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The map label for this gene is dprE1 [H]

Identifier: 21673011

GI number: 21673011

Start: 177167

End: 178474

Strand: Reverse

Name: dprE1 [H]

Synonym: CT0170

Alternate gene names: 21673011

Gene position: 178474-177167 (Counterclockwise)

Preceding gene: 21673012

Following gene: 21673010

Centisome position: 8.28

GC content: 50.69

Gene sequence:

>1308_bases
ATGAACACGTCCGGATGGGGAAAATACCCTGAAATTGAGGCACAAGTACTGACCCCTTCTTCCGAAAAAGCACTGCAAGA
CCTCATCGGAACCGGAAGTTATGATGGCGTTACGCCGCGAGGACTTGGGCGGAGTTATGGTGACAGCTCACTCGGCAAGC
TGATGGTAAAAACGCTCCGTTTGAACCATATGCTCTCTTTTGAGCTGCAATCGGGTCTGCTTCATTGTCAGTCAGGCGTC
AGCCTCGCCGAAATTCTGGAAGTTTTCGTGCCGCGTGGCTGGTTTTTACCGGTAACACCCGGCACAAAACTGGTGACTGT
TGGCGGGGCCATCGCCAGTGACATCCACGGAAAAAATCACCACATCGACGGCTGCTTCTGTGATCACGTCGATTTTCTTG
ATCTCCTGACCGGCTCAGGGGAGATCATCCGCTGCTCTCCTCATGAGCAGGCGCAACTCTTCCATGCGACCTGTGGCGGC
ATGGGACTTACCGGAATCATCCTTTCAGCAGCGATTCGCCTCACACCAATAAAAAGCGCTTACATCGACCAGGTCACCTT
CAAATCAGCCAACCTCGGAGAAAGTTTTGAACTCTTTGAAAAACAGGCTGAACAGCCCTATTCCGTAGCCTGGATCGATT
GTATCTCCAGCGGTGACAAGCTTGGCCGGTCACTGCTCATGACCGGCAAGCACGCACAGCATGGAGCACTTGCCGCCCAT
CATAATCCAGGGCTTTCGGTACCTCTTGACCTGCCGTCGTTCATCCTGAATCCATACTCCATAAAAGCATTCAATACACT
GTACTATCACAAAGCAAGGCAACGGGAAACGCATGCAACGGTTCATTACGATCCGTTTTTTTATCCGCTTGACGGCATTG
GTCACTGGAACCGGATGTATGGCAAAAACGGCTTTACCCAGTATCAGTTCGTCATTCCGAAAGAGGCCGGCCTACAGGCC
ATGGACTTGATTCTTCGTACCATTGTGAACTCGAAAAAAGGCTCATTTCTTGCCGTGCTCAAAGCATTCGGCAAAGAGAA
CCGGAACCTGCTGAGCTTTCCAATGGAAGGTTATACCCTGGCTCTCGATTTTAAAATCGAGCCGGATCTGTTTCCGCTTC
TGGACCGGCTTGATGCCATGGTACTCGATCATGGGGGCAGGCTCTATCTGACAAAAGACGCAAGGATGAACGCTGAAACC
TTCAGAAAATGCTACCCAAAATGGGAACAGTTTCAGAATATCAGGCAGCAATATGGTGCCCGACATACATTCCTCTCAAT
GCAATCACAACGCCTGGGACTTGACTAA

Upstream 100 bases:

>100_bases
AAGAGTCAAGATATCTTGGTGCCGTTATCGGCCTTGCGATCGGATACGCATCAAAATACCAGCTCGACAAGCGATTTGTT
TTTAAACAGGAGGGCGCTTC

Downstream 100 bases:

>100_bases
TGCAGAATATCCTTATCATCGGCGCAACATCAGCTATCGCCGAAGCAACGGCTCAACAATTTGCTGCAAAAGGCCATCGG
TTTTATCTGCTCGCCCGCAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MNTSGWGKYPEIEAQVLTPSSEKALQDLIGTGSYDGVTPRGLGRSYGDSSLGKLMVKTLRLNHMLSFELQSGLLHCQSGV
SLAEILEVFVPRGWFLPVTPGTKLVTVGGAIASDIHGKNHHIDGCFCDHVDFLDLLTGSGEIIRCSPHEQAQLFHATCGG
MGLTGIILSAAIRLTPIKSAYIDQVTFKSANLGESFELFEKQAEQPYSVAWIDCISSGDKLGRSLLMTGKHAQHGALAAH
HNPGLSVPLDLPSFILNPYSIKAFNTLYYHKARQRETHATVHYDPFFYPLDGIGHWNRMYGKNGFTQYQFVIPKEAGLQA
MDLILRTIVNSKKGSFLAVLKAFGKENRNLLSFPMEGYTLALDFKIEPDLFPLLDRLDAMVLDHGGRLYLTKDARMNAET
FRKCYPKWEQFQNIRQQYGARHTFLSMQSQRLGLD

Sequences:

>Translated_435_residues
MNTSGWGKYPEIEAQVLTPSSEKALQDLIGTGSYDGVTPRGLGRSYGDSSLGKLMVKTLRLNHMLSFELQSGLLHCQSGV
SLAEILEVFVPRGWFLPVTPGTKLVTVGGAIASDIHGKNHHIDGCFCDHVDFLDLLTGSGEIIRCSPHEQAQLFHATCGG
MGLTGIILSAAIRLTPIKSAYIDQVTFKSANLGESFELFEKQAEQPYSVAWIDCISSGDKLGRSLLMTGKHAQHGALAAH
HNPGLSVPLDLPSFILNPYSIKAFNTLYYHKARQRETHATVHYDPFFYPLDGIGHWNRMYGKNGFTQYQFVIPKEAGLQA
MDLILRTIVNSKKGSFLAVLKAFGKENRNLLSFPMEGYTLALDFKIEPDLFPLLDRLDAMVLDHGGRLYLTKDARMNAET
FRKCYPKWEQFQNIRQQYGARHTFLSMQSQRLGLD
>Mature_435_residues
MNTSGWGKYPEIEAQVLTPSSEKALQDLIGTGSYDGVTPRGLGRSYGDSSLGKLMVKTLRLNHMLSFELQSGLLHCQSGV
SLAEILEVFVPRGWFLPVTPGTKLVTVGGAIASDIHGKNHHIDGCFCDHVDFLDLLTGSGEIIRCSPHEQAQLFHATCGG
MGLTGIILSAAIRLTPIKSAYIDQVTFKSANLGESFELFEKQAEQPYSVAWIDCISSGDKLGRSLLMTGKHAQHGALAAH
HNPGLSVPLDLPSFILNPYSIKAFNTLYYHKARQRETHATVHYDPFFYPLDGIGHWNRMYGKNGFTQYQFVIPKEAGLQA
MDLILRTIVNSKKGSFLAVLKAFGKENRNLLSFPMEGYTLALDFKIEPDLFPLLDRLDAMVLDHGGRLYLTKDARMNAET
FRKCYPKWEQFQNIRQQYGARHTFLSMQSQRLGLD

Specific function: Involved in the epimerization of decaprenylphosphoryl ribose (DPR) to decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Probably catalyzes the oxidation at C-2 of decaprenylphosphoryl ribose (

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007173
- InterPro:   IPR016166
- InterPro:   IPR016168
- InterPro:   IPR006094 [H]

Pfam domain/function: PF04030 ALO; PF01565 FAD_binding_4 [H]

EC number: NA

Molecular weight: Translated: 48418; Mature: 48418

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSGWGKYPEIEAQVLTPSSEKALQDLIGTGSYDGVTPRGLGRSYGDSSLGKLMVKTLR
CCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LNHMLSFELQSGLLHCQSGVSLAEILEVFVPRGWFLPVTPGTKLVTVGGAIASDIHGKNH
HHHHEEHHHHHCHHHHHCCCCHHHHHHHHCCCCCEEECCCCCEEEEECCHHHHCCCCCCC
HIDGCFCDHVDFLDLLTGSGEIIRCSPHEQAQLFHATCGGMGLTGIILSAAIRLTPIKSA
CCCCEEECCHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHEEECHHH
YIDQVTFKSANLGESFELFEKQAEQPYSVAWIDCISSGDKLGRSLLMTGKHAQHGALAAH
HHHHEEECCCCCCCHHHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHHCCCCCCCCCEEEE
HNPGLSVPLDLPSFILNPYSIKAFNTLYYHKARQRETHATVHYDPFFYPLDGIGHWNRMY
CCCCCEECCCCHHHHCCCCEEEHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCCHHHHH
GKNGFTQYQFVIPKEAGLQAMDLILRTIVNSKKGSFLAVLKAFGKENRNLLSFPMEGYTL
CCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCCEEE
ALDFKIEPDLFPLLDRLDAMVLDHGGRLYLTKDARMNAETFRKCYPKWEQFQNIRQQYGA
EEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHCC
RHTFLSMQSQRLGLD
HHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTSGWGKYPEIEAQVLTPSSEKALQDLIGTGSYDGVTPRGLGRSYGDSSLGKLMVKTLR
CCCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LNHMLSFELQSGLLHCQSGVSLAEILEVFVPRGWFLPVTPGTKLVTVGGAIASDIHGKNH
HHHHEEHHHHHCHHHHHCCCCHHHHHHHHCCCCCEEECCCCCEEEEECCHHHHCCCCCCC
HIDGCFCDHVDFLDLLTGSGEIIRCSPHEQAQLFHATCGGMGLTGIILSAAIRLTPIKSA
CCCCEEECCHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHEEECHHH
YIDQVTFKSANLGESFELFEKQAEQPYSVAWIDCISSGDKLGRSLLMTGKHAQHGALAAH
HHHHEEECCCCCCCHHHHHHHHCCCCCEEEEEHHHCCCHHHHHHHHHCCCCCCCCCEEEE
HNPGLSVPLDLPSFILNPYSIKAFNTLYYHKARQRETHATVHYDPFFYPLDGIGHWNRMY
CCCCCEECCCCHHHHCCCCEEEHHHHHHHHHHHCCCCCEEEEECCEEEECCCCCCHHHHH
GKNGFTQYQFVIPKEAGLQAMDLILRTIVNSKKGSFLAVLKAFGKENRNLLSFPMEGYTL
CCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCCEEE
ALDFKIEPDLFPLLDRLDAMVLDHGGRLYLTKDARMNAETFRKCYPKWEQFQNIRQQYGA
EEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHCC
RHTFLSMQSQRLGLD
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]