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The map label for this gene is serS [H]

Identifier: 21673441

GI number: 21673441

Start: 608846

End: 610129

Strand: Reverse

Name: serS [H]

Synonym: CT0606

Alternate gene names: 21673441

Gene position: 610129-608846 (Counterclockwise)

Preceding gene: 21673442

Following gene: 21673438

Centisome position: 28.31

GC content: 60.12

Gene sequence:

>1284_bases
ATGCTCGACATTACTTACATCCGCCAGAATCCGGATGATGTCAAAGAGATGCTGCGCCGCCGCCAGCAACAGGGCGATGC
ACCGAAGGTTGACCGTCTGCTCGAACGTGACGCCGAACGCAAGGCGATGGTGCAACGCACCGACGACCTCAAGGCGCTGC
GCAACCGGGTATCGAAAGAGATCGCCAACATCAAGCGCACCGGACAGGGGTCGGCCGACGAGCTGATCGGCCAGATGAAA
CAGGTCTCCGACGAAATCGCCGATCTCGATCTGGCGCTCTCGGCACTCGAAGCCGAGATTGAAGAGCTGCTGCTCACCCT
GCCGAACAAGCTCCACAAAAGCGTGCCGGAAGGGCGCTCGGCAGAGGAGAACGTGCTCTACAAAGGGCCGGTTTCGTTTG
AGCACAATCTGGACTTCCCTGTTAAGAACCACCTCGAACTTGGCAAGAGCCTTGGCATTCTCGACTTCGAGCGCGGCGCG
AAGATCAGCGGCGCAGGCTTCCCGGTCTATACTGGTAAAGGCGCAAGGCTTGAGCGAGCGCTCATCAACTTCATGCTCGA
CACGCACAGCGCAAACCACGGCTACACCGAGGTGTTCCCGCCATTCATGGTGAACCAGGAGTCGCTGCGCGGCACCGGCC
AGTGGCCGAAATTTGCCGACCAGGTCTATCACATGCCGGAGGACGGGCTGTACGCCATCCCGACAGCCGAGGTTCCCGTG
ACCAACCTGCATCGCGGCGAGATACTCGATGCCGACAAATTGCCAATCGCATACGCCGCCTACTCGGCCTGCTTCCGGCG
CGAGGCGGGAAGCTACGGCAAGGACACGCGCGGCTTCCTGCGGGTTCACCAGTTCAACAAGGTGGAGATGGTGCGCTTCA
CGCGGCCCGAAGCGTCGTACGAAGCGCTCGAAGAGATTCTCGGCCACGCCGAAGCAATCCTCGTCGCCCTGAAGATTCCC
TACCGCGTCATCACGCTCTGCAGCGGCGACATCAGTGCCAACGCCGCCAAGTGCTACGACATCGAGGTGTGGTCACCTGC
CGAGAACAAATATCTCGAAGCATCGAGCGTCTCGAACTTCGAAGACTACCAGGCGCGCCGCTCGAACATCCGCTTCAAGC
CCGACAGCAAATCGAAACCGGAGTTCGTGCACACCCTCAACGGTTCAGGCCTGGCCACCTCGCGCCTGATGGTCTCGCTG
CTCGAACACTACCAGACCGCCGACGGCAAGCTTATGGTGCCGGAAGCGCTAAAGCCTTACACGGGATTTGAGATCATTGA
GTGA

Upstream 100 bases:

>100_bases
CCTCGCCATGAAAACCCTCAAGGGCAAAGCCGATGGCGGCAAAGTCCAGAACCTCGTGAAATCGCTCCTCTCAGCCTAAC
CCACATTCTCCGCAAGATAT

Downstream 100 bases:

>100_bases
AGGTGGACGTTGTGAACTGATTGAACGAGGTGGGCAGGATACAAAAGAAGAGGCGCGGCAAAATACCGCGCCTCTTTCAT
TATCAACTATCAATTGTCAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLDITYIRQNPDDVKEMLRRRQQQGDAPKVDRLLERDAERKAMVQRTDDLKALRNRVSKEIANIKRTGQGSADELIGQMK
QVSDEIADLDLALSALEAEIEELLLTLPNKLHKSVPEGRSAEENVLYKGPVSFEHNLDFPVKNHLELGKSLGILDFERGA
KISGAGFPVYTGKGARLERALINFMLDTHSANHGYTEVFPPFMVNQESLRGTGQWPKFADQVYHMPEDGLYAIPTAEVPV
TNLHRGEILDADKLPIAYAAYSACFRREAGSYGKDTRGFLRVHQFNKVEMVRFTRPEASYEALEEILGHAEAILVALKIP
YRVITLCSGDISANAAKCYDIEVWSPAENKYLEASSVSNFEDYQARRSNIRFKPDSKSKPEFVHTLNGSGLATSRLMVSL
LEHYQTADGKLMVPEALKPYTGFEIIE

Sequences:

>Translated_427_residues
MLDITYIRQNPDDVKEMLRRRQQQGDAPKVDRLLERDAERKAMVQRTDDLKALRNRVSKEIANIKRTGQGSADELIGQMK
QVSDEIADLDLALSALEAEIEELLLTLPNKLHKSVPEGRSAEENVLYKGPVSFEHNLDFPVKNHLELGKSLGILDFERGA
KISGAGFPVYTGKGARLERALINFMLDTHSANHGYTEVFPPFMVNQESLRGTGQWPKFADQVYHMPEDGLYAIPTAEVPV
TNLHRGEILDADKLPIAYAAYSACFRREAGSYGKDTRGFLRVHQFNKVEMVRFTRPEASYEALEEILGHAEAILVALKIP
YRVITLCSGDISANAAKCYDIEVWSPAENKYLEASSVSNFEDYQARRSNIRFKPDSKSKPEFVHTLNGSGLATSRLMVSL
LEHYQTADGKLMVPEALKPYTGFEIIE
>Mature_427_residues
MLDITYIRQNPDDVKEMLRRRQQQGDAPKVDRLLERDAERKAMVQRTDDLKALRNRVSKEIANIKRTGQGSADELIGQMK
QVSDEIADLDLALSALEAEIEELLLTLPNKLHKSVPEGRSAEENVLYKGPVSFEHNLDFPVKNHLELGKSLGILDFERGA
KISGAGFPVYTGKGARLERALINFMLDTHSANHGYTEVFPPFMVNQESLRGTGQWPKFADQVYHMPEDGLYAIPTAEVPV
TNLHRGEILDADKLPIAYAAYSACFRREAGSYGKDTRGFLRVHQFNKVEMVRFTRPEASYEALEEILGHAEAILVALKIP
YRVITLCSGDISANAAKCYDIEVWSPAENKYLEASSVSNFEDYQARRSNIRFKPDSKSKPEFVHTLNGSGLATSRLMVSL
LEHYQTADGKLMVPEALKPYTGFEIIE

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=462, Percent_Identity=33.3333333333333, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI8923421, Length=438, Percent_Identity=28.7671232876712, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI225579074, Length=341, Percent_Identity=32.5513196480938, Blast_Score=166, Evalue=3e-41,
Organism=Escherichia coli, GI1787120, Length=437, Percent_Identity=47.1395881006865, Blast_Score=378, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17539260, Length=465, Percent_Identity=30.752688172043, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=265, Percent_Identity=31.3207547169811, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320226, Length=438, Percent_Identity=32.648401826484, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6321799, Length=405, Percent_Identity=30.3703703703704, Blast_Score=198, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24581334, Length=466, Percent_Identity=31.9742489270386, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI17737985, Length=330, Percent_Identity=30.9090909090909, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47991; Mature: 47991

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDITYIRQNPDDVKEMLRRRQQQGDAPKVDRLLERDAERKAMVQRTDDLKALRNRVSKE
CCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IANIKRTGQGSADELIGQMKQVSDEIADLDLALSALEAEIEELLLTLPNKLHKSVPEGRS
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
AEENVLYKGPVSFEHNLDFPVKNHLELGKSLGILDFERGAKISGAGFPVYTGKGARLERA
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCEECCCCCEECCCCCCEECCCCCHHHHH
LINFMLDTHSANHGYTEVFPPFMVNQESLRGTGQWPKFADQVYHMPEDGLYAIPTAEVPV
HHHHHHHCCCCCCCCHHCCCCHHCCHHHHCCCCCCHHHHHHHHCCCCCCEEECCCCCCCC
TNLHRGEILDADKLPIAYAAYSACFRREAGSYGKDTRGFLRVHQFNKVEMVRFTRPEASY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEEEECCCHHH
EALEEILGHAEAILVALKIPYRVITLCSGDISANAAKCYDIEVWSPAENKYLEASSVSNF
HHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEEEECCCCCCEECCCCCCCH
EDYQARRSNIRFKPDSKSKPEFVHTLNGSGLATSRLMVSLLEHYQTADGKLMVPEALKPY
HHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCEECCHHCCCC
TGFEIIE
CCCEECC
>Mature Secondary Structure
MLDITYIRQNPDDVKEMLRRRQQQGDAPKVDRLLERDAERKAMVQRTDDLKALRNRVSKE
CCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IANIKRTGQGSADELIGQMKQVSDEIADLDLALSALEAEIEELLLTLPNKLHKSVPEGRS
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
AEENVLYKGPVSFEHNLDFPVKNHLELGKSLGILDFERGAKISGAGFPVYTGKGARLERA
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCEECCCCCEECCCCCCEECCCCCHHHHH
LINFMLDTHSANHGYTEVFPPFMVNQESLRGTGQWPKFADQVYHMPEDGLYAIPTAEVPV
HHHHHHHCCCCCCCCHHCCCCHHCCHHHHCCCCCCHHHHHHHHCCCCCCEEECCCCCCCC
TNLHRGEILDADKLPIAYAAYSACFRREAGSYGKDTRGFLRVHQFNKVEMVRFTRPEASY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEEEECCCHHH
EALEEILGHAEAILVALKIPYRVITLCSGDISANAAKCYDIEVWSPAENKYLEASSVSNF
HHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEEEECCCCCCEECCCCCCCH
EDYQARRSNIRFKPDSKSKPEFVHTLNGSGLATSRLMVSLLEHYQTADGKLMVPEALKPY
HHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCEECCHHCCCC
TGFEIIE
CCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA