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The map label for this gene is alr

Identifier: 21674734

GI number: 21674734

Start: 1817496

End: 1818647

Strand: Direct

Name: alr

Synonym: CT1922

Alternate gene names: 21674734

Gene position: 1817496-1818647 (Clockwise)

Preceding gene: 21674728

Following gene: 21674735

Centisome position: 84.34

GC content: 61.72

Gene sequence:

>1152_bases
GTGAGCGCCAGTCACGAACAGAACTCCGCCGCCGCGCCGAACGGCCCTAACCTTTCGGAAGCGCTCATTTCACTCGGCAA
TCTCCGCCACAACCTCGCCTGCATCCGCGCCATCACCGGGCCGCAATGCCGTGTCATGGGCATCGTCAAGGCCAACGCCT
ATGGTCACGGAGCCACGCAGGTCACGGCAACGCTCGAAGCAGAGGGAGTGCGGGATTTCGGCGTGGCCAACATTTACGAA
GCGATCGAACTTCTTCAGGAGCACCGGATGCTGCCGGACTCGCGCATCCTCGCTTTCGCCTCGCCTCTCGCCGGACATAT
CGATCTGTATCTGCAACACGGCGTGGAAATGACCGTCTGCGACCACGAAACTGCCCGAGCTGCCGAATCGATTGCCGCCG
CATGCGGTAGACGGCTCCAGGTGCAGCTCAAGGTCGATACCGGCATGGGGCGGCTCGGCGTCACGCCCGAAGAAGCAGCG
GAACTGCTGGAGCTGATCGAGGCCTGCCCGAACCTTGAGTTGACCGGCATCTACACCCATTTCGCTGAAAGCGACAAGCC
TGAAGGATTCACTGCCCGGCAACTCGAACGTTTCCTGCACGTAACCGGCGCTTACGAGCGTCGAACGGGCAAAACCGTGA
CGAAGCATGCGGCAAACAGCGGAGCCATTATCTCGATGCCAGACGCACGGCTCGACATGGTGCGCCCGGGGATTCTGCTC
TATGGCTGCCATCCGGTTGACGCCGCACCCTCGACCGTTCCCGTCAGGCCGGTGATGCAGTTCCAGAGCCGTGTGATCTT
CGTCAAGGAGGTGCCCGCAGGCACGGCCATCAGCTACAACCGCACATGGAGCGCGCCTAAAGCGACACGAATCGCGACGA
TCTCCGCCGGATATGCCGACGGCTTCCATCGCGCGCTTTCCAACCAAGCGCGGGTGAGCATCGGCGGCAAAAGCTTCCCG
CAGGTCGGCACGATCACAATGGATCAGACGATGGTCAATCTGGGTAGTGATGATTCGGTCAAGGTCGGCGACACGGCAGT
GCTCTTCGGCTGGGACGGCCCGTCGGCAGGTGAGCAGGCCCTCGCCGCCGGAACGATCAGCTACGAACTGCTCTGTTCGG
TTTCCCGCCGCGTCAGAAGAATAGTTGTTTAA

Upstream 100 bases:

>100_bases
TCCCGTCAGTTAATCGCCATTGTTTTGAAAATCATGGGCAAAAAGCGTTTTTTAGAGCATGTCCGGCTTCCAGCCTGAAC
CTCAACCATAAATCACCCTT

Downstream 100 bases:

>100_bases
CAAGCATCGCCATTGCGATGACCTGAATCCCCTAACAGAAAATTCAACCCCTATGAATTTTCTCAACAACATCGCCGTCA
AACTCGGCATCACCAGAGCG

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MSASHEQNSAAAPNGPNLSEALISLGNLRHNLACIRAITGPQCRVMGIVKANAYGHGATQVTATLEAEGVRDFGVANIYE
AIELLQEHRMLPDSRILAFASPLAGHIDLYLQHGVEMTVCDHETARAAESIAAACGRRLQVQLKVDTGMGRLGVTPEEAA
ELLELIEACPNLELTGIYTHFAESDKPEGFTARQLERFLHVTGAYERRTGKTVTKHAANSGAIISMPDARLDMVRPGILL
YGCHPVDAAPSTVPVRPVMQFQSRVIFVKEVPAGTAISYNRTWSAPKATRIATISAGYADGFHRALSNQARVSIGGKSFP
QVGTITMDQTMVNLGSDDSVKVGDTAVLFGWDGPSAGEQALAAGTISYELLCSVSRRVRRIVV

Sequences:

>Translated_383_residues
MSASHEQNSAAAPNGPNLSEALISLGNLRHNLACIRAITGPQCRVMGIVKANAYGHGATQVTATLEAEGVRDFGVANIYE
AIELLQEHRMLPDSRILAFASPLAGHIDLYLQHGVEMTVCDHETARAAESIAAACGRRLQVQLKVDTGMGRLGVTPEEAA
ELLELIEACPNLELTGIYTHFAESDKPEGFTARQLERFLHVTGAYERRTGKTVTKHAANSGAIISMPDARLDMVRPGILL
YGCHPVDAAPSTVPVRPVMQFQSRVIFVKEVPAGTAISYNRTWSAPKATRIATISAGYADGFHRALSNQARVSIGGKSFP
QVGTITMDQTMVNLGSDDSVKVGDTAVLFGWDGPSAGEQALAAGTISYELLCSVSRRVRRIVV
>Mature_382_residues
SASHEQNSAAAPNGPNLSEALISLGNLRHNLACIRAITGPQCRVMGIVKANAYGHGATQVTATLEAEGVRDFGVANIYEA
IELLQEHRMLPDSRILAFASPLAGHIDLYLQHGVEMTVCDHETARAAESIAAACGRRLQVQLKVDTGMGRLGVTPEEAAE
LLELIEACPNLELTGIYTHFAESDKPEGFTARQLERFLHVTGAYERRTGKTVTKHAANSGAIISMPDARLDMVRPGILLY
GCHPVDAAPSTVPVRPVMQFQSRVIFVKEVPAGTAISYNRTWSAPKATRIATISAGYADGFHRALSNQARVSIGGKSFPQ
VGTITMDQTMVNLGSDDSVKVGDTAVLFGWDGPSAGEQALAAGTISYELLCSVSRRVRRIVV

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=365, Percent_Identity=33.6986301369863, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1787439, Length=366, Percent_Identity=31.1475409836066, Blast_Score=161, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_CHLTE (Q8KB67)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662799.1
- ProteinModelPortal:   Q8KB67
- SMR:   Q8KB67
- GeneID:   1007880
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1922
- NMPDR:   fig|194439.1.peg.1893
- TIGR:   CT1922
- HOGENOM:   HBG712172
- OMA:   IYTHFAE
- ProtClustDB:   CLSK637997
- BioCyc:   CTEP194439:CT_1922-MONOMER
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 40987; Mature: 40856

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 50-50 ACT_SITE 279-279

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASHEQNSAAAPNGPNLSEALISLGNLRHNLACIRAITGPQCRVMGIVKANAYGHGATQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEEEEECCCCCCCEE
VTATLEAEGVRDFGVANIYEAIELLQEHRMLPDSRILAFASPLAGHIDLYLQHGVEMTVC
EEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHCCCEEEEE
DHETARAAESIAAACGRRLQVQLKVDTGMGRLGVTPEEAAELLELIEACPNLELTGIYTH
CCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEE
FAESDKPEGFTARQLERFLHVTGAYERRTGKTVTKHAANSGAIISMPDARLDMVRPGILL
CCCCCCCCCCCHHHHHHHHHHCCCHHHCCCCHHHHHCCCCCCEEECCCCHHHHCCCCEEE
YGCHPVDAAPSTVPVRPVMQFQSRVIFVKEVPAGTAISYNRTWSAPKATRIATISAGYAD
EECCCCCCCCCCCCCHHHHHHCCCEEEEEECCCCCEEEECCCCCCCCCEEEEEEECCCHH
GFHRALSNQARVSIGGKSFPQVGTITMDQTMVNLGSDDSVKVGDTAVLFGWDGPSAGEQA
HHHHHHCCCCEEEECCCCCCCCCEEEECHHHEECCCCCCEEECCEEEEEECCCCCCCCHH
LAAGTISYELLCSVSRRVRRIVV
HHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SASHEQNSAAAPNGPNLSEALISLGNLRHNLACIRAITGPQCRVMGIVKANAYGHGATQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEEEEECCCCCCCEE
VTATLEAEGVRDFGVANIYEAIELLQEHRMLPDSRILAFASPLAGHIDLYLQHGVEMTVC
EEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHCCCEEEEE
DHETARAAESIAAACGRRLQVQLKVDTGMGRLGVTPEEAAELLELIEACPNLELTGIYTH
CCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEE
FAESDKPEGFTARQLERFLHVTGAYERRTGKTVTKHAANSGAIISMPDARLDMVRPGILL
CCCCCCCCCCCHHHHHHHHHHCCCHHHCCCCHHHHHCCCCCCEEECCCCHHHHCCCCEEE
YGCHPVDAAPSTVPVRPVMQFQSRVIFVKEVPAGTAISYNRTWSAPKATRIATISAGYAD
EECCCCCCCCCCCCCHHHHHHCCCEEEEEECCCCCEEEECCCCCCCCCEEEEEEECCCHH
GFHRALSNQARVSIGGKSFPQVGTITMDQTMVNLGSDDSVKVGDTAVLFGWDGPSAGEQA
HHHHHHCCCCEEEECCCCCCCCCEEEECHHHEECCCCCCEEECCEEEEEECCCCCCCCHH
LAAGTISYELLCSVSRRVRRIVV
HHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901