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The map label for this gene is dnaA

Identifier: 21672843

GI number: 21672843

Start: 1398

End: 2879

Strand: Reverse

Name: dnaA

Synonym: CT0002

Alternate gene names: 21672843

Gene position: 2879-1398 (Counterclockwise)

Preceding gene: 21672851

Following gene: 21672842

Centisome position: 0.13

GC content: 53.51

Gene sequence:

>1482_bases
ATGTCTGATACGATCCAGCAAGAAGCTCCGGACAACCTACAAGTAACCCCGACGCATGGTCGATCATTTGCGGAGAAGGT
ATGGAGTGCCTGCCTTGGACTTATCCAGGAGAACATCAACACGCTTGCTTTCAAAACCTGGTTCCTGCCAATCAGACCTC
TTTCATTTTCGGGTAGCGAACTGACCATCGAGGTACCGAGCCAGTTTTTCTATGAGTGGATCGAGGAGAACTATTCGGTG
CACGTCAAGCAGGCGCTCCGGCAGGTGATCGGTCCGGAGGCGAAGCTGATGTACTCCATCGTGATAGACAAATCACAGGG
GCAGCCGGTGACCATCGAATTGCCGCACCAGATCGATGCCGCGCCAGCGGAAAGATCGGTCCGGCCTGAGGCGCCTGGTC
AAAAAGCCTCCGCCGAACGTGAACGGCTCGAGATCGCACGCCCCAGATTCGAGAGCAACCTCAATCCGAAATACACCTTT
TCGACGCTTGTCAGGGGAGATTGCAACTCTCTGGCATTTGCCGCATCCAAATCGATCGCCCAGAACCCGGGACAAAATGC
CTTCAACCCGCTGGTCATTTACGGCGGCGTTGGACTCGGCAAGACCCATATGATGCAGGCTATTGGCAACTCGGTACTTG
AAAACCGCATCACTGACGCCGTGCTGTACGTTTCAAGCGAAAAGTTCGCCATCGATTTTGTCAACGCCATCCAGAACGGC
AACATCCAGGAGTTCTCCGCGTTCTACCGAAACATCGACGTCCTGATTATCGACGACATCCAGTTTTTCGCGGGCAAGGA
GAAGACGCAGGAGGAGATATTCCACATCTTCAACACCCTGCACCAGTCCAACAAGCAGATCATCCTGTCGGCAGACCGGC
CAATCAAGGAGATCAAGGGCATCGAAGACCGCCTCATATCCCGTTTCAACTGGGGCCTCTCCACAGACATCCAGGCGCCG
GATTACGAAACCCGCAAGGCGATCATCCAGAGCAAGCTCAAGCAGAGCGGCGTCAGTCTGGATCCGGTAGTCATTGAGTT
TATCGCAACCAACGTCACCAGCAACGTCAGGGAACTCGAAGGGTGCATCGTCAAGCTGCTAGCGGCCCACTCGCTCGACA
ACCAGGAGATCGACCTCCAGTTCGCCAAATCGACGCTCAAGGACATCATCCGGTACAACACCAAACAACTGACTCTCGAA
ACCATTGAAAAAGCGGTCTGCTCCTATTTTTCGATCACCTCGAACGACCTGAAAGGGAAATCGAAAAAAAAGGAGATCGC
CGTCGGACGGCAGATTGCCATGTACCTGTCGAAGGACATGACCGACTCATCGCTCAAGACCATCGGCCTTCACTTCGGCG
GACGCGATCACTCCACGGTCATTCACGCCCTGAACACCATCGAAAAAAAGATCGCAGCTTCCAACGAAGAGCGAAAGAAG
ATCGAGGAGTTGAGAAAAAGGATCGAAATCATGTCGATGTAA

Upstream 100 bases:

>100_bases
AAATCAGAAGCAGGATTGTTTTTTGTCCACCGAAAGCCGTACCTTGTAAACAGAAAATGTTGATGAATCACCGAAACAAC
GCATCTCACAGCCAATTCCC

Downstream 100 bases:

>100_bases
CCTGTGTATAACCTGTTCAAAACCTGTTGGCGCAATCTTGATTTCAGGGGAGTTATCAACACTGTGGGGTTGCCGCATGA
AATCACCAACAAACCGTCAA

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MSDTIQQEAPDNLQVTPTHGRSFAEKVWSACLGLIQENINTLAFKTWFLPIRPLSFSGSELTIEVPSQFFYEWIEENYSV
HVKQALRQVIGPEAKLMYSIVIDKSQGQPVTIELPHQIDAAPAERSVRPEAPGQKASAERERLEIARPRFESNLNPKYTF
STLVRGDCNSLAFAASKSIAQNPGQNAFNPLVIYGGVGLGKTHMMQAIGNSVLENRITDAVLYVSSEKFAIDFVNAIQNG
NIQEFSAFYRNIDVLIIDDIQFFAGKEKTQEEIFHIFNTLHQSNKQIILSADRPIKEIKGIEDRLISRFNWGLSTDIQAP
DYETRKAIIQSKLKQSGVSLDPVVIEFIATNVTSNVRELEGCIVKLLAAHSLDNQEIDLQFAKSTLKDIIRYNTKQLTLE
TIEKAVCSYFSITSNDLKGKSKKKEIAVGRQIAMYLSKDMTDSSLKTIGLHFGGRDHSTVIHALNTIEKKIAASNEERKK
IEELRKRIEIMSM

Sequences:

>Translated_493_residues
MSDTIQQEAPDNLQVTPTHGRSFAEKVWSACLGLIQENINTLAFKTWFLPIRPLSFSGSELTIEVPSQFFYEWIEENYSV
HVKQALRQVIGPEAKLMYSIVIDKSQGQPVTIELPHQIDAAPAERSVRPEAPGQKASAERERLEIARPRFESNLNPKYTF
STLVRGDCNSLAFAASKSIAQNPGQNAFNPLVIYGGVGLGKTHMMQAIGNSVLENRITDAVLYVSSEKFAIDFVNAIQNG
NIQEFSAFYRNIDVLIIDDIQFFAGKEKTQEEIFHIFNTLHQSNKQIILSADRPIKEIKGIEDRLISRFNWGLSTDIQAP
DYETRKAIIQSKLKQSGVSLDPVVIEFIATNVTSNVRELEGCIVKLLAAHSLDNQEIDLQFAKSTLKDIIRYNTKQLTLE
TIEKAVCSYFSITSNDLKGKSKKKEIAVGRQIAMYLSKDMTDSSLKTIGLHFGGRDHSTVIHALNTIEKKIAASNEERKK
IEELRKRIEIMSM
>Mature_492_residues
SDTIQQEAPDNLQVTPTHGRSFAEKVWSACLGLIQENINTLAFKTWFLPIRPLSFSGSELTIEVPSQFFYEWIEENYSVH
VKQALRQVIGPEAKLMYSIVIDKSQGQPVTIELPHQIDAAPAERSVRPEAPGQKASAERERLEIARPRFESNLNPKYTFS
TLVRGDCNSLAFAASKSIAQNPGQNAFNPLVIYGGVGLGKTHMMQAIGNSVLENRITDAVLYVSSEKFAIDFVNAIQNGN
IQEFSAFYRNIDVLIIDDIQFFAGKEKTQEEIFHIFNTLHQSNKQIILSADRPIKEIKGIEDRLISRFNWGLSTDIQAPD
YETRKAIIQSKLKQSGVSLDPVVIEFIATNVTSNVRELEGCIVKLLAAHSLDNQEIDLQFAKSTLKDIIRYNTKQLTLET
IEKAVCSYFSITSNDLKGKSKKKEIAVGRQIAMYLSKDMTDSSLKTIGLHFGGRDHSTVIHALNTIEKKIAASNEERKKI
EELRKRIEIMSM

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=449, Percent_Identity=40.3118040089087, Blast_Score=347, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_CHLTE (Q8KGG6)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_660908.1
- ProteinModelPortal:   Q8KGG6
- GeneID:   1006023
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0002
- NMPDR:   fig|194439.1.peg.2
- TIGR:   CT0002
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- ProtClustDB:   PRK00149
- BioCyc:   CTEP194439:CT_0002-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 55428; Mature: 55297

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTIQQEAPDNLQVTPTHGRSFAEKVWSACLGLIQENINTLAFKTWFLPIRPLSFSGSE
CCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCHHHHEEEEEEEEEEECCCCCCE
LTIEVPSQFFYEWIEENYSVHVKQALRQVIGPEAKLMYSIVIDKSQGQPVTIELPHQIDA
EEEECCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHEEEEEEEECCCCCEEEEECCCCCCC
APAERSVRPEAPGQKASAERERLEIARPRFESNLNPKYTFSTLVRGDCNSLAFAASKSIA
CCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCEEHHHHHHCCCCHHHHHHHHHHH
QNPGQNAFNPLVIYGGVGLGKTHMMQAIGNSVLENRITDAVLYVSSEKFAIDFVNAIQNG
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHCCC
NIQEFSAFYRNIDVLIIDDIQFFAGKEKTQEEIFHIFNTLHQSNKQIILSADRPIKEIKG
CHHHHHHHHCCCCEEEEECHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHCC
IEDRLISRFNWGLSTDIQAPDYETRKAIIQSKLKQSGVSLDPVVIEFIATNVTSNVRELE
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GCIVKLLAAHSLDNQEIDLQFAKSTLKDIIRYNTKQLTLETIEKAVCSYFSITSNDLKGK
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
SKKKEIAVGRQIAMYLSKDMTDSSLKTIGLHFGGRDHSTVIHALNTIEKKIAASNEERKK
CHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHH
IEELRKRIEIMSM
HHHHHHHHHHHCC
>Mature Secondary Structure 
SDTIQQEAPDNLQVTPTHGRSFAEKVWSACLGLIQENINTLAFKTWFLPIRPLSFSGSE
CCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCHHHHEEEEEEEEEEECCCCCCE
LTIEVPSQFFYEWIEENYSVHVKQALRQVIGPEAKLMYSIVIDKSQGQPVTIELPHQIDA
EEEECCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHEEEEEEEECCCCCEEEEECCCCCCC
APAERSVRPEAPGQKASAERERLEIARPRFESNLNPKYTFSTLVRGDCNSLAFAASKSIA
CCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCEEHHHHHHCCCCHHHHHHHHHHH
QNPGQNAFNPLVIYGGVGLGKTHMMQAIGNSVLENRITDAVLYVSSEKFAIDFVNAIQNG
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHCCC
NIQEFSAFYRNIDVLIIDDIQFFAGKEKTQEEIFHIFNTLHQSNKQIILSADRPIKEIKG
CHHHHHHHHCCCCEEEEECHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHCC
IEDRLISRFNWGLSTDIQAPDYETRKAIIQSKLKQSGVSLDPVVIEFIATNVTSNVRELE
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GCIVKLLAAHSLDNQEIDLQFAKSTLKDIIRYNTKQLTLETIEKAVCSYFSITSNDLKGK
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
SKKKEIAVGRQIAMYLSKDMTDSSLKTIGLHFGGRDHSTVIHALNTIEKKIAASNEERKK
CHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHH
IEELRKRIEIMSM
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901