Click here to switch to the map view.

The map label for this gene is trxB-2 [H]

Identifier: 15899481

GI number: 15899481

Start: 2523283

End: 2524260

Strand: Direct

Name: trxB-2 [H]

Synonym: SSO2765

Alternate gene names: 15899481

Gene position: 2523283-2524260 (Clockwise)

Preceding gene: 15899480

Following gene: 15899482

Centisome position: 84.33

GC content: 38.14

Gene sequence:

>978_bases
ATGCCGTTAAAGACATATGATACAATAATAGTTGGGGCAGGGATTGCTGGATTAAGTGCGGCATTATATTCTTCAAGACA
AAAACTATCAACGTTAGTACTTTCAAAAGATCTTGGTGGACAATTAACGTTAACTGATTTAATAGAAAATTATCCAGGGA
TAGAGTCAACCGGAGGGTTAACTCTAGCGCAAAAGATTGAGAAACAAGCTAAGAAGTTCGGAGCGGAATTCATTTATGGA
GAGGAAGTTAAAGAGATCGCACAAGAGTCGGATTTATTCATAATAAAGGGTATTAAAGGTGAATATGCTGGAAGGGCTCT
AATTTTAGCGTTTGGTAAAACTCCAAGGGAAATTAATGTACCAGGTGAGCAAGAGTTTAAAGGGAAAGGGGTATCATACT
GTGCAATATGTGATGCAGCATTCTTCAAGGGTAAGCCAGCGGCTGTAATAGGCGAAGGTGAACCTGGAATAGAAGCTATA
GAATTGTTATCAAATTACGCAAACCCAGCATATTATATTACCTCATCTTCTTATCTAGCAGGTGAGGAGGAGATTGTAAA
AAATGTAGTGAATAAACCCACAGTTAAAATATTAACATCTTCAAGAGTCTTAGAAATAAGAGGGAATAGTAAGGTTGAAG
AGTTAGTGATAAAGAGAGGGGATGAAATATTACAATTGAAAGTAGATGGTGTGATAATAGAGATGGGCTATACTCTTAAA
ACGGAGTTTCTAAAAGGATTTGTTGAGTTAAATGAGAAAGGCGAGATAATTGTGGATGAGTTAGGAAGAACGAGTAGGGA
GGGAGTATTTGCAGCTGGTGATGTTACTCAAACACCGTATAAGCAAGCAGTTGTAGCTGCTGCTGAGGGAGTTAAGGCTG
CATTGTCAGCCTATAACTATATTAGAAGTAAAAGAGGTCTTCCGCCAGTTACCGTAGACTGGAAAGCAGAAAAGAAGAAG
GTTAGCTTTAGACTCTAA

Upstream 100 bases:

>100_bases
AGCGGTTTAAACACTAAGTAGATTTTTTATTCATACTTAACTTTTTTACAGACTATCAAAAGATAACTTTTTATTATATA
AAGTATAAAAGAGATATAGT

Downstream 100 bases:

>100_bases
CTTTTTATCTTTATCTTTTAAATATTATTGATGCAAACGTACTTTGTTCCTTTAGCTGTTGATCAGAATTATAATGAGAT
AAATTTTCATAAACAAATTG

Product: thioredoxin reductase (trxB-2)

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MPLKTYDTIIVGAGIAGLSAALYSSRQKLSTLVLSKDLGGQLTLTDLIENYPGIESTGGLTLAQKIEKQAKKFGAEFIYG
EEVKEIAQESDLFIIKGIKGEYAGRALILAFGKTPREINVPGEQEFKGKGVSYCAICDAAFFKGKPAAVIGEGEPGIEAI
ELLSNYANPAYYITSSSYLAGEEEIVKNVVNKPTVKILTSSRVLEIRGNSKVEELVIKRGDEILQLKVDGVIIEMGYTLK
TEFLKGFVELNEKGEIIVDELGRTSREGVFAAGDVTQTPYKQAVVAAAEGVKAALSAYNYIRSKRGLPPVTVDWKAEKKK
VSFRL

Sequences:

>Translated_325_residues
MPLKTYDTIIVGAGIAGLSAALYSSRQKLSTLVLSKDLGGQLTLTDLIENYPGIESTGGLTLAQKIEKQAKKFGAEFIYG
EEVKEIAQESDLFIIKGIKGEYAGRALILAFGKTPREINVPGEQEFKGKGVSYCAICDAAFFKGKPAAVIGEGEPGIEAI
ELLSNYANPAYYITSSSYLAGEEEIVKNVVNKPTVKILTSSRVLEIRGNSKVEELVIKRGDEILQLKVDGVIIEMGYTLK
TEFLKGFVELNEKGEIIVDELGRTSREGVFAAGDVTQTPYKQAVVAAAEGVKAALSAYNYIRSKRGLPPVTVDWKAEKKK
VSFRL
>Mature_324_residues
PLKTYDTIIVGAGIAGLSAALYSSRQKLSTLVLSKDLGGQLTLTDLIENYPGIESTGGLTLAQKIEKQAKKFGAEFIYGE
EVKEIAQESDLFIIKGIKGEYAGRALILAFGKTPREINVPGEQEFKGKGVSYCAICDAAFFKGKPAAVIGEGEPGIEAIE
LLSNYANPAYYITSSSYLAGEEEIVKNVVNKPTVKILTSSRVLEIRGNSKVEELVIKRGDEILQLKVDGVIIEMGYTLKT
EFLKGFVELNEKGEIIVDELGRTSREGVFAAGDVTQTPYKQAVVAAAEGVKAALSAYNYIRSKRGLPPVTVDWKAEKKKV
SFRL

Specific function: Serves To Protect The Cell Against DNA Damage By Alkyl Hydroperoxides. It Can Use Either NADH Or NADPH As Electron Donor For Direct Reduction Of Redox Dyes Or Of Alkyl Hydroperoxides When Combined With The Ahpc Protein. [C]

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081763, Length=308, Percent_Identity=36.038961038961, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1787114, Length=308, Percent_Identity=35.3896103896104, Blast_Score=160, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6321898, Length=316, Percent_Identity=32.9113924050633, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6320560, Length=311, Percent_Identity=33.4405144694534, Blast_Score=145, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 35229; Mature: 35098

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLKTYDTIIVGAGIAGLSAALYSSRQKLSTLVLSKDLGGQLTLTDLIENYPGIESTGGL
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCCH
TLAQKIEKQAKKFGAEFIYGEEVKEIAQESDLFIIKGIKGEYAGRALILAFGKTPREINV
HHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEECCCCCEECC
PGEQEFKGKGVSYCAICDAAFFKGKPAAVIGEGEPGIEAIELLSNYANPAYYITSSSYLA
CCCCCCCCCCCEEEEEHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCC
GEEEIVKNVVNKPTVKILTSSRVLEIRGNSKVEELVIKRGDEILQLKVDGVIIEMGYTLK
CHHHHHHHHHCCCEEEEEECCEEEEECCCCHHHHHHHHCCCEEEEEEECEEEEEECCHHH
TEFLKGFVELNEKGEIIVDELGRTSREGVFAAGDVTQTPYKQAVVAAAEGVKAALSAYNY
HHHHHHHHHCCCCCCEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
IRSKRGLPPVTVDWKAEKKKVSFRL
HHHCCCCCCEEEECCCCCCEEEECC
>Mature Secondary Structure 
PLKTYDTIIVGAGIAGLSAALYSSRQKLSTLVLSKDLGGQLTLTDLIENYPGIESTGGL
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCCH
TLAQKIEKQAKKFGAEFIYGEEVKEIAQESDLFIIKGIKGEYAGRALILAFGKTPREINV
HHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEECCCCCEECC
PGEQEFKGKGVSYCAICDAAFFKGKPAAVIGEGEPGIEAIELLSNYANPAYYITSSSYLA
CCCCCCCCCCCEEEEEHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCC
GEEEIVKNVVNKPTVKILTSSRVLEIRGNSKVEELVIKRGDEILQLKVDGVIIEMGYTLK
CHHHHHHHHHCCCEEEEEECCEEEEECCCCHHHHHHHHCCCEEEEEEECEEEEEECCHHH
TEFLKGFVELNEKGEIIVDELGRTSREGVFAAGDVTQTPYKQAVVAAAEGVKAALSAYNY
HHHHHHHHHCCCCCCEEEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
IRSKRGLPPVTVDWKAEKKKVSFRL
HHHCCCCCCEEEECCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]