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The map label for this gene is ubiE [C]

Identifier: 21674563

GI number: 21674563

Start: 1657386

End: 1658258

Strand: Reverse

Name: ubiE [C]

Synonym: CT1748

Alternate gene names: 21674563

Gene position: 1658258-1657386 (Counterclockwise)

Preceding gene: 21674564

Following gene: 21674560

Centisome position: 76.95

GC content: 60.6

Gene sequence:

>873_bases
TTGTTGAAGAGTTGGCAATTGTTGAAGAGTTTTCATTGCAGGAGTAATAGCTTTATCAATCAAGAACGAGAGGTTTTTAT
GGCGAAGTATAAACTCGATGTCAACATCGCCAACGTCAACGAAGTGTACGACGGCGCGGGCGGAATCCTCTGGGAGATGC
TGATGGGCGAGCAGATTCACGTCGGCGCGGAAGCGGAAACTGACGTACTGGCGCGGAAGGCCGGGGTCACGGCGGAGACG
CATCTGCTTGACGTGTGCAGCGCACTCGGCGGCCCGGCGCGGTATCTGGCGAAAAATTACGGCTGCCGCGTCACCGGCCT
CGACGCCACGCAGCGGATGCACGCGGAGGCGATCCGCCGCACGATCGAGGCTGGCCTGTCCGGCAAGATCGATTACGTTT
TGGGCAACGCGCTCGACATGCCGTTTCCCGCCAGCAGCTTCGACGTGGTGTGGGGGCAGGACGCCTGGTGCTACATCACC
GACAAGCAGCGCCTCATCGGGGAGTGCGCCCGCGTGCTCAAGCCGGGCGGTGTGCTCGCCTTCACCGACTGGCTGGAGGC
TGGCCCGATGACCGACGAAGAGTTGACAGCGCTGAACACCTTCATGGTCTTTCCCTACATGGAGACGCTCGACGGCTACG
CCATGCTCGCCGAACAGGCTGGCTTGACGGTCATCGAAAAAGAAGACCTCACGCCCGATTTCGCAGCGCATGTGCAAGGC
TACCTCGATATGGTGCAGAACCAGTACCGGCAAGCCATCGTGGACAACTACGGTCAGGAGATGTACGACGCCGTCGAGCA
GGGCATTATGCTCTGGCGCGACGCTTCGGCAGCCGGAAAGGTAGGGCGGGGGAGGCTTGTCGCCCGCAAGTAG

Upstream 100 bases:

>100_bases
ATAATTTGCAAAAGTCAACAGATGAAGAAATTGGGCTAAAGCCCTGATTCATTTTGTTTTATCCGTAAACCCTGTCCCGA
AAGTTTTCGGGACAGGGCAA

Downstream 100 bases:

>100_bases
TCAGGCCGGATCGCTGACCTTGTCTGCTTATACTGCTTCGGCCGCAATAATTTCGCAGAGTTGCCGAAAAAGGGGCTGTC
ATTCTGAATGGAGCGAAGCG

Product: UbiE/COQ5 family methlytransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: Methyltransferase; SAM-Dependent Methyltransferase; Cyclopropane-Fatty-Acyl-Phospholipid Synthase; Sterol-C-Methyltransferase; Cyclopropane-Fatty-Acyl-Phospholipid Synthase Superfamily; Delta(24)-Sterol C-Methyltransferase; Gamma-copherol Methyltransferase; UbiE/COQ5 Family Methlytransferase; Glycine-Sarcosine Methyltransferase; C5-O-Methyltransferase; Ubiquinone/Menaquinone Biosynthesis Methylase-Like Protein; D-Glucose O-Methyltransferase; Sarcosine-Dimethylglycine Methyltransferase; Glycine/Sarcosine N-Methyltransferase; Staurosporine Biosynthesis Methyltransferase StaMB; Sterol Methyltransferase; NDP-Hexose 3-O-Methyltransferase; Sarcosine/Dimethylglycine N-Methyltransferase; Glycine Sarcosine N-Methyltransferase; Methylase Involved In Ubiquinone/Menaquinone Biosynthesis; Sam-Dependent Methyltransferase Protein; Sterol; Copherol O-Methyltransferase; Staurosporine Biosynthesis Methyltransferase StaMA; UbiE/COQ5 Family Methyltransferase

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MLKSWQLLKSFHCRSNSFINQEREVFMAKYKLDVNIANVNEVYDGAGGILWEMLMGEQIHVGAEAETDVLARKAGVTAET
HLLDVCSALGGPARYLAKNYGCRVTGLDATQRMHAEAIRRTIEAGLSGKIDYVLGNALDMPFPASSFDVVWGQDAWCYIT
DKQRLIGECARVLKPGGVLAFTDWLEAGPMTDEELTALNTFMVFPYMETLDGYAMLAEQAGLTVIEKEDLTPDFAAHVQG
YLDMVQNQYRQAIVDNYGQEMYDAVEQGIMLWRDASAAGKVGRGRLVARK

Sequences:

>Translated_290_residues
MLKSWQLLKSFHCRSNSFINQEREVFMAKYKLDVNIANVNEVYDGAGGILWEMLMGEQIHVGAEAETDVLARKAGVTAET
HLLDVCSALGGPARYLAKNYGCRVTGLDATQRMHAEAIRRTIEAGLSGKIDYVLGNALDMPFPASSFDVVWGQDAWCYIT
DKQRLIGECARVLKPGGVLAFTDWLEAGPMTDEELTALNTFMVFPYMETLDGYAMLAEQAGLTVIEKEDLTPDFAAHVQG
YLDMVQNQYRQAIVDNYGQEMYDAVEQGIMLWRDASAAGKVGRGRLVARK
>Mature_290_residues
MLKSWQLLKSFHCRSNSFINQEREVFMAKYKLDVNIANVNEVYDGAGGILWEMLMGEQIHVGAEAETDVLARKAGVTAET
HLLDVCSALGGPARYLAKNYGCRVTGLDATQRMHAEAIRRTIEAGLSGKIDYVLGNALDMPFPASSFDVVWGQDAWCYIT
DKQRLIGECARVLKPGGVLAFTDWLEAGPMTDEELTALNTFMVFPYMETLDGYAMLAEQAGLTVIEKEDLTPDFAAHVQG
YLDMVQNQYRQAIVDNYGQEMYDAVEQGIMLWRDASAAGKVGRGRLVARK

Specific function: Methyltransferase Required For The Conversion Of Dimethylmenaquinone (Dmkh2) To Menaquinone (Mkh2) And The Conversion Of 2-Polyprenyl-6-Methoxy-1,4-Benzoquinol (Ddmqh2) To 2-Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol (Dmqh2). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Caenorhabditis elegans, GI17561380, Length=174, Percent_Identity=28.1609195402299, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323635, Length=138, Percent_Identity=34.0579710144928, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.1.1.- [C]

Molecular weight: Translated: 32197; Mature: 32197

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSWQLLKSFHCRSNSFINQEREVFMAKYKLDVNIANVNEVYDGAGGILWEMLMGEQIH
CCCHHHHHHHHHCCCCCCCCHHHHHEEEEEEEEEEEECHHHHHCCCCHHHHHHHCCCEEE
VGAEAETDVLARKAGVTAETHLLDVCSALGGPARYLAKNYGCRVTGLDATQRMHAEAIRR
ECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHCCCCEEECCCHHHHHHHHHHHH
TIEAGLSGKIDYVLGNALDMPFPASSFDVVWGQDAWCYITDKQRLIGECARVLKPGGVLA
HHHHCCCCCEEEEECCCCCCCCCCCCCEEEECCCEEEEECCHHHHHHHHHHHHCCCCEEE
FTDWLEAGPMTDEELTALNTFMVFPYMETLDGYAMLAEQAGLTVIEKEDLTPDFAAHVQG
EEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHH
YLDMVQNQYRQAIVDNYGQEMYDAVEQGIMLWRDASAAGKVGRGRLVARK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCEECCC
>Mature Secondary Structure
MLKSWQLLKSFHCRSNSFINQEREVFMAKYKLDVNIANVNEVYDGAGGILWEMLMGEQIH
CCCHHHHHHHHHCCCCCCCCHHHHHEEEEEEEEEEEECHHHHHCCCCHHHHHHHCCCEEE
VGAEAETDVLARKAGVTAETHLLDVCSALGGPARYLAKNYGCRVTGLDATQRMHAEAIRR
ECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHCCCCEEECCCHHHHHHHHHHHH
TIEAGLSGKIDYVLGNALDMPFPASSFDVVWGQDAWCYITDKQRLIGECARVLKPGGVLA
HHHHCCCCCEEEEECCCCCCCCCCCCCEEEECCCEEEEECCHHHHHHHHHHHHCCCCEEE
FTDWLEAGPMTDEELTALNTFMVFPYMETLDGYAMLAEQAGLTVIEKEDLTPDFAAHVQG
EEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHH
YLDMVQNQYRQAIVDNYGQEMYDAVEQGIMLWRDASAAGKVGRGRLVARK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA