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The map label for this gene is mntH [H]

Identifier: 21673838

GI number: 21673838

Start: 953677

End: 954936

Strand: Direct

Name: mntH [H]

Synonym: CT1010

Alternate gene names: 21673838

Gene position: 953677-954936 (Clockwise)

Preceding gene: 21673837

Following gene: 21673839

Centisome position: 44.26

GC content: 58.57

Gene sequence:

>1260_bases
ATGGCAGTTTCATTTTCGAAATTGATACAATCCCGCTGGCTTCCTCTCAAAAAGCTTCTGGGATTTCTCGGACCGGGATT
TCTGGTGACGGTTGGATTCATCGACCCTGGCAACTGGGCCACCAATATCGAAGGGGGTGCGCGGTTCGGTTACGAACTGC
TCTGGGTGATCACGCTCAGCACGCTGATTCTGATCGTTATCCAGCACATGGCCGCGCGGCTTGGCATCGCCACGGGCAAG
TCGCTGGCGGTTAACATTCGAGACCATTTTCCCGCGCCGGTTTCATCGCTTCTTGGCTTTACGATTGTTGCCGCCTGCGT
TGCCACCGACGTGGCCGAGCTGGTTGGCGGTGGCATCGGCTTCAGTCTCCTTTTTGGGATGCCGCTCTGGGCCGGGGCGC
TTCTGACCGTGGTGCTCGAAGTGTTCCTCGTGGTCAGCCAGCGCTACCATCGCATCGAGACCATTATCGTCGGCTTTCTC
GGCATCATCGCGCTCTGCTATCTCGCTGAACTCTGGATCGTCCGACCGGCCTGGCACGAAGTGCTGCCCGCCACGGTCAC
GCCGGTGCTGGGCCGTGAGAGCATCTACGTCGCCATTGCCATTCTTGGTGCAGTGGTCATGCCGCACAACGTGTATCTGC
ACTCCAACGTCATTCACAGCCGGAAATGGGGGATGACCGATGATGAGAAAAAAGAGCTGCTTCGCTACGAAAAAGCCGAT
ACTCTTTTTGCCATGACGCTTGGCTGGGTGGTCAATTCAGCGATGATCGTTGTCGCCGCCGCCGTGTTTCACCAGCATGG
CGTGCGGGTCGAGAGCATCGAGCAGGCATCCGCGACGCTCAGACCGCTGGCCGGGCCGCTGGCGGGGTTGCTCTTCGCCG
TGGCGCTTGTGTTCGCGGGAGTCGGTTCATCGATCACCTCCTCGATGGCCGAGGCCAACGTCATCACCGGCTTTCTCGGC
AAGCCCGAAGACCCGGAGAGCCTGCTCTGGCGCGTGTCGGTGTTCCTGACCGCCATCCCTTCCTTTATCATCATTCTGTT
CAAGGTCGATACCTACAAAATCCTGATTTTCAGCCAGGTGGTGCTGAGCCTTCAACTGCCCTTCACGCTTTTGCCGCTCT
TGGTGCTCTGCCGGAGCGAAAAGGTGATGGGGGTCTTCCGGAGCCGGGGCGTCGAATTCGTTGCGGCGGTGCTGATTACC
ATGGTGGTCGTTGCGCTCAATCTCTATCTGCTCTCTACCACAGTGACCGGAGACTCATGA

Upstream 100 bases:

>100_bases
AAGGCTGCGATTGATCTCTTCTGATGTTCCTGATGCCGGGTGACGCGAACTGAAATCGCGGAGCCCCCTCACCGGCAAGG
GATTTCCTCAATCCTCGATT

Downstream 100 bases:

>100_bases
TATGAAGGCATACCAAAACATACTGGTGGCTATCGATGGTTCCGGGGCCGACGACGCGCTGATCGAACAGGTCTCGGCTC
TTGCCGCGCCGCTGGGATCG

Product: natural resistance-associated macrophage protein family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MAVSFSKLIQSRWLPLKKLLGFLGPGFLVTVGFIDPGNWATNIEGGARFGYELLWVITLSTLILIVIQHMAARLGIATGK
SLAVNIRDHFPAPVSSLLGFTIVAACVATDVAELVGGGIGFSLLFGMPLWAGALLTVVLEVFLVVSQRYHRIETIIVGFL
GIIALCYLAELWIVRPAWHEVLPATVTPVLGRESIYVAIAILGAVVMPHNVYLHSNVIHSRKWGMTDDEKKELLRYEKAD
TLFAMTLGWVVNSAMIVVAAAVFHQHGVRVESIEQASATLRPLAGPLAGLLFAVALVFAGVGSSITSSMAEANVITGFLG
KPEDPESLLWRVSVFLTAIPSFIIILFKVDTYKILIFSQVVLSLQLPFTLLPLLVLCRSEKVMGVFRSRGVEFVAAVLIT
MVVVALNLYLLSTTVTGDS

Sequences:

>Translated_419_residues
MAVSFSKLIQSRWLPLKKLLGFLGPGFLVTVGFIDPGNWATNIEGGARFGYELLWVITLSTLILIVIQHMAARLGIATGK
SLAVNIRDHFPAPVSSLLGFTIVAACVATDVAELVGGGIGFSLLFGMPLWAGALLTVVLEVFLVVSQRYHRIETIIVGFL
GIIALCYLAELWIVRPAWHEVLPATVTPVLGRESIYVAIAILGAVVMPHNVYLHSNVIHSRKWGMTDDEKKELLRYEKAD
TLFAMTLGWVVNSAMIVVAAAVFHQHGVRVESIEQASATLRPLAGPLAGLLFAVALVFAGVGSSITSSMAEANVITGFLG
KPEDPESLLWRVSVFLTAIPSFIIILFKVDTYKILIFSQVVLSLQLPFTLLPLLVLCRSEKVMGVFRSRGVEFVAAVLIT
MVVVALNLYLLSTTVTGDS
>Mature_418_residues
AVSFSKLIQSRWLPLKKLLGFLGPGFLVTVGFIDPGNWATNIEGGARFGYELLWVITLSTLILIVIQHMAARLGIATGKS
LAVNIRDHFPAPVSSLLGFTIVAACVATDVAELVGGGIGFSLLFGMPLWAGALLTVVLEVFLVVSQRYHRIETIIVGFLG
IIALCYLAELWIVRPAWHEVLPATVTPVLGRESIYVAIAILGAVVMPHNVYLHSNVIHSRKWGMTDDEKKELLRYEKADT
LFAMTLGWVVNSAMIVVAAAVFHQHGVRVESIEQASATLRPLAGPLAGLLFAVALVFAGVGSSITSSMAEANVITGFLGK
PEDPESLLWRVSVFLTAIPSFIIILFKVDTYKILIFSQVVLSLQLPFTLLPLLVLCRSEKVMGVFRSRGVEFVAAVLITM
VVVALNLYLLSTTVTGDS

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=440, Percent_Identity=29.5454545454545, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI295293167, Length=438, Percent_Identity=29.4520547945205, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI295293175, Length=437, Percent_Identity=29.0617848970252, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI295293173, Length=437, Percent_Identity=29.0617848970252, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI10835169, Length=437, Percent_Identity=29.0617848970252, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI295293171, Length=437, Percent_Identity=29.0617848970252, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI295293169, Length=437, Percent_Identity=29.0617848970252, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI295293178, Length=437, Percent_Identity=29.0617848970252, Blast_Score=135, Evalue=6e-32,
Organism=Escherichia coli, GI1788736, Length=406, Percent_Identity=38.6699507389163, Blast_Score=239, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17569473, Length=374, Percent_Identity=29.6791443850267, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI193210616, Length=439, Percent_Identity=28.0182232346241, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71999499, Length=437, Percent_Identity=26.3157894736842, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71993856, Length=211, Percent_Identity=34.5971563981043, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323062, Length=408, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6321841, Length=425, Percent_Identity=32, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324450, Length=428, Percent_Identity=29.9065420560748, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24648607, Length=448, Percent_Identity=26.3392857142857, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI281362176, Length=448, Percent_Identity=26.3392857142857, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24648609, Length=448, Percent_Identity=26.3392857142857, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI45553443, Length=419, Percent_Identity=26.2529832935561, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 45368; Mature: 45236

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSFSKLIQSRWLPLKKLLGFLGPGFLVTVGFIDPGNWATNIEGGARFGYELLWVITLS
CCCCHHHHHHHHCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
TLILIVIQHMAARLGIATGKSLAVNIRDHFPAPVSSLLGFTIVAACVATDVAELVGGGIG
HHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
FSLLFGMPLWAGALLTVVLEVFLVVSQRYHRIETIIVGFLGIIALCYLAELWIVRPAWHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VLPATVTPVLGRESIYVAIAILGAVVMPHNVYLHSNVIHSRKWGMTDDEKKELLRYEKAD
HCCHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHH
TLFAMTLGWVVNSAMIVVAAAVFHQHGVRVESIEQASATLRPLAGPLAGLLFAVALVFAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VGSSITSSMAEANVITGFLGKPEDPESLLWRVSVFLTAIPSFIIILFKVDTYKILIFSQV
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHH
VLSLQLPFTLLPLLVLCRSEKVMGVFRSRGVEFVAAVLITMVVVALNLYLLSTTVTGDS
HHHHCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEECCCCC
>Mature Secondary Structure 
AVSFSKLIQSRWLPLKKLLGFLGPGFLVTVGFIDPGNWATNIEGGARFGYELLWVITLS
CCCHHHHHHHHCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
TLILIVIQHMAARLGIATGKSLAVNIRDHFPAPVSSLLGFTIVAACVATDVAELVGGGIG
HHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
FSLLFGMPLWAGALLTVVLEVFLVVSQRYHRIETIIVGFLGIIALCYLAELWIVRPAWHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VLPATVTPVLGRESIYVAIAILGAVVMPHNVYLHSNVIHSRKWGMTDDEKKELLRYEKAD
HCCHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHH
TLFAMTLGWVVNSAMIVVAAAVFHQHGVRVESIEQASATLRPLAGPLAGLLFAVALVFAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
VGSSITSSMAEANVITGFLGKPEDPESLLWRVSVFLTAIPSFIIILFKVDTYKILIFSQV
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHH
VLSLQLPFTLLPLLVLCRSEKVMGVFRSRGVEFVAAVLITMVVVALNLYLLSTTVTGDS
HHHHCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]