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The map label for this gene is mgrA

Identifier: 15923676

GI number: 15923676

Start: 759666

End: 760109

Strand: Reverse

Name: mgrA

Synonym: SAV0686

Alternate gene names: 15923676

Gene position: 760109-759666 (Counterclockwise)

Preceding gene: 15923682

Following gene: 15923673

Centisome position: 26.41

GC content: 32.88

Gene sequence:

>444_bases
ATGTCTGATCAACATAATTTAAAAGAACAGCTATGCTTTAGTTTGTACAATGCTCAAAGACAAGTTAATCGCTACTACTC
TAACAAAGTTTTTAAGAAGTACAATCTAACATACCCACAATTTCTTGTCTTAACAATTTTATGGGATGAATCTCCTGTAA
ACGTCAAGAAAGTCGTAACTGAATTAGCACTCGATACTGGTACAGTATCACCATTATTAAAACGAATGGAACAAGTAGAC
TTAATTAAGCGTGAACGTTCCGAAGTCGATCAACGTGAAGTATTTATTCACTTGACTGACAAAAGTGAAACTATTAGACC
AGAATTAAGTAATGCATCTGACAAAGTCGCTTCAGCTTCTTCTTTATCTCAAGATGAAGTTAAAGAACTTAATCGCTTAT
TAGGTAAAGTCATTCATGCATTTGATGAAACAAAGGAAAAATAA

Upstream 100 bases:

>100_bases
TGAATCAAAGAAAGTTGTGAATTAATAAACAATCAACTTTTTAATGATTACCAATCCGAAAAGAGAAAAAAACGGATAGT
ATGTCTGGAGGAGAACTTTA

Downstream 100 bases:

>100_bases
TTAACTTTTGTCATGACAATTAAAGTAATGTTTAGAATTTATTAAGAATAGAAAAACAATTAGCACGCGTAAGCTTGTTA
GTTAAAAAACTGCTTGAAAG

Product: transcriptional regulator

Products: NA

Alternate protein names: Regulator of autolytic activity

Number of amino acids: Translated: 147; Mature: 146

Protein sequence:

>147_residues
MSDQHNLKEQLCFSLYNAQRQVNRYYSNKVFKKYNLTYPQFLVLTILWDESPVNVKKVVTELALDTGTVSPLLKRMEQVD
LIKRERSEVDQREVFIHLTDKSETIRPELSNASDKVASASSLSQDEVKELNRLLGKVIHAFDETKEK

Sequences:

>Translated_147_residues
MSDQHNLKEQLCFSLYNAQRQVNRYYSNKVFKKYNLTYPQFLVLTILWDESPVNVKKVVTELALDTGTVSPLLKRMEQVD
LIKRERSEVDQREVFIHLTDKSETIRPELSNASDKVASASSLSQDEVKELNRLLGKVIHAFDETKEK
>Mature_146_residues
SDQHNLKEQLCFSLYNAQRQVNRYYSNKVFKKYNLTYPQFLVLTILWDESPVNVKKVVTELALDTGTVSPLLKRMEQVDL
IKRERSEVDQREVFIHLTDKSETIRPELSNASDKVASASSLSQDEVKELNRLLGKVIHAFDETKEK

Specific function: Regulatory protein involved in autolytic activity, multidrug resistance and virulence. Controls autolysis by inactivating lytM, lytN (autolysins) and sarV (autolysis activator) and activating arlRS, lrgAB and lytSR (autolysis inhibitors). Acts as a dual r

COG id: COG1846

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH marR-type DNA-binding domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MGRA_STAA8 (Q2G0B1)

Other databases:

- EMBL:   AY266422
- EMBL:   CP000253
- RefSeq:   YP_499253.1
- ProteinModelPortal:   Q2G0B1
- SMR:   Q2G0B1
- STRING:   Q2G0B1
- PhosSite:   Q2G0B1
- EnsemblBacteria:   EBSTAT00000029297
- GeneID:   3920998
- GenomeReviews:   CP000253_GR
- KEGG:   sao:SAOUHSC_00694
- eggNOG:   COG1846
- GeneTree:   EBGT00050000024454
- HOGENOM:   HBG728159
- OMA:   RPLLEPM
- ProtClustDB:   CLSK884821
- BioCyc:   SAUR93061:SAOUHSC_00694-MONOMER
- GO:   GO:0005737
- GO:   GO:0009405
- InterPro:   IPR000835
- InterPro:   IPR023187
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00347

Pfam domain/function: PF01047 MarR

EC number: NA

Molecular weight: Translated: 17090; Mature: 16958

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS01117 HTH_MARR_1; PS50995 HTH_MARR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQHNLKEQLCFSLYNAQRQVNRYYSNKVFKKYNLTYPQFLVLTILWDESPVNVKKVVT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCHHHHHH
ELALDTGTVSPLLKRMEQVDLIKRERSEVDQREVFIHLTDKSETIRPELSNASDKVASAS
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCCHHHHHHHHH
SLSQDEVKELNRLLGKVIHAFDETKEK
CCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDQHNLKEQLCFSLYNAQRQVNRYYSNKVFKKYNLTYPQFLVLTILWDESPVNVKKVVT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCCHHHHHH
ELALDTGTVSPLLKRMEQVDLIKRERSEVDQREVFIHLTDKSETIRPELSNASDKVASAS
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCCHHHHHHHHH
SLSQDEVKELNRLLGKVIHAFDETKEK
CCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12791130