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The map label for this gene is xerD

Identifier: 21673437

GI number: 21673437

Start: 603874

End: 604788

Strand: Reverse

Name: xerD

Synonym: CT0602

Alternate gene names: 21673437

Gene position: 604788-603874 (Counterclockwise)

Preceding gene: 21673438

Following gene: 21673435

Centisome position: 28.07

GC content: 60.87

Gene sequence:

>915_bases
ATGCCAGAACGCGAGGAGCCGTGGCGGAAAACGCTCGAAACCTTCCTGAACTACCTGACCCTCGAACGCAATTTTTCGGG
CAACACGCGCGCCTCGTACCTGAACGACCTTGGCCGCTACCTTGCCTGGCTGCACGAGTGCGGCGTCAAACCTGAAGAGG
CCGCGCCGGGCGACATCCGGAAATTCATTCAGGAGCTGCATGAGATCGGCCTCGAAGCGAGTTCGATCGCCCGGAACATC
TCTGCTATCCGCTCCTTCCACAAATTCCTGCTGACTGAGCGGCTCGCGACGATGAACCCCGCCGAGAACATCCACCAGCC
GAAACTCGCCCGCTACCTCCCCTCAGTGCTGACCATCGAGGAGATGGCTACGCTGCTCGACGCCCCGCTCAAGCGGCATC
CGACTAGCACTTTCATGCTGCGCGACAAGGCGATGCTCGAATTTCTCTACGCCACGGGAGTCCGCGTCAGCGAACTGCTG
GGGCTCAGCCGACTGAATCTGCACATGGATGACGGCTTCGTGCGGGTCTTCGGCAAAGGATCGAAAGAGCGGCTTGTACC
CGTCGGCCAGACGGCCATCTCGTGGATGAAACGCTACCTCGACGAGCTGCGCCCCGGCATGATGAGCGCAACCTCGCACG
ACACTATTTTCCTGAACTCGCGAGGCGGCCCGCTCTCGCGCATGGCTGCGTGGAACATCGTGCGTGAGCACGCAGTCATC
GCAGGTATTGAAAAACCGATCAGCCCGCACACCTTCCGCCACTCCTTCGCCACCCACCTGCTCGAAGGCGGCGCAGACCT
GCGCGTTGTGCAGGAGATGCTCGGCCACAGCTCCATCATCGCCACCCAGATCTACACCCACATCGACCGCTCGTTCATCA
AGGAAGTGCACAAAACATTCCACCCGCGGGGATAA

Upstream 100 bases:

>100_bases
CGGAGTTCATCGCCGAAGCGTCGCGACTGACGCTGCCCGGTTCGCACGAGGGCTTCGACGGCGGCTTCGCCGCACGGTTC
CGCAAAACGGAGGGGTAAAG

Downstream 100 bases:

>100_bases
TAAATTCGGAGAAAAGGAAGGGCAAGCAGTGCCCCCTCTTTCTTAATTCTCTTCACCCTTTCATCACCCCTACCGGTACG
AGCCTCACCACTTTTCGGGC

Product: integrase/recombinase XerD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MPEREEPWRKTLETFLNYLTLERNFSGNTRASYLNDLGRYLAWLHECGVKPEEAAPGDIRKFIQELHEIGLEASSIARNI
SAIRSFHKFLLTERLATMNPAENIHQPKLARYLPSVLTIEEMATLLDAPLKRHPTSTFMLRDKAMLEFLYATGVRVSELL
GLSRLNLHMDDGFVRVFGKGSKERLVPVGQTAISWMKRYLDELRPGMMSATSHDTIFLNSRGGPLSRMAAWNIVREHAVI
AGIEKPISPHTFRHSFATHLLEGGADLRVVQEMLGHSSIIATQIYTHIDRSFIKEVHKTFHPRG

Sequences:

>Translated_304_residues
MPEREEPWRKTLETFLNYLTLERNFSGNTRASYLNDLGRYLAWLHECGVKPEEAAPGDIRKFIQELHEIGLEASSIARNI
SAIRSFHKFLLTERLATMNPAENIHQPKLARYLPSVLTIEEMATLLDAPLKRHPTSTFMLRDKAMLEFLYATGVRVSELL
GLSRLNLHMDDGFVRVFGKGSKERLVPVGQTAISWMKRYLDELRPGMMSATSHDTIFLNSRGGPLSRMAAWNIVREHAVI
AGIEKPISPHTFRHSFATHLLEGGADLRVVQEMLGHSSIIATQIYTHIDRSFIKEVHKTFHPRG
>Mature_303_residues
PEREEPWRKTLETFLNYLTLERNFSGNTRASYLNDLGRYLAWLHECGVKPEEAAPGDIRKFIQELHEIGLEASSIARNIS
AIRSFHKFLLTERLATMNPAENIHQPKLARYLPSVLTIEEMATLLDAPLKRHPTSTFMLRDKAMLEFLYATGVRVSELLG
LSRLNLHMDDGFVRVFGKGSKERLVPVGQTAISWMKRYLDELRPGMMSATSHDTIFLNSRGGPLSRMAAWNIVREHAVIA
GIEKPISPHTFRHSFATHLLEGGADLRVVQEMLGHSSIIATQIYTHIDRSFIKEVHKTFHPRG

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG4974

COG function: function code L; Site-specific recombinase XerD

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerD subfamily

Homologues:

Organism=Escherichia coli, GI1789261, Length=294, Percent_Identity=43.1972789115646, Blast_Score=248, Evalue=3e-67,
Organism=Escherichia coli, GI1790244, Length=297, Percent_Identity=37.037037037037, Blast_Score=194, Evalue=5e-51,
Organism=Escherichia coli, GI1790768, Length=147, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERD_CHLTE (Q8KET0)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661502.1
- ProteinModelPortal:   Q8KET0
- SMR:   Q8KET0
- GeneID:   1006250
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0602
- NMPDR:   fig|194439.1.peg.596
- TIGR:   CT0602
- HOGENOM:   HBG727654
- OMA:   YLEYGRP
- ProtClustDB:   CLSK637388
- BioCyc:   CTEP194439:CT_0602-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01807
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- InterPro:   IPR011932
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10
- TIGRFAMs:   TIGR02225

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 34609; Mature: 34478

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: ACT_SITE 155-155 ACT_SITE 179-179 ACT_SITE 250-250 ACT_SITE 253-253 ACT_SITE 276-276 ACT_SITE 285-285

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEREEPWRKTLETFLNYLTLERNFSGNTRASYLNDLGRYLAWLHECGVKPEEAAPGDIR
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
KFIQELHEIGLEASSIARNISAIRSFHKFLLTERLATMNPAENIHQPKLARYLPSVLTIE
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHH
EMATLLDAPLKRHPTSTFMLRDKAMLEFLYATGVRVSELLGLSRLNLHMDDGFVRVFGKG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEECCCEEEEECCC
SKERLVPVGQTAISWMKRYLDELRPGMMSATSHDTIFLNSRGGPLSRMAAWNIVREHAVI
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
AGIEKPISPHTFRHSFATHLLEGGADLRVVQEMLGHSSIIATQIYTHIDRSFIKEVHKTF
HHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
HPRG
CCCC
>Mature Secondary Structure 
PEREEPWRKTLETFLNYLTLERNFSGNTRASYLNDLGRYLAWLHECGVKPEEAAPGDIR
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
KFIQELHEIGLEASSIARNISAIRSFHKFLLTERLATMNPAENIHQPKLARYLPSVLTIE
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHH
EMATLLDAPLKRHPTSTFMLRDKAMLEFLYATGVRVSELLGLSRLNLHMDDGFVRVFGKG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEECCCEEEEECCC
SKERLVPVGQTAISWMKRYLDELRPGMMSATSHDTIFLNSRGGPLSRMAAWNIVREHAVI
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
AGIEKPISPHTFRHSFATHLLEGGADLRVVQEMLGHSSIIATQIYTHIDRSFIKEVHKTF
HHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
HPRG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901