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The map label for this gene is 21673433

Identifier: 21673433

GI number: 21673433

Start: 599789

End: 601198

Strand: Direct

Name: 21673433

Synonym: CT0598

Alternate gene names: NA

Gene position: 599789-601198 (Clockwise)

Preceding gene: 21673432

Following gene: 21673434

Centisome position: 27.83

GC content: 62.55

Gene sequence:

>1410_bases
ATGGAGATCGAGTTTTACGGGGCGACGCGGCGGGTGACGGGTTCCTGCCATATCCTCAGGGCTGCCGGTTACACGGTGCT
GCTCGATTGCGGGCTGGTGCAGGGGAGCCGCGAGGTCGAGGCGCTGAACCGCGAGCCGTTTCCGTTCGAGCCGTCCGAAA
TCGATGCCGTGGTGCTCAGCCACGGCCATATCGATCACTCGGGTCGCCTACCACTGCTCGTCAATCGTGGCTTTCGTGGG
CCGATCTACACCCATCACGGCACCATCGAGCTGTGCGAGATTCTGCTTCGGGACTCGGCGACGCTGTCCGAAAACGATGC
CCGTTTCATGCGAAAGCACGGTCAGCGCGACGACGAGCCGCTCTACACGGTCGATGACGCCCAGCGCTGCGTCAGGCAGA
TGGAGGGCGTCAGGTACGGCGAGCGGCGCGAGGTTCTGCCCGGCATCGCCGTGACGCTGCTCGATGCGGGGCACATCCTC
GCCTCAGCGTTCGTCAAGCTTGAAATCACGGAGGGCGACGCCACCCGTACACTCGTTTTCAGCGGTGACCTCGGGCAGTA
CGATTCGCCGATTCTGAACAATCCCGACGCCATCGCCTACGCGGACGTAGTGCTCGTCGAGAGCACCTACGGCGACCGAT
TGCACCGCAATTTTGACAGCACCGTGAAGGAGATCGGCGAGATCATCGAAACCTCGCGGCGCGACTGCGGCAACATTCTG
ATTCCCGCCTTTTCGATTGGCCGCAGCCAAGAGCTGCTCTACCTTTTCGGCGAGCACTACCGCGAGTGGGAGCTGGAGCA
ATGGCAGGTGTTCCTCGATAGCCCGATGGCCATCGAAGCAAGCCGTATCTACTGGCTGCACGAGGAGTTATGGGACGCCG
AGGCCCGCCTGTTCCGCCGTCACATGCGCGGTATGCCGCCCGTCGGCAACCTGCACCTGACCCGCAGGGTGGAGGAGTCG
ATGAAGATCAACGAACTCCGCGAGGGCGCGATCATCATCGCCGGAAGCGGCATGTGCAACGGCGGGCGCATCGTGCACCA
CCTGAAGCGCAACATCGAGCGGCCCGAGTGCCACATCATCATCACCGGCTTCCAGGCGGAAGGGACGCTTGGTCGGGAGA
TCGTGGAAGGACGCAAGGAGGTTCGGCTACACGGGCGGAGCTACCGGGTTCGCGCACAACTGCACACCATCGGCGGCCTG
TCGGCGCATGGCGACCGCAGCGATCTGTTGCGCTGGTTGAAGAGCCGGGAGGGTTCTCCGCAGGTGATGATTGTGCATGG
CGAGGAGGGCGTGAAGGAGTCGTTCAAAGGCTTTCTGCGCGATGAACTTTCGGTCGAAGCGCTCATCCCGAAACCCGGCG
ACCGGCTCGACCTCGTATCGAACGAACTCTATCGGGTTGAATCTGAATAA

Upstream 100 bases:

>100_bases
CTCTTTTGCTTTTCACCCCACAGCGCATACATTTTAATCATAAGTACTTTTCGCATCCAGTCTGCCGGTGATCCGGTTCA
CGAAAACAGGGAGTTGCGAT

Downstream 100 bases:

>100_bases
TGTTCAAAATGCTCATGACGATTACGACCATTAAAGAACTCATTCCTGTCTTGCAAACAGCCATCGGCCCGGTTATTCTC
ATCTCAGGTATTGGCCTGCT

Product: metallo-beta-lactamase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MEIEFYGATRRVTGSCHILRAAGYTVLLDCGLVQGSREVEALNREPFPFEPSEIDAVVLSHGHIDHSGRLPLLVNRGFRG
PIYTHHGTIELCEILLRDSATLSENDARFMRKHGQRDDEPLYTVDDAQRCVRQMEGVRYGERREVLPGIAVTLLDAGHIL
ASAFVKLEITEGDATRTLVFSGDLGQYDSPILNNPDAIAYADVVLVESTYGDRLHRNFDSTVKEIGEIIETSRRDCGNIL
IPAFSIGRSQELLYLFGEHYREWELEQWQVFLDSPMAIEASRIYWLHEELWDAEARLFRRHMRGMPPVGNLHLTRRVEES
MKINELREGAIIIAGSGMCNGGRIVHHLKRNIERPECHIIITGFQAEGTLGREIVEGRKEVRLHGRSYRVRAQLHTIGGL
SAHGDRSDLLRWLKSREGSPQVMIVHGEEGVKESFKGFLRDELSVEALIPKPGDRLDLVSNELYRVESE

Sequences:

>Translated_469_residues
MEIEFYGATRRVTGSCHILRAAGYTVLLDCGLVQGSREVEALNREPFPFEPSEIDAVVLSHGHIDHSGRLPLLVNRGFRG
PIYTHHGTIELCEILLRDSATLSENDARFMRKHGQRDDEPLYTVDDAQRCVRQMEGVRYGERREVLPGIAVTLLDAGHIL
ASAFVKLEITEGDATRTLVFSGDLGQYDSPILNNPDAIAYADVVLVESTYGDRLHRNFDSTVKEIGEIIETSRRDCGNIL
IPAFSIGRSQELLYLFGEHYREWELEQWQVFLDSPMAIEASRIYWLHEELWDAEARLFRRHMRGMPPVGNLHLTRRVEES
MKINELREGAIIIAGSGMCNGGRIVHHLKRNIERPECHIIITGFQAEGTLGREIVEGRKEVRLHGRSYRVRAQLHTIGGL
SAHGDRSDLLRWLKSREGSPQVMIVHGEEGVKESFKGFLRDELSVEALIPKPGDRLDLVSNELYRVESE
>Mature_469_residues
MEIEFYGATRRVTGSCHILRAAGYTVLLDCGLVQGSREVEALNREPFPFEPSEIDAVVLSHGHIDHSGRLPLLVNRGFRG
PIYTHHGTIELCEILLRDSATLSENDARFMRKHGQRDDEPLYTVDDAQRCVRQMEGVRYGERREVLPGIAVTLLDAGHIL
ASAFVKLEITEGDATRTLVFSGDLGQYDSPILNNPDAIAYADVVLVESTYGDRLHRNFDSTVKEIGEIIETSRRDCGNIL
IPAFSIGRSQELLYLFGEHYREWELEQWQVFLDSPMAIEASRIYWLHEELWDAEARLFRRHMRGMPPVGNLHLTRRVEES
MKINELREGAIIIAGSGMCNGGRIVHHLKRNIERPECHIIITGFQAEGTLGREIVEGRKEVRLHGRSYRVRAQLHTIGGL
SAHGDRSDLLRWLKSREGSPQVMIVHGEEGVKESFKGFLRDELSVEALIPKPGDRLDLVSNELYRVESE

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=472, Percent_Identity=27.5423728813559, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI33300633, Length=478, Percent_Identity=23.8493723849372, Blast_Score=129, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI32566029, Length=466, Percent_Identity=27.0386266094421, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI32564696, Length=469, Percent_Identity=24.3070362473348, Blast_Score=131, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323307, Length=434, Percent_Identity=26.2672811059908, Blast_Score=137, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24648013, Length=458, Percent_Identity=26.8558951965066, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI21358523, Length=470, Percent_Identity=24.0425531914894, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 53147; Mature: 53147

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIEFYGATRRVTGSCHILRAAGYTVLLDCGLVQGSREVEALNREPFPFEPSEIDAVVLS
CEEEEECCCEEECCCEEEEEECCCEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCEEEEE
HGHIDHSGRLPLLVNRGFRGPIYTHHGTIELCEILLRDSATLSENDARFMRKHGQRDDEP
CCCCCCCCCCCEEEECCCCCCEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCC
LYTVDDAQRCVRQMEGVRYGERREVLPGIAVTLLDAGHILASAFVKLEITEGDATRTLVF
EEEEHHHHHHHHHHHCCCCCCCHHCCCCCEEEEHHHHHHHEEEEEEEEEECCCCEEEEEE
SGDLGQYDSPILNNPDAIAYADVVLVESTYGDRLHRNFDSTVKEIGEIIETSRRDCGNIL
ECCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
IPAFSIGRSQELLYLFGEHYREWELEQWQVFLDSPMAIEASRIYWLHEELWDAEARLFRR
EEEECCCCCCHHHHEEHHHHCCCCCCEEHEEECCCCEEEEHEEEEEHHHHHHHHHHHHHH
HMRGMPPVGNLHLTRRVEESMKINELREGAIIIAGSGMCNGGRIVHHLKRNIERPECHII
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCCCCCEEEE
ITGFQAEGTLGREIVEGRKEVRLHGRSYRVRAQLHTIGGLSAHGDRSDLLRWLKSREGSP
EEEEECCCCHHHHHHCCCHHEEECCCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCC
QVMIVHGEEGVKESFKGFLRDELSVEALIPKPGDRLDLVSNELYRVESE
CEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCEEEECCC
>Mature Secondary Structure
MEIEFYGATRRVTGSCHILRAAGYTVLLDCGLVQGSREVEALNREPFPFEPSEIDAVVLS
CEEEEECCCEEECCCEEEEEECCCEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCEEEEE
HGHIDHSGRLPLLVNRGFRGPIYTHHGTIELCEILLRDSATLSENDARFMRKHGQRDDEP
CCCCCCCCCCCEEEECCCCCCEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCC
LYTVDDAQRCVRQMEGVRYGERREVLPGIAVTLLDAGHILASAFVKLEITEGDATRTLVF
EEEEHHHHHHHHHHHCCCCCCCHHCCCCCEEEEHHHHHHHEEEEEEEEEECCCCEEEEEE
SGDLGQYDSPILNNPDAIAYADVVLVESTYGDRLHRNFDSTVKEIGEIIETSRRDCGNIL
ECCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
IPAFSIGRSQELLYLFGEHYREWELEQWQVFLDSPMAIEASRIYWLHEELWDAEARLFRR
EEEECCCCCCHHHHEEHHHHCCCCCCEEHEEECCCCEEEEHEEEEEHHHHHHHHHHHHHH
HMRGMPPVGNLHLTRRVEESMKINELREGAIIIAGSGMCNGGRIVHHLKRNIERPECHII
HHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCCCCCEEEE
ITGFQAEGTLGREIVEGRKEVRLHGRSYRVRAQLHTIGGLSAHGDRSDLLRWLKSREGSP
EEEEECCCCHHHHHHCCCHHEEECCCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCC
QVMIVHGEEGVKESFKGFLRDELSVEALIPKPGDRLDLVSNELYRVESE
CEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA