGTCCGCCC
TGACGGCGGCGATTCGGGCGAGGCGGTGA

Upstream 100 bases:

>100_bases
GTGCGGGTGTGATTCTCGAGGGCGACGCCGGGGCGATGGCTGCTCGGGTGCTTGAAATTCTCGAAGCTAAAGGGCTCGTT
TCCGGCAAAGGAGGTGCGCG

Downstream 100 bases:

>100_bases
GCGGGCAGTTTTTTCAACGACAATCAAAACGCGGATGAATCAGCAAACCTACGCCTTCACGCTTGAAATGGAGGTGCGCG
ACTACGAGTGCGACATGCAG

Product: electron transfer flavoprotein, alpha subunit

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MKLLLVGEVRDGRVTAETAELFGFAACFSAEVSMVLAGSTDDLPSFEGKLYRADGVNAFDLACHKRLVLAAVEREQPDAV
VFLHSSHGWELAPRVAFAMQSAQVSGVVGLDDGGYVVESCNGKMRRTVKPLTDRVVLTLQLGAFDAPAMAGIPEVTALDV
EPDSTIEFLDCVQPERGIDLTRAGVIVSAGRGVGSAERVELVRALADALGGEVGASRPVVDAGWLERARQVGSSGQSVSP
ALYVACGISGAIQHLAGMKGSGFVLAINTDRDTPITSVADVLAVADVAEFLSALTAAIRARR

Sequences:

>Translated_302_residues
MKLLLVGEVRDGRVTAETAELFGFAACFSAEVSMVLAGSTDDLPSFEGKLYRADGVNAFDLACHKRLVLAAVEREQPDAV
VFLHSSHGWELAPRVAFAMQSAQVSGVVGLDDGGYVVESCNGKMRRTVKPLTDRVVLTLQLGAFDAPAMAGIPEVTALDV
EPDSTIEFLDCVQPERGIDLTRAGVIVSAGRGVGSAERVELVRALADALGGEVGASRPVVDAGWLERARQVGSSGQSVSP
ALYVACGISGAIQHLAGMKGSGFVLAINTDRDTPITSVADVLAVADVAEFLSALTAAIRARR
>Mature_302_residues
MKLLLVGEVRDGRVTAETAELFGFAACFSAEVSMVLAGSTDDLPSFEGKLYRADGVNAFDLACHKRLVLAAVEREQPDAV
VFLHSSHGWELAPRVAFAMQSAQVSGVVGLDDGGYVVESCNGKMRRTVKPLTDRVVLTLQLGAFDAPAMAGIPEVTALDV
EPDSTIEFLDCVQPERGIDLTRAGVIVSAGRGVGSAERVELVRALADALGGEVGASRPVVDAGWLERARQVGSSGQSVSP
ALYVACGISGAIQHLAGMKGSGFVLAINTDRDTPITSVADVLAVADVAEFLSALTAAIRARR

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI189181759, Length=222, Percent_Identity=39.1891891891892, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI4503607, Length=240, Percent_Identity=37.5, Blast_Score=126, Evalue=2e-29,
Organism=Escherichia coli, GI1786226, Length=172, Percent_Identity=38.3720930232558, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787990, Length=301, Percent_Identity=28.2392026578073, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI87082157, Length=233, Percent_Identity=30.4721030042918, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17506929, Length=313, Percent_Identity=33.2268370607029, Blast_Score=128, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6325261, Length=226, Percent_Identity=33.1858407079646, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17136898, Length=310, Percent_Identity=33.8709677419355, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24652801, Length=310, Percent_Identity=33.8709677419355, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 31552; Mature: 31552

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLLVGEVRDGRVTAETAELFGFAACFSAEVSMVLAGSTDDLPSFEGKLYRADGVNAFD
CEEEEEEECCCCEEEHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEECCCCCHHH
LACHKRLVLAAVEREQPDAVVFLHSSHGWELAPRVAFAMQSAQVSGVVGLDDGGYVVESC
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCEEEECC
NGKMRRTVKPLTDRVVLTLQLGAFDAPAMAGIPEVTALDVEPDSTIEFLDCVQPERGIDL
CCCHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCCCCE
TRAGVIVSAGRGVGSAERVELVRALADALGGEVGASRPVVDAGWLERARQVGSSGQSVSP
ECCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
ALYVACGISGAIQHLAGMKGSGFVLAINTDRDTPITSVADVLAVADVAEFLSALTAAIRA
EEEEEECCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
RR
CC
>Mature Secondary Structure
MKLLLVGEVRDGRVTAETAELFGFAACFSAEVSMVLAGSTDDLPSFEGKLYRADGVNAFD
CEEEEEEECCCCEEEHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCEEEECCCCCHHH
LACHKRLVLAAVEREQPDAVVFLHSSHGWELAPRVAFAMQSAQVSGVVGLDDGGYVVESC
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCEEEECC
NGKMRRTVKPLTDRVVLTLQLGAFDAPAMAGIPEVTALDVEPDSTIEFLDCVQPERGIDL
CCCHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCCCCE
TRAGVIVSAGRGVGSAERVELVRALADALGGEVGASRPVVDAGWLERARQVGSSGQSVSP
ECCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
ALYVACGISGAIQHLAGMKGSGFVLAINTDRDTPITSVADVLAVADVAEFLSALTAAIRA
EEEEEECCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
RR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]