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The map label for this gene is gpmA

Identifier: 21673238

GI number: 21673238

Start: 412646

End: 413389

Strand: Direct

Name: gpmA

Synonym: CT0399

Alternate gene names: 21673238

Gene position: 412646-413389 (Clockwise)

Preceding gene: 21673222

Following gene: 21673240

Centisome position: 19.15

GC content: 56.59

Gene sequence:

>744_bases
ATGAAGAAACTTGTCCTGCTGAGGCACGGCGAAAGCCAGTGGAACCGGGAGAACCGTTTCACCGGATGGGTGGATGTTGA
TCTTTCCGAGAAAGGAAGAGAAGAGGCGAGAACCGCTGGCCAGCTGCTCAAGGATGAGGGTTTCGTGTTTGACCTCGCCT
ACACTTCGGTGCTCAAGCGCGCCATCAGGACGCTCTGGACGGTGCTCGACGAGATGAATCTCATGTGGATTCCCGTCACA
AAAAACTGGCGTCTCAACGAACGCCATTACGGAGCATTGCAGGGGCTCAACAAGGCAGAGACTGCCCAGCGCCACGGCGA
CGAGCAGGTGCTGATCTGGCGCCGCAGCTACGACACGCCGCCACCGGCTCTCACCGAGAGCGATGAGTTCTGGCCGGGCA
AGGACCCGCGCTATGCTTCGCTGTCCTCTCAGGAACTGCCTGCCACGGAGTGCCTGAAGGATACGGTTGCGCGCTTCCTT
CCCTACTGGCACGAGACTATTGCACCGCAGATTCGCGATGGCAAGAATGTCATTATTACAGCTCACGGTAATTCGCTCAG
GGCGCTGGTCAAATATCTCGACAACATTTCGGATGAGGATATCGTCGGTCTGAACATTCCTACCGGTATTCCGCTGGTGT
ACGAGCTTGACGACGATCTCAAGCCGCTGAAGAGTTACTATCTGGGCGACCAGGAGGAGCTGAAGAAAAAGGTGGAGGTC
GTCGTCAAACAGGGCAAAGCCTGA

Upstream 100 bases:

>100_bases
ATGTTTGAGAATGGTTTTTCAGAATATTAAATTGCCAAGCCTGTAAATGGCGCACTCTTTCCTTTTTCAAGAATCAATTT
ACGAGCACAAGGAGCGTTAC

Downstream 100 bases:

>100_bases
ACTTTCAAGGACTTCCGGTTTCGCGACATTCTGTTTGGCCTGAAGCTTTTGGCTTGAAGGTAAAAGGTCATGAATTTTCT
GTTCAATACCTTATATTCTG

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MKKLVLLRHGESQWNRENRFTGWVDVDLSEKGREEARTAGQLLKDEGFVFDLAYTSVLKRAIRTLWTVLDEMNLMWIPVT
KNWRLNERHYGALQGLNKAETAQRHGDEQVLIWRRSYDTPPPALTESDEFWPGKDPRYASLSSQELPATECLKDTVARFL
PYWHETIAPQIRDGKNVIITAHGNSLRALVKYLDNISDEDIVGLNIPTGIPLVYELDDDLKPLKSYYLGDQEELKKKVEV
VVKQGKA

Sequences:

>Translated_247_residues
MKKLVLLRHGESQWNRENRFTGWVDVDLSEKGREEARTAGQLLKDEGFVFDLAYTSVLKRAIRTLWTVLDEMNLMWIPVT
KNWRLNERHYGALQGLNKAETAQRHGDEQVLIWRRSYDTPPPALTESDEFWPGKDPRYASLSSQELPATECLKDTVARFL
PYWHETIAPQIRDGKNVIITAHGNSLRALVKYLDNISDEDIVGLNIPTGIPLVYELDDDLKPLKSYYLGDQEELKKKVEV
VVKQGKA
>Mature_247_residues
MKKLVLLRHGESQWNRENRFTGWVDVDLSEKGREEARTAGQLLKDEGFVFDLAYTSVLKRAIRTLWTVLDEMNLMWIPVT
KNWRLNERHYGALQGLNKAETAQRHGDEQVLIWRRSYDTPPPALTESDEFWPGKDPRYASLSSQELPATECLKDTVARFL
PYWHETIAPQIRDGKNVIITAHGNSLRALVKYLDNISDEDIVGLNIPTGIPLVYELDDDLKPLKSYYLGDQEELKKKVEV
VVKQGKA

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=248, Percent_Identity=58.8709677419355, Blast_Score=313, Evalue=9e-86,
Organism=Homo sapiens, GI4505753, Length=248, Percent_Identity=60.8870967741936, Blast_Score=312, Evalue=2e-85,
Organism=Homo sapiens, GI71274132, Length=248, Percent_Identity=58.4677419354839, Blast_Score=297, Evalue=7e-81,
Organism=Homo sapiens, GI4502445, Length=250, Percent_Identity=50, Blast_Score=264, Evalue=4e-71,
Organism=Homo sapiens, GI40353764, Length=250, Percent_Identity=50, Blast_Score=264, Evalue=4e-71,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=62.7329192546584, Blast_Score=206, Evalue=1e-53,
Organism=Escherichia coli, GI1786970, Length=247, Percent_Identity=66.8016194331984, Blast_Score=349, Evalue=8e-98,
Organism=Saccharomyces cerevisiae, GI6322697, Length=246, Percent_Identity=52.8455284552846, Blast_Score=258, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6324516, Length=293, Percent_Identity=33.7883959044369, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6320183, Length=297, Percent_Identity=34.006734006734, Blast_Score=149, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24646216, Length=249, Percent_Identity=56.2248995983936, Blast_Score=287, Evalue=5e-78,
Organism=Drosophila melanogaster, GI85725270, Length=249, Percent_Identity=55.0200803212851, Blast_Score=277, Evalue=4e-75,
Organism=Drosophila melanogaster, GI85725272, Length=249, Percent_Identity=55.0200803212851, Blast_Score=277, Evalue=4e-75,
Organism=Drosophila melanogaster, GI24650981, Length=249, Percent_Identity=55.0200803212851, Blast_Score=277, Evalue=4e-75,
Organism=Drosophila melanogaster, GI28571815, Length=249, Percent_Identity=39.7590361445783, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI28571817, Length=249, Percent_Identity=39.7590361445783, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24648979, Length=249, Percent_Identity=39.7590361445783, Blast_Score=181, Evalue=6e-46,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_CHLTE (Q8KFC8)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661303.1
- ProteinModelPortal:   Q8KFC8
- SMR:   Q8KFC8
- GeneID:   1008102
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0399
- NMPDR:   fig|194439.1.peg.397
- TIGR:   CT0399
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- ProtClustDB:   PRK14115
- BioCyc:   CTEP194439:CT_0399-MONOMER
- BRENDA:   5.4.2.1
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 28435; Mature: 28435

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLVLLRHGESQWNRENRFTGWVDVDLSEKGREEARTAGQLLKDEGFVFDLAYTSVLKR
CCCEEEEECCCHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHH
AIRTLWTVLDEMNLMWIPVTKNWRLNERHYGALQGLNKAETAQRHGDEQVLIWRRSYDTP
HHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHCCCCEEEEEECCCCCC
PPALTESDEFWPGKDPRYASLSSQELPATECLKDTVARFLPYWHETIAPQIRDGKNVIIT
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
AHGNSLRALVKYLDNISDEDIVGLNIPTGIPLVYELDDDLKPLKSYYLGDQEELKKKVEV
ECCCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHH
VVKQGKA
HHHCCCC
>Mature Secondary Structure
MKKLVLLRHGESQWNRENRFTGWVDVDLSEKGREEARTAGQLLKDEGFVFDLAYTSVLKR
CCCEEEEECCCHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEHHHHHHHHH
AIRTLWTVLDEMNLMWIPVTKNWRLNERHYGALQGLNKAETAQRHGDEQVLIWRRSYDTP
HHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHCCCCEEEEEECCCCCC
PPALTESDEFWPGKDPRYASLSSQELPATECLKDTVARFLPYWHETIAPQIRDGKNVIIT
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
AHGNSLRALVKYLDNISDEDIVGLNIPTGIPLVYELDDDLKPLKSYYLGDQEELKKKVEV
ECCCHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHCCCHHHHHHHHHH
VVKQGKA
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901