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The map label for this gene is fabG [C]

Identifier: 21673010

GI number: 21673010

Start: 176427

End: 177167

Strand: Reverse

Name: fabG [C]

Synonym: CT0169

Alternate gene names: 21673010

Gene position: 177167-176427 (Counterclockwise)

Preceding gene: 21673011

Following gene: 21673005

Centisome position: 8.22

GC content: 49.26

Gene sequence:

>741_bases
ATGCAGAATATCCTTATCATCGGCGCAACATCAGCTATCGCCGAAGCAACGGCTCAACAATTTGCTGCAAAAGGCCATCG
GTTTTATCTGCTCGCCCGCAATGAAGAGCGCCTGAAGACCATCGCTTCAGATCTGCTTGTCAGAGGAGCATCTGCTGTTG
AAACCGCCCTATTTGATGCGAACGACACAGTGAACCACCGGACTGTACTTGAAAAAGCAAAAGCGACAATAGGCTCTTTC
GACATAGTTCTTATTGCCCACGGCACTCTTGGCAATCAAAAAGAGTGTGAAACCAACCCTGAGCTGGCGCTGAAAGAACT
GCAGACCAATGCCCTGAGCACGATATCGTTACTTACCCATACAGCGAACACCATGGAACAACAGCATCATGGTACAATCG
CCGTGATCAGTTCCGTTGCGGGTGATCGGGGACGGCCATCCAACTATGTCTATGGAACAGCAAAGGCCGCCGTTACGACC
TTCTGCGAGGGACTTCGTGCCCGCCTTCACAAAAGCGGCGTTCACGTGCTGACCATCAAGCCCGGCATGGTCGAAACACC
TATGACAGAAGGCATTTCCGCACCGGACATGCTTTTAGCGAAGCCAGAGCAGATCGCCAGCGATATTGTCAATGCAATTG
AAAAGAAAAAGGACGTGCTTTATACCCCGTGGTTCTGGAAATATATCATGATGGCCATCATTCATATCCCGAATACCATA
TTCAAAAAGTCTTCGTTATAA

Upstream 100 bases:

>100_bases
AATGCTACCCAAAATGGGAACAGTTTCAGAATATCAGGCAGCAATATGGTGCCCGACATACATTCCTCTCAATGCAATCA
CAACGCCTGGGACTTGACTA

Downstream 100 bases:

>100_bases
TCCTCAAGACCATATTCCAGAACATATCAGAACATTGCTGGGAATCTGGTTGCAACTCCTGTAAAGCCAGTGTCTTGCCG
CTGAGATTACTCAATATACT

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: ORF3 [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MQNILIIGATSAIAEATAQQFAAKGHRFYLLARNEERLKTIASDLLVRGASAVETALFDANDTVNHRTVLEKAKATIGSF
DIVLIAHGTLGNQKECETNPELALKELQTNALSTISLLTHTANTMEQQHHGTIAVISSVAGDRGRPSNYVYGTAKAAVTT
FCEGLRARLHKSGVHVLTIKPGMVETPMTEGISAPDMLLAKPEQIASDIVNAIEKKKDVLYTPWFWKYIMMAIIHIPNTI
FKKSSL

Sequences:

>Translated_246_residues
MQNILIIGATSAIAEATAQQFAAKGHRFYLLARNEERLKTIASDLLVRGASAVETALFDANDTVNHRTVLEKAKATIGSF
DIVLIAHGTLGNQKECETNPELALKELQTNALSTISLLTHTANTMEQQHHGTIAVISSVAGDRGRPSNYVYGTAKAAVTT
FCEGLRARLHKSGVHVLTIKPGMVETPMTEGISAPDMLLAKPEQIASDIVNAIEKKKDVLYTPWFWKYIMMAIIHIPNTI
FKKSSL
>Mature_246_residues
MQNILIIGATSAIAEATAQQFAAKGHRFYLLARNEERLKTIASDLLVRGASAVETALFDANDTVNHRTVLEKAKATIGSF
DIVLIAHGTLGNQKECETNPELALKELQTNALSTISLLTHTANTMEQQHHGTIAVISSVAGDRGRPSNYVYGTAKAAVTT
FCEGLRARLHKSGVHVLTIKPGMVETPMTEGISAPDMLLAKPEQIASDIVNAIEKKKDVLYTPWFWKYIMMAIIHIPNTI
FKKSSL

Specific function: May be involved in the biosynthesis of a heptaene-type antibiotic [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=187, Percent_Identity=28.8770053475936, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI20149619, Length=234, Percent_Identity=26.0683760683761, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787335, Length=189, Percent_Identity=29.6296296296296, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787820, Length=186, Percent_Identity=27.9569892473118, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082100, Length=223, Percent_Identity=26.9058295964126, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21358495, Length=189, Percent_Identity=25.3968253968254, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26809; Mature: 26809

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNILIIGATSAIAEATAQQFAAKGHRFYLLARNEERLKTIASDLLVRGASAVETALFDA
CCCEEEEECHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHCCC
NDTVNHRTVLEKAKATIGSFDIVLIAHGTLGNQKECETNPELALKELQTNALSTISLLTH
CCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TANTMEQQHHGTIAVISSVAGDRGRPSNYVYGTAKAAVTTFCEGLRARLHKSGVHVLTIK
HHHHHHHHHCCHHEEEEHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PGMVETPMTEGISAPDMLLAKPEQIASDIVNAIEKKKDVLYTPWFWKYIMMAIIHIPNTI
CCCCCCCHHCCCCCCHHHHCCHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHCCHHH
FKKSSL
HHCCCC
>Mature Secondary Structure
MQNILIIGATSAIAEATAQQFAAKGHRFYLLARNEERLKTIASDLLVRGASAVETALFDA
CCCEEEEECHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHHHHCCC
NDTVNHRTVLEKAKATIGSFDIVLIAHGTLGNQKECETNPELALKELQTNALSTISLLTH
CCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TANTMEQQHHGTIAVISSVAGDRGRPSNYVYGTAKAAVTTFCEGLRARLHKSGVHVLTIK
HHHHHHHHHCCHHEEEEHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PGMVETPMTEGISAPDMLLAKPEQIASDIVNAIEKKKDVLYTPWFWKYIMMAIIHIPNTI
CCCCCCCHHCCCCCCHHHHCCHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHCCHHH
FKKSSL
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1406267 [H]