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The map label for this gene is pacS [H]

Identifier: 15899375

GI number: 15899375

Start: 2409368

End: 2411635

Strand: Reverse

Name: pacS [H]

Synonym: SSO2651

Alternate gene names: 15899375

Gene position: 2411635-2409368 (Counterclockwise)

Preceding gene: 15899376

Following gene: 15899373

Centisome position: 80.6

GC content: 37.65

Gene sequence:

>2268_bases
ATGGACCTAAGGGAATGCCACATGGCCACTGAGAAGAAAGAAGAGCTAAGAATTACAGATAATGAGGAACAACTAAGAAT
AGTTGGGATGCATTGTGCAACATGCGTAACAACTGTCTCTAAATCTTTGAAGTCAGTTAGTGGTGTAAAAGATGCCGAAG
TAAATCTAGCAACTGGGAGCGCAAAAGTAATCCTAAGTGGTAATGTAAGATTAAAGGAATTAGTAAAGGCCGTGAGAAAA
GCTGGATATGATGTTGCAACAGAGAAGTTTACTATAAAATTGAATGTTAACCCAGAGGAAATGCCTAAAATAGAGAGGAA
ATTCGAAAACGTTAAGGGGGTAGTTGATGTAAAGTCCAATCCAGGTTTAGGAATAGTGAGCGTAGAGTACAATCCAGAGA
CCACTACTCCAGAGGAGATATTAAAGGAAGCTGGAGTTAAGGGGGAAATAGTAAATGAACAACGTAGTGAAAAGAGTATA
CTCTATAAGGATTTCCATGACTTATTAAGGAGATTGGCAGTAGGTATAATATTTACACCTTTAACATATCTACTTCCATT
CTTTTTTGGCATATTGGTATCCATAGCAGTACAGTTTTACTCAGGATTAAGATTTCATAAAGGTGCGTATAGGGCATTAA
AGAATAAAACTACTAATATGGATGTACTAGTCTCCTTAGCATCAAACATATTGTGGCTCTCTAGTATTTTCCTTCACAAC
ACATTTTACGCCGACGCTTCATTATTAATAACCTTCATACTTGTGGGTAAAACACTAGAAGCGTATATTAAAGCTAAGAT
GAGTGCAGAGATACGTATAGAACCTTATAAAGCCACTCTGAAAGACGGAAGAGTAGTTAACTCTAATGAACTAAAAGTAG
GCGATGTAGTAATTGTTAGGGCGGGAGAGAGAATACCAGCTGATGGAATAATTGAGAATGGAGAAGGAGAAGTAAACGAG
GCTATACTTACTGGAGAGCAGAAGCCAGTACTGAAGAAAAAAGGAGATAACGTCCTAGCTGGTGGTATTTTAGTAAATGG
TTACTTAGAAGTATACGTTACTAGAAACTGGGATAGAAGTTATATTGTACAAGTAACAGAGAGTGTAAGAGGGGCTTATA
ATACAAGAGTTTCCATCCAAAATCTAGTGGACAAAGTTTCCTCAATATTTGTGCCTATAGTTATTAGCATCTCAGCACTT
ACGTTCCTAGTTTGGAAATTTGTCTTGGACTATAACCTCTATTCTTCTCTACTTTTCAGTGTAGCAGTATTAGCTGCAGC
GTGTCCTTGTGCACTAGGGTTAGCATCGCCTATGGCAATGTTAGTTAGTGTTCGGAGAGCATTAAAAAGAGGTATTATAA
TTAGGGATGGTAGTATTTTTGAGGAAATGAGAAATATCAACGTTGCAATCTTGGACAAAACTGGTACTGTAACTGAGGGT
GAATATGTAATTGTTAGTAAGAAGGAGTTCATTGAAGGAGCGTTAAATTTGGCTGCAATTGCAGAAAGTAGAAGTATACA
TCCTATCGCTAAAGCATTCCATAAAATGAACGTAAGAGCGGGAGAGATTGAGCAGTTTGAGGAGTTTCCTGGAAGAGGAA
TATATGCTAGAGTAAATGGTAACGATGTAATTGTGGGGAGTAAAGATTTCGTGAGGGACAATTGTAACTGGAATGTCGAA
GATGAAGGAGATATTTTTATTTGCATTAATGGAAATGCTGGAGGGATAGTTAACATAAGGGATAAGCTCAGGGATGATGC
CAAAAAGGTAATAAGCTATCTGAAAGGAAGGGGAATTAGGATAATAATAGCAACTGGAGATAGTAGTAATTATGCTGATG
AAATAGGGAAGGAGTTAGGTGTTGAAGTTCGTAAGGAGTTAACTCCAGATGATAAAGCGGAGTTGGTGAAGGAATTAAGG
GAAAATGGCAATAAAGTAATGTTTATAGGTGACGGAATAAATGATTCCATCGCTATGAGAGAAGCTGACATAGGTATAGC
TATTTCTAGCGGTACTGATTTGGCTAAGAGTGCTGGTAAAGTTGTGGTTAATTCATTAGATGACATAATAGGGTTATTTG
AGCAAACTGAATTGGCAGTTAGAAAAATTAAGGAGAATTTGGCATGGGCCTTTGGCTATAATACAGCAATAATACCTATT
GCAGCAGGAGTATTTTACCCATTCATAACGTTACCACCGGAATATGCTGCACTTGCGATGGGATTTAGTAGTGTGATAGT
GAGTTTATGGTCCCTAGTCCCAATTTAG

Upstream 100 bases:

>100_bases
AAAAGTCAATATAAGACAATGTATAAGGGAAAAATCTACTATTTCTGCTCATCTCATTGTCTAAGGGAGTTTCAGAGAAA
TCCGGAAGAGTATTTAAGGA

Downstream 100 bases:

>100_bases
CATTCATAAAAGAAGTTGGAGTATAACTTAAAAATCGTGACATATATTAACTATATTTATCAATTAAAAATATTCTCTTT
TATTAAGCGTTGACAACAAC

Product: cation transporting ATPase (pacS)

Products: ADP; Orthophosphate. [C]

Alternate protein names: Protein CopA [H]

Number of amino acids: Translated: 755; Mature: 755

Protein sequence:

>755_residues
MDLRECHMATEKKEELRITDNEEQLRIVGMHCATCVTTVSKSLKSVSGVKDAEVNLATGSAKVILSGNVRLKELVKAVRK
AGYDVATEKFTIKLNVNPEEMPKIERKFENVKGVVDVKSNPGLGIVSVEYNPETTTPEEILKEAGVKGEIVNEQRSEKSI
LYKDFHDLLRRLAVGIIFTPLTYLLPFFFGILVSIAVQFYSGLRFHKGAYRALKNKTTNMDVLVSLASNILWLSSIFLHN
TFYADASLLITFILVGKTLEAYIKAKMSAEIRIEPYKATLKDGRVVNSNELKVGDVVIVRAGERIPADGIIENGEGEVNE
AILTGEQKPVLKKKGDNVLAGGILVNGYLEVYVTRNWDRSYIVQVTESVRGAYNTRVSIQNLVDKVSSIFVPIVISISAL
TFLVWKFVLDYNLYSSLLFSVAVLAAACPCALGLASPMAMLVSVRRALKRGIIIRDGSIFEEMRNINVAILDKTGTVTEG
EYVIVSKKEFIEGALNLAAIAESRSIHPIAKAFHKMNVRAGEIEQFEEFPGRGIYARVNGNDVIVGSKDFVRDNCNWNVE
DEGDIFICINGNAGGIVNIRDKLRDDAKKVISYLKGRGIRIIIATGDSSNYADEIGKELGVEVRKELTPDDKAELVKELR
ENGNKVMFIGDGINDSIAMREADIGIAISSGTDLAKSAGKVVVNSLDDIIGLFEQTELAVRKIKENLAWAFGYNTAIIPI
AAGVFYPFITLPPEYAALAMGFSSVIVSLWSLVPI

Sequences:

>Translated_755_residues
MDLRECHMATEKKEELRITDNEEQLRIVGMHCATCVTTVSKSLKSVSGVKDAEVNLATGSAKVILSGNVRLKELVKAVRK
AGYDVATEKFTIKLNVNPEEMPKIERKFENVKGVVDVKSNPGLGIVSVEYNPETTTPEEILKEAGVKGEIVNEQRSEKSI
LYKDFHDLLRRLAVGIIFTPLTYLLPFFFGILVSIAVQFYSGLRFHKGAYRALKNKTTNMDVLVSLASNILWLSSIFLHN
TFYADASLLITFILVGKTLEAYIKAKMSAEIRIEPYKATLKDGRVVNSNELKVGDVVIVRAGERIPADGIIENGEGEVNE
AILTGEQKPVLKKKGDNVLAGGILVNGYLEVYVTRNWDRSYIVQVTESVRGAYNTRVSIQNLVDKVSSIFVPIVISISAL
TFLVWKFVLDYNLYSSLLFSVAVLAAACPCALGLASPMAMLVSVRRALKRGIIIRDGSIFEEMRNINVAILDKTGTVTEG
EYVIVSKKEFIEGALNLAAIAESRSIHPIAKAFHKMNVRAGEIEQFEEFPGRGIYARVNGNDVIVGSKDFVRDNCNWNVE
DEGDIFICINGNAGGIVNIRDKLRDDAKKVISYLKGRGIRIIIATGDSSNYADEIGKELGVEVRKELTPDDKAELVKELR
ENGNKVMFIGDGINDSIAMREADIGIAISSGTDLAKSAGKVVVNSLDDIIGLFEQTELAVRKIKENLAWAFGYNTAIIPI
AAGVFYPFITLPPEYAALAMGFSSVIVSLWSLVPI
>Mature_755_residues
MDLRECHMATEKKEELRITDNEEQLRIVGMHCATCVTTVSKSLKSVSGVKDAEVNLATGSAKVILSGNVRLKELVKAVRK
AGYDVATEKFTIKLNVNPEEMPKIERKFENVKGVVDVKSNPGLGIVSVEYNPETTTPEEILKEAGVKGEIVNEQRSEKSI
LYKDFHDLLRRLAVGIIFTPLTYLLPFFFGILVSIAVQFYSGLRFHKGAYRALKNKTTNMDVLVSLASNILWLSSIFLHN
TFYADASLLITFILVGKTLEAYIKAKMSAEIRIEPYKATLKDGRVVNSNELKVGDVVIVRAGERIPADGIIENGEGEVNE
AILTGEQKPVLKKKGDNVLAGGILVNGYLEVYVTRNWDRSYIVQVTESVRGAYNTRVSIQNLVDKVSSIFVPIVISISAL
TFLVWKFVLDYNLYSSLLFSVAVLAAACPCALGLASPMAMLVSVRRALKRGIIIRDGSIFEEMRNINVAILDKTGTVTEG
EYVIVSKKEFIEGALNLAAIAESRSIHPIAKAFHKMNVRAGEIEQFEEFPGRGIYARVNGNDVIVGSKDFVRDNCNWNVE
DEGDIFICINGNAGGIVNIRDKLRDDAKKVISYLKGRGIRIIIATGDSSNYADEIGKELGVEVRKELTPDDKAELVKELR
ENGNKVMFIGDGINDSIAMREADIGIAISSGTDLAKSAGKVVVNSLDDIIGLFEQTELAVRKIKENLAWAFGYNTAIIPI
AAGVFYPFITLPPEYAALAMGFSSVIVSLWSLVPI

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=862, Percent_Identity=26.2180974477958, Blast_Score=283, Evalue=6e-76,
Organism=Homo sapiens, GI115529486, Length=655, Percent_Identity=25.9541984732824, Blast_Score=202, Evalue=9e-52,
Organism=Homo sapiens, GI55743073, Length=504, Percent_Identity=28.3730158730159, Blast_Score=196, Evalue=7e-50,
Organism=Homo sapiens, GI83700225, Length=263, Percent_Identity=23.9543726235741, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI51944966, Length=224, Percent_Identity=23.2142857142857, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1786691, Length=821, Percent_Identity=27.5274056029233, Blast_Score=291, Evalue=9e-80,
Organism=Escherichia coli, GI1789879, Length=611, Percent_Identity=29.2962356792144, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1786914, Length=497, Percent_Identity=25.9557344064386, Blast_Score=127, Evalue=4e-30,
Organism=Escherichia coli, GI2367363, Length=225, Percent_Identity=25.3333333333333, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17556548, Length=610, Percent_Identity=27.0491803278689, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17554158, Length=141, Percent_Identity=29.7872340425532, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193210130, Length=141, Percent_Identity=29.7872340425532, Blast_Score=67, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71988506, Length=141, Percent_Identity=29.7872340425532, Blast_Score=67, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=875, Percent_Identity=28.4571428571429, Blast_Score=301, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6319772, Length=806, Percent_Identity=27.6674937965261, Blast_Score=243, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6321271, Length=181, Percent_Identity=27.6243093922652, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321430, Length=404, Percent_Identity=22.7722772277228, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325221, Length=404, Percent_Identity=22.5247524752475, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221329854, Length=620, Percent_Identity=27.258064516129, Blast_Score=182, Evalue=7e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR006122
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 83009; Mature: 83009

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRECHMATEKKEELRITDNEEQLRIVGMHCATCVTTVSKSLKSVSGVKDAEVNLATGS
CCHHHHHHHCCCCCCEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
AKVILSGNVRLKELVKAVRKAGYDVATEKFTIKLNVNPEEMPKIERKFENVKGVVDVKSN
EEEEEECCCCHHHHHHHHHHCCCCEECEEEEEEEECCHHHHHHHHHHHHCCCEEEEECCC
PGLGIVSVEYNPETTTPEEILKEAGVKGEIVNEQRSEKSILYKDFHDLLRRLAVGIIFTP
CCEEEEEEEECCCCCCHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTYLLPFFFGILVSIAVQFYSGLRFHKGAYRALKNKTTNMDVLVSLASNILWLSSIFLHN
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
TFYADASLLITFILVGKTLEAYIKAKMSAEIRIEPYKATLKDGRVVNSNELKVGDVVIVR
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEHHCCCEEECCCCEEECCEEEEE
AGERIPADGIIENGEGEVNEAILTGEQKPVLKKKGDNVLAGGILVNGYLEVYVTRNWDRS
CCCCCCCCCCEECCCCCCCHHEECCCCCCHHHCCCCCEEECCEEEEEEEEEEEECCCCCH
YIVQVTESVRGAYNTRVSIQNLVDKVSSIFVPIVISISALTFLVWKFVLDYNLYSSLLFS
HHHHHHHHHCCHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAVLAAACPCALGLASPMAMLVSVRRALKRGIIIRDGSIFEEMRNINVAILDKTGTVTEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHCCCEEEEECCCCEECC
EYVIVSKKEFIEGALNLAAIAESRSIHPIAKAFHKMNVRAGEIEQFEEFPGRGIYARVNG
CEEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEECC
NDVIVGSKDFVRDNCNWNVEDEGDIFICINGNAGGIVNIRDKLRDDAKKVISYLKGRGIR
CEEEECCHHHHCCCCCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHCCCCEE
IIIATGDSSNYADEIGKELGVEVRKELTPDDKAELVKELRENGNKVMFIGDGINDSIAMR
EEEEECCCCCHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCEEE
EADIGIAISSGTDLAKSAGKVVVNSLDDIIGLFEQTELAVRKIKENLAWAFGYNTAIIPI
ECCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHH
AAGVFYPFITLPPEYAALAMGFSSVIVSLWSLVPI
HHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLRECHMATEKKEELRITDNEEQLRIVGMHCATCVTTVSKSLKSVSGVKDAEVNLATGS
CCHHHHHHHCCCCCCEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
AKVILSGNVRLKELVKAVRKAGYDVATEKFTIKLNVNPEEMPKIERKFENVKGVVDVKSN
EEEEEECCCCHHHHHHHHHHCCCCEECEEEEEEEECCHHHHHHHHHHHHCCCEEEEECCC
PGLGIVSVEYNPETTTPEEILKEAGVKGEIVNEQRSEKSILYKDFHDLLRRLAVGIIFTP
CCEEEEEEEECCCCCCHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTYLLPFFFGILVSIAVQFYSGLRFHKGAYRALKNKTTNMDVLVSLASNILWLSSIFLHN
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
TFYADASLLITFILVGKTLEAYIKAKMSAEIRIEPYKATLKDGRVVNSNELKVGDVVIVR
HHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEHHCCCEEECCCCEEECCEEEEE
AGERIPADGIIENGEGEVNEAILTGEQKPVLKKKGDNVLAGGILVNGYLEVYVTRNWDRS
CCCCCCCCCCEECCCCCCCHHEECCCCCCHHHCCCCCEEECCEEEEEEEEEEEECCCCCH
YIVQVTESVRGAYNTRVSIQNLVDKVSSIFVPIVISISALTFLVWKFVLDYNLYSSLLFS
HHHHHHHHHCCHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAVLAAACPCALGLASPMAMLVSVRRALKRGIIIRDGSIFEEMRNINVAILDKTGTVTEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHCCCEEEEECCCCEECC
EYVIVSKKEFIEGALNLAAIAESRSIHPIAKAFHKMNVRAGEIEQFEEFPGRGIYARVNG
CEEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEECC
NDVIVGSKDFVRDNCNWNVEDEGDIFICINGNAGGIVNIRDKLRDDAKKVISYLKGRGIR
CEEEECCHHHHCCCCCCCCCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHCCCCEE
IIIATGDSSNYADEIGKELGVEVRKELTPDDKAELVKELRENGNKVMFIGDGINDSIAMR
EEEEECCCCCHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCEEE
EADIGIAISSGTDLAKSAGKVVVNSLDDIIGLFEQTELAVRKIKENLAWAFGYNTAIIPI
ECCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHH
AAGVFYPFITLPPEYAALAMGFSSVIVSLWSLVPI
HHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 12644235; 11922674; 12590580 [H]