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The map label for this gene is lpxD

Identifier: 21674182

GI number: 21674182

Start: 1279534

End: 1280595

Strand: Reverse

Name: lpxD

Synonym: CT1360

Alternate gene names: 21674182

Gene position: 1280595-1279534 (Counterclockwise)

Preceding gene: 21674185

Following gene: 21674177

Centisome position: 59.43

GC content: 58.66

Gene sequence:

>1062_bases
ATGAAGATTGCAGATATCAAAGCCTTTCTTGGACGTTATTTTGATCCGGTCGAACTGGTTGGCACGGGTGACATCGAAAT
AGTAGGGCCAGCCAAAATCGAAGAGGCCTCGACGGGCCATGTCAGTTTTGTGGCCAATGAGAAGTATTACCGTTACATCG
CCCAGACCGGCGCTTCGCTTGTTATTGTTAGCCAGAAGGCTCCTCTTGACGACGCATCTCCCGGAACCAGTTTCCTGAAG
GTGGCGGATCCATACACCGCCTTTGTGTTCATTCTTCAGCACTTCTCGGGCAAACGCCGCATTGCGGATACCGGCATCGC
GGCTTCGGCCTCGGTCGCCGCTTCTGTTCGTCTTGGTGAGAACGTTTCTCTTGGTGAGCATGTTGTCATTGGCGAGAACT
GTGTCATCGGTGACGGTACGGTGATCGGCCCCGGCACGGTGCTTATGGACGGCGTGACTGTCGGTTCCGGATGCACGATC
TTTCCGCTTGTGACGATTTACGACGGTACGGTGATCGGTGACCGGGTCACGATTCACAGCGGTACGGTCGTCGGTGCGGA
CGGCTTTGGTTTCGCGCCGCAGAAGGATGGCTCCTATATCAAGATTCCGCAGATGGGTACGGTCGAGATCGGTGACGATG
TCGAGATCGGCGCGAACACCACCATCGACCGCGCGACCATGGGCGCGACGGTGATTGAAAAGGGGGCGAAGATCGACAAC
CTCGTGCAGATCGCCCACAACTGCCGGATCGGCGGCGACACGGTTATCGCCTCGCAGGCCGGTATTTCAGGCAGCGTCAA
GATTGGCCGCCAGTGCCTCATTGGCGGGCAGGCCGGATTCGCGGGCCATCTCGAACTTGCCGATCGCACTTCGGTGGCGG
CCAAGGCCGGGATTTCGAAATCATTTCTCGAACCGGGGCTGGCGATCCGCGGCGTGCCTGCACAGCCGATGCGCGATCAG
CTCCGTCAGGAGGCGCAGGTGCGGGGGCTTGGCGAAATGAAGTCGAAGCTCGAAGCGCTCGAGGCAAAGCTGCTGGCGTT
ACAGCAACAGCTCGGTGAGTGA

Upstream 100 bases:

>100_bases
CACGGCTGTCGCAACCGGAACGGTAAAAGGATTCAGAATATAGCAAAACGGATTAAAATTTTTAAGAAATTTTCTGCCTC
ACCTTGCTGGTGACTAAATC

Downstream 100 bases:

>100_bases
GGTCTTTACACACCAGCTCCGGGGTTGGAGGGTTCTGTGTCAAGGTGAAGTCCCTGTTCTCATCGATACGAGCTTTTCCT
GACGAGATCAGTCTCAAAGT

Product: UDP-3-O-3-hydroxymyristoyl glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKIADIKAFLGRYFDPVELVGTGDIEIVGPAKIEEASTGHVSFVANEKYYRYIAQTGASLVIVSQKAPLDDASPGTSFLK
VADPYTAFVFILQHFSGKRRIADTGIAASASVAASVRLGENVSLGEHVVIGENCVIGDGTVIGPGTVLMDGVTVGSGCTI
FPLVTIYDGTVIGDRVTIHSGTVVGADGFGFAPQKDGSYIKIPQMGTVEIGDDVEIGANTTIDRATMGATVIEKGAKIDN
LVQIAHNCRIGGDTVIASQAGISGSVKIGRQCLIGGQAGFAGHLELADRTSVAAKAGISKSFLEPGLAIRGVPAQPMRDQ
LRQEAQVRGLGEMKSKLEALEAKLLALQQQLGE

Sequences:

>Translated_353_residues
MKIADIKAFLGRYFDPVELVGTGDIEIVGPAKIEEASTGHVSFVANEKYYRYIAQTGASLVIVSQKAPLDDASPGTSFLK
VADPYTAFVFILQHFSGKRRIADTGIAASASVAASVRLGENVSLGEHVVIGENCVIGDGTVIGPGTVLMDGVTVGSGCTI
FPLVTIYDGTVIGDRVTIHSGTVVGADGFGFAPQKDGSYIKIPQMGTVEIGDDVEIGANTTIDRATMGATVIEKGAKIDN
LVQIAHNCRIGGDTVIASQAGISGSVKIGRQCLIGGQAGFAGHLELADRTSVAAKAGISKSFLEPGLAIRGVPAQPMRDQ
LRQEAQVRGLGEMKSKLEALEAKLLALQQQLGE
>Mature_353_residues
MKIADIKAFLGRYFDPVELVGTGDIEIVGPAKIEEASTGHVSFVANEKYYRYIAQTGASLVIVSQKAPLDDASPGTSFLK
VADPYTAFVFILQHFSGKRRIADTGIAASASVAASVRLGENVSLGEHVVIGENCVIGDGTVIGPGTVLMDGVTVGSGCTI
FPLVTIYDGTVIGDRVTIHSGTVVGADGFGFAPQKDGSYIKIPQMGTVEIGDDVEIGANTTIDRATMGATVIEKGAKIDN
LVQIAHNCRIGGDTVIASQAGISGSVKIGRQCLIGGQAGFAGHLELADRTSVAAKAGISKSFLEPGLAIRGVPAQPMRDQ
LRQEAQVRGLGEMKSKLEALEAKLLALQQQLGE

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=337, Percent_Identity=39.7626112759644, Blast_Score=228, Evalue=4e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_CHLTE (Q8KCQ3)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662247.1
- ProteinModelPortal:   Q8KCQ3
- SMR:   Q8KCQ3
- GeneID:   1006735
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1360
- NMPDR:   fig|194439.1.peg.1341
- TIGR:   CT1360
- HOGENOM:   HBG469615
- OMA:   AKIMKSA
- BioCyc:   CTEP194439:CT_1360-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 36726; Mature: 36726

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIADIKAFLGRYFDPVELVGTGDIEIVGPAKIEEASTGHVSFVANEKYYRYIAQTGASL
CCCHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCCCCCEEEEEECCHHHHHHHHCCCEE
VIVSQKAPLDDASPGTSFLKVADPYTAFVFILQHFSGKRRIADTGIAASASVAASVRLGE
EEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEEECC
NVSLGEHVVIGENCVIGDGTVIGPGTVLMDGVTVGSGCTIFPLVTIYDGTVIGDRVTIHS
CCCCCCEEEECCCEEECCCEEECCCEEEEECEEECCCCEEEEEEEEECCEEECCEEEEEC
GTVVGADGFGFAPQKDGSYIKIPQMGTVEIGDDVEIGANTTIDRATMGATVIEKGAKIDN
CEEECCCCCCCCCCCCCCEEECCCCCEEEECCCEEECCCCCCCHHHHCHHHHHCCCCHHH
LVQIAHNCRIGGDTVIASQAGISGSVKIGRQCLIGGQAGFAGHLELADRTSVAAKAGISK
HHHHHHHCCCCCCEEEEECCCCCCCEEECCEEEECCCCCCCEEEEECCHHHHHHHHCCCH
SFLEPGLAIRGVPAQPMRDQLRQEAQVRGLGEMKSKLEALEAKLLALQQQLGE
HHHCCCCEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIADIKAFLGRYFDPVELVGTGDIEIVGPAKIEEASTGHVSFVANEKYYRYIAQTGASL
CCCHHHHHHHHCCCCCEEEEECCCEEEECCCCCCCCCCCEEEEEECCHHHHHHHHCCCEE
VIVSQKAPLDDASPGTSFLKVADPYTAFVFILQHFSGKRRIADTGIAASASVAASVRLGE
EEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEEECC
NVSLGEHVVIGENCVIGDGTVIGPGTVLMDGVTVGSGCTIFPLVTIYDGTVIGDRVTIHS
CCCCCCEEEECCCEEECCCEEECCCEEEEECEEECCCCEEEEEEEEECCEEECCEEEEEC
GTVVGADGFGFAPQKDGSYIKIPQMGTVEIGDDVEIGANTTIDRATMGATVIEKGAKIDN
CEEECCCCCCCCCCCCCCEEECCCCCEEEECCCEEECCCCCCCHHHHCHHHHHCCCCHHH
LVQIAHNCRIGGDTVIASQAGISGSVKIGRQCLIGGQAGFAGHLELADRTSVAAKAGISK
HHHHHHHCCCCCCEEEEECCCCCCCEEECCEEEECCCCCCCEEEEECCHHHHHHHHCCCH
SFLEPGLAIRGVPAQPMRDQLRQEAQVRGLGEMKSKLEALEAKLLALQQQLGE
HHHCCCCEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901