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The map label for this gene is ubiB [C]

Identifier: 15899331

GI number: 15899331

Start: 2370190

End: 2371680

Strand: Reverse

Name: ubiB [C]

Synonym: SSO2605

Alternate gene names: 15899331

Gene position: 2371680-2370190 (Counterclockwise)

Preceding gene: 15899333

Following gene: 15899329

Centisome position: 79.26

GC content: 33.53

Gene sequence:

>1491_bases
GTGATTAGAAGATTACTGGAAGTGTTTTTCAAATTGGCCCCTAGAGTACTAGCGTATAGAGAGTTTAGAAATAAAATCCT
AAAGGAAATTCCAATCGATGAAAAAGAGATGGCAGAAGAGGCTAAGAAATTTGTTGACACGCTAATTGAACTAGGTCCCA
CATTCATCAAGTTCGGACAAATTCTTTCAGTTAGACCTGACATTATGCCGGAAACGTATATTAAAGAATTAGCCAGATTA
CAAGATGAAGTCCCACCTGCTCCATTTAGCCAAGTAAGTAAAATTATCGATGAGGAACTCGGCAATAGTGTAAAAATTTT
AAAAGAACTGTCTTCAGCGTCTTTAGGTCAAGTCTATCTAGGAGAATATAATGGAAAGATCGTTGCTATTAAGGTAAATA
GACCTGGAATAAAGGAAACTGTAAATGAAGATATTCAAGTAGTAAAGAAATTGTTGCCACTCCTTAGATTTGTATTTGAT
GAATCATTCATCGAAATAATAAAAGTATTCCTAGAAGAATTTTCCAGAAGAATATTTGAAGAAATGGATTATACTAAGGA
AGCCTTTTATTTAAATAAGATCAAAGAGGAATTGTCAGATTATCCGTCCTTAAGAATACCTTCAATAATAAAGGCTACTA
AAAGAGTTTTAGTGATGGAGTATATTAAAGGGTATAAAGTTACAAGCGAAGAGGCAAAAAAGATAGTTGATAACAGAATA
TTGGCATATAGAGTATTTAGATTGTTCATGTATATGTTGCTTAATAAGGACTATTTTCATGCAGATCCTCACCCTGGTAA
TATAGCGGTTGACGAGCAAGGGAATTTGGTACTCTACGACTTTGGAATGTCTGGAAAAATAGATGAAAAGACTAGAAATC
TATTGATTAGGGCATATGTGGCAATGATTAGAATGGATGCAGATTCACTAGTAAGGGTACTAGACGAGTTAGGGGCAATA
CAGCCTTTCGCGGATAGGAGGGTATTAGCGAAGGGATTGAGGCTTTTCATGCAAGCAATGCAAGGAATAGAAGTTAGTGA
ATTAGAGCTGGAAGATTTTATGAAACTGGCTGATCAAGTATTCTTTAAGTTTCCACTTAGAATGCCATCTAAACTTGTTC
TGCCTTTTAGAATGGTTAACGTTTTAGATGGGACATGTAGAGAAATAGATAAAGATTTTGACTTTGTCAAATCATCTATA
ACTTTTTTAGAAGAAGAAGGGTATACAACGAAAGTTGTTATAGAACAAGTAAGAGAACTAGTTAATGGAATTTGGAATAG
ATTTAGGAGCTTTCTATTATCATATTCACAACAGCAAGAGCTGATAAACATACAAAGCAGTAGGAAAGGTAGTGCAATAA
CTAATTATATTCCTCAAATGATATTGGTTATAACCATAATATTTTATGCTATAACAAAAGATATTATCATTACCCTCCTT
ATGGTTATTCTAGCATTCTCAATATCACTAAGTGGAAGAAAAAATACATAA

Upstream 100 bases:

>100_bases
AATCTTTAATACTATTAAGAAAAATTTATTTAGAACTTTATTACTGCACTCTAACAACTTAGAATAGGTACAAATACTTC
CTTTTTACTATATTATAGTT

Downstream 100 bases:

>100_bases
CTTAAAAAAAATTATTCTATTCTGATTGAGACTGAACCCTCCACTGGTATCCTTATAGTCAATACACCATTTTCATATTT
CGCTGTAACTTGAGAATCCC

Product: ABC transporter

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MIRRLLEVFFKLAPRVLAYREFRNKILKEIPIDEKEMAEEAKKFVDTLIELGPTFIKFGQILSVRPDIMPETYIKELARL
QDEVPPAPFSQVSKIIDEELGNSVKILKELSSASLGQVYLGEYNGKIVAIKVNRPGIKETVNEDIQVVKKLLPLLRFVFD
ESFIEIIKVFLEEFSRRIFEEMDYTKEAFYLNKIKEELSDYPSLRIPSIIKATKRVLVMEYIKGYKVTSEEAKKIVDNRI
LAYRVFRLFMYMLLNKDYFHADPHPGNIAVDEQGNLVLYDFGMSGKIDEKTRNLLIRAYVAMIRMDADSLVRVLDELGAI
QPFADRRVLAKGLRLFMQAMQGIEVSELELEDFMKLADQVFFKFPLRMPSKLVLPFRMVNVLDGTCREIDKDFDFVKSSI
TFLEEEGYTTKVVIEQVRELVNGIWNRFRSFLLSYSQQQELINIQSSRKGSAITNYIPQMILVITIIFYAITKDIIITLL
MVILAFSISLSGRKNT

Sequences:

>Translated_496_residues
MIRRLLEVFFKLAPRVLAYREFRNKILKEIPIDEKEMAEEAKKFVDTLIELGPTFIKFGQILSVRPDIMPETYIKELARL
QDEVPPAPFSQVSKIIDEELGNSVKILKELSSASLGQVYLGEYNGKIVAIKVNRPGIKETVNEDIQVVKKLLPLLRFVFD
ESFIEIIKVFLEEFSRRIFEEMDYTKEAFYLNKIKEELSDYPSLRIPSIIKATKRVLVMEYIKGYKVTSEEAKKIVDNRI
LAYRVFRLFMYMLLNKDYFHADPHPGNIAVDEQGNLVLYDFGMSGKIDEKTRNLLIRAYVAMIRMDADSLVRVLDELGAI
QPFADRRVLAKGLRLFMQAMQGIEVSELELEDFMKLADQVFFKFPLRMPSKLVLPFRMVNVLDGTCREIDKDFDFVKSSI
TFLEEEGYTTKVVIEQVRELVNGIWNRFRSFLLSYSQQQELINIQSSRKGSAITNYIPQMILVITIIFYAITKDIIITLL
MVILAFSISLSGRKNT
>Mature_496_residues
MIRRLLEVFFKLAPRVLAYREFRNKILKEIPIDEKEMAEEAKKFVDTLIELGPTFIKFGQILSVRPDIMPETYIKELARL
QDEVPPAPFSQVSKIIDEELGNSVKILKELSSASLGQVYLGEYNGKIVAIKVNRPGIKETVNEDIQVVKKLLPLLRFVFD
ESFIEIIKVFLEEFSRRIFEEMDYTKEAFYLNKIKEELSDYPSLRIPSIIKATKRVLVMEYIKGYKVTSEEAKKIVDNRI
LAYRVFRLFMYMLLNKDYFHADPHPGNIAVDEQGNLVLYDFGMSGKIDEKTRNLLIRAYVAMIRMDADSLVRVLDELGAI
QPFADRRVLAKGLRLFMQAMQGIEVSELELEDFMKLADQVFFKFPLRMPSKLVLPFRMVNVLDGTCREIDKDFDFVKSSI
TFLEEEGYTTKVVIEQVRELVNGIWNRFRSFLLSYSQQQELINIQSSRKGSAITNYIPQMILVITIIFYAITKDIIITLL
MVILAFSISLSGRKNT

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=319, Percent_Identity=26.0188087774295, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI41393593, Length=284, Percent_Identity=26.4084507042254, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI34147522, Length=284, Percent_Identity=25.3521126760563, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI27363457, Length=290, Percent_Identity=26.8965517241379, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI217035081, Length=222, Percent_Identity=27.027027027027, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI217416386, Length=240, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI2367309, Length=376, Percent_Identity=26.3297872340426, Blast_Score=120, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17559152, Length=316, Percent_Identity=26.8987341772152, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI32565180, Length=265, Percent_Identity=24.9056603773585, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323282, Length=282, Percent_Identity=24.468085106383, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6321319, Length=263, Percent_Identity=25.8555133079848, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6325148, Length=253, Percent_Identity=22.9249011857708, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI22024280, Length=323, Percent_Identity=26.3157894736842, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24662575, Length=297, Percent_Identity=23.5690235690236, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI18859849, Length=255, Percent_Identity=27.0588235294118, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 57517; Mature: 57517

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRRLLEVFFKLAPRVLAYREFRNKILKEIPIDEKEMAEEAKKFVDTLIELGPTFIKFGQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHH
ILSVRPDIMPETYIKELARLQDEVPPAPFSQVSKIIDEELGNSVKILKELSSASLGQVYL
HHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEE
GEYNGKIVAIKVNRPGIKETVNEDIQVVKKLLPLLRFVFDESFIEIIKVFLEEFSRRIFE
ECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMDYTKEAFYLNKIKEELSDYPSLRIPSIIKATKRVLVMEYIKGYKVTSEEAKKIVDNRI
HHCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LAYRVFRLFMYMLLNKDYFHADPHPGNIAVDEQGNLVLYDFGMSGKIDEKTRNLLIRAYV
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHH
AMIRMDADSLVRVLDELGAIQPFADRRVLAKGLRLFMQAMQGIEVSELELEDFMKLADQV
HHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FFKFPLRMPSKLVLPFRMVNVLDGTCREIDKDFDFVKSSITFLEEEGYTTKVVIEQVREL
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VNGIWNRFRSFLLSYSQQQELINIQSSRKGSAITNYIPQMILVITIIFYAITKDIIITLL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVILAFSISLSGRKNT
HHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIRRLLEVFFKLAPRVLAYREFRNKILKEIPIDEKEMAEEAKKFVDTLIELGPTFIKFGQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHH
ILSVRPDIMPETYIKELARLQDEVPPAPFSQVSKIIDEELGNSVKILKELSSASLGQVYL
HHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEE
GEYNGKIVAIKVNRPGIKETVNEDIQVVKKLLPLLRFVFDESFIEIIKVFLEEFSRRIFE
ECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMDYTKEAFYLNKIKEELSDYPSLRIPSIIKATKRVLVMEYIKGYKVTSEEAKKIVDNRI
HHCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
LAYRVFRLFMYMLLNKDYFHADPHPGNIAVDEQGNLVLYDFGMSGKIDEKTRNLLIRAYV
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHH
AMIRMDADSLVRVLDELGAIQPFADRRVLAKGLRLFMQAMQGIEVSELELEDFMKLADQV
HHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
FFKFPLRMPSKLVLPFRMVNVLDGTCREIDKDFDFVKSSITFLEEEGYTTKVVIEQVREL
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
VNGIWNRFRSFLLSYSQQQELINIQSSRKGSAITNYIPQMILVITIIFYAITKDIIITLL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVILAFSISLSGRKNT
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]