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The map label for this gene is comEB [H]

Identifier: 21673576

GI number: 21673576

Start: 723617

End: 724144

Strand: Direct

Name: comEB [H]

Synonym: CT0746

Alternate gene names: 21673576

Gene position: 723617-724144 (Clockwise)

Preceding gene: 21673573

Following gene: 21673577

Centisome position: 33.58

GC content: 59.28

Gene sequence:

>528_bases
ATGCAGGAAGAAAGCAAAAGTGGTTGCTGCTGCGCATCGTCCTCCGGTCAGCACGATAGCGATGGGGCAGAAAAGCGGCT
CGGGTGGCACGAATATTTCATGTGTGTGGCGCACCTCATTTCGCGCCGTGCGACCTGCACTCGGGGCCACGTCGGCGCGG
TGATCGTGCGCGACAACAACATCCTTTCGACCGGTTACAACGGCGCGCCCTCCGGCCTGCCTCACTGCAACGAGACCAAC
TGCAAAATCTACCGCAGCATCCACCCCGACGGCACGGTCGAGGAGAATTGCGTCAATACGATCCACGCCGAGATCAACGC
CATCGCGCAGGCGGCCAAGCACGGCGTATCGATCAAGGACGCCGACATTTACATCACGGCGAGCCCCTGCATTCACTGCC
TGAAGGTGCTCATCAATGTGGGCATCAAGACGATCTACTACGACAAGCCCTACAAGATCGAGCACATTGCCGAACTGCTG
CGCTTGTCGGGCATCAGGCTGGTGCAGGTCAACGCCGTCAACTGCTGA

Upstream 100 bases:

>100_bases
CGTGGTAAAGCGTAAAGTAGTTGCGGAGCATGGACTTGAATGGTTGCGGAGGCGCTTTCTTTCCTCTATTTTCCTGAAAT
AATCTAAACACAAGATAGCA

Downstream 100 bases:

>100_bases
TCGGAAAGATGGGTATGGCAACGAATCCAGCGTTAGCGGCGCGTCCGGAGGATGAAACGTACATGTGGCGCTGCCTTGAA
CTGGCTGAACGCGGCGCAGG

Product: deoxycytidylate deaminase, putative

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MQEESKSGCCCASSSGQHDSDGAEKRLGWHEYFMCVAHLISRRATCTRGHVGAVIVRDNNILSTGYNGAPSGLPHCNETN
CKIYRSIHPDGTVEENCVNTIHAEINAIAQAAKHGVSIKDADIYITASPCIHCLKVLINVGIKTIYYDKPYKIEHIAELL
RLSGIRLVQVNAVNC

Sequences:

>Translated_175_residues
MQEESKSGCCCASSSGQHDSDGAEKRLGWHEYFMCVAHLISRRATCTRGHVGAVIVRDNNILSTGYNGAPSGLPHCNETN
CKIYRSIHPDGTVEENCVNTIHAEINAIAQAAKHGVSIKDADIYITASPCIHCLKVLINVGIKTIYYDKPYKIEHIAELL
RLSGIRLVQVNAVNC
>Mature_175_residues
MQEESKSGCCCASSSGQHDSDGAEKRLGWHEYFMCVAHLISRRATCTRGHVGAVIVRDNNILSTGYNGAPSGLPHCNETN
CKIYRSIHPDGTVEENCVNTIHAEINAIAQAAKHGVSIKDADIYITASPCIHCLKVLINVGIKTIYYDKPYKIEHIAELL
RLSGIRLVQVNAVNC

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742819, Length=127, Percent_Identity=35.4330708661417, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI61742821, Length=127, Percent_Identity=35.4330708661417, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321938, Length=147, Percent_Identity=32.6530612244898, Blast_Score=79, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24667298, Length=143, Percent_Identity=31.4685314685315, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24667302, Length=143, Percent_Identity=31.4685314685315, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 19122; Mature: 19122

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

6.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
6.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEESKSGCCCASSSGQHDSDGAEKRLGWHEYFMCVAHLISRRATCTRGHVGAVIVRDNN
CCCCCCCCCEEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCC
ILSTGYNGAPSGLPHCNETNCKIYRSIHPDGTVEENCVNTIHAEINAIAQAAKHGVSIKD
EEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEC
ADIYITASPCIHCLKVLINVGIKTIYYDKPYKIEHIAELLRLSGIRLVQVNAVNC
CEEEEECHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCC
>Mature Secondary Structure
MQEESKSGCCCASSSGQHDSDGAEKRLGWHEYFMCVAHLISRRATCTRGHVGAVIVRDNN
CCCCCCCCCEEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCC
ILSTGYNGAPSGLPHCNETNCKIYRSIHPDGTVEENCVNTIHAEINAIAQAAKHGVSIKD
EEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEC
ADIYITASPCIHCLKVLINVGIKTIYYDKPYKIEHIAELLRLSGIRLVQVNAVNC
CEEEEECHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]