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The map label for this gene is dxr

Identifier: 21672966

GI number: 21672966

Start: 119318

End: 120466

Strand: Reverse

Name: dxr

Synonym: CT0125

Alternate gene names: 21672966

Gene position: 120466-119318 (Counterclockwise)

Preceding gene: 21672967

Following gene: 21672965

Centisome position: 5.59

GC content: 60.49

Gene sequence:

>1149_bases
ATGAAATCCTTATCCATTCTCGGCAGTACCGGCTCCATTGGACTCAGCACACTCGACGTCGTCAGGCGTCATCCTGAAAG
GTTTTCGATTGCGGCCCTTGCCGAGGGCCACGACGTCGAAATGCTTCTCAAGCAAATCGATGAATTCAGGCCGTCACTGG
TCTCGGTGCGTGACGAGGCGTCGCGGGAGCGCCTCAAGGGGATGCTCGGCGATCACAAGCCCGAAATTCTCTGCGGCCTC
GAAGGTGCAGCTGAAGTTGCGGCCGTCGATGGAGCAGACATGGTAGTTTCGGCCATCGTGGGTGCGGCAGGACTGGTGCC
AACCGTCAGGGCTATTGAAGCCGGAAAGGACATCGCGCTGGCCAACAAGGAGACGCTCGTCGTCGCCGGTCAGCTCGTTT
CGGACCTCGTCAAAAAGCACGATGTCAAACTGCTGCCAGTGGACAGCGAGCACTCGGCGATCTTTCAGTCGCTGGTCGGC
CACCGCACGGAAGATATCGAACGCATCATCCTGACCGCATCAGGTGGCCCATTCCGTAAAACGCCCGCCGAAGAGTTGAA
AAACGTCGGCCCGGAACAGGCGCTCAAGCACCCGCAGTGGTCGATGGGCGCGAAGATCACCATCGACTCGGCGACCCTTA
TGAACAAAGGGCTCGAGGTAATCGAGGCGCACTGGCTCTTCGACATGCCCGCAGAGAAGATCGGCGTCGTGGTGCACCCG
CAGAGCATCATTCACTCGATGGTTGAGTACATCGACGGCTGCGTCATCGCCCAGCTCGGCGTGCCCGACATGCGCGCTCC
CATCGCCTATGCCCTCGCCTGGCCGGAGCGCTGCGAAACCGGCATCGGCAAGCTCGATCTCACCAAGGTCGCCACACTCA
CCTTCGAGGAGCCAGACATGGAGCGCTTCCCGGCCCTGCGCCTGGCCTTCGACGCCCTCAAGGCGGGCCAGACCTATCCT
GCGGTACTGAACGCGGCCAACGAAATCGCTGTCGCGGCGTTCCTCGACAAGAAAATCGGCTTTACCGACATCGCCGGAAC
GGTCGATAAAACCATGCAGGCACACGAAGCATGGACGCCGATCACGCTGGAGGAGTACCTTCAGGCAGACAAATGGGCCC
GCGAAACCGCACGGCAGCTTATCGGATAA

Upstream 100 bases:

>100_bases
TGTACCCGCCGCGTCGAAAAGCCTTGTTTGTTCGACGCTCCGAAAAAGCATAAATTCAGGCCTCGAATTCGTCCCTCTTT
TCACGCCAATGTCATGACAC

Downstream 100 bases:

>100_bases
TTCCGGGCTAAACATCACGAAACAACCGAACGACCTGCATTTGACATGGAGCTACTGAACACGATATTCTTCTTCGTCAT
CGCCATCTTCATCCTCGTCA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKSLSILGSTGSIGLSTLDVVRRHPERFSIAALAEGHDVEMLLKQIDEFRPSLVSVRDEASRERLKGMLGDHKPEILCGL
EGAAEVAAVDGADMVVSAIVGAAGLVPTVRAIEAGKDIALANKETLVVAGQLVSDLVKKHDVKLLPVDSEHSAIFQSLVG
HRTEDIERIILTASGGPFRKTPAEELKNVGPEQALKHPQWSMGAKITIDSATLMNKGLEVIEAHWLFDMPAEKIGVVVHP
QSIIHSMVEYIDGCVIAQLGVPDMRAPIAYALAWPERCETGIGKLDLTKVATLTFEEPDMERFPALRLAFDALKAGQTYP
AVLNAANEIAVAAFLDKKIGFTDIAGTVDKTMQAHEAWTPITLEEYLQADKWARETARQLIG

Sequences:

>Translated_382_residues
MKSLSILGSTGSIGLSTLDVVRRHPERFSIAALAEGHDVEMLLKQIDEFRPSLVSVRDEASRERLKGMLGDHKPEILCGL
EGAAEVAAVDGADMVVSAIVGAAGLVPTVRAIEAGKDIALANKETLVVAGQLVSDLVKKHDVKLLPVDSEHSAIFQSLVG
HRTEDIERIILTASGGPFRKTPAEELKNVGPEQALKHPQWSMGAKITIDSATLMNKGLEVIEAHWLFDMPAEKIGVVVHP
QSIIHSMVEYIDGCVIAQLGVPDMRAPIAYALAWPERCETGIGKLDLTKVATLTFEEPDMERFPALRLAFDALKAGQTYP
AVLNAANEIAVAAFLDKKIGFTDIAGTVDKTMQAHEAWTPITLEEYLQADKWARETARQLIG
>Mature_382_residues
MKSLSILGSTGSIGLSTLDVVRRHPERFSIAALAEGHDVEMLLKQIDEFRPSLVSVRDEASRERLKGMLGDHKPEILCGL
EGAAEVAAVDGADMVVSAIVGAAGLVPTVRAIEAGKDIALANKETLVVAGQLVSDLVKKHDVKLLPVDSEHSAIFQSLVG
HRTEDIERIILTASGGPFRKTPAEELKNVGPEQALKHPQWSMGAKITIDSATLMNKGLEVIEAHWLFDMPAEKIGVVVHP
QSIIHSMVEYIDGCVIAQLGVPDMRAPIAYALAWPERCETGIGKLDLTKVATLTFEEPDMERFPALRLAFDALKAGQTYP
AVLNAANEIAVAAFLDKKIGFTDIAGTVDKTMQAHEAWTPITLEEYLQADKWARETARQLIG

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=391, Percent_Identity=51.9181585677749, Blast_Score=387, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_CHLTE (Q8KG43)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_661031.1
- ProteinModelPortal:   Q8KG43
- SMR:   Q8KG43
- GeneID:   1006807
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0125
- NMPDR:   fig|194439.1.peg.125
- TIGR:   CT0125
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   CTEP194439:CT_0125-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41344; Mature: 41344

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: BINDING 123-123 BINDING 150-150 BINDING 174-174 BINDING 197-197 BINDING 219-219

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLSILGSTGSIGLSTLDVVRRHPERFSIAALAEGHDVEMLLKQIDEFRPSLVSVRDEA
CCCCEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHH
SRERLKGMLGDHKPEILCGLEGAAEVAAVDGADMVVSAIVGAAGLVPTVRAIEAGKDIAL
HHHHHHHHHCCCCCCEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ANKETLVVAGQLVSDLVKKHDVKLLPVDSEHSAIFQSLVGHRTEDIERIILTASGGPFRK
CCCCEEEEHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCHHCCEEEEEEECCCCCCC
TPAEELKNVGPEQALKHPQWSMGAKITIDSATLMNKGLEVIEAHWLFDMPAEKIGVVVHP
CCHHHHHCCCHHHHHCCCCCCCCCEEEECHHHHHHHCHHHHHHHHHCCCCHHHCEEEECC
QSIIHSMVEYIDGCVIAQLGVPDMRAPIAYALAWPERCETGIGKLDLTKVATLTFEEPDM
HHHHHHHHHHHCCEEEEECCCCCHHCCHHHHHHCHHHHHCCCCCEEHHHEEEEEECCCCH
ERFPALRLAFDALKAGQTYPAVLNAANEIAVAAFLDKKIGFTDIAGTVDKTMQAHEAWTP
HHHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
ITLEEYLQADKWARETARQLIG
CCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSLSILGSTGSIGLSTLDVVRRHPERFSIAALAEGHDVEMLLKQIDEFRPSLVSVRDEA
CCCCEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHH
SRERLKGMLGDHKPEILCGLEGAAEVAAVDGADMVVSAIVGAAGLVPTVRAIEAGKDIAL
HHHHHHHHHCCCCCCEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ANKETLVVAGQLVSDLVKKHDVKLLPVDSEHSAIFQSLVGHRTEDIERIILTASGGPFRK
CCCCEEEEHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCHHCCEEEEEEECCCCCCC
TPAEELKNVGPEQALKHPQWSMGAKITIDSATLMNKGLEVIEAHWLFDMPAEKIGVVVHP
CCHHHHHCCCHHHHHCCCCCCCCCEEEECHHHHHHHCHHHHHHHHHCCCCHHHCEEEECC
QSIIHSMVEYIDGCVIAQLGVPDMRAPIAYALAWPERCETGIGKLDLTKVATLTFEEPDM
HHHHHHHHHHHCCEEEEECCCCCHHCCHHHHHHCHHHHHCCCCCEEHHHEEEEEECCCCH
ERFPALRLAFDALKAGQTYPAVLNAANEIAVAAFLDKKIGFTDIAGTVDKTMQAHEAWTP
HHHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
ITLEEYLQADKWARETARQLIG
CCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901