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The map label for this gene is dapA

Identifier: 21674442

GI number: 21674442

Start: 1530590

End: 1531480

Strand: Direct

Name: dapA

Synonym: CT1624

Alternate gene names: 21674442

Gene position: 1530590-1531480 (Clockwise)

Preceding gene: 21674441

Following gene: 21674446

Centisome position: 71.03

GC content: 61.73

Gene sequence:

>891_bases
ATGTCCAATCGCCTTATTTCAGGTTCAGCCGTAGCCCTTGTTACTCCGTTTCATCAGGACGGATCGATCGATTTCGAAGC
CATGCGGCGGCTGGTGCGGTTCCATCGCGAGGCCGGAACCGACATCGTTCTTCCCTGCGGCACCACCGGCGAGTCGCCGA
CTCTCACGAATGAGGAGGAGGCGGAGATCATCCGCGTCGTCTGCGAGGAGGCTGGCGAGTCGATGATGGTCGCCGCCGGC
GCAGGCAACAATGACACCCGGCACGCGATCGAGCTGGCGCGCAACGCCGAAAAGGCCGGGGCACAGGCCATCCTTTCGGT
CGCACCATACTACAACAAACCTTCGCAGGAGGGGTACTACCAGCACTTCCGCCACGTGGCCGAAGCGGTTTCGATTCCGG
TGATCATCTACAACGTGCCGGGGCGCACGGGCAGCAACGTGAACGCCCAGACGATTCTGCGGCTGGCGCGGGACATCGAG
AACGTGGTCGCCGTCAAGGAGGCGTCGGATAACTTCGAGCAGATCATGACGCTCATCGACGAGCGCCCGGAGAACTTCTC
GGTGATGACTGGCGAGGATGGGCTGATGCTGCCCTTCATGGCGCTCGGCGGCGACGGCGTGATTTCAGTGGCGGCCAACC
AGGTGCCAAAGGTGGTCAAGGGGCTGATCGACGCAATGAAGGCGGGCAACCTCGAAGAGGCCCGCGCCATCAACCGCAAG
TACCGCAAGCTGTTCAGACTGAACTTCATCGAGAGCAACCCCGTGCCGGTCAAGTACGCGCTCTCGCTGATGGGCATGAT
CGAAGAGGTCTATCGCCTGCCGCTCGTGCCAATGGCCGACGCCAACAAAGCGATTCTGCGAGCGGAGCTGGAGAAGCTCA
GCCTGGTATGA

Upstream 100 bases:

>100_bases
TACATTCAATTCATTATGAAGGCTGAATCGAGTGCGCTTCCGACCCGATGTCTTCTGAACGCCTGACAGCCTTTAACCAC
TTTAGAATCAAGCAGTTCTC

Downstream 100 bases:

>100_bases
ACAAAAAGATCGATCTTCAAACAAAAAAGCCACCCCAAACGGTGGCTTTTTTTATGCGATGCATAAGAAGCTTTTCAGCC
GAGCGCAGCGAGTTCGCTGA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSNRLISGSAVALVTPFHQDGSIDFEAMRRLVRFHREAGTDIVLPCGTTGESPTLTNEEEAEIIRVVCEEAGESMMVAAG
AGNNDTRHAIELARNAEKAGAQAILSVAPYYNKPSQEGYYQHFRHVAEAVSIPVIIYNVPGRTGSNVNAQTILRLARDIE
NVVAVKEASDNFEQIMTLIDERPENFSVMTGEDGLMLPFMALGGDGVISVAANQVPKVVKGLIDAMKAGNLEEARAINRK
YRKLFRLNFIESNPVPVKYALSLMGMIEEVYRLPLVPMADANKAILRAELEKLSLV

Sequences:

>Translated_296_residues
MSNRLISGSAVALVTPFHQDGSIDFEAMRRLVRFHREAGTDIVLPCGTTGESPTLTNEEEAEIIRVVCEEAGESMMVAAG
AGNNDTRHAIELARNAEKAGAQAILSVAPYYNKPSQEGYYQHFRHVAEAVSIPVIIYNVPGRTGSNVNAQTILRLARDIE
NVVAVKEASDNFEQIMTLIDERPENFSVMTGEDGLMLPFMALGGDGVISVAANQVPKVVKGLIDAMKAGNLEEARAINRK
YRKLFRLNFIESNPVPVKYALSLMGMIEEVYRLPLVPMADANKAILRAELEKLSLV
>Mature_295_residues
SNRLISGSAVALVTPFHQDGSIDFEAMRRLVRFHREAGTDIVLPCGTTGESPTLTNEEEAEIIRVVCEEAGESMMVAAGA
GNNDTRHAIELARNAEKAGAQAILSVAPYYNKPSQEGYYQHFRHVAEAVSIPVIIYNVPGRTGSNVNAQTILRLARDIEN
VVAVKEASDNFEQIMTLIDERPENFSVMTGEDGLMLPFMALGGDGVISVAANQVPKVVKGLIDAMKAGNLEEARAINRKY
RKLFRLNFIESNPVPVKYALSLMGMIEEVYRLPLVPMADANKAILRAELEKLSLV

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=300, Percent_Identity=24.6666666666667, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI13540533, Length=283, Percent_Identity=22.9681978798587, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1788823, Length=293, Percent_Identity=37.2013651877133, Blast_Score=224, Evalue=5e-60,
Organism=Escherichia coli, GI87082415, Length=283, Percent_Identity=31.8021201413428, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1786463, Length=285, Percent_Identity=28.7719298245614, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789620, Length=243, Percent_Identity=27.9835390946502, Blast_Score=108, Evalue=5e-25,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_CHLTE (Q8KC06)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662507.1
- ProteinModelPortal:   Q8KC06
- SMR:   Q8KC06
- GeneID:   1007268
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1624
- NMPDR:   fig|194439.1.peg.1601
- TIGR:   CT1624
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- ProtClustDB:   PRK03170
- BioCyc:   CTEP194439:CT_1624-MONOMER
- BRENDA:   4.2.1.52
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32387; Mature: 32255

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 166-166 BINDING 110-110

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNRLISGSAVALVTPFHQDGSIDFEAMRRLVRFHREAGTDIVLPCGTTGESPTLTNEEE
CCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHH
AEIIRVVCEEAGESMMVAAGAGNNDTRHAIELARNAEKAGAQAILSVAPYYNKPSQEGYY
HHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
QHFRHVAEAVSIPVIIYNVPGRTGSNVNAQTILRLARDIENVVAVKEASDNFEQIMTLID
HHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ERPENFSVMTGEDGLMLPFMALGGDGVISVAANQVPKVVKGLIDAMKAGNLEEARAINRK
CCCCCCEEEECCCCCEEHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
YRKLFRLNFIESNPVPVKYALSLMGMIEEVYRLPLVPMADANKAILRAELEKLSLV
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNRLISGSAVALVTPFHQDGSIDFEAMRRLVRFHREAGTDIVLPCGTTGESPTLTNEEE
CCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHH
AEIIRVVCEEAGESMMVAAGAGNNDTRHAIELARNAEKAGAQAILSVAPYYNKPSQEGYY
HHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
QHFRHVAEAVSIPVIIYNVPGRTGSNVNAQTILRLARDIENVVAVKEASDNFEQIMTLID
HHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
ERPENFSVMTGEDGLMLPFMALGGDGVISVAANQVPKVVKGLIDAMKAGNLEEARAINRK
CCCCCCEEEECCCCCEEHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
YRKLFRLNFIESNPVPVKYALSLMGMIEEVYRLPLVPMADANKAILRAELEKLSLV
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901