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The map label for this gene is tpx

Identifier: 21673584

GI number: 21673584

Start: 728087

End: 728593

Strand: Direct

Name: tpx

Synonym: CT0754

Alternate gene names: 21673584

Gene position: 728087-728593 (Clockwise)

Preceding gene: 21673583

Following gene: 21673585

Centisome position: 33.79

GC content: 57.2

Gene sequence:

>507_bases
ATGATTATGGCAACCATTACGCTCAAGGGAAATTCCATTCACACCGCAGGTGAGCTTCCGGCTGTCGGCAGTCAGCTCCC
AGCGTTTACCCTTGTGAAAAGTGATCTTTCGGAGGTTTCGCCTGCTGATTTCGCTGGCAAGAAACTCGTGCTGAACATTT
TTCCGAGTCTCGATACGGCTGTTTGCGCGGCTTCGGTGAGGCGCTTCAACAAGGAGGCGGGCGAGCGTGGTGATGCTGTC
GTGCTCTGCATTTCCGCCGATCTTCCGTTCGCGCAGGGGCGCTTCTGCACCACCGAGGGTCTCGACAATGTGGTTCCCCT
GTCGGTGTACCGTTCACCGGAGTTTGGCTTGGATTATGGCCTGACCATTACCGATGGCCCGCTGAAAGGATTGCTCTCTC
GCGCGGTGATCGTTACCGATGCTTCCGGCAAGGTGCTCTATGCCGAGCAGGTACCCGAGATCGTACAGGAGCCGGATTAC
GACAAGGCTCTGGCTGCGCTCGCCTGA

Upstream 100 bases:

>100_bases
TCTTCCATCCTGTTTGTTTTTTCCCAAGGAACGGAACGCCATCGCTTCCGGTTTATGGTGCAACTGCTTCTGAAATCTTC
ATCTCACCTCAACCATTGAC

Downstream 100 bases:

>100_bases
TTGTCTGCTGACATTTTTCTCTCTGAAGCCATGCCGTCGCGCGACCGCATGGCTTCTGTTTTCCTGCCCGATTTTTCATT
TCAGCCACGGTATAACGCCT

Product: thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MIMATITLKGNSIHTAGELPAVGSQLPAFTLVKSDLSEVSPADFAGKKLVLNIFPSLDTAVCAASVRRFNKEAGERGDAV
VLCISADLPFAQGRFCTTEGLDNVVPLSVYRSPEFGLDYGLTITDGPLKGLLSRAVIVTDASGKVLYAEQVPEIVQEPDY
DKALAALA

Sequences:

>Translated_168_residues
MIMATITLKGNSIHTAGELPAVGSQLPAFTLVKSDLSEVSPADFAGKKLVLNIFPSLDTAVCAASVRRFNKEAGERGDAV
VLCISADLPFAQGRFCTTEGLDNVVPLSVYRSPEFGLDYGLTITDGPLKGLLSRAVIVTDASGKVLYAEQVPEIVQEPDY
DKALAALA
>Mature_168_residues
MIMATITLKGNSIHTAGELPAVGSQLPAFTLVKSDLSEVSPADFAGKKLVLNIFPSLDTAVCAASVRRFNKEAGERGDAV
VLCISADLPFAQGRFCTTEGLDNVVPLSVYRSPEFGLDYGLTITDGPLKGLLSRAVIVTDASGKVLYAEQVPEIVQEPDY
DKALAALA

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2)

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Escherichia coli, GI1787584, Length=163, Percent_Identity=56.441717791411, Blast_Score=191, Evalue=1e-50,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): TPX_CHLTE (Q8KED5)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661649.1
- ProteinModelPortal:   Q8KED5
- SMR:   Q8KED5
- GeneID:   1006386
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0754
- NMPDR:   fig|194439.1.peg.743
- TIGR:   CT0754
- HOGENOM:   HBG493509
- OMA:   VRKFNAQ
- ProtClustDB:   PRK00522
- BioCyc:   CTEP194439:CT_0754-MONOMER
- HAMAP:   MF_00269
- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10681:SF3

Pfam domain/function: PF08534 Redoxin; SSF52833 Thiordxn-like_fd

EC number: 1.11.1.- [C]

Molecular weight: Translated: 17714; Mature: 17714

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS51352 THIOREDOXIN_2; PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMATITLKGNSIHTAGELPAVGSQLPAFTLVKSDLSEVSPADFAGKKLVLNIFPSLDTA
CEEEEEEEECCEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHH
VCAASVRRFNKEAGERGDAVVLCISADLPFAQGRFCTTEGLDNVVPLSVYRSPEFGLDYG
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEECCCCCCCCEEEEEECCCCCCCCCC
LTITDGPLKGLLSRAVIVTDASGKVLYAEQVPEIVQEPDYDKALAALA
EEEECCHHHHHHCCEEEEECCCCCEEEHHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure
MIMATITLKGNSIHTAGELPAVGSQLPAFTLVKSDLSEVSPADFAGKKLVLNIFPSLDTA
CEEEEEEEECCEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHH
VCAASVRRFNKEAGERGDAVVLCISADLPFAQGRFCTTEGLDNVVPLSVYRSPEFGLDYG
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEECCCCCCCCEEEEEECCCCCCCCCC
LTITDGPLKGLLSRAVIVTDASGKVLYAEQVPEIVQEPDYDKALAALA
EEEECCHHHHHHCCEEEEECCCCCEEEHHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901