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The map label for this gene is mutY [H]

Identifier: 21673988

GI number: 21673988

Start: 1094133

End: 1094954

Strand: Reverse

Name: mutY [H]

Synonym: CT1162

Alternate gene names: 21673988

Gene position: 1094954-1094133 (Counterclockwise)

Preceding gene: 21673989

Following gene: 21673981

Centisome position: 50.81

GC content: 59.61

Gene sequence:

>822_bases
ATGAATACCGCTCTCGTTGAGGCTTTTCAGGCGAAGATTTTCGATTTTTACGAAAAGAACAGGCGCAGCTTTCCCTGGCG
TTTGACCACTGACCGCTATGCCGTCATGGTGAGCGAGGTGATGCTGCAACAGACCCAGGCTGACCGTGTCGCGTCGCGAT
TCGCACGCTGGCTCGAGCGCTTTCCCGATGTACGCTCGCTCGCTTCCGCTTCATTGCGTGAAGTGCTCGAAGAGTGGAGT
GGTCTTGGCTACAACGGACGTGGCCAGCGCCTGCACCGCGCGGCGGCGATGATCATCGAGCGGTACGGCGGTGAGGTGCC
TGCCGAGCCTGCGCAACTCATCGAGCTGCCCGGTATTGGCGTTTACACGAGTCGCTCCATTCCCGTCTTTGCCGACAACC
TCGATATCGCCGCCGTCGATACCAACATCCGGCGCGTGCTGATTCACGAACTCAACCTTTCTGAATCGATCACTCCGAAA
GCGCTGCTCGACGTGGCCGAAGTGGTGTTGCCGAAAGGACGCAGTCGCGACTGGCACAATGCGCTGATGGATTACGGCGC
GATGGAGCTGACCGGCAAAAAAACCGGTATCGCGCCGCTGACGAAGCAGTCGAGCTTCAAAGGCTCGCGCCGATGGTATC
GAGGGGCACTCTTGCGCGAGCTGATTGCAGCGGGGGAGTTGTCACGCGAGGCGGTCGAGGAGCGATATGCGGATTGCCCG
CATGGCATCGGCTCGATTGTCGATTCGCTGGTCATGGAGTCGATGATCGAGGAGTACGGCGAGCAGCGAATGCTGCGGAT
TGCAGGTGAGAACTCGCCGTAG

Upstream 100 bases:

>100_bases
GTTGCGCTGCTTTCTTGCTTTGTGTACGCCAGTGAACCTTTAGGACGCTGTGGACGGAGAGTGATGACTATTTTTCCTCT
TCTGATTTTTACCCGAAACG

Downstream 100 bases:

>100_bases
AGGCAGGTCAACGTTCGAGCTAAGCTGCCTGCCGTAGCGGGTCAGCTTGAGCGAGGGGTTAGGCCGCACCCGCTATGGTA
GAGCGATTCCTCCCTCGCGA

Product: A/G-specific adenine glycosylase, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MNTALVEAFQAKIFDFYEKNRRSFPWRLTTDRYAVMVSEVMLQQTQADRVASRFARWLERFPDVRSLASASLREVLEEWS
GLGYNGRGQRLHRAAAMIIERYGGEVPAEPAQLIELPGIGVYTSRSIPVFADNLDIAAVDTNIRRVLIHELNLSESITPK
ALLDVAEVVLPKGRSRDWHNALMDYGAMELTGKKTGIAPLTKQSSFKGSRRWYRGALLRELIAAGELSREAVEERYADCP
HGIGSIVDSLVMESMIEEYGEQRMLRIAGENSP

Sequences:

>Translated_273_residues
MNTALVEAFQAKIFDFYEKNRRSFPWRLTTDRYAVMVSEVMLQQTQADRVASRFARWLERFPDVRSLASASLREVLEEWS
GLGYNGRGQRLHRAAAMIIERYGGEVPAEPAQLIELPGIGVYTSRSIPVFADNLDIAAVDTNIRRVLIHELNLSESITPK
ALLDVAEVVLPKGRSRDWHNALMDYGAMELTGKKTGIAPLTKQSSFKGSRRWYRGALLRELIAAGELSREAVEERYADCP
HGIGSIVDSLVMESMIEEYGEQRMLRIAGENSP
>Mature_273_residues
MNTALVEAFQAKIFDFYEKNRRSFPWRLTTDRYAVMVSEVMLQQTQADRVASRFARWLERFPDVRSLASASLREVLEEWS
GLGYNGRGQRLHRAAAMIIERYGGEVPAEPAQLIELPGIGVYTSRSIPVFADNLDIAAVDTNIRRVLIHELNLSESITPK
ALLDVAEVVLPKGRSRDWHNALMDYGAMELTGKKTGIAPLTKQSSFKGSRRWYRGALLRELIAAGELSREAVEERYADCP
HGIGSIVDSLVMESMIEEYGEQRMLRIAGENSP

Specific function: Adenine glycosylase active on G-A and C-A mispairs [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI6912520, Length=241, Percent_Identity=35.2697095435685, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI190358497, Length=241, Percent_Identity=35.2697095435685, Blast_Score=131, Evalue=6e-31,
Organism=Homo sapiens, GI115298648, Length=241, Percent_Identity=35.2697095435685, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI115298654, Length=241, Percent_Identity=35.2697095435685, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI115298652, Length=241, Percent_Identity=35.2697095435685, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI115298650, Length=241, Percent_Identity=35.2697095435685, Blast_Score=131, Evalue=7e-31,
Organism=Escherichia coli, GI1789331, Length=211, Percent_Identity=35.0710900473934, Blast_Score=123, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 30763; Mature: 30763

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTALVEAFQAKIFDFYEKNRRSFPWRLTTDRYAVMVSEVMLQQTQADRVASRFARWLER
CCHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPDVRSLASASLREVLEEWSGLGYNGRGQRLHRAAAMIIERYGGEVPAEPAQLIELPGIG
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCC
VYTSRSIPVFADNLDIAAVDTNIRRVLIHELNLSESITPKALLDVAEVVLPKGRSRDWHN
EEECCCCCEEECCCCEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHH
ALMDYGAMELTGKKTGIAPLTKQSSFKGSRRWYRGALLRELIAAGELSREAVEERYADCP
HHHHCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HGIGSIVDSLVMESMIEEYGEQRMLRIAGENSP
CHHHHHHHHHHHHHHHHHHHHHHEEHHCCCCCC
>Mature Secondary Structure
MNTALVEAFQAKIFDFYEKNRRSFPWRLTTDRYAVMVSEVMLQQTQADRVASRFARWLER
CCHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FPDVRSLASASLREVLEEWSGLGYNGRGQRLHRAAAMIIERYGGEVPAEPAQLIELPGIG
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCC
VYTSRSIPVFADNLDIAAVDTNIRRVLIHELNLSESITPKALLDVAEVVLPKGRSRDWHN
EEECCCCCEEECCCCEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHH
ALMDYGAMELTGKKTGIAPLTKQSSFKGSRRWYRGALLRELIAAGELSREAVEERYADCP
HHHHCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
HGIGSIVDSLVMESMIEEYGEQRMLRIAGENSP
CHHHHHHHHHHHHHHHHHHHHHHEEHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12522265 [H]