Click here to switch to the map view.

The map label for this gene is trx-2

Identifier: 21673670

GI number: 21673670

Start: 806160

End: 806489

Strand: Direct

Name: trx-2

Synonym: CT0841

Alternate gene names: 21673670

Gene position: 806160-806489 (Clockwise)

Preceding gene: 21673669

Following gene: 21673671

Centisome position: 37.41

GC content: 52.73

Gene sequence:

>330_bases
ATGAGTGGAAAATATTTCGAGGCGACTGACCAGAATTTTCAGGCAGAAATTCTTAATTCCGATAAAGTTGCGCTGGTCGA
TTTCTGGGCTGCATGGTGTGGTCCGTGCATGATGCTCGGCCCGGTCATCGAGGAACTTGCCGGTGATTACGAAGGCAAAG
CCATCATCGCCAAACTCAACGTCGATGAGAACCCGAACACCGCCGGCCAGTACGGCATCCGCAGCATTCCCACCATGCTG
ATCATCAAGGGTGGCAAGGTTGTTGACCAGATGGTTGGCGCTCTGCCTAAGAACATGATCGCCAAGAAGCTCGACGAGCA
TATCGGCTGA

Upstream 100 bases:

>100_bases
AATTTCAGGCATTTGTTGCCAAGTTGCATTTTATTCAATTATATTTGCACAGAGTAATGGTATGTCTCTTATCAATTGTT
AACCCTTTATTTGAGAACTT

Downstream 100 bases:

>100_bases
TCTTCCATCCGTTTCTATTCTTTGCTATCCCGGTTCAAGCCGGGATAGTTTTGTTATAATCCCAACCCTACCTCCCGGAG
ACAAACGATGGACAAAGATA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2

Number of amino acids: Translated: 109; Mature: 108

Protein sequence:

>109_residues
MSGKYFEATDQNFQAEILNSDKVALVDFWAAWCGPCMMLGPVIEELAGDYEGKAIIAKLNVDENPNTAGQYGIRSIPTML
IIKGGKVVDQMVGALPKNMIAKKLDEHIG

Sequences:

>Translated_109_residues
MSGKYFEATDQNFQAEILNSDKVALVDFWAAWCGPCMMLGPVIEELAGDYEGKAIIAKLNVDENPNTAGQYGIRSIPTML
IIKGGKVVDQMVGALPKNMIAKKLDEHIG
>Mature_108_residues
SGKYFEATDQNFQAEILNSDKVALVDFWAAWCGPCMMLGPVIEELAGDYEGKAIIAKLNVDENPNTAGQYGIRSIPTMLI
IKGGKVVDQMVGALPKNMIAKKLDEHIG

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI21361403, Length=98, Percent_Identity=37.7551020408163, Blast_Score=86, Evalue=4e-18,
Organism=Homo sapiens, GI21361657, Length=106, Percent_Identity=33.0188679245283, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI87082331, Length=109, Percent_Identity=48.6238532110092, Blast_Score=122, Evalue=6e-30,
Organism=Escherichia coli, GI1788936, Length=108, Percent_Identity=37.037037037037, Blast_Score=88, Evalue=1e-19,
Organism=Escherichia coli, GI87081747, Length=82, Percent_Identity=37.8048780487805, Blast_Score=69, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=85, Percent_Identity=37.6470588235294, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71980562, Length=107, Percent_Identity=30.8411214953271, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17507705, Length=89, Percent_Identity=33.7078651685393, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71980565, Length=91, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=86, Percent_Identity=38.3720930232558, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=67, Percent_Identity=44.7761194029851, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71998175, Length=96, Percent_Identity=35.4166666666667, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=80, Percent_Identity=32.5, Blast_Score=61, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=41.8604651162791, Blast_Score=79, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323072, Length=79, Percent_Identity=43.0379746835443, Blast_Score=73, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=84, Percent_Identity=34.5238095238095, Blast_Score=62, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639826, Length=96, Percent_Identity=40.625, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24664269, Length=74, Percent_Identity=50, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573567, Length=85, Percent_Identity=38.8235294117647, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17648013, Length=80, Percent_Identity=37.5, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24583090, Length=80, Percent_Identity=37.5, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17530795, Length=85, Percent_Identity=34.1176470588235, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24658597, Length=100, Percent_Identity=35, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21358065, Length=83, Percent_Identity=36.144578313253, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19921434, Length=80, Percent_Identity=36.25, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THIO2_CHLTE (Q8KE49)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661735.1
- ProteinModelPortal:   Q8KE49
- SMR:   Q8KE49
- GeneID:   1007243
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0841
- NMPDR:   fig|194439.1.peg.829
- TIGR:   CT0841
- HOGENOM:   HBG493509
- OMA:   SELKICK
- ProtClustDB:   CLSK637484
- BioCyc:   CTEP194439:CT_0841-MONOMER
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 11859; Mature: 11728

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGKYFEATDQNFQAEILNSDKVALVDFWAAWCGPCMMLGPVIEELAGDYEGKAIIAKLN
CCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
VDENPNTAGQYGIRSIPTMLIIKGGKVVDQMVGALPKNMIAKKLDEHIG
CCCCCCCCCCCCHHCCCEEEEEECCHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SGKYFEATDQNFQAEILNSDKVALVDFWAAWCGPCMMLGPVIEELAGDYEGKAIIAKLN
CCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
VDENPNTAGQYGIRSIPTMLIIKGGKVVDQMVGALPKNMIAKKLDEHIG
CCCCCCCCCCCCHHCCCEEEEEECCHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901