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The map label for this gene is ywrD [H]

Identifier: 15899918

GI number: 15899918

Start: 2963286

End: 2964722

Strand: Direct

Name: ywrD [H]

Synonym: SSO3216

Alternate gene names: 15899918

Gene position: 2963286-2964722 (Clockwise)

Preceding gene: 15899914

Following gene: 15899923

Centisome position: 99.03

GC content: 38.34

Gene sequence:

>1437_bases
ATGCCTTCAGCAGTAGGTAAAAAAGTTGTCACAACGCAAAATTACATAGCAAGTTACGTTGGAGCTAAGGTTTTAGAAGA
AGGGGGAAATGCGTTTGACGCTGCTATCGCAATAAGTGCTACCTTATCTGTAGTGATACCGCATACCAGTGGCCTTGGAG
GTGATGGATTTCTATTAGCGAAAACACCGGAGGGTTTAATTGCTTATAATGCATCTGGCTGGGCTCCTAAGGAGTTGAAA
GTAGACAAAATAAACAGTGATAGAGGTCCGCTTACTGTGGTTGTCCCTGGGTTAGTAGATCTATGGGAATTCATTTATGA
AAACTACGCCTCAAAATCACTACATGAATTGCTTATTCCTGCGATTTCATTAGCGACCAATGGGTTTATGGTGGGAAGAG
GATTACACCACGCAATAATAAGTTCGTTTAAATTATCTGATGATTGGAATAGGGTTTATGGAAGCAAAAGATTTGGTGAT
GAAATAAAGCTCAGGGGAATTGCTAAGGTCTTGAAGGAGATTTCAAAAGACCCTAGAAGTTTCTATGAAGGAAAGATCGC
AGAGGAGTTAACCAAAGGATTAAGAGAAAGGGGAGTACCAGTGAGTTATGAAGATTTTAGTGAATTTCACGGTGAGATTA
TAAATCCAATAAAAATGAAGTATAAGGATTTTATGCTATATGAGTTACCACCAAATACACAAGGACTTACTACACTAGAA
TTACTTAAAATGATTGAAGTAACTGAAATAAACAAATTGCCCTTCAACGACGTGAGGAGAGTAAATGATCACGTGCGATT
AAGTGCACTAGCTTATGCTGATAGAAATAACTATATAGCTGATCCAAGATTTGTAAACGTGCCCGTAGAAATGTTATTAT
CGGAGAAGTATATTGCAAATAAGATAGCTGAATATGGATTCGAGGTAAAAGTAAACGTTACTGGAGATACAACGTTTTTC
GCTGTTGCTGATGGCGAAAATGAAATTGGATTTATACAAAGTCTATTTTATCCCTTTGGCTCTGGGATAGTGGTAAACGA
TATACCGTTTAACAATAGAGGTGCAGGATTTTCTGAAGGAAATAATAAACCAGAACCTAGGAAGAGACCCTTACACACAC
TTTCTATACTAATGGCCGAGAAGGACGATGAGAGAATCTTTATAGGTTGTGCTGGTGGAGATCTGAGACCACAAATCCAT
GCTGAAGTATTTGAGTATTATGCCGATTATAACATGGAAATTGATGAAGCAGTTCAAGCTCCTAGGTTCATGTATTTGGG
AAATAAGGTTATTGCCGAAAAGAGACTCGGTGTACCTGCTACACAAACAGACTATTATTCGCCTGAGGTGGGAATAGTGC
AAGCCCTAAAGTATAAGAAAGGAAGATATATCGGAGTTGCTGACATTAGAAGTGAAGGCATAGTATTACCTATTTAG

Upstream 100 bases:

>100_bases
GCACGTTAGACATAGGCCATCACTTAGATTATTCCTAACTTCTGCCGGAAATTCCATGATAGTGATAAATATTTTATGCT
CAACCAACTATTAAATAATT

Downstream 100 bases:

>100_bases
TTATTTTCCTTTGGATCTGCTTTGTTGATCCAACTGGATATCTTTTCACAGAACTGAACTACTATTTTCCTTCAATTAAT
ATTCAAGGTGTACAATTTTG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MPSAVGKKVVTTQNYIASYVGAKVLEEGGNAFDAAIAISATLSVVIPHTSGLGGDGFLLAKTPEGLIAYNASGWAPKELK
VDKINSDRGPLTVVVPGLVDLWEFIYENYASKSLHELLIPAISLATNGFMVGRGLHHAIISSFKLSDDWNRVYGSKRFGD
EIKLRGIAKVLKEISKDPRSFYEGKIAEELTKGLRERGVPVSYEDFSEFHGEIINPIKMKYKDFMLYELPPNTQGLTTLE
LLKMIEVTEINKLPFNDVRRVNDHVRLSALAYADRNNYIADPRFVNVPVEMLLSEKYIANKIAEYGFEVKVNVTGDTTFF
AVADGENEIGFIQSLFYPFGSGIVVNDIPFNNRGAGFSEGNNKPEPRKRPLHTLSILMAEKDDERIFIGCAGGDLRPQIH
AEVFEYYADYNMEIDEAVQAPRFMYLGNKVIAEKRLGVPATQTDYYSPEVGIVQALKYKKGRYIGVADIRSEGIVLPI

Sequences:

>Translated_478_residues
MPSAVGKKVVTTQNYIASYVGAKVLEEGGNAFDAAIAISATLSVVIPHTSGLGGDGFLLAKTPEGLIAYNASGWAPKELK
VDKINSDRGPLTVVVPGLVDLWEFIYENYASKSLHELLIPAISLATNGFMVGRGLHHAIISSFKLSDDWNRVYGSKRFGD
EIKLRGIAKVLKEISKDPRSFYEGKIAEELTKGLRERGVPVSYEDFSEFHGEIINPIKMKYKDFMLYELPPNTQGLTTLE
LLKMIEVTEINKLPFNDVRRVNDHVRLSALAYADRNNYIADPRFVNVPVEMLLSEKYIANKIAEYGFEVKVNVTGDTTFF
AVADGENEIGFIQSLFYPFGSGIVVNDIPFNNRGAGFSEGNNKPEPRKRPLHTLSILMAEKDDERIFIGCAGGDLRPQIH
AEVFEYYADYNMEIDEAVQAPRFMYLGNKVIAEKRLGVPATQTDYYSPEVGIVQALKYKKGRYIGVADIRSEGIVLPI
>Mature_477_residues
PSAVGKKVVTTQNYIASYVGAKVLEEGGNAFDAAIAISATLSVVIPHTSGLGGDGFLLAKTPEGLIAYNASGWAPKELKV
DKINSDRGPLTVVVPGLVDLWEFIYENYASKSLHELLIPAISLATNGFMVGRGLHHAIISSFKLSDDWNRVYGSKRFGDE
IKLRGIAKVLKEISKDPRSFYEGKIAEELTKGLRERGVPVSYEDFSEFHGEIINPIKMKYKDFMLYELPPNTQGLTTLEL
LKMIEVTEINKLPFNDVRRVNDHVRLSALAYADRNNYIADPRFVNVPVEMLLSEKYIANKIAEYGFEVKVNVTGDTTFFA
VADGENEIGFIQSLFYPFGSGIVVNDIPFNNRGAGFSEGNNKPEPRKRPLHTLSILMAEKDDERIFIGCAGGDLRPQIHA
EVFEYYADYNMEIDEAVQAPRFMYLGNKVIAEKRLGVPATQTDYYSPEVGIVQALKYKKGRYIGVADIRSEGIVLPI

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=522, Percent_Identity=25.2873563218391, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI73915090, Length=522, Percent_Identity=25.2873563218391, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI73915096, Length=522, Percent_Identity=25.2873563218391, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI73915094, Length=522, Percent_Identity=25.2873563218391, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI113429326, Length=525, Percent_Identity=24.5714285714286, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI113429324, Length=519, Percent_Identity=24.8554913294798, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1789856, Length=485, Percent_Identity=27.2164948453608, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17506189, Length=480, Percent_Identity=26.0416666666667, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17542894, Length=427, Percent_Identity=23.8875878220141, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193208245, Length=540, Percent_Identity=25.3703703703704, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193208247, Length=475, Percent_Identity=25.8947368421053, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI212646519, Length=477, Percent_Identity=24.9475890985325, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI72000294, Length=477, Percent_Identity=25.5765199161426, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI161077878, Length=471, Percent_Identity=23.9915074309979, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI45551474, Length=471, Percent_Identity=23.9915074309979, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI161077880, Length=471, Percent_Identity=23.9915074309979, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24642670, Length=471, Percent_Identity=23.9915074309979, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24642666, Length=471, Percent_Identity=23.9915074309979, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI18859893, Length=450, Percent_Identity=24.4444444444444, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 53112; Mature: 52981

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSAVGKKVVTTQNYIASYVGAKVLEEGGNAFDAAIAISATLSVVIPHTSGLGGDGFLLA
CCCCCCCEEEHHHHHHHHHHHHHHHHCCCCEEHHHEEEEEEEEEEEECCCCCCCCCEEEE
KTPEGLIAYNASGWAPKELKVDKINSDRGPLTVVVPGLVDLWEFIYENYASKSLHELLIP
ECCCCEEEECCCCCCCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
AISLATNGFMVGRGLHHAIISSFKLSDDWNRVYGSKRFGDEIKLRGIAKVLKEISKDPRS
HHHHHCCCEEECCCHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHH
FYEGKIAEELTKGLRERGVPVSYEDFSEFHGEIINPIKMKYKDFMLYELPPNTQGLTTLE
HHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHEEEEEEECCCCCCCCHHHH
LLKMIEVTEINKLPFNDVRRVNDHVRLSALAYADRNNYIADPRFVNVPVEMLLSEKYIAN
HHHHHHHHHCCCCCHHHHHHHCCCEEEEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHH
KIAEYGFEVKVNVTGDTTFFAVADGENEIGFIQSLFYPFGSGIVVNDIPFNNRGAGFSEG
HHHHCCCEEEEEEECCEEEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCC
NNKPEPRKRPLHTLSILMAEKDDERIFIGCAGGDLRPQIHAEVFEYYADYNMEIDEAVQA
CCCCCCCCCCHHEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHCC
PRFMYLGNKVIAEKRLGVPATQTDYYSPEVGIVQALKYKKGRYIGVADIRSEGIVLPI
CEEEEECCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCEEECC
>Mature Secondary Structure 
PSAVGKKVVTTQNYIASYVGAKVLEEGGNAFDAAIAISATLSVVIPHTSGLGGDGFLLA
CCCCCCEEEHHHHHHHHHHHHHHHHCCCCEEHHHEEEEEEEEEEEECCCCCCCCCEEEE
KTPEGLIAYNASGWAPKELKVDKINSDRGPLTVVVPGLVDLWEFIYENYASKSLHELLIP
ECCCCEEEECCCCCCCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
AISLATNGFMVGRGLHHAIISSFKLSDDWNRVYGSKRFGDEIKLRGIAKVLKEISKDPRS
HHHHHCCCEEECCCHHHHHHHHCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHH
FYEGKIAEELTKGLRERGVPVSYEDFSEFHGEIINPIKMKYKDFMLYELPPNTQGLTTLE
HHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHEEEEEEECCCCCCCCHHHH
LLKMIEVTEINKLPFNDVRRVNDHVRLSALAYADRNNYIADPRFVNVPVEMLLSEKYIAN
HHHHHHHHHCCCCCHHHHHHHCCCEEEEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHH
KIAEYGFEVKVNVTGDTTFFAVADGENEIGFIQSLFYPFGSGIVVNDIPFNNRGAGFSEG
HHHHCCCEEEEEEECCEEEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCC
NNKPEPRKRPLHTLSILMAEKDDERIFIGCAGGDLRPQIHAEVFEYYADYNMEIDEAVQA
CCCCCCCCCCHHEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHCC
PRFMYLGNKVIAEKRLGVPATQTDYYSPEVGIVQALKYKKGRYIGVADIRSEGIVLPI
CEEEEECCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]