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The map label for this gene is kdtA [H]

Identifier: 21673428

GI number: 21673428

Start: 594764

End: 596050

Strand: Reverse

Name: kdtA [H]

Synonym: CT0593

Alternate gene names: 21673428

Gene position: 596050-594764 (Counterclockwise)

Preceding gene: 21673431

Following gene: 21673427

Centisome position: 27.66

GC content: 61.23

Gene sequence:

>1287_bases
ATGGCCTCACTCGCCCTCGCCGCATACCGGTTGCTCTCCCCGCTTCAGCCGAATCTGCTGCGGCTTTTGTCGTCGCGCAA
GCCGAGACTGAAGAGCTTTCTGGATGCGCGAGAAAACCTGTTCGAGGAGCTTGAAGCGCGCCTGCATGCGCTGCCGGAAC
CATCGTGCCGTTTGTGGATTCACGCCTCGTCGGTCGGCGAATTCGAGCAGGCCCGCACGATCATCGCCGAACTCCGAGCG
CAGATTCCGGACATGGACGTCGCGGTTTCGTTTTTTTCCGACTCCGGTTACGAAGCGCGCAAGCACTACCCCGACGCGGC
GGCGGTCTTCTACCTGCCGCTCGACACGCCGGAGAACGCCCGGAGACTGGTCGATATGATCGGCGCGGACATCTTCATGC
TGATGCGTTACGACTTCTGGCCAAACCACCTCGAAGCCATCAGAAAAAGCGGAGCGCGAATGATACTCGCCGCTGCCGCG
CTCCCGCCGGGTTCGCCCTATCTCAAGCCCTGGCTCAGGGGACTTTACCGGGACCTCTTTTCGCTGTTCGACGCCATCTA
CACCATCGACAGCAAAGATCGCGAAATGTTCCTGAACCAGTTCGCCTGCAAGAACGTCTTCACCGCCGGCGATCCGCGAT
TTGACCAGGTCGTCGAACGGCAGAAAAAAAGCGACGAGCGGGCGGCGAAGCTCAAGCCGCTGTTCCGCGACAGGATGGTG
CTTGTCGGCGGAAGCACCTGGGAGCCGGACGAGGCGATTCTGATCCCCGCGTGGCTTTCGCTCCGCCAGAAGCTCAGCCT
GGTGCTGGTGCCGCACAAGGTGGATCGACCGAACATCGAGCGCCTGCTAAACAACCTGCGGCAACAGGGCATCAAAGCGG
TGACCATTTCGGAGATGGATGAGCAATTCGACCCCGCACAGCAGGTGCTGGTGGTTAACCAGACCGGCTACCTCGCCGAA
CTCTACACCATCGCCGCTATCGCCTACGTTGGCGGGGGCTTCGGCGTGAACGTGCACAACACCATCGAACCCGCAGTCCA
CGGCATTCCGGTGCTCTTCGGCCCGCGATACGGCAATTCGCCCGAAGCCACCGGACTGATCGAAGCCGGAGCGGCCACGG
TCATCACCGATGAACCGGAACTCCGCAAAGCCCTGAGCGCTTTGGTCGAGGATGCCGGGCATCTGAAGCATACCGGAGCA
AAATCCAGCAGCTTCGTCAACGCCCGGCTCGGAGCCACCGCGATTATCGCCAGGGATATAGCACAGCATTGCCGGACGAA
ATCGTGA

Upstream 100 bases:

>100_bases
TTAGGCACCTCGAAAAAGTGTCGTGAGCGAACGGGGAGCAAGTTTTTCGAGGTGACCTTTTTTCTTACCTTGAGCAAAGC
CTTGACCAATTCAACGAACC

Downstream 100 bases:

>100_bases
TTTCCGTATATTCCGTACATATCTGACCACTTGACAAAACACCGCGAACCATGTTAAGCAGAATCCAAAGTCTCTACCTC
TTCATCGCCGCGCTGCTCGC

Product: 3-deoxy-D-manno-octulosonic-acid transferase

Products: NA

Alternate protein names: KDO transferase [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MASLALAAYRLLSPLQPNLLRLLSSRKPRLKSFLDARENLFEELEARLHALPEPSCRLWIHASSVGEFEQARTIIAELRA
QIPDMDVAVSFFSDSGYEARKHYPDAAAVFYLPLDTPENARRLVDMIGADIFMLMRYDFWPNHLEAIRKSGARMILAAAA
LPPGSPYLKPWLRGLYRDLFSLFDAIYTIDSKDREMFLNQFACKNVFTAGDPRFDQVVERQKKSDERAAKLKPLFRDRMV
LVGGSTWEPDEAILIPAWLSLRQKLSLVLVPHKVDRPNIERLLNNLRQQGIKAVTISEMDEQFDPAQQVLVVNQTGYLAE
LYTIAAIAYVGGGFGVNVHNTIEPAVHGIPVLFGPRYGNSPEATGLIEAGAATVITDEPELRKALSALVEDAGHLKHTGA
KSSSFVNARLGATAIIARDIAQHCRTKS

Sequences:

>Translated_428_residues
MASLALAAYRLLSPLQPNLLRLLSSRKPRLKSFLDARENLFEELEARLHALPEPSCRLWIHASSVGEFEQARTIIAELRA
QIPDMDVAVSFFSDSGYEARKHYPDAAAVFYLPLDTPENARRLVDMIGADIFMLMRYDFWPNHLEAIRKSGARMILAAAA
LPPGSPYLKPWLRGLYRDLFSLFDAIYTIDSKDREMFLNQFACKNVFTAGDPRFDQVVERQKKSDERAAKLKPLFRDRMV
LVGGSTWEPDEAILIPAWLSLRQKLSLVLVPHKVDRPNIERLLNNLRQQGIKAVTISEMDEQFDPAQQVLVVNQTGYLAE
LYTIAAIAYVGGGFGVNVHNTIEPAVHGIPVLFGPRYGNSPEATGLIEAGAATVITDEPELRKALSALVEDAGHLKHTGA
KSSSFVNARLGATAIIARDIAQHCRTKS
>Mature_427_residues
ASLALAAYRLLSPLQPNLLRLLSSRKPRLKSFLDARENLFEELEARLHALPEPSCRLWIHASSVGEFEQARTIIAELRAQ
IPDMDVAVSFFSDSGYEARKHYPDAAAVFYLPLDTPENARRLVDMIGADIFMLMRYDFWPNHLEAIRKSGARMILAAAAL
PPGSPYLKPWLRGLYRDLFSLFDAIYTIDSKDREMFLNQFACKNVFTAGDPRFDQVVERQKKSDERAAKLKPLFRDRMVL
VGGSTWEPDEAILIPAWLSLRQKLSLVLVPHKVDRPNIERLLNNLRQQGIKAVTISEMDEQFDPAQQVLVVNQTGYLAEL
YTIAAIAYVGGGFGVNVHNTIEPAVHGIPVLFGPRYGNSPEATGLIEAGAATVITDEPELRKALSALVEDAGHLKHTGAK
SSSFVNARLGATAIIARDIAQHCRTKS

Specific function: Essential step in lipopolysaccharides biosynthesis. Acts at transfer of 3-deoxy-D-mono octulonic acid (KDO) from CMP-KDO to a tetraacyldisaccharide 1,4'-bisphosphate precursor of lipid A (lipid IVA). Transfers two molecules of KDO to lipid IVA [H]

COG id: COG1519

COG function: function code M; 3-deoxy-D-manno-octulosonic-acid transferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 1 family [H]

Homologues:

Organism=Escherichia coli, GI1790064, Length=364, Percent_Identity=29.3956043956044, Blast_Score=119, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001296
- InterPro:   IPR007507 [H]

Pfam domain/function: PF00534 Glycos_transf_1; PF04413 Glycos_transf_N [H]

EC number: 2.-.-.-

Molecular weight: Translated: 47702; Mature: 47571

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLALAAYRLLSPLQPNLLRLLSSRKPRLKSFLDARENLFEELEARLHALPEPSCRLWI
CCHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
HASSVGEFEQARTIIAELRAQIPDMDVAVSFFSDSGYEARKHYPDAAAVFYLPLDTPENA
EECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCCCCEEEEEEECCCCHHH
RRLVDMIGADIFMLMRYDFWPNHLEAIRKSGARMILAAAALPPGSPYLKPWLRGLYRDLF
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHH
SLFDAIYTIDSKDREMFLNQFACKNVFTAGDPRFDQVVERQKKSDERAAKLKPLFRDRMV
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEE
LVGGSTWEPDEAILIPAWLSLRQKLSLVLVPHKVDRPNIERLLNNLRQQGIKAVTISEMD
EEECCCCCCCCCEEEHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEHHHHH
EQFDPAQQVLVVNQTGYLAELYTIAAIAYVGGGFGVNVHNTIEPAVHGIPVLFGPRYGNS
HHCCCHHEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEECCCCCCC
PEATGLIEAGAATVITDEPELRKALSALVEDAGHLKHTGAKSSSFVNARLGATAIIARDI
CCCCCEEECCCEEEEECCHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHH
AQHCRTKS
HHHCCCCC
>Mature Secondary Structure 
ASLALAAYRLLSPLQPNLLRLLSSRKPRLKSFLDARENLFEELEARLHALPEPSCRLWI
CHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
HASSVGEFEQARTIIAELRAQIPDMDVAVSFFSDSGYEARKHYPDAAAVFYLPLDTPENA
EECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCCCCEEEEEEECCCCHHH
RRLVDMIGADIFMLMRYDFWPNHLEAIRKSGARMILAAAALPPGSPYLKPWLRGLYRDLF
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHH
SLFDAIYTIDSKDREMFLNQFACKNVFTAGDPRFDQVVERQKKSDERAAKLKPLFRDRMV
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEE
LVGGSTWEPDEAILIPAWLSLRQKLSLVLVPHKVDRPNIERLLNNLRQQGIKAVTISEMD
EEECCCCCCCCCEEEHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEHHHHH
EQFDPAQQVLVVNQTGYLAELYTIAAIAYVGGGFGVNVHNTIEPAVHGIPVLFGPRYGNS
HHCCCHHEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEECCCCCCC
PEATGLIEAGAATVITDEPELRKALSALVEDAGHLKHTGAKSSSFVNARLGATAIIARDI
CCCCCEEECCCEEEEECCHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHH
AQHCRTKS
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]