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The map label for this gene is cutA-4 [H]

Identifier: 15899365

GI number: 15899365

Start: 2400889

End: 2403138

Strand: Direct

Name: cutA-4 [H]

Synonym: SSO2639

Alternate gene names: 15899365

Gene position: 2400889-2403138 (Clockwise)

Preceding gene: 15899363

Following gene: 15899366

Centisome position: 80.24

GC content: 39.78

Gene sequence:

>2250_bases
ATGAGCTACGTTGGCAAGCCAGTAAAAAGAATTTATGACGATAAATTCGTAACAGGTAGAAGCACTTATGTTGACGATAT
AAGGATACCAGCTCTATATGCCGGTTTTGTTAGAAGTACTTATCCCCATGCAATTATTAAGAGAATTGATGTTAGTGATG
CGTTAAAGGTTAATGGTATAGTTGCAGTATTTACTGCAAAGGAAATTAACCCCTTATTAAAAGGTGGAATTAGACCTTGG
CCTACGTATATAGATATACGATCATTTAGGTACAGTGAGAGGAAGGCATTTCCAGAAAATAAGGTCAAATATGTAGGTGA
ACCAGTAGCAATTGTGCTTGGCCAAGACAAGTATAGCGTTAGAGACGCCATAGATAAGGTAGTAGTTGAGTATGAACCCT
TAAAACCAGTTATTAGAATGGAAGAAGCAGAAAAAGATCAAGTAATAATCCATGAGGAGTTAAAAACTAACATATCCTAT
AAGATTCCATTTAAAGCAGGAGAAGTTGACAAGGCATTCAGTGAATCTGATAAGGTAGTTAGAGTTGAGGCCATAAATGA
AAGATTAATTCCAAATCCCATGGAACCTAGAGGAATTGTATCTAGGTTTGAAGCAGGAACACTATCAATATGGTACTCTA
CTCAAGTTCCTCATTATATGCGTTCAGAATTTGCCAGGATACTTGGTATACCCGAAAGTAAGATAAAAGTCAGTATGCCG
GATGTGGGAGGTGCCTTTGGGGCTAAAGTTCATTTAATGCCAGAAGAGTTAGCAGTAGTAGCATCGTCAATCATTTTAGG
GAGGCCAGTAAGATGGACAGCTACTAGAAGTGAGGAGATGTTAGCCAGTGAAGCGAGGCATAACGTTTTCACTGGTGAGG
TAGCAGTTAAAAGAGATGGTACTATTCTAGGTATAAAGGGTAAACTATTGCTAGATCTAGGAGCCTATATAACAGTAACT
GCCGGTATCCAACCATTAATAATACCAATGATGATACCCGGCCCCTACAAAATACGTAATCTGGATATCGAAAGCGTTGC
AGTCTACACTAATACCCCACCAATTACTATGTACAGAGGAGCCAGTAGACCAGAGGCAACATATATAATTGAAAGGATAA
TGAGTACAGTGGCTGACGAGTTAGGGTTAGATGATGTAAGTATTAGGGAAAAGAATCTAGTCACTGAATTACCATATACA
AATCCGTTTGGTTTAAGGTATGATAGTGGAGACTATGTTGGATTATTAAGAGAAGGCGTGAAGAGGTTAGGTTATTACGA
ACTTAAGAAGTGGGCTGAAGAGGAGAGAAAGAAGGGGCATAGGGTTGGAGTAGGGTTAGCGTATTATCTGGAAATATGTA
GTTTTGGTCCATGGGAATACGCTGAAGTTAGAGTGGATGAGAGGGGTGATGTATTAGTCGTTACTGGTACAACACCTCAT
GGACAAGGTACAGAAACTGCAATAGCTCAAATAGTTGCAGACGCCTTACAAATAGATATAAGTAGAGTTAGGGTAATATG
GGGAGATACTGATACTGTTGCAGCCAGTATGGGAACTTATGGTTCAAGATCTGTAACAATAGGTGGCTCTGCAGCAATTA
AAGTTGCAGAAAAAATCTTAGATAAGATGAAGAGAATTGCAGCATCTACTTGGAATGTCGATGTTCAAGAAGTTCAATAT
GAGAAAGGAGAGTTTAAGTTAAAGAATGATCCAAGTAAGAAGATGAGTTGGGACGACGTTGCTAGCATAGCGTATAGAAG
TCATGATCCTGGGCTAGTAGAGAAGATAATCTACGAGAACGATGTGACTTTCCCCTATGGAGTCCATATAGCGACAGTGG
AGGTAGATGATACTGGAGTTGCTAGAGTTTTAGAATATAGGGCATACGATGATATTGGGAAGGTTGTAAATCCAGCATTA
GCAGAAGCGCAGATTCATGGTGGAGGTGTCCAGGCTGTTGGACAAGCACTATATGAGCAAGCTTTACTCAATGAGAATGG
ACAGTTAATCGTAACTTATGCAGATTATTATGTCCCAACTGCTGTTGAGGCGCCTAAGTTTACGTCAGTCTTTGCTGATC
AATATCATCCATCTAACTATCCAACTGGTAGTAAGGGTGTTGGAGAGGCAGCATTAATCGTAGGTCCTGCAGTGATAATT
AGAGCATTGGAGGACGCTATTGGCACTAGATTCACTAAAACTCCAACTACTCCAGAGGAAATTTTAAGGGCTATCGCTAG
TAAAAGATGA

Upstream 100 bases:

>100_bases
AAGAGGAGGTTAGAGATGGACTTCACGGTAACATTTGTAGGTGTACTGGATATCAAAATATTGTTAAGGCAGTTTTAGAT
GCTTCAAGGAGGTTGAGAGC

Downstream 100 bases:

>100_bases
TAGCATTTTTCTTAACTACTTTTTATAAATATAATTTATAAATAACTTTTAGATTTAGTGCAAAAAGTTATTATTTTGAA
GGTAAAGTTTATTTATGGAA

Product: carbon monoxide dehydrogenase, large chain (cutA-4)

Products: NA

Alternate protein names: CO dehydrogenase subunit L; CO-DH L [H]

Number of amino acids: Translated: 749; Mature: 748

Protein sequence:

>749_residues
MSYVGKPVKRIYDDKFVTGRSTYVDDIRIPALYAGFVRSTYPHAIIKRIDVSDALKVNGIVAVFTAKEINPLLKGGIRPW
PTYIDIRSFRYSERKAFPENKVKYVGEPVAIVLGQDKYSVRDAIDKVVVEYEPLKPVIRMEEAEKDQVIIHEELKTNISY
KIPFKAGEVDKAFSESDKVVRVEAINERLIPNPMEPRGIVSRFEAGTLSIWYSTQVPHYMRSEFARILGIPESKIKVSMP
DVGGAFGAKVHLMPEELAVVASSIILGRPVRWTATRSEEMLASEARHNVFTGEVAVKRDGTILGIKGKLLLDLGAYITVT
AGIQPLIIPMMIPGPYKIRNLDIESVAVYTNTPPITMYRGASRPEATYIIERIMSTVADELGLDDVSIREKNLVTELPYT
NPFGLRYDSGDYVGLLREGVKRLGYYELKKWAEEERKKGHRVGVGLAYYLEICSFGPWEYAEVRVDERGDVLVVTGTTPH
GQGTETAIAQIVADALQIDISRVRVIWGDTDTVAASMGTYGSRSVTIGGSAAIKVAEKILDKMKRIAASTWNVDVQEVQY
EKGEFKLKNDPSKKMSWDDVASIAYRSHDPGLVEKIIYENDVTFPYGVHIATVEVDDTGVARVLEYRAYDDIGKVVNPAL
AEAQIHGGGVQAVGQALYEQALLNENGQLIVTYADYYVPTAVEAPKFTSVFADQYHPSNYPTGSKGVGEAALIVGPAVII
RALEDAIGTRFTKTPTTPEEILRAIASKR

Sequences:

>Translated_749_residues
MSYVGKPVKRIYDDKFVTGRSTYVDDIRIPALYAGFVRSTYPHAIIKRIDVSDALKVNGIVAVFTAKEINPLLKGGIRPW
PTYIDIRSFRYSERKAFPENKVKYVGEPVAIVLGQDKYSVRDAIDKVVVEYEPLKPVIRMEEAEKDQVIIHEELKTNISY
KIPFKAGEVDKAFSESDKVVRVEAINERLIPNPMEPRGIVSRFEAGTLSIWYSTQVPHYMRSEFARILGIPESKIKVSMP
DVGGAFGAKVHLMPEELAVVASSIILGRPVRWTATRSEEMLASEARHNVFTGEVAVKRDGTILGIKGKLLLDLGAYITVT
AGIQPLIIPMMIPGPYKIRNLDIESVAVYTNTPPITMYRGASRPEATYIIERIMSTVADELGLDDVSIREKNLVTELPYT
NPFGLRYDSGDYVGLLREGVKRLGYYELKKWAEEERKKGHRVGVGLAYYLEICSFGPWEYAEVRVDERGDVLVVTGTTPH
GQGTETAIAQIVADALQIDISRVRVIWGDTDTVAASMGTYGSRSVTIGGSAAIKVAEKILDKMKRIAASTWNVDVQEVQY
EKGEFKLKNDPSKKMSWDDVASIAYRSHDPGLVEKIIYENDVTFPYGVHIATVEVDDTGVARVLEYRAYDDIGKVVNPAL
AEAQIHGGGVQAVGQALYEQALLNENGQLIVTYADYYVPTAVEAPKFTSVFADQYHPSNYPTGSKGVGEAALIVGPAVII
RALEDAIGTRFTKTPTTPEEILRAIASKR
>Mature_748_residues
SYVGKPVKRIYDDKFVTGRSTYVDDIRIPALYAGFVRSTYPHAIIKRIDVSDALKVNGIVAVFTAKEINPLLKGGIRPWP
TYIDIRSFRYSERKAFPENKVKYVGEPVAIVLGQDKYSVRDAIDKVVVEYEPLKPVIRMEEAEKDQVIIHEELKTNISYK
IPFKAGEVDKAFSESDKVVRVEAINERLIPNPMEPRGIVSRFEAGTLSIWYSTQVPHYMRSEFARILGIPESKIKVSMPD
VGGAFGAKVHLMPEELAVVASSIILGRPVRWTATRSEEMLASEARHNVFTGEVAVKRDGTILGIKGKLLLDLGAYITVTA
GIQPLIIPMMIPGPYKIRNLDIESVAVYTNTPPITMYRGASRPEATYIIERIMSTVADELGLDDVSIREKNLVTELPYTN
PFGLRYDSGDYVGLLREGVKRLGYYELKKWAEEERKKGHRVGVGLAYYLEICSFGPWEYAEVRVDERGDVLVVTGTTPHG
QGTETAIAQIVADALQIDISRVRVIWGDTDTVAASMGTYGSRSVTIGGSAAIKVAEKILDKMKRIAASTWNVDVQEVQYE
KGEFKLKNDPSKKMSWDDVASIAYRSHDPGLVEKIIYENDVTFPYGVHIATVEVDDTGVARVLEYRAYDDIGKVVNPALA
EAQIHGGGVQAVGQALYEQALLNENGQLIVTYADYYVPTAVEAPKFTSVFADQYHPSNYPTGSKGVGEAALIVGPAVIIR
ALEDAIGTRFTKTPTTPEEILRAIASKR

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI71773480, Length=792, Percent_Identity=26.6414141414141, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI91823271, Length=798, Percent_Identity=27.1929824561404, Blast_Score=182, Evalue=8e-46,
Organism=Escherichia coli, GI1789246, Length=813, Percent_Identity=26.9372693726937, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1789230, Length=755, Percent_Identity=28.7417218543046, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1786478, Length=770, Percent_Identity=24.2857142857143, Blast_Score=116, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17540638, Length=801, Percent_Identity=25.2184769038702, Blast_Score=186, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17539860, Length=755, Percent_Identity=24.5033112582781, Blast_Score=155, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI32566215, Length=751, Percent_Identity=24.7669773635153, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17737937, Length=764, Percent_Identity=24.4764397905759, Blast_Score=137, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24647193, Length=739, Percent_Identity=25.1691474966171, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24647199, Length=767, Percent_Identity=25.4237288135593, Blast_Score=118, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24647201, Length=763, Percent_Identity=25.0327653997379, Blast_Score=112, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274
- InterPro:   IPR012780 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 83014; Mature: 82883

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYVGKPVKRIYDDKFVTGRSTYVDDIRIPALYAGFVRSTYPHAIIKRIDVSDALKVNGI
CCCCCHHHHHHHCCCEECCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHCCCCCCEEECCE
VAVFTAKEINPLLKGGIRPWPTYIDIRSFRYSERKAFPENKVKYVGEPVAIVLGQDKYSV
EEEEEHHHCCHHHHCCCCCCCCEEEEECCCCHHHHCCCCCCHHHCCCCEEEEECCCCHHH
RDAIDKVVVEYEPLKPVIRMEEAEKDQVIIHEELKTNISYKIPFKAGEVDKAFSESDKVV
HHHHHHHHEECCCCCHHHHHCCCCCCCEEEEEHHHCCCEEEECCCCCCCHHHHCCCCCEE
RVEAINERLIPNPMEPRGIVSRFEAGTLSIWYSTQVPHYMRSEFARILGIPESKIKVSMP
EEEECCCCCCCCCCCCHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEECC
DVGGAFGAKVHLMPEELAVVASSIILGRPVRWTATRSEEMLASEARHNVFTGEVAVKRDG
CCCCCCCCEEEECHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCEEECEEEEECCC
TILGIKGKLLLDLGAYITVTAGIQPLIIPMMIPGPYKIRNLDIESVAVYTNTPPITMYRG
EEEEECCEEEEECCCEEEEECCCCEEEEEEECCCCCEEEECCCCEEEEEECCCCEEEECC
ASRPEATYIIERIMSTVADELGLDDVSIREKNLVTELPYTNPFGLRYDSGDYVGLLREGV
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCEEECCCCHHHHHHHHH
KRLGYYELKKWAEEERKKGHRVGVGLAYYLEICSFGPWEYAEVRVDERGDVLVVTGTTPH
HHCCHHHHHHHHHHHHHCCCEECCHHHHHHHHHCCCCCCEEEEEECCCCCEEEEECCCCC
GQGTETAIAQIVADALQIDISRVRVIWGDTDTVAASMGTYGSRSVTIGGSAAIKVAEKIL
CCCHHHHHHHHHHHHHHEEEEEEEEEECCCHHHHHHCCCCCCCEEEECCHHHHHHHHHHH
DKMKRIAASTWNVDVQEVQYEKGEFKLKNDPSKKMSWDDVASIAYRSHDPGLVEKIIYEN
HHHHHHHHHCCCCCHHHHEECCCCEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCC
DVTFPYGVHIATVEVDDTGVARVLEYRAYDDIGKVVNPALAEAQIHGGGVQAVGQALYEQ
CCCCEECEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHEEECCCCHHHHHHHHHHH
ALLNENGQLIVTYADYYVPTAVEAPKFTSVFADQYHPSNYPTGSKGVGEAALIVGPAVII
HHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
RALEDAIGTRFTKTPTTPEEILRAIASKR
HHHHHHHCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SYVGKPVKRIYDDKFVTGRSTYVDDIRIPALYAGFVRSTYPHAIIKRIDVSDALKVNGI
CCCCHHHHHHHCCCEECCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHCCCCCCEEECCE
VAVFTAKEINPLLKGGIRPWPTYIDIRSFRYSERKAFPENKVKYVGEPVAIVLGQDKYSV
EEEEEHHHCCHHHHCCCCCCCCEEEEECCCCHHHHCCCCCCHHHCCCCEEEEECCCCHHH
RDAIDKVVVEYEPLKPVIRMEEAEKDQVIIHEELKTNISYKIPFKAGEVDKAFSESDKVV
HHHHHHHHEECCCCCHHHHHCCCCCCCEEEEEHHHCCCEEEECCCCCCCHHHHCCCCCEE
RVEAINERLIPNPMEPRGIVSRFEAGTLSIWYSTQVPHYMRSEFARILGIPESKIKVSMP
EEEECCCCCCCCCCCCHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEECC
DVGGAFGAKVHLMPEELAVVASSIILGRPVRWTATRSEEMLASEARHNVFTGEVAVKRDG
CCCCCCCCEEEECHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCEEECEEEEECCC
TILGIKGKLLLDLGAYITVTAGIQPLIIPMMIPGPYKIRNLDIESVAVYTNTPPITMYRG
EEEEECCEEEEECCCEEEEECCCCEEEEEEECCCCCEEEECCCCEEEEEECCCCEEEECC
ASRPEATYIIERIMSTVADELGLDDVSIREKNLVTELPYTNPFGLRYDSGDYVGLLREGV
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCEEECCCCHHHHHHHHH
KRLGYYELKKWAEEERKKGHRVGVGLAYYLEICSFGPWEYAEVRVDERGDVLVVTGTTPH
HHCCHHHHHHHHHHHHHCCCEECCHHHHHHHHHCCCCCCEEEEEECCCCCEEEEECCCCC
GQGTETAIAQIVADALQIDISRVRVIWGDTDTVAASMGTYGSRSVTIGGSAAIKVAEKIL
CCCHHHHHHHHHHHHHHEEEEEEEEEECCCHHHHHHCCCCCCCEEEECCHHHHHHHHHHH
DKMKRIAASTWNVDVQEVQYEKGEFKLKNDPSKKMSWDDVASIAYRSHDPGLVEKIIYEN
HHHHHHHHHCCCCCHHHHEECCCCEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCC
DVTFPYGVHIATVEVDDTGVARVLEYRAYDDIGKVVNPALAEAQIHGGGVQAVGQALYEQ
CCCCEECEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHEEECCCCHHHHHHHHHHH
ALLNENGQLIVTYADYYVPTAVEAPKFTSVFADQYHPSNYPTGSKGVGEAALIVGPAVII
HHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHH
RALEDAIGTRFTKTPTTPEEILRAIASKR
HHHHHHHCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721710; 2818128; 12515558; 10430865; 12475995 [H]