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The map label for this gene is dfp [H]

Identifier: 21673048

GI number: 21673048

Start: 220363

End: 221583

Strand: Reverse

Name: dfp [H]

Synonym: CT0207

Alternate gene names: 21673048

Gene position: 221583-220363 (Counterclockwise)

Preceding gene: 21673049

Following gene: 21673047

Centisome position: 10.28

GC content: 63.8

Gene sequence:

>1221_bases
GTGCTGACTGGCAGAAACATTCTTCTCGGCATCTCCGGCGGCATCGCTGCCTACAAAACGCCGCAACTGGTCAGGCTTCT
GAAAAAGTCGGGAGCCGGCGTGCAGGTGCTGGCCACCGCGTCGGCGCTGAAGTTTGTCAGCGAACTGTCGCTTGCTACGG
TCTCGAACCATCCAGTGCTCACAGGCATTTTCCCAAGCCATGAGGCACGGGAAGACGAATACACCCGCCACATTGCGCTC
GGCGAGTGGGCCGACGCGTTCGTCATCGCACCCGCCACCGCCAACACCCTCGCTCGCCTCGCCACCGGGCTCTGCGACGA
CATGCTCTCGCTCTGTTTTCTCACCCTCCGCCCCGGCAAGCCGGTGCTCATCGTTCCGGCGATGGACGGCCATATGTACG
ACTCCCCCTCGGTGCAGCGCAACCTCGCGACGCTCAGGGCGCAGGGGTGCCGCTTGATGGAACCCGAAAGCGGCTCGCTC
GCCTCGGGCCAGTGCGGCCTGGGGCGAATGCCCGAACCGGAGACGATCTTCGAGGCGCTCACAGGAATGCTCGCCGCGCC
GGAAGCGTCCGCGCTTTGCGGCAAATCGGTGGTCGTGACCGCCGGGCCAACGCGGGAGAAAATCGATGGTGTGCGCTTTC
TCTCGAACTACTCCTCCGGCAAGATGGGCTTCGCCATCGCCGCCAACGCAGCGCGGCGCGGCGCAAGGGTTCACCTTGTA
ACGGGGCCAGTCAATCTGCCGACGCCGTCGGGCGTGGAGCGAATCGACGTCGAGAGCGCGGTCGAAATGCTGGAAGCGGC
ACAACCATTGTTCGGCGAATGCGATCTCTTCATCGGCGCAGCGGCGGTGGCCGACTACCGCCCCGAAGCGCCGGTCGAGG
GCAAGATCAAGAAGAACGAAGCGGAGATGGAGATTCGTCTTGTCAGGAATCCGGACATTCTCGCCGAATTCGCGACGAAC
CGAAAGCTAGGCCAGCTCGCCGTCGGCTTCGCGCTGGAGACGGCCGGCGGCATCGATTACGCACGGAAAAAACTGGCAGA
CAAAAAGCTCGACCTGGTCGCCTTCAACGTGTACGATGGCCGCACTTCGGGCTTCGAAGTCGATACCAACGCACTGACGC
TCCTCGCTCGCGACGGCGGCGTCACCGAACTGCCGCTACTCCCGAAGGAAGAGGCCGCAGCCAGACTGCTCGACGCGGTC
GAATCGCTTCTGCCCCGTTAA

Upstream 100 bases:

>100_bases
AAGACAAAGACAAAAAAGAGTAAAGCTTCGTATAGTTGTTATTTTTAATACCTTTAAGAATATTTTTCACAGAACGGAAC
CATCGATTCCTGAGTCAACA

Downstream 100 bases:

>100_bases
TTTCAAAGCACGACCGTTCATGATAACGCAGGAATCCCTGTTCGATCCCGCTCCGGAAGAAGCCGCGCAGCCGAACTCTC
CGCTGGAGGGCCTCGGCGAA

Product: pantothenate metabolism flavoprotein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MLTGRNILLGISGGIAAYKTPQLVRLLKKSGAGVQVLATASALKFVSELSLATVSNHPVLTGIFPSHEAREDEYTRHIAL
GEWADAFVIAPATANTLARLATGLCDDMLSLCFLTLRPGKPVLIVPAMDGHMYDSPSVQRNLATLRAQGCRLMEPESGSL
ASGQCGLGRMPEPETIFEALTGMLAAPEASALCGKSVVVTAGPTREKIDGVRFLSNYSSGKMGFAIAANAARRGARVHLV
TGPVNLPTPSGVERIDVESAVEMLEAAQPLFGECDLFIGAAAVADYRPEAPVEGKIKKNEAEMEIRLVRNPDILAEFATN
RKLGQLAVGFALETAGGIDYARKKLADKKLDLVAFNVYDGRTSGFEVDTNALTLLARDGGVTELPLLPKEEAAARLLDAV
ESLLPR

Sequences:

>Translated_406_residues
MLTGRNILLGISGGIAAYKTPQLVRLLKKSGAGVQVLATASALKFVSELSLATVSNHPVLTGIFPSHEAREDEYTRHIAL
GEWADAFVIAPATANTLARLATGLCDDMLSLCFLTLRPGKPVLIVPAMDGHMYDSPSVQRNLATLRAQGCRLMEPESGSL
ASGQCGLGRMPEPETIFEALTGMLAAPEASALCGKSVVVTAGPTREKIDGVRFLSNYSSGKMGFAIAANAARRGARVHLV
TGPVNLPTPSGVERIDVESAVEMLEAAQPLFGECDLFIGAAAVADYRPEAPVEGKIKKNEAEMEIRLVRNPDILAEFATN
RKLGQLAVGFALETAGGIDYARKKLADKKLDLVAFNVYDGRTSGFEVDTNALTLLARDGGVTELPLLPKEEAAARLLDAV
ESLLPR
>Mature_406_residues
MLTGRNILLGISGGIAAYKTPQLVRLLKKSGAGVQVLATASALKFVSELSLATVSNHPVLTGIFPSHEAREDEYTRHIAL
GEWADAFVIAPATANTLARLATGLCDDMLSLCFLTLRPGKPVLIVPAMDGHMYDSPSVQRNLATLRAQGCRLMEPESGSL
ASGQCGLGRMPEPETIFEALTGMLAAPEASALCGKSVVVTAGPTREKIDGVRFLSNYSSGKMGFAIAANAARRGARVHLV
TGPVNLPTPSGVERIDVESAVEMLEAAQPLFGECDLFIGAAAVADYRPEAPVEGKIKKNEAEMEIRLVRNPDILAEFATN
RKLGQLAVGFALETAGGIDYARKKLADKKLDLVAFNVYDGRTSGFEVDTNALTLLARDGGVTELPLLPKEEAAARLLDAV
ESLLPR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=181, Percent_Identity=33.7016574585635, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI87082301, Length=404, Percent_Identity=45.7920792079208, Blast_Score=290, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17560194, Length=207, Percent_Identity=28.9855072463768, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322762, Length=185, Percent_Identity=31.3513513513514, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322925, Length=210, Percent_Identity=23.3333333333333, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24657262, Length=188, Percent_Identity=31.9148936170213, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43050; Mature: 43050

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTGRNILLGISGGIAAYKTPQLVRLLKKSGAGVQVLATASALKFVSELSLATVSNHPVL
CCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHEEECCCCEE
TGIFPSHEAREDEYTRHIALGEWADAFVIAPATANTLARLATGLCDDMLSLCFLTLRPGK
EEECCCCCCCCCHHHHEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHEEECCCC
PVLIVPAMDGHMYDSPSVQRNLATLRAQGCRLMEPESGSLASGQCGLGRMPEPETIFEAL
CEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
TGMLAAPEASALCGKSVVVTAGPTREKIDGVRFLSNYSSGKMGFAIAANAARRGARVHLV
HHHHCCCCHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEEECHHHCCCEEEEE
TGPVNLPTPSGVERIDVESAVEMLEAAQPLFGECDLFIGAAAVADYRPEAPVEGKIKKNE
ECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHEHHHHHHCCCCCCCCCCCEECCC
AEMEIRLVRNPDILAEFATNRKLGQLAVGFALETAGGIDYARKKLADKKLDLVAFNVYDG
CEEEEEEECCCHHHHHHHCCCCHHHHHEEEEECCCCCHHHHHHHHHCCCEEEEEEEEECC
RTSGFEVDTNALTLLARDGGVTELPLLPKEEAAARLLDAVESLLPR
CCCCEEECCCEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLTGRNILLGISGGIAAYKTPQLVRLLKKSGAGVQVLATASALKFVSELSLATVSNHPVL
CCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHEEECCCCEE
TGIFPSHEAREDEYTRHIALGEWADAFVIAPATANTLARLATGLCDDMLSLCFLTLRPGK
EEECCCCCCCCCHHHHEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHEEECCCC
PVLIVPAMDGHMYDSPSVQRNLATLRAQGCRLMEPESGSLASGQCGLGRMPEPETIFEAL
CEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
TGMLAAPEASALCGKSVVVTAGPTREKIDGVRFLSNYSSGKMGFAIAANAARRGARVHLV
HHHHCCCCHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEEECHHHCCCEEEEE
TGPVNLPTPSGVERIDVESAVEMLEAAQPLFGECDLFIGAAAVADYRPEAPVEGKIKKNE
ECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHEHHHHHHCCCCCCCCCCCEECCC
AEMEIRLVRNPDILAEFATNRKLGQLAVGFALETAGGIDYARKKLADKKLDLVAFNVYDG
CEEEEEEECCCHHHHHHHCCCCHHHHHEEEEECCCCCHHHHHHHHHCCCEEEEEEEEECC
RTSGFEVDTNALTLLARDGGVTELPLLPKEEAAARLLDAVESLLPR
CCCCEEECCCEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]