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The map label for this gene is aroE

Identifier: 21674623

GI number: 21674623

Start: 1714662

End: 1715549

Strand: Direct

Name: aroE

Synonym: CT1809

Alternate gene names: 21674623

Gene position: 1714662-1715549 (Clockwise)

Preceding gene: 21674622

Following gene: 21674624

Centisome position: 79.57

GC content: 58.9

Gene sequence:

>888_bases
GTGTCAAACTCTCAGTCCAAAAAGATTTTCGGACTCATCGGCAAACACGTCGATTACTCCTGGTCGCCACTGATTCACAA
TACCGGATTCGAGGCACTCGGGCTTCCCTGCGTCTACACCATTTTCAACATCCCTTCGCCCGAAATGATCGGCGATGCAC
TCAAAGGAAGCCGTGCTCTCGGCATTGCGGGATTCAGCGTAACCATTCCGTACAAGAAAACCGTCGTGCCATTCCTTGAC
GAACTCTCACCTGAAGCGCTCTCCATCGGGGCGGTCAACACCATCGTCAACGACAACGGACGGCTGCTCGGCTACAATAC
GGACATCGACGGTTTCGCTGCTCCGCTCCTTCCGATGGCGGAGTCGATCCGGAACAGGCCGGTCTGCATCTTCGGCAACG
GCGGAGCCGCGCTGGCCGCCGTCGAAGCTTTCAGGCTCCGCTTCAACCCTTCATCGGTGCTCCTCGTGGTGCGGGATACG
CAGAAAGCCGAAGATATGCTCGAAGAGTACGCATACCGCGACCTCGTCACCATCCATGCGGGCCGGGAGATCGACCAGCC
CGCGTGCAGCAAACTGATCCGCGATTGCCGCGTACTGGTCAACGCAACGCCGGTCGGCACTGCCGGAAGAAACGATCACA
TCCACAGCATCCTGCCGACCGGACACGGGCTCCTGCACGATGGCCAGATCGTTTACGACATGGTCTACAATCCGCCCGAA
ACACCCCTGCTCGCCGAAGCCCGCGCCGCAGGAGCAACTGTCATTGCGGGCATCGAGATGCTCATCGCCCAGGCCGCCCG
TGCCTTCTCCATCTGGACAGGACAGGAACTTCCGGTCGATCTGGTCAGAAAAACCGTACTCGCTGCAATCGAAAAGAGCG
AAGGCTGA

Upstream 100 bases:

>100_bases
CAAAAAGCAGCTGTTTCAGAGCGTCTTCCCCGAGCTGTACCAGCAAGATGCGGTACGCCGGCTGCTGGAAATTTCCTGAA
CCACCAGCGAAACAAACATC

Downstream 100 bases:

>100_bases
GGCGGCGGTTTGAAAGAGGCCTGAATGGTATTACATTCTCTTCGACCTCTTTTGACCTCCTGACAACAACACTACTCTAT
GGCCCTTTTTTATCTGCTCG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSNSQSKKIFGLIGKHVDYSWSPLIHNTGFEALGLPCVYTIFNIPSPEMIGDALKGSRALGIAGFSVTIPYKKTVVPFLD
ELSPEALSIGAVNTIVNDNGRLLGYNTDIDGFAAPLLPMAESIRNRPVCIFGNGGAALAAVEAFRLRFNPSSVLLVVRDT
QKAEDMLEEYAYRDLVTIHAGREIDQPACSKLIRDCRVLVNATPVGTAGRNDHIHSILPTGHGLLHDGQIVYDMVYNPPE
TPLLAEARAAGATVIAGIEMLIAQAARAFSIWTGQELPVDLVRKTVLAAIEKSEG

Sequences:

>Translated_295_residues
MSNSQSKKIFGLIGKHVDYSWSPLIHNTGFEALGLPCVYTIFNIPSPEMIGDALKGSRALGIAGFSVTIPYKKTVVPFLD
ELSPEALSIGAVNTIVNDNGRLLGYNTDIDGFAAPLLPMAESIRNRPVCIFGNGGAALAAVEAFRLRFNPSSVLLVVRDT
QKAEDMLEEYAYRDLVTIHAGREIDQPACSKLIRDCRVLVNATPVGTAGRNDHIHSILPTGHGLLHDGQIVYDMVYNPPE
TPLLAEARAAGATVIAGIEMLIAQAARAFSIWTGQELPVDLVRKTVLAAIEKSEG
>Mature_294_residues
SNSQSKKIFGLIGKHVDYSWSPLIHNTGFEALGLPCVYTIFNIPSPEMIGDALKGSRALGIAGFSVTIPYKKTVVPFLDE
LSPEALSIGAVNTIVNDNGRLLGYNTDIDGFAAPLLPMAESIRNRPVCIFGNGGAALAAVEAFRLRFNPSSVLLVVRDTQ
KAEDMLEEYAYRDLVTIHAGREIDQPACSKLIRDCRVLVNATPVGTAGRNDHIHSILPTGHGLLHDGQIVYDMVYNPPET
PLLAEARAAGATVIAGIEMLIAQAARAFSIWTGQELPVDLVRKTVLAAIEKSEG

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=293, Percent_Identity=31.3993174061433, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1789675, Length=269, Percent_Identity=28.996282527881, Blast_Score=90, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320332, Length=303, Percent_Identity=27.0627062706271, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_CHLTE (Q8KBH8)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662688.1
- ProteinModelPortal:   Q8KBH8
- SMR:   Q8KBH8
- GeneID:   1008183
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1809
- NMPDR:   fig|194439.1.peg.1782
- TIGR:   CT1809
- HOGENOM:   HBG553408
- OMA:   LIHNTAC
- ProtClustDB:   CLSK637945
- BioCyc:   CTEP194439:CT_1809-MONOMER
- BRENDA:   1.1.1.25
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 31734; Mature: 31603

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: ACT_SITE 72-72

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSQSKKIFGLIGKHVDYSWSPLIHNTGFEALGLPCVYTIFNIPSPEMIGDALKGSRAL
CCCCCHHHHHHHHHCCCCCCCCCCEECCCCCHHCCCCEEEEECCCCHHHHHHHHCCCCEE
GIAGFSVTIPYKKTVVPFLDELSPEALSIGAVNTIVNDNGRLLGYNTDIDGFAAPLLPMA
EEEEEEEECCCHHHHHHHHHHCCCCCEEECCEEEEECCCCEEEEECCCCCHHHHHHHHHH
ESIRNRPVCIFGNGGAALAAVEAFRLRFNPSSVLLVVRDTQKAEDMLEEYAYRDLVTIHA
HHHCCCCEEEEECCCHHHHHEEHHHEEECCCEEEEEEECCHHHHHHHHHHHHHCEEEEEC
GREIDQPACSKLIRDCRVLVNATPVGTAGRNDHIHSILPTGHGLLHDGQIVYDMVYNPPE
CCCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCCEEECCCCCCEEECCEEEEEEECCCCC
TPLLAEARAAGATVIAGIEMLIAQAARAFSIWTGQELPVDLVRKTVLAAIEKSEG
CCHHHHHHHCCHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNSQSKKIFGLIGKHVDYSWSPLIHNTGFEALGLPCVYTIFNIPSPEMIGDALKGSRAL
CCCCHHHHHHHHHCCCCCCCCCCEECCCCCHHCCCCEEEEECCCCHHHHHHHHCCCCEE
GIAGFSVTIPYKKTVVPFLDELSPEALSIGAVNTIVNDNGRLLGYNTDIDGFAAPLLPMA
EEEEEEEECCCHHHHHHHHHHCCCCCEEECCEEEEECCCCEEEEECCCCCHHHHHHHHHH
ESIRNRPVCIFGNGGAALAAVEAFRLRFNPSSVLLVVRDTQKAEDMLEEYAYRDLVTIHA
HHHCCCCEEEEECCCHHHHHEEHHHEEECCCEEEEEEECCHHHHHHHHHHHHHCEEEEEC
GREIDQPACSKLIRDCRVLVNATPVGTAGRNDHIHSILPTGHGLLHDGQIVYDMVYNPPE
CCCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCCEEECCCCCCEEECCEEEEEEECCCCC
TPLLAEARAAGATVIAGIEMLIAQAARAFSIWTGQELPVDLVRKTVLAAIEKSEG
CCHHHHHHHCCHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901