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The map label for this gene is purL

Identifier: 21674063

GI number: 21674063

Start: 1164858

End: 1167137

Strand: Direct

Name: purL

Synonym: CT1240

Alternate gene names: 21674063

Gene position: 1164858-1167137 (Clockwise)

Preceding gene: 21674062

Following gene: 21674064

Centisome position: 54.06

GC content: 61.45

Gene sequence:

>2280_bases
ATGAGCACCGAACCTGAAGTGAACCTGAAGCTGGCCCAGGAGCATGGCCTGAACGAAGAGGAGTACGCTAAGATTTGTGA
AATCCTTGGCCGGACGCCCTCCTTTACCGAGTTGGGCATCTACTCAGTGATGTGGTCCGAGCATTGCAGCTACAAGAACT
CCATCGCCGTGCTCAAGACCCTGCCGCGCGACGGTGCTTCGCTGCTCACGCAGGCAGGCGAGGAGAACGCTGGCCTTGTC
GATATTGGCGACAACCTCGCTGTGGCATTCAAGATCGAGTCGCACAACCACCCTTCAGCAGTCGAACCTTACCAGGGCGC
GGCCACGGGTGTCGGTGGTATCCATCGCGACATCTTCACGATGGGCGCAAGGCCGGTGGCGTCGCTTGACTCGCTGCGCT
TCGGCTCGCCGCGCGACCCTCGTGTGCGTTACCTCGTGGACGGCGTGGTGCGAGGCATCGGCGACTACGGCAACTCGTTC
GGGGTGCCGACCGTTGGCGGCGAAATCTACTTCGAGGATTGCTACACCGGCAACCCGCTGGTCAACGTCATGTCGGTCGG
CCTCGTGGAGCATCACAAAACCGTGAGCGCCACGGCCTGGGGCAAGGGCAATCCGGTACTGATCGTCGGTTCATCGACTG
GCCGCGACGGCATCCACGGCGCAACCTTCGCATCGGAAGACCTCAGCGAGGCATCGGAAGACAAGCGACCGAGCGTGCAG
GTGGGCGATCCCTTCGCCGAGAAGCTGCTGCTCGAAGCCACGCTCGAAGCGATCGCGACCGGCGCAGTGGTAGGCTTGCA
GGACATGGGCGCAGCTGGGCTGACCAGCTCCACCTCAGAGATGAGCGCGCGCGGCATCGAGAAAACCGGCAGCGGCGGCA
TCGAGATCGACCTCGACTTGACGCCCGCCCGCGAAAAGGGCATGACCGCCTACGAGCTGATGCTTTCGGAGTCACAGGAG
CGGATGCTGATCGTAGCCGAGAAAGGGCGCGAGCATGAGATCATCGACGTCTATAAAAAGTGGGATGTGAGCGCCGTGGT
GATCGGACAGGTGACGGACGACAACATGCTGCGCGTACGCCATCACGGCGAGGTGGTCGCAGAGATTCCGGCCACCTCAC
TCGTACTCGGCGGCGGCGCGCCGGTCTACATCCGCGAGGCAGTCGAGAAAAAGCCTGACACTCCGGCGGCAGACCTCGTG
GCCGACGACTCGCTCGACTTCAAGGCGCTCTCGCTGCAACTGCTCTCCCGCCCGAACATCGCCAGCAAGGCGTGGGTCTA
CCAGCAATACGACTCGATGGTGCAGACCAACACCGTCACCCCGGCGGGCCAGACCGACGCGGCGGTCATCCGCATCAAGG
GCACCAAAAAGGGTCTCGCAATGAAGACCGACTGCAACTCGCGCTACGTCTATCTCAATCCGAAAGCGGGCGGCGCGATC
GCCGTGGCCGAGTGCGCGCGCAACATCGCCTGCACCGGCGCAAAACCGCTCGCCGTGACCAACTGCCTGAACTTCGGCAA
TCCCTACAAGCCGGAGGTTTACTTCCAGTTCAAAAGCGCCGTCGAAGGCATAGGCGATGCCTGCCGCATGTTCGACACAC
CCATAACCGGCGGTAATGTAAGCTTCTACAACGAGACCTCGCTTGGCGGTGGACGCACGGCGATCTATCCGACACCGACC
ATCGGCATGATCGGTCTGCTCGACAATATCGACAATCTGGTGGAATCGACCTTCCGAAAGGCGGGCGACGCCATCGTGCT
GCTCGGCGCTCCGGAACTCTCGCTCGACGGCTCGGAGTACCTCGTGATGCAATACGGCACGCCGGGCACAGACTCTCCCG
CTGTCGATCTGAACCATGAGAAAAACCTTCAGGAACTGCTCGTCACGCTCGCCTCAAAGAAGCTCATCAACTCTGCGCAC
GACGTTTCAGATGGTGGTCTTGCGGTCACGCTTGCCGAAAAGTCGATCATGAACCGCGAGCGGATGCTCGGCTTCGAGGT
CGATCTCGAATGCTCCTGCAAGGAGGGCACGGCCATCCAGAAGCAGCTCTTCTCTGAGGCGCAGGGGCGCGTAGTGATCT
CGGTCGATCCCGGCAGGGTCGGGGCGGTCATCGAAGAGGCCGACCGCCTGAACATACCAGGACGTGTTATCGGCAAGGTG
ACGCCAGAGGGCGCAAGCATCGCCGTAAACGGCAAGCCTGTGGCGGAGTTTATGATTGACGAACTGCTGCACGCTTACGG
GCATGCGCTTGAATCGGCGTTGCATCTCGAAGAATTGTAA

Upstream 100 bases:

>100_bases
CTGTTTTGTGGACGATGTAGACAATGAGTTTTATTTTCAACCCTGTTTGGCCTACACGTCCTGTTCGACCTGTTAGACCT
ATAAAAATTTCCACCATACC

Downstream 100 bases:

>100_bases
AAGAGACAAAAAATGAATCCGGTATTAACGGCGCGGGAAATGAGCCTTGCAGATCGGGCGGCCATCGAGGAGCTGCGCAC
CGGGGAAACCCGGCTGATGG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 759; Mature: 758

Protein sequence:

>759_residues
MSTEPEVNLKLAQEHGLNEEEYAKICEILGRTPSFTELGIYSVMWSEHCSYKNSIAVLKTLPRDGASLLTQAGEENAGLV
DIGDNLAVAFKIESHNHPSAVEPYQGAATGVGGIHRDIFTMGARPVASLDSLRFGSPRDPRVRYLVDGVVRGIGDYGNSF
GVPTVGGEIYFEDCYTGNPLVNVMSVGLVEHHKTVSATAWGKGNPVLIVGSSTGRDGIHGATFASEDLSEASEDKRPSVQ
VGDPFAEKLLLEATLEAIATGAVVGLQDMGAAGLTSSTSEMSARGIEKTGSGGIEIDLDLTPAREKGMTAYELMLSESQE
RMLIVAEKGREHEIIDVYKKWDVSAVVIGQVTDDNMLRVRHHGEVVAEIPATSLVLGGGAPVYIREAVEKKPDTPAADLV
ADDSLDFKALSLQLLSRPNIASKAWVYQQYDSMVQTNTVTPAGQTDAAVIRIKGTKKGLAMKTDCNSRYVYLNPKAGGAI
AVAECARNIACTGAKPLAVTNCLNFGNPYKPEVYFQFKSAVEGIGDACRMFDTPITGGNVSFYNETSLGGGRTAIYPTPT
IGMIGLLDNIDNLVESTFRKAGDAIVLLGAPELSLDGSEYLVMQYGTPGTDSPAVDLNHEKNLQELLVTLASKKLINSAH
DVSDGGLAVTLAEKSIMNRERMLGFEVDLECSCKEGTAIQKQLFSEAQGRVVISVDPGRVGAVIEEADRLNIPGRVIGKV
TPEGASIAVNGKPVAEFMIDELLHAYGHALESALHLEEL

Sequences:

>Translated_759_residues
MSTEPEVNLKLAQEHGLNEEEYAKICEILGRTPSFTELGIYSVMWSEHCSYKNSIAVLKTLPRDGASLLTQAGEENAGLV
DIGDNLAVAFKIESHNHPSAVEPYQGAATGVGGIHRDIFTMGARPVASLDSLRFGSPRDPRVRYLVDGVVRGIGDYGNSF
GVPTVGGEIYFEDCYTGNPLVNVMSVGLVEHHKTVSATAWGKGNPVLIVGSSTGRDGIHGATFASEDLSEASEDKRPSVQ
VGDPFAEKLLLEATLEAIATGAVVGLQDMGAAGLTSSTSEMSARGIEKTGSGGIEIDLDLTPAREKGMTAYELMLSESQE
RMLIVAEKGREHEIIDVYKKWDVSAVVIGQVTDDNMLRVRHHGEVVAEIPATSLVLGGGAPVYIREAVEKKPDTPAADLV
ADDSLDFKALSLQLLSRPNIASKAWVYQQYDSMVQTNTVTPAGQTDAAVIRIKGTKKGLAMKTDCNSRYVYLNPKAGGAI
AVAECARNIACTGAKPLAVTNCLNFGNPYKPEVYFQFKSAVEGIGDACRMFDTPITGGNVSFYNETSLGGGRTAIYPTPT
IGMIGLLDNIDNLVESTFRKAGDAIVLLGAPELSLDGSEYLVMQYGTPGTDSPAVDLNHEKNLQELLVTLASKKLINSAH
DVSDGGLAVTLAEKSIMNRERMLGFEVDLECSCKEGTAIQKQLFSEAQGRVVISVDPGRVGAVIEEADRLNIPGRVIGKV
TPEGASIAVNGKPVAEFMIDELLHAYGHALESALHLEEL
>Mature_758_residues
STEPEVNLKLAQEHGLNEEEYAKICEILGRTPSFTELGIYSVMWSEHCSYKNSIAVLKTLPRDGASLLTQAGEENAGLVD
IGDNLAVAFKIESHNHPSAVEPYQGAATGVGGIHRDIFTMGARPVASLDSLRFGSPRDPRVRYLVDGVVRGIGDYGNSFG
VPTVGGEIYFEDCYTGNPLVNVMSVGLVEHHKTVSATAWGKGNPVLIVGSSTGRDGIHGATFASEDLSEASEDKRPSVQV
GDPFAEKLLLEATLEAIATGAVVGLQDMGAAGLTSSTSEMSARGIEKTGSGGIEIDLDLTPAREKGMTAYELMLSESQER
MLIVAEKGREHEIIDVYKKWDVSAVVIGQVTDDNMLRVRHHGEVVAEIPATSLVLGGGAPVYIREAVEKKPDTPAADLVA
DDSLDFKALSLQLLSRPNIASKAWVYQQYDSMVQTNTVTPAGQTDAAVIRIKGTKKGLAMKTDCNSRYVYLNPKAGGAIA
VAECARNIACTGAKPLAVTNCLNFGNPYKPEVYFQFKSAVEGIGDACRMFDTPITGGNVSFYNETSLGGGRTAIYPTPTI
GMIGLLDNIDNLVESTFRKAGDAIVLLGAPELSLDGSEYLVMQYGTPGTDSPAVDLNHEKNLQELLVTLASKKLINSAHD
VSDGGLAVTLAEKSIMNRERMLGFEVDLECSCKEGTAIQKQLFSEAQGRVVISVDPGRVGAVIEEADRLNIPGRVIGKVT
PEGASIAVNGKPVAEFMIDELLHAYGHALESALHLEEL

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=644, Percent_Identity=23.7577639751553, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI48994899, Length=781, Percent_Identity=23.943661971831, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321498, Length=782, Percent_Identity=22.8900255754476, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_CHLTE (Q8KD17)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662128.1
- ProteinModelPortal:   Q8KD17
- SMR:   Q8KD17
- GeneID:   1006598
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1240
- NMPDR:   fig|194439.1.peg.1222
- TIGR:   CT1240
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   CTEP194439:CT_1240-MONOMER
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 80963; Mature: 80831

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEPEVNLKLAQEHGLNEEEYAKICEILGRTPSFTELGIYSVMWSEHCSYKNSIAVLKT
CCCCCCCEEEEHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEE
LPRDGASLLTQAGEENAGLVDIGDNLAVAFKIESHNHPSAVEPYQGAATGVGGIHRDIFT
CCCCCHHHHHHCCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
MGARPVASLDSLRFGSPRDPRVRYLVDGVVRGIGDYGNSFGVPTVGGEIYFEDCYTGNPL
CCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCH
VNVMSVGLVEHHKTVSATAWGKGNPVLIVGSSTGRDGIHGATFASEDLSEASEDKRPSVQ
HHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCEE
VGDPFAEKLLLEATLEAIATGAVVGLQDMGAAGLTSSTSEMSARGIEKTGSGGIEIDLDL
ECCHHHHHHHHHHHHHHHHHCCEEEHHHCCCCCCCCCCHHHHHCCCCCCCCCCEEEEEEC
TPAREKGMTAYELMLSESQERMLIVAEKGREHEIIDVYKKWDVSAVVIGQVTDDNMLRVR
CCCHHHCCCHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEEEECCCCEEEEE
HHGEVVAEIPATSLVLGGGAPVYIREAVEKKPDTPAADLVADDSLDFKALSLQLLSRPNI
ECCCEEEECCCEEEEECCCCCHHHHHHHHCCCCCCHHHHEECCCCCHHHHHHHHHCCCCC
ASKAWVYQQYDSMVQTNTVTPAGQTDAAVIRIKGTKKGLAMKTDCNSRYVYLNPKAGGAI
CHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCEEEEECCCCCCEE
AVAECARNIACTGAKPLAVTNCLNFGNPYKPEVYFQFKSAVEGIGDACRMFDTPITGGNV
EHHHHHCCCCCCCCCCEEHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCE
SFYNETSLGGGRTAIYPTPTIGMIGLLDNIDNLVESTFRKAGDAIVLLGAPELSLDGSEY
EEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEE
LVMQYGTPGTDSPAVDLNHEKNLQELLVTLASKKLINSAHDVSDGGLAVTLAEKSIMNRE
EEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHCHH
RMLGFEVDLECSCKEGTAIQKQLFSEAQGRVVISVDPGRVGAVIEEADRLNIPGRVIGKV
HHCCEEECEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEEE
TPEGASIAVNGKPVAEFMIDELLHAYGHALESALHLEEL
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STEPEVNLKLAQEHGLNEEEYAKICEILGRTPSFTELGIYSVMWSEHCSYKNSIAVLKT
CCCCCCEEEEHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEE
LPRDGASLLTQAGEENAGLVDIGDNLAVAFKIESHNHPSAVEPYQGAATGVGGIHRDIFT
CCCCCHHHHHHCCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
MGARPVASLDSLRFGSPRDPRVRYLVDGVVRGIGDYGNSFGVPTVGGEIYFEDCYTGNPL
CCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCH
VNVMSVGLVEHHKTVSATAWGKGNPVLIVGSSTGRDGIHGATFASEDLSEASEDKRPSVQ
HHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCEE
VGDPFAEKLLLEATLEAIATGAVVGLQDMGAAGLTSSTSEMSARGIEKTGSGGIEIDLDL
ECCHHHHHHHHHHHHHHHHHCCEEEHHHCCCCCCCCCCHHHHHCCCCCCCCCCEEEEEEC
TPAREKGMTAYELMLSESQERMLIVAEKGREHEIIDVYKKWDVSAVVIGQVTDDNMLRVR
CCCHHHCCCHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCCEEEEEEEECCCCEEEEE
HHGEVVAEIPATSLVLGGGAPVYIREAVEKKPDTPAADLVADDSLDFKALSLQLLSRPNI
ECCCEEEECCCEEEEECCCCCHHHHHHHHCCCCCCHHHHEECCCCCHHHHHHHHHCCCCC
ASKAWVYQQYDSMVQTNTVTPAGQTDAAVIRIKGTKKGLAMKTDCNSRYVYLNPKAGGAI
CHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCEEEEECCCCCCEE
AVAECARNIACTGAKPLAVTNCLNFGNPYKPEVYFQFKSAVEGIGDACRMFDTPITGGNV
EHHHHHCCCCCCCCCCEEHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCE
SFYNETSLGGGRTAIYPTPTIGMIGLLDNIDNLVESTFRKAGDAIVLLGAPELSLDGSEY
EEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEE
LVMQYGTPGTDSPAVDLNHEKNLQELLVTLASKKLINSAHDVSDGGLAVTLAEKSIMNRE
EEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHCHH
RMLGFEVDLECSCKEGTAIQKQLFSEAQGRVVISVDPGRVGAVIEEADRLNIPGRVIGKV
HHCCEEECEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEEE
TPEGASIAVNGKPVAEFMIDELLHAYGHALESALHLEEL
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901