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The map label for this gene is mtnA

Identifier: 21674630

GI number: 21674630

Start: 1719920

End: 1720984

Strand: Direct

Name: mtnA

Synonym: CT1816

Alternate gene names: 21674630

Gene position: 1719920-1720984 (Clockwise)

Preceding gene: 21674629

Following gene: 21674631

Centisome position: 79.81

GC content: 59.81

Gene sequence:

>1065_bases
ATGATAGACGCTATCTCATTTAAAAACGGAACGTTCCGTTACCTCGACCAGCGCTTTCTGCCCCTGCAGGAGATCCATGT
TGAAACGAAGAATCACCAGGAAGCTATCGAGGCCATCAAAACCCTCGCCGTGCGCGGCGCTCCGCTTATCGGCGCTTCGG
CGGGCTATACGGTCGTGCTCGGCATCAACGAATACACGGGCGACAAGGCAGGCTTCCCGGAATATTTCAAGAACCTGATC
GCCGAGGTCAACGCTTCGCGCCCGACCGCCGTGAACCTGTTCTTCGCGACGAAGAAAATGCAGGAGGTTTATGACGCCAA
CTTCGAGAACGATTCGCTCGAAGCGCTCTTCGCGAAGATGACCGACATGGCCTACAAAATCCACAACGACGAAATCGACA
ACTGCGACAAGATCGCCCGCCACGGCGTCGAGCTCCTGAAACAGGATTTCGCCGACGTGCTCAAAACCCGCAAGCTCAAT
GTGCTGACTCACTGCAACACCGGCACGCTCGCCTGCTGCGGCATCGGCACGGCACTCGGCGTGATCCGCCTGGCGTATCA
GGAGGGGCTGATCGAGCGCGTCATCACCTCCGAAAGCCGACCGCTCCTTCAGGGTCTGCGCCTCACTGCCTGGGAGCTGG
AGCATGACGGGATTCCGTTCGCCTCGATCTCCGACTCTTCGTCGGCGATTCTGATGCAGCGCGGCATGATCGACTTCGCC
ATCACTGGCGCGGATCGCATCACGGCCAACGGCGACACGGCTAACAAAATCGGCACCTACGCCCACGCCATCAGCGCCAG
GTATCACGGCCTGCCGTTCTACATCGCCGCACCGGTCTCGACTATCGACATCACAATGGCCGAAGGCTCGGAGATTCCGA
TCGAGGAGCGCAACCCCGACGAGCTGCGCAAAATCTTCGGCACGCAGGTCGCCACCCCGACCACGCCGGTGGTGAACTTC
GCCTTCGACGTAACCCCAGGCACGCTCATCCGCGGCATCATCACCGAGAAAGGGGCCGTCGTTGGAAACTACAACGAAGG
ACTCGCCCGCGTAGTCAACGGCTGA

Upstream 100 bases:

>100_bases
ATCATCGAAGTCTCCAGCCGCGCCGAGCCGAACATGACCACCATTTTCAGGAACGTCGTAGCCAATCTTTAATCCTTAAC
AAGGCAATACCTGTTCTCTC

Downstream 100 bases:

>100_bases
ACCGTTCACTTCTGACAGATCGATACACCAGAAAGGCTCCCTCGCCAGGGGGCCTTTCGCATTCCACCCGGCCCCGCAAA
AACTACTCTTCGCCGATGCC

Product: translation initiation factor, eIF-2B, putative

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MIDAISFKNGTFRYLDQRFLPLQEIHVETKNHQEAIEAIKTLAVRGAPLIGASAGYTVVLGINEYTGDKAGFPEYFKNLI
AEVNASRPTAVNLFFATKKMQEVYDANFENDSLEALFAKMTDMAYKIHNDEIDNCDKIARHGVELLKQDFADVLKTRKLN
VLTHCNTGTLACCGIGTALGVIRLAYQEGLIERVITSESRPLLQGLRLTAWELEHDGIPFASISDSSSAILMQRGMIDFA
ITGADRITANGDTANKIGTYAHAISARYHGLPFYIAAPVSTIDITMAEGSEIPIEERNPDELRKIFGTQVATPTTPVVNF
AFDVTPGTLIRGIITEKGAVVGNYNEGLARVVNG

Sequences:

>Translated_354_residues
MIDAISFKNGTFRYLDQRFLPLQEIHVETKNHQEAIEAIKTLAVRGAPLIGASAGYTVVLGINEYTGDKAGFPEYFKNLI
AEVNASRPTAVNLFFATKKMQEVYDANFENDSLEALFAKMTDMAYKIHNDEIDNCDKIARHGVELLKQDFADVLKTRKLN
VLTHCNTGTLACCGIGTALGVIRLAYQEGLIERVITSESRPLLQGLRLTAWELEHDGIPFASISDSSSAILMQRGMIDFA
ITGADRITANGDTANKIGTYAHAISARYHGLPFYIAAPVSTIDITMAEGSEIPIEERNPDELRKIFGTQVATPTTPVVNF
AFDVTPGTLIRGIITEKGAVVGNYNEGLARVVNG
>Mature_354_residues
MIDAISFKNGTFRYLDQRFLPLQEIHVETKNHQEAIEAIKTLAVRGAPLIGASAGYTVVLGINEYTGDKAGFPEYFKNLI
AEVNASRPTAVNLFFATKKMQEVYDANFENDSLEALFAKMTDMAYKIHNDEIDNCDKIARHGVELLKQDFADVLKTRKLN
VLTHCNTGTLACCGIGTALGVIRLAYQEGLIERVITSESRPLLQGLRLTAWELEHDGIPFASISDSSSAILMQRGMIDFA
ITGADRITANGDTANKIGTYAHAISARYHGLPFYIAAPVSTIDITMAEGSEIPIEERNPDELRKIFGTQVATPTTPVVNF
AFDVTPGTLIRGIITEKGAVVGNYNEGLARVVNG

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=346, Percent_Identity=40.1734104046243, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI23943880, Length=340, Percent_Identity=34.1176470588235, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17557462, Length=340, Percent_Identity=35.2941176470588, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6325375, Length=395, Percent_Identity=33.1645569620253, Blast_Score=167, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21357667, Length=345, Percent_Identity=35.6521739130435, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24651647, Length=345, Percent_Identity=35.6521739130435, Blast_Score=214, Evalue=7e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_CHLTE (Q8KBH1)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662695.1
- HSSP:   Q9X013
- ProteinModelPortal:   Q8KBH1
- SMR:   Q8KBH1
- GeneID:   1008145
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1816
- NMPDR:   fig|194439.1.peg.1789
- TIGR:   CT1816
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- ProtClustDB:   CLSK637951
- BioCyc:   CTEP194439:CT_1816-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 38691; Mature: 38691

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: ACT_SITE 245-245 BINDING 87-87 BINDING 204-204

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDAISFKNGTFRYLDQRFLPLQEIHVETKNHQEAIEAIKTLAVRGAPLIGASAGYTVVL
CCCCEECCCCCHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCEEEEE
GINEYTGDKAGFPEYFKNLIAEVNASRPTAVNLFFATKKMQEVYDANFENDSLEALFAKM
ECCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHCCCCCCCHHHHHHHHH
TDMAYKIHNDEIDNCDKIARHGVELLKQDFADVLKTRKLNVLTHCNTGTLACCGIGTALG
HHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEHHHHHHHH
VIRLAYQEGLIERVITSESRPLLQGLRLTAWELEHDGIPFASISDSSSAILMQRGMIDFA
HHHHHHHHHHHHHHHCCCCCHHHHCCCCEEEEECCCCCCEEECCCCCCEEEHHCCCEEEE
ITGADRITANGDTANKIGTYAHAISARYHGLPFYIAAPVSTIDITMAEGSEIPIEERNPD
EECCCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEEECCCCCCCCCCCHH
ELRKIFGTQVATPTTPVVNFAFDVTPGTLIRGIITEKGAVVGNYNEGLARVVNG
HHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCEEECCCHHHHHHCCC
>Mature Secondary Structure
MIDAISFKNGTFRYLDQRFLPLQEIHVETKNHQEAIEAIKTLAVRGAPLIGASAGYTVVL
CCCCEECCCCCHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCEEEEE
GINEYTGDKAGFPEYFKNLIAEVNASRPTAVNLFFATKKMQEVYDANFENDSLEALFAKM
ECCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHCCCCCCCHHHHHHHHH
TDMAYKIHNDEIDNCDKIARHGVELLKQDFADVLKTRKLNVLTHCNTGTLACCGIGTALG
HHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEHHHHHHHH
VIRLAYQEGLIERVITSESRPLLQGLRLTAWELEHDGIPFASISDSSSAILMQRGMIDFA
HHHHHHHHHHHHHHHCCCCCHHHHCCCCEEEEECCCCCCEEECCCCCCEEEHHCCCEEEE
ITGADRITANGDTANKIGTYAHAISARYHGLPFYIAAPVSTIDITMAEGSEIPIEERNPD
EECCCEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEEECCCCCCCCCCCHH
ELRKIFGTQVATPTTPVVNFAFDVTPGTLIRGIITEKGAVVGNYNEGLARVVNG
HHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHCCCCEEECCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901