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The map label for this gene is mutL

Identifier: 21674838

GI number: 21674838

Start: 1923782

End: 1925656

Strand: Reverse

Name: mutL

Synonym: CT2028

Alternate gene names: 21674838

Gene position: 1925656-1923782 (Counterclockwise)

Preceding gene: 21674839

Following gene: 21674837

Centisome position: 89.36

GC content: 58.03

Gene sequence:

>1875_bases
ATGGCTTCCATTGCAAGACTTCCTGATATTGTCGCTAACAAAATTTCAGCTGGCGAGGTGGTGCAGCGCCCTGCCTCGGT
GGTCAAGGAGCTGATCGAAAACTCCATTGACGCCGGCGCGAGCCGCATCACCGTCATCATAAAAGATGCCGGGCGGCAGC
TCGTGCAGATCATCGATAATGGCTGCGGCATGGAGAGCGACGATGTGCTGCTCAGCGTTGAGCGCTTTGCCACCAGCAAG
ATTTCTGAGGTTGACGACCTTGACGCGCTCCGTACGCTCGGCTTCCGTGGCGAGGCGCTGGCGAGCATCTCCTCGGTCTC
ACATTTCGAGTTGAAGACTCGCAAGGCAGGCAATTCGCTCGGTACGCTGCTCAGGAGCGACGGCGGCGTCATCGAAACAC
CGCAACCCGCGCAGTGCGAACCCGGCACCTCCATCGCTGTCCGGAACCTCTTTTTTAACGTGCCCGCCCGGCGCAAGTTC
CTCAAATCCAACGCTACCGAGTTCAAGCACATCCATGAGACGGTCAAGGCGTTCGTGCTCTCCTATCCCGAGATCGAGTG
GCGGATGATGAACGATGACGAGGAGCTGTTCCACTTCCGCACCTCCGACGTGCGCGAGCGGCTGAGCCACTTTTATGGGG
AGGGATTCGGCGAGAGCCTCATCGAGGTGACCGAGGAGAATGACTACATGACTATCGGCGGCTACCTCGGCAAGCCAGGC
ATGATGGTGCGGCAGAAGTACGATCAGTACTTTTTTATCAACCGGCGCCTCATCCAGAACCGGATGCTCGTGCAGGCGGT
GCAGCAGGCTTATGGCGAGCTGCTCGAAGAGCGGCAGTCGCCATTCGCATTGCTCTTTCTCGGTCTCGACCCGTCGCTGG
TGGATGTGAATGTCCATCCGGCCAAGCTCGAAGTGCGTTTCGAGGATGAAAAAAGCATCCGGAGCATGGTTTATCCGGTG
GTCAAGCGAGCCGTCCGAACGGCTGATTTTTCATCCGAGGCGTCGTTTGCGGCTCCATCCGCACCCACAGTTTCCGGCGA
GGTTGACTTGCCGGAAGTTTCGTCGCGGAAGCTTTCGTATTCCTCGTTTTCAGGCAAAGCGTCGACCACCGGCGATCTGT
ACCGGAACTACCGGGCGGGAGCGTTCAGTGCTCCTTCATCCGTTTCTCCGATGCTTTTCGATTCTTCGCTGGAAACATCG
CTGTCCGCCGGAAGTCGCCCCACTCCGATGGTTCAGGAGTCGCTGCTGACCCCGTCGGTGGACCAGCCCGATACCGGTGA
CGGGGAGAATCCGGTTGCGCCGGAGAAGGAACCGAAAATCTGGCAGTTGCACAACAAGTACATCATCTGCCAGATCAAGA
CCGGGCTGATGATTATCGACCAGCATGTGGCGCACGAGCGGGTGCTCTACGAACGCGCCATCGACATCATGAACGAGGCC
GCGCCGAATTCGCAGCAGTTGCTTTTTCCGCAGAAGATCGACCTCAAACCGTGGCAGTACGAGGTTTTCGAGGAGATCAG
CGACGAGTTGTACCGGCTCGGCTTTAACATTCGGCCGTTTGGCGGCATGAGCGTCATGATCGAGGGGGTGCCGCCCGACG
TGCGAGACGGCGCGGAGGCAACGATTTTACAGGATATGATCGCCGAGTACCAGGAGAACGCCGCGAAGCTGAAGCTCGAA
AAGCGCGACAACCTCGCCAAATCCTACTCTTGCCGCAATGCTATCATGACTGGCCAGAAGCTCAGTGTTGAAGAGATGCG
AATGCTCATCGACCGCCTTTTCGCCACCCGGATGCCCTATGTCTGTCCGCACGGTCGTCCGGTGATCATAAGGCTTTCAC
TCGGCGAACTCGACCGCATGTTCGGAAGAACATAG

Upstream 100 bases:

>100_bases
TTCAAAAGCTTCCGGAATATGCCACATTTGTCGAATGATACTTATGACCTGGGAGTGCCCCGAACGAGACTGGATTCATT
GAAAACCGTGTGTTCATTGT

Downstream 100 bases:

>100_bases
GAGCGGTTAGCCGCGAATGTTGCGGACATCGTGGATCAAAAAAGATATGAAAAAAGCCGAGGGCCTCTTTTCAGAGGTTT
GTTTCCTGAAAAATAAGTTC

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MASIARLPDIVANKISAGEVVQRPASVVKELIENSIDAGASRITVIIKDAGRQLVQIIDNGCGMESDDVLLSVERFATSK
ISEVDDLDALRTLGFRGEALASISSVSHFELKTRKAGNSLGTLLRSDGGVIETPQPAQCEPGTSIAVRNLFFNVPARRKF
LKSNATEFKHIHETVKAFVLSYPEIEWRMMNDDEELFHFRTSDVRERLSHFYGEGFGESLIEVTEENDYMTIGGYLGKPG
MMVRQKYDQYFFINRRLIQNRMLVQAVQQAYGELLEERQSPFALLFLGLDPSLVDVNVHPAKLEVRFEDEKSIRSMVYPV
VKRAVRTADFSSEASFAAPSAPTVSGEVDLPEVSSRKLSYSSFSGKASTTGDLYRNYRAGAFSAPSSVSPMLFDSSLETS
LSAGSRPTPMVQESLLTPSVDQPDTGDGENPVAPEKEPKIWQLHNKYIICQIKTGLMIIDQHVAHERVLYERAIDIMNEA
APNSQQLLFPQKIDLKPWQYEVFEEISDELYRLGFNIRPFGGMSVMIEGVPPDVRDGAEATILQDMIAEYQENAAKLKLE
KRDNLAKSYSCRNAIMTGQKLSVEEMRMLIDRLFATRMPYVCPHGRPVIIRLSLGELDRMFGRT

Sequences:

>Translated_624_residues
MASIARLPDIVANKISAGEVVQRPASVVKELIENSIDAGASRITVIIKDAGRQLVQIIDNGCGMESDDVLLSVERFATSK
ISEVDDLDALRTLGFRGEALASISSVSHFELKTRKAGNSLGTLLRSDGGVIETPQPAQCEPGTSIAVRNLFFNVPARRKF
LKSNATEFKHIHETVKAFVLSYPEIEWRMMNDDEELFHFRTSDVRERLSHFYGEGFGESLIEVTEENDYMTIGGYLGKPG
MMVRQKYDQYFFINRRLIQNRMLVQAVQQAYGELLEERQSPFALLFLGLDPSLVDVNVHPAKLEVRFEDEKSIRSMVYPV
VKRAVRTADFSSEASFAAPSAPTVSGEVDLPEVSSRKLSYSSFSGKASTTGDLYRNYRAGAFSAPSSVSPMLFDSSLETS
LSAGSRPTPMVQESLLTPSVDQPDTGDGENPVAPEKEPKIWQLHNKYIICQIKTGLMIIDQHVAHERVLYERAIDIMNEA
APNSQQLLFPQKIDLKPWQYEVFEEISDELYRLGFNIRPFGGMSVMIEGVPPDVRDGAEATILQDMIAEYQENAAKLKLE
KRDNLAKSYSCRNAIMTGQKLSVEEMRMLIDRLFATRMPYVCPHGRPVIIRLSLGELDRMFGRT
>Mature_623_residues
ASIARLPDIVANKISAGEVVQRPASVVKELIENSIDAGASRITVIIKDAGRQLVQIIDNGCGMESDDVLLSVERFATSKI
SEVDDLDALRTLGFRGEALASISSVSHFELKTRKAGNSLGTLLRSDGGVIETPQPAQCEPGTSIAVRNLFFNVPARRKFL
KSNATEFKHIHETVKAFVLSYPEIEWRMMNDDEELFHFRTSDVRERLSHFYGEGFGESLIEVTEENDYMTIGGYLGKPGM
MVRQKYDQYFFINRRLIQNRMLVQAVQQAYGELLEERQSPFALLFLGLDPSLVDVNVHPAKLEVRFEDEKSIRSMVYPVV
KRAVRTADFSSEASFAAPSAPTVSGEVDLPEVSSRKLSYSSFSGKASTTGDLYRNYRAGAFSAPSSVSPMLFDSSLETSL
SAGSRPTPMVQESLLTPSVDQPDTGDGENPVAPEKEPKIWQLHNKYIICQIKTGLMIIDQHVAHERVLYERAIDIMNEAA
PNSQQLLFPQKIDLKPWQYEVFEEISDELYRLGFNIRPFGGMSVMIEGVPPDVRDGAEATILQDMIAEYQENAAKLKLEK
RDNLAKSYSCRNAIMTGQKLSVEEMRMLIDRLFATRMPYVCPHGRPVIIRLSLGELDRMFGRT

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=349, Percent_Identity=36.3896848137536, Blast_Score=213, Evalue=6e-55,
Organism=Homo sapiens, GI4505913, Length=330, Percent_Identity=31.2121212121212, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI310128478, Length=330, Percent_Identity=31.2121212121212, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI4505911, Length=325, Percent_Identity=28.3076923076923, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI189458898, Length=325, Percent_Identity=28.3076923076923, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI189458896, Length=317, Percent_Identity=28.0757097791798, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI91992162, Length=255, Percent_Identity=31.7647058823529, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI91992160, Length=255, Percent_Identity=31.7647058823529, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI263191589, Length=255, Percent_Identity=31.3725490196078, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI310128480, Length=296, Percent_Identity=29.3918918918919, Blast_Score=110, Evalue=4e-24,
Organism=Escherichia coli, GI1790612, Length=321, Percent_Identity=40.4984423676012, Blast_Score=243, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=32.6086956521739, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17562796, Length=412, Percent_Identity=28.1553398058252, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323819, Length=349, Percent_Identity=32.6647564469914, Blast_Score=190, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6324247, Length=412, Percent_Identity=25, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6325093, Length=284, Percent_Identity=26.7605633802817, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323063, Length=153, Percent_Identity=30.718954248366, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17136968, Length=316, Percent_Identity=35.7594936708861, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI17136970, Length=172, Percent_Identity=37.7906976744186, Blast_Score=113, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_CHLTE (Q8KAX3)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662903.1
- ProteinModelPortal:   Q8KAX3
- SMR:   Q8KAX3
- GeneID:   1007532
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT2028
- NMPDR:   fig|194439.1.peg.1997
- TIGR:   CT2028
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- ProtClustDB:   CLSK638049
- BioCyc:   CTEP194439:CT_2028-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 69838; Mature: 69706

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASIARLPDIVANKISAGEVVQRPASVVKELIENSIDAGASRITVIIKDAGRQLVQIIDN
CCCHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHC
GCGMESDDVLLSVERFATSKISEVDDLDALRTLGFRGEALASISSVSHFELKTRKAGNSL
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHH
GTLLRSDGGVIETPQPAQCEPGTSIAVRNLFFNVPARRKFLKSNATEFKHIHETVKAFVL
HHHHHCCCCEECCCCCCCCCCCCHHEEHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHH
SYPEIEWRMMNDDEELFHFRTSDVRERLSHFYGEGFGESLIEVTEENDYMTIGGYLGKPG
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECCCCCCCC
MMVRQKYDQYFFINRRLIQNRMLVQAVQQAYGELLEERQSPFALLFLGLDPSLVDVNVHP
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECC
AKLEVRFEDEKSIRSMVYPVVKRAVRTADFSSEASFAAPSAPTVSGEVDLPEVSSRKLSY
EEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SSFSGKASTTGDLYRNYRAGAFSAPSSVSPMLFDSSLETSLSAGSRPTPMVQESLLTPSV
CCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHCCCCCCCHHHHHHHCCCCC
DQPDTGDGENPVAPEKEPKIWQLHNKYIICQIKTGLMIIDQHVAHERVLYERAIDIMNEA
CCCCCCCCCCCCCCCCCCCEEEECCCEEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHC
APNSQQLLFPQKIDLKPWQYEVFEEISDELYRLGFNIRPFGGMSVMIEGVPPDVRDGAEA
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHH
TILQDMIAEYQENAAKLKLEKRDNLAKSYSCRNAIMTGQKLSVEEMRMLIDRLFATRMPY
HHHHHHHHHHHCCHHEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
VCPHGRPVIIRLSLGELDRMFGRT
CCCCCCEEEEEECHHHHHHHHCCC
>Mature Secondary Structure 
ASIARLPDIVANKISAGEVVQRPASVVKELIENSIDAGASRITVIIKDAGRQLVQIIDN
CCHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHC
GCGMESDDVLLSVERFATSKISEVDDLDALRTLGFRGEALASISSVSHFELKTRKAGNSL
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHH
GTLLRSDGGVIETPQPAQCEPGTSIAVRNLFFNVPARRKFLKSNATEFKHIHETVKAFVL
HHHHHCCCCEECCCCCCCCCCCCHHEEHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHH
SYPEIEWRMMNDDEELFHFRTSDVRERLSHFYGEGFGESLIEVTEENDYMTIGGYLGKPG
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEECCCCCCCC
MMVRQKYDQYFFINRRLIQNRMLVQAVQQAYGELLEERQSPFALLFLGLDPSLVDVNVHP
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECC
AKLEVRFEDEKSIRSMVYPVVKRAVRTADFSSEASFAAPSAPTVSGEVDLPEVSSRKLSY
EEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SSFSGKASTTGDLYRNYRAGAFSAPSSVSPMLFDSSLETSLSAGSRPTPMVQESLLTPSV
CCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHCCCCCCCHHHHHHHCCCCC
DQPDTGDGENPVAPEKEPKIWQLHNKYIICQIKTGLMIIDQHVAHERVLYERAIDIMNEA
CCCCCCCCCCCCCCCCCCCEEEECCCEEEEEEECCEEEEHHHHHHHHHHHHHHHHHHHHC
APNSQQLLFPQKIDLKPWQYEVFEEISDELYRLGFNIRPFGGMSVMIEGVPPDVRDGAEA
CCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHH
TILQDMIAEYQENAAKLKLEKRDNLAKSYSCRNAIMTGQKLSVEEMRMLIDRLFATRMPY
HHHHHHHHHHHCCHHEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
VCPHGRPVIIRLSLGELDRMFGRT
CCCCCCEEEEEECHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901