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The map label for this gene is trxA [H]

Identifier: 21674040

GI number: 21674040

Start: 1140916

End: 1141722

Strand: Reverse

Name: trxA [H]

Synonym: CT1215

Alternate gene names: 21674040

Gene position: 1141722-1140916 (Counterclockwise)

Preceding gene: 21674041

Following gene: 21674039

Centisome position: 52.98

GC content: 56.13

Gene sequence:

>807_bases
ATGCAGAGCCGTATCCCTTTTGATTTTCAGAACGATGTCATCGAGCGAAGCAAAACCGTTCCGGTTCTTGTGGATTTCTG
GGCGCAGTGGTGCGGGCCTTGCCGCATTCTCGCTCCAGTGCTTGAGAAACTTGCTGAGCGTCATGCCGGAAAATGGGTGC
TCGTGAAGGTCAATACCGAAGAGTTTCCCGAGATTTCGGCGCAATATGGCATCAGGAGTATTCCCAATGTGAAGCTGTTT
TCAAACGGTGTGGTTATCGACGAATTCACCGGAGCTCTTCCGGAATACCAGATTGAACAGTGGCTCGCCAAAGCGTTGCC
AAGTCCCTGGGCCGAGGAGGTGGCGCGTGCAGCTGCCGAGATGGCCGCAGGCAACGACGCAGTGGCAATCACGCTGCTCG
AGGGAGTTTTGGCCAAAGAGCCGGAGAACAGGGACGCTGCCGCCATGCTGGCCCGGCTGATTCTGTTTTCACGTCCAGAA
GAGGCGCTCAGACTTGCCGAGACGCTCGAAGCAGAGCCGGATTACGCTGATCTGAGCGAGTCTGTCCGGACTCTCGGTGC
GTTGCTTGTTCGTCCCGCATCAGCCTTTCCGGATGGGGAGGGCCGCGAGGCTTATGGTGAGGCTGTCGAAAGCCTGCGGA
AGGGAGATATGGACAGTGCGCTCGAACATTTCATCTCGGTTCTGCGGACAAACCGCTATTACGACGACGATGGTTCACGC
AAGGCCTGTATCGCCATTTTCCGGTTTCTCGGCGAAGAGCATGAAATTACGATGAAATACCGTCGAGCGTTTGACCGGGC
GTTCTGA

Upstream 100 bases:

>100_bases
TTAAACCTGAAAAGTGTTTTATTAGAACGCAGTTGGTTTTTTTGACTTTTTCCGGCACAAATGCACATGGCCGGAATCTA
ATGATAAAACTACACGATTA

Downstream 100 bases:

>100_bases
AGAAAAAATCATGAATGGTTGGCCTTGGGCGCCAGCTGAATTGTTTTCCCTGTCTTTTCCTATAAGTCGTGTAAGTCCTA
TACGACGTGGGCACCCGCTG

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MQSRIPFDFQNDVIERSKTVPVLVDFWAQWCGPCRILAPVLEKLAERHAGKWVLVKVNTEEFPEISAQYGIRSIPNVKLF
SNGVVIDEFTGALPEYQIEQWLAKALPSPWAEEVARAAAEMAAGNDAVAITLLEGVLAKEPENRDAAAMLARLILFSRPE
EALRLAETLEAEPDYADLSESVRTLGALLVRPASAFPDGEGREAYGEAVESLRKGDMDSALEHFISVLRTNRYYDDDGSR
KACIAIFRFLGEEHEITMKYRRAFDRAF

Sequences:

>Translated_268_residues
MQSRIPFDFQNDVIERSKTVPVLVDFWAQWCGPCRILAPVLEKLAERHAGKWVLVKVNTEEFPEISAQYGIRSIPNVKLF
SNGVVIDEFTGALPEYQIEQWLAKALPSPWAEEVARAAAEMAAGNDAVAITLLEGVLAKEPENRDAAAMLARLILFSRPE
EALRLAETLEAEPDYADLSESVRTLGALLVRPASAFPDGEGREAYGEAVESLRKGDMDSALEHFISVLRTNRYYDDDGSR
KACIAIFRFLGEEHEITMKYRRAFDRAF
>Mature_268_residues
MQSRIPFDFQNDVIERSKTVPVLVDFWAQWCGPCRILAPVLEKLAERHAGKWVLVKVNTEEFPEISAQYGIRSIPNVKLF
SNGVVIDEFTGALPEYQIEQWLAKALPSPWAEEVARAAAEMAAGNDAVAITLLEGVLAKEPENRDAAAMLARLILFSRPE
EALRLAETLEAEPDYADLSESVRTLGALLVRPASAFPDGEGREAYGEAVESLRKGDMDSALEHFISVLRTNRYYDDDGSR
KACIAIFRFLGEEHEITMKYRRAFDRAF

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG3118

COG function: function code O; Thioredoxin domain-containing protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=99, Percent_Identity=41.4141414141414, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1788936, Length=87, Percent_Identity=49.4252873563218, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87081747, Length=268, Percent_Identity=29.4776119402985, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082331, Length=94, Percent_Identity=41.4893617021277, Blast_Score=92, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI212646193, Length=99, Percent_Identity=40.4040404040404, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17509965, Length=80, Percent_Identity=35, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=71, Percent_Identity=39.4366197183099, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573567, Length=107, Percent_Identity=36.4485981308411, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24639826, Length=71, Percent_Identity=39.4366197183099, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17648013, Length=71, Percent_Identity=40.8450704225352, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24583090, Length=71, Percent_Identity=40.8450704225352, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24664269, Length=87, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 30037; Mature: 30037

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSRIPFDFQNDVIERSKTVPVLVDFWAQWCGPCRILAPVLEKLAERHAGKWVLVKVNTE
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEEEEECCH
EFPEISAQYGIRSIPNVKLFSNGVVIDEFTGALPEYQIEQWLAKALPSPWAEEVARAAAE
HCHHHHHHCCCCCCCCCEEECCCEEEEHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
MAAGNDAVAITLLEGVLAKEPENRDAAAMLARLILFSRPEEALRLAETLEAEPDYADLSE
HHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHH
SVRTLGALLVRPASAFPDGEGREAYGEAVESLRKGDMDSALEHFISVLRTNRYYDDDGSR
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCH
KACIAIFRFLGEEHEITMKYRRAFDRAF
HHHHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQSRIPFDFQNDVIERSKTVPVLVDFWAQWCGPCRILAPVLEKLAERHAGKWVLVKVNTE
CCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEEEEEECCH
EFPEISAQYGIRSIPNVKLFSNGVVIDEFTGALPEYQIEQWLAKALPSPWAEEVARAAAE
HCHHHHHHCCCCCCCCCEEECCCEEEEHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
MAAGNDAVAITLLEGVLAKEPENRDAAAMLARLILFSRPEEALRLAETLEAEPDYADLSE
HHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHH
SVRTLGALLVRPASAFPDGEGREAYGEAVESLRKGDMDSALEHFISVLRTNRYYDDDGSR
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCH
KACIAIFRFLGEEHEITMKYRRAFDRAF
HHHHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]