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The map label for this gene is argF

Identifier: 21673938

GI number: 21673938

Start: 1045645

End: 1046661

Strand: Direct

Name: argF

Synonym: CT1112

Alternate gene names: 21673938

Gene position: 1045645-1046661 (Clockwise)

Preceding gene: 21673937

Following gene: 21673939

Centisome position: 48.52

GC content: 59.29

Gene sequence:

>1017_bases
ATGAGCCAGGACAACAAAGGCAACGGATCAAAAAAACGCGACTTTCTCGGATTCACCGGCCTCGATGCAGCCAAAATCAT
TGAACTGTTCGACTACTCGCTTTTTATCAAACAGCAGCGCGAAACCAACCGTAACAGTGACGAGTTCCGCCCGATCCGCC
ACAAAACCGTGGCCATGATCTTCAACAAGCCCTCGCTGCGCACGCGGGTGTCGTTCGAACTTGGCGTCTATGAACTTGGC
GGCCACGCCATCAGCCTCGAAGGCAAGTCGATCGGCGTTGGCGAACGCGAGTCGATCGAAGACATCGCCCGCCTGCTCTC
GCGCTACAACGACGCGATTGTCGCCCGCCTGCACGAGCACGAGATCATCGAAACCCTCGCCAAGCACGCAGATATTCCGG
TCATCAACGCGCTGACCGACCTGTCGCACCCGTGCCAGGTTCTGGCCGACGCCTTCACGCTCTATGAAAAGGGGCTGTGG
CGCGACGACATCAAAGTGGTCTTTGTCGGCGACGGCAACAACGTGGCGAACTCGTGGATCGAACTGGCCGGCATCCTGCC
GTTCCACTTCGTACTCGCCTGCCCTGAGGGCTACCTGCCCGATGAAACGCTGTTGAAGCAGGCGCGCAGCAACGCTAAGG
GCACGATCGAGATTCTGCACGATCCGATGGAGGCGGCAAAACAGGCCGATGTGCTCTATACCGACGTCTGGACGAGCATG
GGTCAGGAAGAGGAGATGGCCGAGCGCCTGAAGGCGTTCGCACCGTTCCAAATCAACGCGAAGATGGTGGCCGAAGCCAA
ACCGTCGGCGGTGATCATGCACTGCATGCCCGCGCATCGCGGCCAGGAGATCAGCGCCGAGGTGATGGACGGCCCGCAGT
CGATCATCATCGACGAGGCCGAAAATCGCCTGCATGTGCAGAAGGCGCTCATGGTGAAGCTGATGAACCACGACGTTTAC
CGCAAGTTCCACCTGACGCACCGCCTGCACCGGGCTGCAAATCGCCTCAAAGCCTGA

Upstream 100 bases:

>100_bases
TCACCCATTCGCTGCTGCTTGAAGTCTTCACCAACGAAGGCGTCGGCACGCAGTTTGTCAACGAACTTGAACAAGAACCA
ACTGCTGAAGAAGGAGCATC

Downstream 100 bases:

>100_bases
CGCGAAAACGATGAACAAGGCCAGCAGGCAGAAAAAGATCAGGGAACTGATCGAAAACCATGAGGTCTCGGGACAGCAGG
AGCTGCTCGGTATGCTCGAA

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSQDNKGNGSKKRDFLGFTGLDAAKIIELFDYSLFIKQQRETNRNSDEFRPIRHKTVAMIFNKPSLRTRVSFELGVYELG
GHAISLEGKSIGVGERESIEDIARLLSRYNDAIVARLHEHEIIETLAKHADIPVINALTDLSHPCQVLADAFTLYEKGLW
RDDIKVVFVGDGNNVANSWIELAGILPFHFVLACPEGYLPDETLLKQARSNAKGTIEILHDPMEAAKQADVLYTDVWTSM
GQEEEMAERLKAFAPFQINAKMVAEAKPSAVIMHCMPAHRGQEISAEVMDGPQSIIIDEAENRLHVQKALMVKLMNHDVY
RKFHLTHRLHRAANRLKA

Sequences:

>Translated_338_residues
MSQDNKGNGSKKRDFLGFTGLDAAKIIELFDYSLFIKQQRETNRNSDEFRPIRHKTVAMIFNKPSLRTRVSFELGVYELG
GHAISLEGKSIGVGERESIEDIARLLSRYNDAIVARLHEHEIIETLAKHADIPVINALTDLSHPCQVLADAFTLYEKGLW
RDDIKVVFVGDGNNVANSWIELAGILPFHFVLACPEGYLPDETLLKQARSNAKGTIEILHDPMEAAKQADVLYTDVWTSM
GQEEEMAERLKAFAPFQINAKMVAEAKPSAVIMHCMPAHRGQEISAEVMDGPQSIIIDEAENRLHVQKALMVKLMNHDVY
RKFHLTHRLHRAANRLKA
>Mature_337_residues
SQDNKGNGSKKRDFLGFTGLDAAKIIELFDYSLFIKQQRETNRNSDEFRPIRHKTVAMIFNKPSLRTRVSFELGVYELGG
HAISLEGKSIGVGERESIEDIARLLSRYNDAIVARLHEHEIIETLAKHADIPVINALTDLSHPCQVLADAFTLYEKGLWR
DDIKVVFVGDGNNVANSWIELAGILPFHFVLACPEGYLPDETLLKQARSNAKGTIEILHDPMEAAKQADVLYTDVWTSMG
QEEEMAERLKAFAPFQINAKMVAEAKPSAVIMHCMPAHRGQEISAEVMDGPQSIIIDEAENRLHVQKALMVKLMNHDVYR
KFHLTHRLHRAANRLKA

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=314, Percent_Identity=40.4458598726115, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI18105007, Length=299, Percent_Identity=29.4314381270903, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1786469, Length=331, Percent_Identity=34.441087613293, Blast_Score=194, Evalue=5e-51,
Organism=Escherichia coli, GI1790703, Length=335, Percent_Identity=33.7313432835821, Blast_Score=190, Evalue=9e-50,
Organism=Escherichia coli, GI2367364, Length=280, Percent_Identity=29.2857142857143, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI193204318, Length=322, Percent_Identity=25.776397515528, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322373, Length=264, Percent_Identity=34.469696969697, Blast_Score=162, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6322331, Length=278, Percent_Identity=29.4964028776978, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24642586, Length=291, Percent_Identity=25.7731958762887, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OTC_CHLTE (Q8KDE2)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662003.1
- ProteinModelPortal:   Q8KDE2
- SMR:   Q8KDE2
- GeneID:   1006896
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1112
- NMPDR:   fig|194439.1.peg.1097
- TIGR:   CT1112
- HOGENOM:   HBG579429
- OMA:   KHETLLE
- ProtClustDB:   PRK00779
- BioCyc:   CTEP194439:CT_1112-MONOMER
- BRENDA:   2.1.3.3
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 38106; Mature: 37975

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 116-116 BINDING 143-143

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQDNKGNGSKKRDFLGFTGLDAAKIIELFDYSLFIKQQRETNRNSDEFRPIRHKTVAMI
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEE
FNKPSLRTRVSFELGVYELGGHAISLEGKSIGVGERESIEDIARLLSRYNDAIVARLHEH
ECCCCCCEEEEEEECEEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHH
EIIETLAKHADIPVINALTDLSHPCQVLADAFTLYEKGLWRDDIKVVFVGDGNNVANSWI
HHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHH
ELAGILPFHFVLACPEGYLPDETLLKQARSNAKGTIEILHDPMEAAKQADVLYTDVWTSM
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHCCHHHHHHHHHC
GQEEEMAERLKAFAPFQINAKMVAEAKPSAVIMHCMPAHRGQEISAEVMDGPQSIIIDEA
CCHHHHHHHHHHCCCEEECCEEEECCCCCEEEEEECCCCCCCCCCHHHHCCCCEEEEECC
ENRLHVQKALMVKLMNHDVYRKFHLTHRLHRAANRLKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQDNKGNGSKKRDFLGFTGLDAAKIIELFDYSLFIKQQRETNRNSDEFRPIRHKTVAMI
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEE
FNKPSLRTRVSFELGVYELGGHAISLEGKSIGVGERESIEDIARLLSRYNDAIVARLHEH
ECCCCCCEEEEEEECEEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHH
EIIETLAKHADIPVINALTDLSHPCQVLADAFTLYEKGLWRDDIKVVFVGDGNNVANSWI
HHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHH
ELAGILPFHFVLACPEGYLPDETLLKQARSNAKGTIEILHDPMEAAKQADVLYTDVWTSM
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHCCHHHHHHHHHC
GQEEEMAERLKAFAPFQINAKMVAEAKPSAVIMHCMPAHRGQEISAEVMDGPQSIIIDEA
CCHHHHHHHHHHCCCEEECCEEEECCCCCEEEEEECCCCCCCCCCHHHHCCCCEEEEECC
ENRLHVQKALMVKLMNHDVYRKFHLTHRLHRAANRLKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901