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The map label for this gene is degP [H]

Identifier: 15899338

GI number: 15899338

Start: 2378160

End: 2379053

Strand: Direct

Name: degP [H]

Synonym: SSO2612

Alternate gene names: 15899338

Gene position: 2378160-2379053 (Clockwise)

Preceding gene: 15899332

Following gene: 15899339

Centisome position: 79.48

GC content: 37.36

Gene sequence:

>894_bases
ATGTACGAGGATTTAGTAGAAAGGGTAACTCCATCAGTAGTCACTATAATAACGAAGCAGATAGCTTTAGACCAGTTTTT
TATGCCACAAGTTGCTGAAGGCATAGGATCTGGTTACTCTATAGGGAAAAATATCCTAATAACATCTTATCATGTTATAT
CAAATGCTGAAGAGATACTGGTAATATCTGAAGATGGATTTAGAGAAGAAGCGCAAGTAATTGCAATAAATCCCTTTCAT
GATTTAGCAATGTTAAGAAGTACCATAGAATTGCCTAGTCTGAAACTAGCTAAAGAGTGCAAAACCGGAGAGGTAGTTTT
AGCAGTAGGAAATCCTCTAGGTCTATATAGTGTAAGTATGGGTATAATTAGCAGTGAGGAAAGGGCCATAATGACACCTA
ATGGTCTTCCCATTTATGTGGTCCAGACAGATGCAGCTGTTAACCCCGGTAATAGTGGAGGGCCTCTTATAAATACCAGA
GGTGAGGTTGTGGGTACTGTTACTGCGATGATAAGAGAAGCTCAGAATATAGGTTTTGCAATCCCTTCTAAACTTGTTGA
TAGTTTCGTAAAAAACGTCATGAAGTTTGGTAGATACATAAGACCGTATGTGGGAATTGGTGTAATAAAGTTAAACAAAG
CTTTAGCGACATACTTGGGAGTGAGGAAACAAAATGGCTTGCTTGTTACGAACATAGATCCAAATGGAAGCGCTTACAAG
TATGGAATAAGGAGAGGTGATATCATACTAAAGGTTAATAATCAAGAAGTTAAATCTCCTATAGATTTGCTAGCTGTATT
AGAAGAGATGGTTGGTTCACAGATTAATGTAAAGATGTTAAGGGATTCTAAGGAGATAGAACTTTCGATACCAGTCCCTG
GTTTATCTACTTAA

Upstream 100 bases:

>100_bases
TACGATAAGTTCTTCTTAATTTAGATGTTTTTAATGATCTTTTTTCAATTTCACCTTAAGGTGAAAGAATATAAATAATT
AGGCAGACTTAATATGTACC

Downstream 100 bases:

>100_bases
ATTTTTTAAAAGTCCTTTAGTGTTAAGCTTTTTACCTCTCTTTGCAAAATCTTTTGTATGGTAGAAATAGGGGAAAAAGC
TCCAGAAATAGAGTTAGTAG

Product: HtrA like serine protease (periplasmic)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MYEDLVERVTPSVVTIITKQIALDQFFMPQVAEGIGSGYSIGKNILITSYHVISNAEEILVISEDGFREEAQVIAINPFH
DLAMLRSTIELPSLKLAKECKTGEVVLAVGNPLGLYSVSMGIISSEERAIMTPNGLPIYVVQTDAAVNPGNSGGPLINTR
GEVVGTVTAMIREAQNIGFAIPSKLVDSFVKNVMKFGRYIRPYVGIGVIKLNKALATYLGVRKQNGLLVTNIDPNGSAYK
YGIRRGDIILKVNNQEVKSPIDLLAVLEEMVGSQINVKMLRDSKEIELSIPVPGLST

Sequences:

>Translated_297_residues
MYEDLVERVTPSVVTIITKQIALDQFFMPQVAEGIGSGYSIGKNILITSYHVISNAEEILVISEDGFREEAQVIAINPFH
DLAMLRSTIELPSLKLAKECKTGEVVLAVGNPLGLYSVSMGIISSEERAIMTPNGLPIYVVQTDAAVNPGNSGGPLINTR
GEVVGTVTAMIREAQNIGFAIPSKLVDSFVKNVMKFGRYIRPYVGIGVIKLNKALATYLGVRKQNGLLVTNIDPNGSAYK
YGIRRGDIILKVNNQEVKSPIDLLAVLEEMVGSQINVKMLRDSKEIELSIPVPGLST
>Mature_297_residues
MYEDLVERVTPSVVTIITKQIALDQFFMPQVAEGIGSGYSIGKNILITSYHVISNAEEILVISEDGFREEAQVIAINPFH
DLAMLRSTIELPSLKLAKECKTGEVVLAVGNPLGLYSVSMGIISSEERAIMTPNGLPIYVVQTDAAVNPGNSGGPLINTR
GEVVGTVTAMIREAQNIGFAIPSKLVDSFVKNVMKFGRYIRPYVGIGVIKLNKALATYLGVRKQNGLLVTNIDPNGSAYK
YGIRRGDIILKVNNQEVKSPIDLLAVLEEMVGSQINVKMLRDSKEIELSIPVPGLST

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI7019477, Length=308, Percent_Identity=31.4935064935065, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4506141, Length=307, Percent_Identity=28.6644951140065, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI24308541, Length=306, Percent_Identity=29.0849673202614, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI22129776, Length=310, Percent_Identity=29.3548387096774, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1786356, Length=267, Percent_Identity=35.2059925093633, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789630, Length=304, Percent_Identity=32.2368421052632, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789629, Length=319, Percent_Identity=30.0940438871473, Blast_Score=130, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24646839, Length=313, Percent_Identity=31.3099041533546, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 32203; Mature: 32203

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYEDLVERVTPSVVTIITKQIALDQFFMPQVAEGIGSGYSIGKNILITSYHVISNAEEIL
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEE
VISEDGFREEAQVIAINPFHDLAMLRSTIELPSLKLAKECKTGEVVLAVGNPLGLYSVSM
EECCCCCCCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEECCCCCEEEEEE
GIISSEERAIMTPNGLPIYVVQTDAAVNPGNSGGPLINTRGEVVGTVTAMIREAQNIGFA
CEECCCCCEEECCCCCEEEEEEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCEE
IPSKLVDSFVKNVMKFGRYIRPYVGIGVIKLNKALATYLGVRKQNGLLVTNIDPNGSAYK
CHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHCCCCCCCEEEEEECCCCCEEE
YGIRRGDIILKVNNQEVKSPIDLLAVLEEMVGSQINVKMLRDSKEIELSIPVPGLST
EECCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCC
>Mature Secondary Structure
MYEDLVERVTPSVVTIITKQIALDQFFMPQVAEGIGSGYSIGKNILITSYHVISNAEEIL
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEE
VISEDGFREEAQVIAINPFHDLAMLRSTIELPSLKLAKECKTGEVVLAVGNPLGLYSVSM
EECCCCCCCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEECCCCCEEEEEE
GIISSEERAIMTPNGLPIYVVQTDAAVNPGNSGGPLINTRGEVVGTVTAMIREAQNIGFA
CEECCCCCEEECCCCCEEEEEEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCEE
IPSKLVDSFVKNVMKFGRYIRPYVGIGVIKLNKALATYLGVRKQNGLLVTNIDPNGSAYK
CHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEHHHHHHHHCCCCCCCEEEEEECCCCCEEE
YGIRRGDIILKVNNQEVKSPIDLLAVLEEMVGSQINVKMLRDSKEIELSIPVPGLST
EECCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893; 9274032 [H]