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The map label for this gene is proC [H]

Identifier: 21672918

GI number: 21672918

Start: 73755

End: 74555

Strand: Direct

Name: proC [H]

Synonym: CT0077

Alternate gene names: 21672918

Gene position: 73755-74555 (Clockwise)

Preceding gene: 21672917

Following gene: 21672919

Centisome position: 3.42

GC content: 61.42

Gene sequence:

>801_bases
ATGGCACGACTTTCCATAGGGTTTATCGGCACCGGACGCATTGCCCAGGCGCTTATTTCCGGACTTTCACACGACCCGAA
CATCGTCATCTGCGGCTACGACAAGATGCCTGATGCACTGCACTCGGTATCCCTGCAATACGGCGTCAATACCGAGGAGT
CAATCGAAAGCCTCGCGCGCGACGCGGAGATCATCGTCATTGCCGTCAAGCCGTACCAGATGGCCGAAGTGCTCGCAGAG
CTGAAACCCGCACTCCACGGGCAGCATCTCATTGTCAGCGTGGCGGCAGGAATCTCGACAGGCTTCATTGAATCGAACTG
CCCTGAGGGCACGAGGGTGGTGCGAGTGATGCCGAATACCCCGGCGTTTGTGGGTGAGGGGATGACCGCCTTGTGCAAAG
GGATGCACGCCACAGCGGACGACCTTCTGGTTGCCGAACGGATTTTCAACGCGATTGGCAAGACGGCCATCATCGAGGAG
AGCGGCATGGATGCCGCGACGGCAGTGTCGGGCAGCGGACCGGCCTACATGTTCAGGATCATCGACTCCCTTGCCGAAGG
TGGAGAGGCGTGCGGCCTCGACCGCGAAACCGCGCAACTGCTCGCTGCCCAGACGATGCTCGGCGCGGCGAAAATGGTGC
TCTCGGGCCACAAAAGCCCCGAAGAGCTGGTGCGCGAAGTGACGACTCCCGGAGGTACCACCGAAGCCGGGCTGAAAGCG
ATGGACGAGCGCGACCTGCGTGGAGCGCTCATCGACACGGTCAGGGCCGCCGCCGCCCGTTCGAAAGAGCTGATGAAGTA
G

Upstream 100 bases:

>100_bases
TCAGCCAACAGCATCACCCTGCTTTTGCTCTTCATCATCCTTTTTTTCAAAATCCGGGATCAAGGCAATTCCAACTCCTG
AATATCATCTTTCCATCATT

Downstream 100 bases:

>100_bases
TGACGATGTTCACGCGCCTCATCCTCTGGCTGCTGCCGCTCCTGCTCGTGCTTCCGGCAGCAAGCGCCGCGGAAACTGCC
GGCGGAAAGCTCTTCATTGA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MARLSIGFIGTGRIAQALISGLSHDPNIVICGYDKMPDALHSVSLQYGVNTEESIESLARDAEIIVIAVKPYQMAEVLAE
LKPALHGQHLIVSVAAGISTGFIESNCPEGTRVVRVMPNTPAFVGEGMTALCKGMHATADDLLVAERIFNAIGKTAIIEE
SGMDAATAVSGSGPAYMFRIIDSLAEGGEACGLDRETAQLLAAQTMLGAAKMVLSGHKSPEELVREVTTPGGTTEAGLKA
MDERDLRGALIDTVRAAAARSKELMK

Sequences:

>Translated_266_residues
MARLSIGFIGTGRIAQALISGLSHDPNIVICGYDKMPDALHSVSLQYGVNTEESIESLARDAEIIVIAVKPYQMAEVLAE
LKPALHGQHLIVSVAAGISTGFIESNCPEGTRVVRVMPNTPAFVGEGMTALCKGMHATADDLLVAERIFNAIGKTAIIEE
SGMDAATAVSGSGPAYMFRIIDSLAEGGEACGLDRETAQLLAAQTMLGAAKMVLSGHKSPEELVREVTTPGGTTEAGLKA
MDERDLRGALIDTVRAAAARSKELMK
>Mature_265_residues
ARLSIGFIGTGRIAQALISGLSHDPNIVICGYDKMPDALHSVSLQYGVNTEESIESLARDAEIIVIAVKPYQMAEVLAEL
KPALHGQHLIVSVAAGISTGFIESNCPEGTRVVRVMPNTPAFVGEGMTALCKGMHATADDLLVAERIFNAIGKTAIIEES
GMDAATAVSGSGPAYMFRIIDSLAEGGEACGLDRETAQLLAAQTMLGAAKMVLSGHKSPEELVREVTTPGGTTEAGLKAM
DERDLRGALIDTVRAAAARSKELMK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=265, Percent_Identity=35.0943396226415, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI21361454, Length=268, Percent_Identity=35.0746268656716, Blast_Score=158, Evalue=5e-39,
Organism=Homo sapiens, GI24797097, Length=268, Percent_Identity=35.4477611940299, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI24797095, Length=268, Percent_Identity=35.4477611940299, Blast_Score=155, Evalue=4e-38,
Organism=Escherichia coli, GI1786585, Length=264, Percent_Identity=34.8484848484849, Blast_Score=160, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=38.7832699619772, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17540664, Length=279, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320861, Length=283, Percent_Identity=29.3286219081272, Blast_Score=114, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21358587, Length=264, Percent_Identity=35.9848484848485, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24648116, Length=285, Percent_Identity=37.1929824561403, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24647700, Length=168, Percent_Identity=38.0952380952381, Blast_Score=118, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27907; Mature: 27775

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00521 P5CR ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLSIGFIGTGRIAQALISGLSHDPNIVICGYDKMPDALHSVSLQYGVNTEESIESLAR
CCEEEEEECCCHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHC
DAEIIVIAVKPYQMAEVLAELKPALHGQHLIVSVAAGISTGFIESNCPEGTRVVRVMPNT
CCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEHHHCCHHCCCCCCCCCCCEEEEECCCC
PAFVGEGMTALCKGMHATADDLLVAERIFNAIGKTAIIEESGMDAATAVSGSGPAYMFRI
CCHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHEECCCCHHHHHHH
IDSLAEGGEACGLDRETAQLLAAQTMLGAAKMVLSGHKSPEELVREVTTPGGTTEAGLKA
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHH
MDERDLRGALIDTVRAAAARSKELMK
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARLSIGFIGTGRIAQALISGLSHDPNIVICGYDKMPDALHSVSLQYGVNTEESIESLAR
CEEEEEECCCHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHC
DAEIIVIAVKPYQMAEVLAELKPALHGQHLIVSVAAGISTGFIESNCPEGTRVVRVMPNT
CCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEHHHCCHHCCCCCCCCCCCEEEEECCCC
PAFVGEGMTALCKGMHATADDLLVAERIFNAIGKTAIIEESGMDAATAVSGSGPAYMFRI
CCHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHEECCCCHHHHHHH
IDSLAEGGEACGLDRETAQLLAAQTMLGAAKMVLSGHKSPEELVREVTTPGGTTEAGLKA
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHH
MDERDLRGALIDTVRAAAARSKELMK
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11844777; 11932238 [H]