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The map label for this gene is ribD [H]

Identifier: 21673577

GI number: 21673577

Start: 724159

End: 725280

Strand: Direct

Name: ribD [H]

Synonym: CT0747

Alternate gene names: 21673577

Gene position: 724159-725280 (Clockwise)

Preceding gene: 21673576

Following gene: 21673578

Centisome position: 33.6

GC content: 60.61

Gene sequence:

>1122_bases
ATGGCAACGAATCCAGCGTTAGCGGCGCGTCCGGAGGATGAAACGTACATGTGGCGCTGCCTTGAACTGGCTGAACGCGG
CGCAGGCAGCGTGAGCCCGAATCCGATGGTCGGTTCAGTGATCGTCTGCGCTGGGCGAGTCATCGGCGAAGGGTGGCACC
GGCAGTACGGCGGTCCGCACGCCGAGGTCGACGCCATTGCCTCGGTCGAGGACGAATCGCTGCTTCGGCAATCGACGCTG
TACGTCAATCTGGAGCCGTGTTCTCACTACGGCAAGACGCCGCCATGCGCTGATCTGATCGTCGAAAAGCGCATCCCGCG
CGTGGTTGTCGGGTGCCTTGATCCGCACGAAAAGGTGGCGGGTAAGGGGATCGCCAGGCTTCGTGAAGCCGGAATCGAGG
TGACGGTCGGCGTGCTCGAAGCGGAGTCCGAGCGGCTCAACGAGGCCTTCATGACCTCGCATCGCAAAGGGCGTCCCTTC
GTGGCGCTCAAGACCGCGCAGACGCTCGACGGGCGTATTGCCACTTCGCTCGGCGCGTCGAAATGGATAACCGGCGAAGA
GTCTCGGTGCCAAGTGCACCGCCTGCGATGCATCTATGATGCCGTTTTGTGCGGCGCTTCGACCGTGCTGGCGGATAACA
CCGAGCTTACCGTGCGTTTTTGCGCTGGCCGCCAGCCGTTGCGCGTGCTGCTTGATCCCCGGCTTCAAGTGCCGCACGAG
TTCCGGATTTTCAACGACGCGGCCAAAACACTCGTCTTCGCACTTCGGGAAGAGGCCGATCCTGATCTTGTCAGGCAGCT
CGAAGCGCGAGGCATCGAGGTGGCAACCGTCGGTGAGGCCGAAGGCAGTCTTGATTTCGCGGAGGTATTCGCGGAGTTGC
ACAAACGCCGTCTGCTCTCAGTGTTGGTTGAAGGTGGAAGCCGGTTGGCGTCGGCGATGGTCAGATCAGGTTTCGTCGAT
AAATACTACGTCTTCATCGCGCCAAAGCTGTTCGGTGGCGATGGCCTGGCAAGTTTCGGAGCGCTCGGCGTGACGCATCC
CGATTATGCTGTCAAACTCAGCTTCAGCGGAATCCGGCGATTTGGCGAAGATCTTCTTCTCGAAGCATATCCTGTACATT
GA

Upstream 100 bases:

>100_bases
ACAAGCCCTACAAGATCGAGCACATTGCCGAACTGCTGCGCTTGTCGGGCATCAGGCTGGTGCAGGTCAACGCCGTCAAC
TGCTGATCGGAAAGATGGGT

Downstream 100 bases:

>100_bases
TGGCTGGATTTTTTAAAAGCACAAGCAATAGCAGGAGGTCCCGCCGAAGCCACAACAATAAAGGAAGAGTCAACACTTCA
TCCGGAGGGTTTATGAATAA

Product: riboflavin biosynthesis protein RibD

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MATNPALAARPEDETYMWRCLELAERGAGSVSPNPMVGSVIVCAGRVIGEGWHRQYGGPHAEVDAIASVEDESLLRQSTL
YVNLEPCSHYGKTPPCADLIVEKRIPRVVVGCLDPHEKVAGKGIARLREAGIEVTVGVLEAESERLNEAFMTSHRKGRPF
VALKTAQTLDGRIATSLGASKWITGEESRCQVHRLRCIYDAVLCGASTVLADNTELTVRFCAGRQPLRVLLDPRLQVPHE
FRIFNDAAKTLVFALREEADPDLVRQLEARGIEVATVGEAEGSLDFAEVFAELHKRRLLSVLVEGGSRLASAMVRSGFVD
KYYVFIAPKLFGGDGLASFGALGVTHPDYAVKLSFSGIRRFGEDLLLEAYPVH

Sequences:

>Translated_373_residues
MATNPALAARPEDETYMWRCLELAERGAGSVSPNPMVGSVIVCAGRVIGEGWHRQYGGPHAEVDAIASVEDESLLRQSTL
YVNLEPCSHYGKTPPCADLIVEKRIPRVVVGCLDPHEKVAGKGIARLREAGIEVTVGVLEAESERLNEAFMTSHRKGRPF
VALKTAQTLDGRIATSLGASKWITGEESRCQVHRLRCIYDAVLCGASTVLADNTELTVRFCAGRQPLRVLLDPRLQVPHE
FRIFNDAAKTLVFALREEADPDLVRQLEARGIEVATVGEAEGSLDFAEVFAELHKRRLLSVLVEGGSRLASAMVRSGFVD
KYYVFIAPKLFGGDGLASFGALGVTHPDYAVKLSFSGIRRFGEDLLLEAYPVH
>Mature_372_residues
ATNPALAARPEDETYMWRCLELAERGAGSVSPNPMVGSVIVCAGRVIGEGWHRQYGGPHAEVDAIASVEDESLLRQSTLY
VNLEPCSHYGKTPPCADLIVEKRIPRVVVGCLDPHEKVAGKGIARLREAGIEVTVGVLEAESERLNEAFMTSHRKGRPFV
ALKTAQTLDGRIATSLGASKWITGEESRCQVHRLRCIYDAVLCGASTVLADNTELTVRFCAGRQPLRVLLDPRLQVPHEF
RIFNDAAKTLVFALREEADPDLVRQLEARGIEVATVGEAEGSLDFAEVFAELHKRRLLSVLVEGGSRLASAMVRSGFVDK
YYVFIAPKLFGGDGLASFGALGVTHPDYAVKLSFSGIRRFGEDLLLEAYPVH

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG0117

COG function: function code H; Pyrimidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=371, Percent_Identity=38.2749326145553, Blast_Score=254, Evalue=8e-69,
Organism=Escherichia coli, GI145693172, Length=166, Percent_Identity=36.144578313253, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 40711; Mature: 40580

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATNPALAARPEDETYMWRCLELAERGAGSVSPNPMVGSVIVCAGRVIGEGWHRQYGGPH
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCC
AEVDAIASVEDESLLRQSTLYVNLEPCSHYGKTPPCADLIVEKRIPRVVVGCLDPHEKVA
CCHHHHHCCCHHHHHHHHEEEEEECCHHCCCCCCCHHHHHHHHCCCEEEEECCCCHHHHH
GKGIARLREAGIEVTVGVLEAESERLNEAFMTSHRKGRPFVALKTAQTLDGRIATSLGAS
HHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHCCCCCCCEEEEECCHHHCCHHHHHCCCC
KWITGEESRCQVHRLRCIYDAVLCGASTVLADNTELTVRFCAGRQPLRVLLDPRLQVPHE
CCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCEEEEECCCCCCCHH
FRIFNDAAKTLVFALREEADPDLVRQLEARGIEVATVGEAEGSLDFAEVFAELHKRRLLS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
VLVEGGSRLASAMVRSGFVDKYYVFIAPKLFGGDGLASFGALGVTHPDYAVKLSFSGIRR
HHHHCHHHHHHHHHHCCCCCEEEEEEEEEEECCCCHHHHCCCCCCCCCEEEEEEHHHHHH
FGEDLLLEAYPVH
HHHHHHCEECCCC
>Mature Secondary Structure 
ATNPALAARPEDETYMWRCLELAERGAGSVSPNPMVGSVIVCAGRVIGEGWHRQYGGPH
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCC
AEVDAIASVEDESLLRQSTLYVNLEPCSHYGKTPPCADLIVEKRIPRVVVGCLDPHEKVA
CCHHHHHCCCHHHHHHHHEEEEEECCHHCCCCCCCHHHHHHHHCCCEEEEECCCCHHHHH
GKGIARLREAGIEVTVGVLEAESERLNEAFMTSHRKGRPFVALKTAQTLDGRIATSLGAS
HHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHCCCCCCCEEEEECCHHHCCHHHHHCCCC
KWITGEESRCQVHRLRCIYDAVLCGASTVLADNTELTVRFCAGRQPLRVLLDPRLQVPHE
CCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCEEEEECCCCCCCHH
FRIFNDAAKTLVFALREEADPDLVRQLEARGIEVATVGEAEGSLDFAEVFAELHKRRLLS
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
VLVEGGSRLASAMVRSGFVDKYYVFIAPKLFGGDGLASFGALGVTHPDYAVKLSFSGIRR
HHHHCHHHHHHHHHHCCCCCEEEEEEEEEEECCCCHHHHCCCCCCCCCEEEEEEHHHHHH
FGEDLLLEAYPVH
HHHHHHCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]