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The map label for this gene is rnr1 [H]

Identifier: 21673828

GI number: 21673828

Start: 948478

End: 949941

Strand: Direct

Name: rnr1 [H]

Synonym: CT1000

Alternate gene names: 21673828

Gene position: 948478-949941 (Clockwise)

Preceding gene: 21673827

Following gene: 21673829

Centisome position: 44.01

GC content: 59.22

Gene sequence:

>1464_bases
ATGAGCAGGAAAAAGGGGAAAGCCGATATCGTTAAAATTGCGGTTGGCGTCATGCTGCTGAACGGTCTGGAGCCGGATTT
TTCACTGGAGGCGGAGCATCAGCTGGAGTCGATTGACGGGCCGGGCAAGGAGAATGGCTCGGAAATTCTCGATCTCACGT
CACTGCTCTGGTGCTCGATCGATAACGACGACTCGCGCGATCTCGACCAGCTTACCGCCTGTGAAGTGCAGGAGGATTCG
TCAATCATCATCTACGTGGCCATCGCCGACGTCGATACCCTGGTGAAAAAAGGCTCGCCAATCGATAAACACGCCTGGAT
AAACACCACCTCGGTCTATACCTCGGCGAAAGTGTTTCCCATGCTCCCTCTGCGCCTCTCTACCGATCTCACCTCCCTCA
ATGCCAACGAGAACCGGCTTGCTATCGTCACCATCATGAAGATCGGAGCGGATGGCGAACTGATCACCTCCACAGTCGAG
CGTGCCTGGGTGCGCAACAAGGCGAAGCTCGCGTACGATTCCGTCGCCGCCTGGCTCGAGGGCAACGGCGAGCTGCCTCC
GGCGGCCCGGGCGGTGCCGGGCATGGATCAGCAGTTGCGGCATCAGGATCAGGTAGCGCAGAAGCTGCGGCTACGCAGGC
ACGCAAAAGGTTCGCTGGAGTTCGAGACCTTCCAGCCGCGCGCCGTTTTCGAGGGAGATCGCGTCGTTGATATCAAGGAA
CAGGAGAAGAACCGGGCGCGGCAGCTCATCGAGGAGTTCATGATCTCCACCAACACCTGCACCGCAAATTTTCTGGCAGA
AAAGGGCGTCGCCTCGATTCGCCGCGTCGTCAAGTCGCCTGAACGGTGGCGGCGCATTGTCAACGTGGCGAGCGAGTACG
GTTACGCCTTGCCCGGCGCACCTGACGGAAAGGCGCTTGAAAGCTTCCTCGCATTGAGGTTCAAGGAAGACCCGCTCCGT
TTCCCCGATCTCTCCCTGACCATCATCAAGCTCATGGGGTCGGGAGAGTATGTCGTGGAGTTCCCGGGGCAGGAGCCGAT
TGGCCATTTCGGCCTTGCCGAGCGCGACTATACCCACTCGACAGCTCCGAACAGGCGCTATCCCGACCTGATCACCCTGA
GAATGACCAAGGCATTTCTGACGAACAGTCCGCCGCCCTACGGCATCGACGAGCTGGAGTATCTCGCGGTACACTGCACG
CGCCAGGAGGATGCGGCCCGCAAGGTGGAGCGGCGCGTGCGCAAATCCGAAGCTGCGTTACTGATGCAGAGCATGATCGG
TCACCATTTTGACGCCATCGTCTCCGGCCACTCGGAAAAGGGTTCGTGGGTGCGGATATTCACGCCGCCAGTCGAGGGGC
GGCTGGTGAGGAACGTCGGGAAAATCAAAGTCGGCCAGAAAATCAAGGTCAAGCTCGTGCTGGCGGACGTCGATCGCGGC
TTCATCGATTTCGAAAGGGTGTGA

Upstream 100 bases:

>100_bases
CGGTCTTCTCGACGATACCAAAATGATGGCGGTCAACAGGGCGCTAGCGCTCTGGTTCGGTTTTGCTTGAGAAACTTATC
TATCAGTAAAGGAGAGGCGT

Downstream 100 bases:

>100_bases
AATGCTGTGCGTGTCGCTTCAGATAGCGATCCTATTTCTTTGCTGTTTGGTTTTGCACAAAGAACTTTACAAAACAAAGT
ATTTGCTTGATTTAAAAAAG

Product: ribonuclease II family protein

Products: NA

Alternate protein names: RNase R 1; VacB protein homolog 1 [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MSRKKGKADIVKIAVGVMLLNGLEPDFSLEAEHQLESIDGPGKENGSEILDLTSLLWCSIDNDDSRDLDQLTACEVQEDS
SIIIYVAIADVDTLVKKGSPIDKHAWINTTSVYTSAKVFPMLPLRLSTDLTSLNANENRLAIVTIMKIGADGELITSTVE
RAWVRNKAKLAYDSVAAWLEGNGELPPAARAVPGMDQQLRHQDQVAQKLRLRRHAKGSLEFETFQPRAVFEGDRVVDIKE
QEKNRARQLIEEFMISTNTCTANFLAEKGVASIRRVVKSPERWRRIVNVASEYGYALPGAPDGKALESFLALRFKEDPLR
FPDLSLTIIKLMGSGEYVVEFPGQEPIGHFGLAERDYTHSTAPNRRYPDLITLRMTKAFLTNSPPPYGIDELEYLAVHCT
RQEDAARKVERRVRKSEAALLMQSMIGHHFDAIVSGHSEKGSWVRIFTPPVEGRLVRNVGKIKVGQKIKVKLVLADVDRG
FIDFERV

Sequences:

>Translated_487_residues
MSRKKGKADIVKIAVGVMLLNGLEPDFSLEAEHQLESIDGPGKENGSEILDLTSLLWCSIDNDDSRDLDQLTACEVQEDS
SIIIYVAIADVDTLVKKGSPIDKHAWINTTSVYTSAKVFPMLPLRLSTDLTSLNANENRLAIVTIMKIGADGELITSTVE
RAWVRNKAKLAYDSVAAWLEGNGELPPAARAVPGMDQQLRHQDQVAQKLRLRRHAKGSLEFETFQPRAVFEGDRVVDIKE
QEKNRARQLIEEFMISTNTCTANFLAEKGVASIRRVVKSPERWRRIVNVASEYGYALPGAPDGKALESFLALRFKEDPLR
FPDLSLTIIKLMGSGEYVVEFPGQEPIGHFGLAERDYTHSTAPNRRYPDLITLRMTKAFLTNSPPPYGIDELEYLAVHCT
RQEDAARKVERRVRKSEAALLMQSMIGHHFDAIVSGHSEKGSWVRIFTPPVEGRLVRNVGKIKVGQKIKVKLVLADVDRG
FIDFERV
>Mature_486_residues
SRKKGKADIVKIAVGVMLLNGLEPDFSLEAEHQLESIDGPGKENGSEILDLTSLLWCSIDNDDSRDLDQLTACEVQEDSS
IIIYVAIADVDTLVKKGSPIDKHAWINTTSVYTSAKVFPMLPLRLSTDLTSLNANENRLAIVTIMKIGADGELITSTVER
AWVRNKAKLAYDSVAAWLEGNGELPPAARAVPGMDQQLRHQDQVAQKLRLRRHAKGSLEFETFQPRAVFEGDRVVDIKEQ
EKNRARQLIEEFMISTNTCTANFLAEKGVASIRRVVKSPERWRRIVNVASEYGYALPGAPDGKALESFLALRFKEDPLRF
PDLSLTIIKLMGSGEYVVEFPGQEPIGHFGLAERDYTHSTAPNRRYPDLITLRMTKAFLTNSPPPYGIDELEYLAVHCTR
QEDAARKVERRVRKSEAALLMQSMIGHHFDAIVSGHSEKGSWVRIFTPPVEGRLVRNVGKIKVGQKIKVKLVLADVDRGF
IDFERV

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=463, Percent_Identity=26.9978401727862, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI190014623, Length=336, Percent_Identity=26.7857142857143, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI190014625, Length=336, Percent_Identity=26.7857142857143, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI219521928, Length=397, Percent_Identity=22.9219143576826, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI19115966, Length=397, Percent_Identity=22.9219143576826, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI87082383, Length=413, Percent_Identity=30.2663438256659, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1787542, Length=378, Percent_Identity=31.4814814814815, Blast_Score=128, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17553506, Length=413, Percent_Identity=29.0556900726392, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI212645896, Length=338, Percent_Identity=27.5147928994083, Blast_Score=106, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324552, Length=412, Percent_Identity=24.7572815533981, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24649634, Length=344, Percent_Identity=24.7093023255814, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI19922976, Length=362, Percent_Identity=24.585635359116, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24654597, Length=362, Percent_Identity=24.585635359116, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24654592, Length=362, Percent_Identity=24.585635359116, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 54461; Mature: 54330

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRKKGKADIVKIAVGVMLLNGLEPDFSLEAEHQLESIDGPGKENGSEILDLTSLLWCSI
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHEEEC
DNDDSRDLDQLTACEVQEDSSIIIYVAIADVDTLVKKGSPIDKHAWINTTSVYTSAKVFP
CCCCCCCHHHHHHHCCCCCCCEEEEEEECCHHHHHHCCCCCCCCCEEECHHHEECCEEEE
MLPLRLSTDLTSLNANENRLAIVTIMKIGADGELITSTVERAWVRNKAKLAYDSVAAWLE
EECEEECCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHC
GNGELPPAARAVPGMDQQLRHQDQVAQKLRLRRHAKGSLEFETFQPRAVFEGDRVVDIKE
CCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCEEEECHH
QEKNRARQLIEEFMISTNTCTANFLAEKGVASIRRVVKSPERWRRIVNVASEYGYALPGA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCC
PDGKALESFLALRFKEDPLRFPDLSLTIIKLMGSGEYVVEFPGQEPIGHFGLAERDYTHS
CCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCC
TAPNRRYPDLITLRMTKAFLTNSPPPYGIDELEYLAVHCTRQEDAARKVERRVRKSEAAL
CCCCCCCCCEEEEEEHHHHHCCCCCCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHHH
LMQSMIGHHFDAIVSGHSEKGSWVRIFTPPVEGRLVRNVGKIKVGQKIKVKLVLADVDRG
HHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHCCCCEECCCEEEEEEEEEECCCC
FIDFERV
CEECCCC
>Mature Secondary Structure 
SRKKGKADIVKIAVGVMLLNGLEPDFSLEAEHQLESIDGPGKENGSEILDLTSLLWCSI
CCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHEEEC
DNDDSRDLDQLTACEVQEDSSIIIYVAIADVDTLVKKGSPIDKHAWINTTSVYTSAKVFP
CCCCCCCHHHHHHHCCCCCCCEEEEEEECCHHHHHHCCCCCCCCCEEECHHHEECCEEEE
MLPLRLSTDLTSLNANENRLAIVTIMKIGADGELITSTVERAWVRNKAKLAYDSVAAWLE
EECEEECCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHC
GNGELPPAARAVPGMDQQLRHQDQVAQKLRLRRHAKGSLEFETFQPRAVFEGDRVVDIKE
CCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCEEEECHH
QEKNRARQLIEEFMISTNTCTANFLAEKGVASIRRVVKSPERWRRIVNVASEYGYALPGA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCC
PDGKALESFLALRFKEDPLRFPDLSLTIIKLMGSGEYVVEFPGQEPIGHFGLAERDYTHS
CCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCC
TAPNRRYPDLITLRMTKAFLTNSPPPYGIDELEYLAVHCTRQEDAARKVERRVRKSEAAL
CCCCCCCCCEEEEEEHHHHHCCCCCCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHHHH
LMQSMIGHHFDAIVSGHSEKGSWVRIFTPPVEGRLVRNVGKIKVGQKIKVKLVLADVDRG
HHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHCCCCEECCCEEEEEEEEEECCCC
FIDFERV
CEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]