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The map label for this gene is hldE [H]

Identifier: 21673050

GI number: 21673050

Start: 226171

End: 226668

Strand: Reverse

Name: hldE [H]

Synonym: CT0209

Alternate gene names: 21673050

Gene position: 226668-226171 (Counterclockwise)

Preceding gene: 21673054

Following gene: 21673049

Centisome position: 10.52

GC content: 59.44

Gene sequence:

>498_bases
ATGCCCCCCAAAGTGCTCACCCGAGACGAAATCGTGCTGAAGACCAGAAACTGGCAGGCTGCCGGAGAAAAAGTCGTCTT
CACCAATGGCTGCTTCGACATTCTCCACGCCGGTCATGTGCGCTATCTTTCAGCAGCCCGGGAACTGGGCGACCGGCTCG
TTGTCGGGCTGAACACTGACGCTTCGGTCAGACGGCTCAAAGGCCCAAACAGACCGGTGGTGCCGGAGCAAGACCGGGCT
GATGTACTCTCGGCGCTGGCGTCGGTCGATGCCGTCACGCTCTTCGACGACGATACGCCTGAAACGCTGATCAAATTGCT
CCTGCCGGACATTCTGGTCAAAGGGGCTGACTGGCCGGTCGAAAAAATCGCGGGAGCCAAAGCCGTCATCGAACACGGCG
GCTCCGTTTTGACCGTGCCGCTGCTTGAGGGCCGCTCGACAACCGGCATCATCGAGACCATCATTCAACTTCATTGCCCC
CAACAGACCGGTGGATAG

Upstream 100 bases:

>100_bases
GCGAACGGAGCGAACAACTTTTTAGGGACTCTTGCGTCTCGGATTATATTTACTATTAATATGAATTTCAGGCCTGAAAT
CTGAAGACCCGAAAAGAGAG

Downstream 100 bases:

>100_bases
AGTCAAGAAATTCAGTTTGTTCGTGATGACCGCCGCATCGGCCGTCGTCATCGTTCTCTGCATCGCCGCCGCCCTGGTGC
TCAACAGCGGCATGGTGGAT

Product: cytidylyltransferase family protein

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MPPKVLTRDEIVLKTRNWQAAGEKVVFTNGCFDILHAGHVRYLSAARELGDRLVVGLNTDASVRRLKGPNRPVVPEQDRA
DVLSALASVDAVTLFDDDTPETLIKLLLPDILVKGADWPVEKIAGAKAVIEHGGSVLTVPLLEGRSTTGIIETIIQLHCP
QQTGG

Sequences:

>Translated_165_residues
MPPKVLTRDEIVLKTRNWQAAGEKVVFTNGCFDILHAGHVRYLSAARELGDRLVVGLNTDASVRRLKGPNRPVVPEQDRA
DVLSALASVDAVTLFDDDTPETLIKLLLPDILVKGADWPVEKIAGAKAVIEHGGSVLTVPLLEGRSTTGIIETIIQLHCP
QQTGG
>Mature_164_residues
PPKVLTRDEIVLKTRNWQAAGEKVVFTNGCFDILHAGHVRYLSAARELGDRLVVGLNTDASVRRLKGPNRPVVPEQDRAD
VLSALASVDAVTLFDDDTPETLIKLLLPDILVKGADWPVEKIAGAKAVIEHGGSVLTVPLLEGRSTTGIIETIIQLHCPQ
QTGG

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=152, Percent_Identity=54.6052631578947, Blast_Score=159, Evalue=9e-41,
Organism=Drosophila melanogaster, GI19921220, Length=66, Percent_Identity=46.969696969697, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550974, Length=66, Percent_Identity=46.969696969697, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550973, Length=66, Percent_Identity=46.969696969697, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550975, Length=66, Percent_Identity=46.969696969697, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.- [C]

Molecular weight: Translated: 17789; Mature: 17658

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPKVLTRDEIVLKTRNWQAAGEKVVFTNGCFDILHAGHVRYLSAARELGDRLVVGLNTD
CCCCCCCCCEEEEEECCCCCCCCEEEEECCHHHHHHCCHHHHHHHHHHCCCEEEEEECCC
ASVRRLKGPNRPVVPEQDRADVLSALASVDAVTLFDDDTPETLIKLLLPDILVKGADWPV
HHHHHHCCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCH
EKIAGAKAVIEHGGSVLTVPLLEGRSTTGIIETIIQLHCPQQTGG
HHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PPKVLTRDEIVLKTRNWQAAGEKVVFTNGCFDILHAGHVRYLSAARELGDRLVVGLNTD
CCCCCCCCEEEEEECCCCCCCCEEEEECCHHHHHHCCHHHHHHHHHHCCCEEEEEECCC
ASVRRLKGPNRPVVPEQDRADVLSALASVDAVTLFDDDTPETLIKLLLPDILVKGADWPV
HHHHHHCCCCCCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCH
EKIAGAKAVIEHGGSVLTVPLLEGRSTTGIIETIIQLHCPQQTGG
HHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA