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The map label for this gene is dut [H]

Identifier: 15924964

GI number: 15924964

Start: 2110492

End: 2111061

Strand: Reverse

Name: dut [H]

Synonym: SAV1974

Alternate gene names: 15924964

Gene position: 2111061-2110492 (Counterclockwise)

Preceding gene: 15924965

Following gene: 15924963

Centisome position: 73.34

GC content: 40.53

Gene sequence:

>570_bases
ATGAATTGGCTGGAATTGATGAGGAGGACAAGGAAAATGACTAACATCCTACAAGTAAAGCTATTATCAGAAAACGCTAG
AATGCCAGAACGAAATCATAAGACGGATGCAGGTTATGACATATTCTCAGCTGAAACTGTCGTACTTGAGCCACAAGAAA
AGGCAGTGATCAAAACAGATGTAGCTGTAAGCATACCAGAGGGCTATGTCGGACTATTAACTAGCCGTAGTGGTGTAAGT
AGTAAAACGCATTTAGTGATTGAAACAGGCAAGATAGACGCGGGATATCACGGCAATTTAGGGATTAATATCAAGAATGA
TAATGAAACGTTAGAGAGTGAGGATATGAGTAACTTTGGTCGGAGTCCTGCTGGGATAGATGGAAAGTATGCCCGACTAC
CTGTAACAGATAAAATTTTATGTATGAATGGTAGTTATGTCATAAACAAAGGCGACAAACTAGCTCAATTGGTTATTGTG
CCTATATGGACACCTGAACTAAAGCAAGTGGAGGAATTCGAGAGTGTTTCAGAACGTGGAGCAAAAGGTTTCGGAAGTAG
CGGAGTGTAA

Upstream 100 bases:

>100_bases
TACATCGACCATGACGAAAAAACAATAATTACAGAATTCCATGATTTAAAGGTATTCGTGTCAGAAGATTTAAAAGATAA
AAGTATGGAGAGCGTTATGT

Downstream 100 bases:

>100_bases
AGACATATTAGATCGAGTCAAGGAGGTTTTGGGGAAGTGAGAGAACGCACTAAAGTTATATATCGTGGTTGGAATAAGGA
GATATTTATTTTACAGGGTA

Product: dUTP pyrophosphatase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MNWLELMRRTRKMTNILQVKLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGLLTSRSGVS
SKTHLVIETGKIDAGYHGNLGINIKNDNETLESEDMSNFGRSPAGIDGKYARLPVTDKILCMNGSYVINKGDKLAQLVIV
PIWTPELKQVEEFESVSERGAKGFGSSGV

Sequences:

>Translated_189_residues
MNWLELMRRTRKMTNILQVKLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGLLTSRSGVS
SKTHLVIETGKIDAGYHGNLGINIKNDNETLESEDMSNFGRSPAGIDGKYARLPVTDKILCMNGSYVINKGDKLAQLVIV
PIWTPELKQVEEFESVSERGAKGFGSSGV
>Mature_189_residues
MNWLELMRRTRKMTNILQVKLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGLLTSRSGVS
SKTHLVIETGKIDAGYHGNLGINIKNDNETLESEDMSNFGRSPAGIDGKYARLPVTDKILCMNGSYVINKGDKLAQLVIV
PIWTPELKQVEEFESVSERGAKGFGSSGV

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=172, Percent_Identity=32.5581395348837, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4503423, Length=172, Percent_Identity=32.5581395348837, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI70906441, Length=172, Percent_Identity=32.5581395348837, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19921126, Length=176, Percent_Identity=31.25, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24583610, Length=176, Percent_Identity=31.25, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 20813; Mature: 20813

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWLELMRRTRKMTNILQVKLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTD
CCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCEEECCCEEEECCCCCEEEEEC
VAVSIPEGYVGLLTSRSGVSSKTHLVIETGKIDAGYHGNLGINIKNDNETLESEDMSNFG
EEEECCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHHHHHC
RSPAGIDGKYARLPVTDKILCMNGSYVINKGDKLAQLVIVPIWTPELKQVEEFESVSERG
CCCCCCCCCEEECCCCCEEEEECCCEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHC
AKGFGSSGV
CCCCCCCCC
>Mature Secondary Structure
MNWLELMRRTRKMTNILQVKLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTD
CCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCEEECCCEEEECCCCCEEEEEC
VAVSIPEGYVGLLTSRSGVSSKTHLVIETGKIDAGYHGNLGINIKNDNETLESEDMSNFG
EEEECCCCEEEEEECCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCHHHHHHHC
RSPAGIDGKYARLPVTDKILCMNGSYVINKGDKLAQLVIVPIWTPELKQVEEFESVSERG
CCCCCCCCCEEECCCCCEEEEECCCEEEECCCCEEEEEEEEECCCCHHHHHHHHHHHHHC
AKGFGSSGV
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12606174 [H]