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The map label for this gene is uppS

Identifier: 21673106

GI number: 21673106

Start: 279557

End: 280354

Strand: Reverse

Name: uppS

Synonym: CT0267

Alternate gene names: 21673106

Gene position: 280354-279557 (Counterclockwise)

Preceding gene: 21673109

Following gene: 21673105

Centisome position: 13.01

GC content: 50.13

Gene sequence:

>798_bases
ATGCCCCAGTGGTTCACATCGAAATCTGATCCTGAAGATACCCGAATCCAGGAAACGCTGAAATCATCCTGCGTGCTTCC
CCGACATATCGGCATCATCATGGACGGAAACGGCCGGTGGGCGAAAATCAAAGGCAAGTCGCGCATTGCAGGCCATGTGG
CTGGTGTTGAATCGGTGAGAGATGTGGTCGAGGCATCCTCGCAACTCGGCATCGAAAACCTGACGCTGTTCACCTTTTCG
ATCGAGAACTGGAAAAGACCGAAACCTGAAATTTCGGCCCTGATGAAGCTGCTCATCAAGGTGCTCAGAAAAGAGGCCGT
GAAACTGCTTGAAAACGATATCCGATTGGAGGTCATCGGAGATATGGAGATGATCCCCGATGACGTGCGCAAGACACTCG
ATGAAACCATAGAGCTGACCAGAAAAAACCGAGGCATGGCCATGACCATCGCCCTGAGCTATAGCGGAAAATGGGACATC
ACCCAGGCTTGTCGGCACATCGCCCTTCAGGTAAAACAGGGTTTGCTCGATCCCGAAACCATAGATGAAAATCTATTTGC
TTCGTATCTTTCAACCGCATCAATGCCTGATCCTGATCTGCTGATACGAACCAGCGGCGAGTACCGCATCAGCAATTTTA
TGCTCTGGCAAAACGCCTATTCCGAAATCATTTTCAGTAACACCCTTTGGCCCGATTTCCGGCGCAACGAATTGTATGAA
GCCATCCGGGAGTTTCAAAAACGCGAACGGCGGTTTGGCAAAACCAGCGAGCAACTGAAGACCAATGAAGTAGAATAA

Upstream 100 bases:

>100_bases
TTTCATGGAGGTTGCGCGCTTCAAGGATAAGAACGAACCCCCCTCTAAAAGCTGCGAGTTCCGATGAACAGCATTAACCC
ATTGATTTTCCTACTCTTAC

Downstream 100 bases:

>100_bases
CACCGAACTGAACCACAGAACCAATCAGCCCTTTCATGAAAACGACACCATTTCCACCAGACAAGTTATCAGCACTCCTG
ATTGTTCTGGCTCTGCTCAA

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MPQWFTSKSDPEDTRIQETLKSSCVLPRHIGIIMDGNGRWAKIKGKSRIAGHVAGVESVRDVVEASSQLGIENLTLFTFS
IENWKRPKPEISALMKLLIKVLRKEAVKLLENDIRLEVIGDMEMIPDDVRKTLDETIELTRKNRGMAMTIALSYSGKWDI
TQACRHIALQVKQGLLDPETIDENLFASYLSTASMPDPDLLIRTSGEYRISNFMLWQNAYSEIIFSNTLWPDFRRNELYE
AIREFQKRERRFGKTSEQLKTNEVE

Sequences:

>Translated_265_residues
MPQWFTSKSDPEDTRIQETLKSSCVLPRHIGIIMDGNGRWAKIKGKSRIAGHVAGVESVRDVVEASSQLGIENLTLFTFS
IENWKRPKPEISALMKLLIKVLRKEAVKLLENDIRLEVIGDMEMIPDDVRKTLDETIELTRKNRGMAMTIALSYSGKWDI
TQACRHIALQVKQGLLDPETIDENLFASYLSTASMPDPDLLIRTSGEYRISNFMLWQNAYSEIIFSNTLWPDFRRNELYE
AIREFQKRERRFGKTSEQLKTNEVE
>Mature_264_residues
PQWFTSKSDPEDTRIQETLKSSCVLPRHIGIIMDGNGRWAKIKGKSRIAGHVAGVESVRDVVEASSQLGIENLTLFTFSI
ENWKRPKPEISALMKLLIKVLRKEAVKLLENDIRLEVIGDMEMIPDDVRKTLDETIELTRKNRGMAMTIALSYSGKWDIT
QACRHIALQVKQGLLDPETIDENLFASYLSTASMPDPDLLIRTSGEYRISNFMLWQNAYSEIIFSNTLWPDFRRNELYEA
IREFQKRERRFGKTSEQLKTNEVE

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=37.9464285714286, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=37.9464285714286, Blast_Score=173, Evalue=1e-43,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=46.4912280701754, Blast_Score=226, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI71993029, Length=230, Percent_Identity=31.7391304347826, Blast_Score=134, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6319474, Length=220, Percent_Identity=35, Blast_Score=135, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6323748, Length=228, Percent_Identity=30.2631578947368, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI18857969, Length=232, Percent_Identity=35.7758620689655, Blast_Score=155, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_CHLTE (Q8KFQ5)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661171.1
- ProteinModelPortal:   Q8KFQ5
- SMR:   Q8KFQ5
- GeneID:   1007794
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0267
- NMPDR:   fig|194439.1.peg.265
- TIGR:   CT0267
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   CLSK2755569
- BioCyc:   CTEP194439:CT_0267-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 30540; Mature: 30409

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 35-35

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQWFTSKSDPEDTRIQETLKSSCVLPRHIGIIMDGNGRWAKIKGKSRIAGHVAGVESVR
CCCCCCCCCCCCHHHHHHHHHHCCCCHHHEEEEECCCCCEEEECCCCHHHHHHHHHHHHH
DVVEASSQLGIENLTLFTFSIENWKRPKPEISALMKLLIKVLRKEAVKLLENDIRLEVIG
HHHHHHHHCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
DMEMIPDDVRKTLDETIELTRKNRGMAMTIALSYSGKWDITQACRHIALQVKQGLLDPET
CHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHH
IDENLFASYLSTASMPDPDLLIRTSGEYRISNFMLWQNAYSEIIFSNTLWPDFRRNELYE
HHHHHHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AIREFQKRERRFGKTSEQLKTNEVE
HHHHHHHHHHHCCCCHHHHHCCCCC
>Mature Secondary Structure 
PQWFTSKSDPEDTRIQETLKSSCVLPRHIGIIMDGNGRWAKIKGKSRIAGHVAGVESVR
CCCCCCCCCCCHHHHHHHHHHCCCCHHHEEEEECCCCCEEEECCCCHHHHHHHHHHHHH
DVVEASSQLGIENLTLFTFSIENWKRPKPEISALMKLLIKVLRKEAVKLLENDIRLEVIG
HHHHHHHHCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
DMEMIPDDVRKTLDETIELTRKNRGMAMTIALSYSGKWDITQACRHIALQVKQGLLDPET
CHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHH
IDENLFASYLSTASMPDPDLLIRTSGEYRISNFMLWQNAYSEIIFSNTLWPDFRRNELYE
HHHHHHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
AIREFQKRERRFGKTSEQLKTNEVE
HHHHHHHHHHHCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901