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The map label for this gene is hpcE-1 [H]

Identifier: 15899256

GI number: 15899256

Start: 2289080

End: 2290036

Strand: Direct

Name: hpcE-1 [H]

Synonym: SSO2520

Alternate gene names: 15899256

Gene position: 2289080-2290036 (Clockwise)

Preceding gene: 15899254

Following gene: 15899259

Centisome position: 76.5

GC content: 37.1

Gene sequence:

>957_bases
ATGAAACTAATAAGTTTCATTAGGGATAATAGGATAAGAAGTGGTGTTTTAGTTAATGACGAGTTTATAGCAGATCTAAA
CACCTCTTGCTACCTAATGCTAATTGAGAAAGGGGAAGAAGAACAATTTGCCGAGAGGTATTGTAATGCAATAGTACCTC
CAGATATGCTAGGGGTACTTCAAGCTGGAGATAAGGGATTTGAAGTGGTTAAAGAAATTCTGGAATGGTCTAAGAAGAGA
AATGATATCCTTTATAATATTAATCAAGTTAAGTTAAAGGCACCCTTAGTAAGGGCTAATATGTTGAGAGATTTCCTAGC
ATTTAGGGGACATGTTGAGGCAACTTATAAGAGGAGAGGACAACCTATACCCGAAGAATGGTTTAGGATTCCCATTTATT
ATAAGGGAGATCCGGCGATATTTTATGGACATTTAGAGGAAGTACCTTGGCCAAAGTATTCTAAGCTCGTCGACATAGAG
CTAGAAATAGCTGCTATAATATATAAGAGAGGTAAGGACATTGATAAGATAAGAGCGAGGGATTACATATTAGGTTTCAC
TATCTTTAATGATTTTAGTGCGAGGGATATACAAATGGCTGAGATGAAAGGTTTACTAGGCCCAGCAAAGGGTAAAGATT
TCGCAAATGGATTGGGACCTTGGATAGTAACAAAGGACGAGTTATCGGATATTAAGGGGTTAAGAGTCTACGCTAAGGTT
AATAATGAAATCTGGTGTGATACTAAGGCAGAGGATATGCAATGGAGTTTTGAGGATATGATAGCGTATGTCTCTCAAGA
CGAGTACATTAGACCGGGCGATGTTTTCGGTAGTGGTACTGTAAGTGGATGTACTGGGTTAGATATAGGCAAATCGTTAA
AGCCAAATAGTAGTATAGAATTATATGTGGAGAAGATAGGGATTCTGAAAAATATTATAGTAAAAAATCATCAATAG

Upstream 100 bases:

>100_bases
GTTGAATGAAGGCATATACATTATCACTAATTCTTTCGAACTTATATTGAACTTCCATAATAACATATATTACCTATTGA
TTAAATAGTTTATAGAGATC

Downstream 100 bases:

>100_bases
AAAACGTTAAACATTTTTCTAATTGATGATGCAATATGATGTATTGCTTCTTTTCCCGTATCTAAATACTCATAAAAACT
CACGAAGCCGTGGATCATGC

Product: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (hpcE-1)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKLISFIRDNRIRSGVLVNDEFIADLNTSCYLMLIEKGEEEQFAERYCNAIVPPDMLGVLQAGDKGFEVVKEILEWSKKR
NDILYNINQVKLKAPLVRANMLRDFLAFRGHVEATYKRRGQPIPEEWFRIPIYYKGDPAIFYGHLEEVPWPKYSKLVDIE
LEIAAIIYKRGKDIDKIRARDYILGFTIFNDFSARDIQMAEMKGLLGPAKGKDFANGLGPWIVTKDELSDIKGLRVYAKV
NNEIWCDTKAEDMQWSFEDMIAYVSQDEYIRPGDVFGSGTVSGCTGLDIGKSLKPNSSIELYVEKIGILKNIIVKNHQ

Sequences:

>Translated_318_residues
MKLISFIRDNRIRSGVLVNDEFIADLNTSCYLMLIEKGEEEQFAERYCNAIVPPDMLGVLQAGDKGFEVVKEILEWSKKR
NDILYNINQVKLKAPLVRANMLRDFLAFRGHVEATYKRRGQPIPEEWFRIPIYYKGDPAIFYGHLEEVPWPKYSKLVDIE
LEIAAIIYKRGKDIDKIRARDYILGFTIFNDFSARDIQMAEMKGLLGPAKGKDFANGLGPWIVTKDELSDIKGLRVYAKV
NNEIWCDTKAEDMQWSFEDMIAYVSQDEYIRPGDVFGSGTVSGCTGLDIGKSLKPNSSIELYVEKIGILKNIIVKNHQ
>Mature_318_residues
MKLISFIRDNRIRSGVLVNDEFIADLNTSCYLMLIEKGEEEQFAERYCNAIVPPDMLGVLQAGDKGFEVVKEILEWSKKR
NDILYNINQVKLKAPLVRANMLRDFLAFRGHVEATYKRRGQPIPEEWFRIPIYYKGDPAIFYGHLEEVPWPKYSKLVDIE
LEIAAIIYKRGKDIDKIRARDYILGFTIFNDFSARDIQMAEMKGLLGPAKGKDFANGLGPWIVTKDELSDIKGLRVYAKV
NNEIWCDTKAEDMQWSFEDMIAYVSQDEYIRPGDVFGSGTVSGCTGLDIGKSLKPNSSIELYVEKIGILKNIIVKNHQ

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=201, Percent_Identity=34.8258706467662, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI40786394, Length=201, Percent_Identity=33.8308457711443, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI28572127, Length=264, Percent_Identity=25.7575757575758, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 36421; Mature: 36421

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLISFIRDNRIRSGVLVNDEFIADLNTSCYLMLIEKGEEEQFAERYCNAIVPPDMLGVL
CCHHHHHHCCCCCCCEEECCHHHCCCCCCEEEEEEECCCHHHHHHHHCCCCCCHHHHHHH
QAGDKGFEVVKEILEWSKKRNDILYNINQVKLKAPLVRANMLRDFLAFRGHVEATYKRRG
HCCCCHHHHHHHHHHHHHCCCCEEEECEEEEEECHHHHHHHHHHHHHHCCCCCHHHHHCC
QPIPEEWFRIPIYYKGDPAIFYGHLEEVPWPKYSKLVDIELEIAAIIYKRGKDIDKIRAR
CCCCHHHEEEEEEECCCCEEEEECCCCCCCCCCCEEEEEEEHEEEHHHHCCCCHHHHHHH
DYILGFTIFNDFSARDIQMAEMKGLLGPAKGKDFANGLGPWIVTKDELSDIKGLRVYAKV
HEEEEEEEECCCCCCCEEHHHHHCCCCCCCCCHHHCCCCCEEEEHHHHHCCCCEEEEEEE
NNEIWCDTKAEDMQWSFEDMIAYVSQDEYIRPGDVFGSGTVSGCTGLDIGKSLKPNSSIE
CCEEEECCCCHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
LYVEKIGILKNIIVKNHQ
EHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLISFIRDNRIRSGVLVNDEFIADLNTSCYLMLIEKGEEEQFAERYCNAIVPPDMLGVL
CCHHHHHHCCCCCCCEEECCHHHCCCCCCEEEEEEECCCHHHHHHHHCCCCCCHHHHHHH
QAGDKGFEVVKEILEWSKKRNDILYNINQVKLKAPLVRANMLRDFLAFRGHVEATYKRRG
HCCCCHHHHHHHHHHHHHCCCCEEEECEEEEEECHHHHHHHHHHHHHHCCCCCHHHHHCC
QPIPEEWFRIPIYYKGDPAIFYGHLEEVPWPKYSKLVDIELEIAAIIYKRGKDIDKIRAR
CCCCHHHEEEEEEECCCCEEEEECCCCCCCCCCCEEEEEEEHEEEHHHHCCCCHHHHHHH
DYILGFTIFNDFSARDIQMAEMKGLLGPAKGKDFANGLGPWIVTKDELSDIKGLRVYAKV
HEEEEEEEECCCCCCCEEHHHHHCCCCCCCCCHHHCCCCCEEEEHHHHHCCCCEEEEEEE
NNEIWCDTKAEDMQWSFEDMIAYVSQDEYIRPGDVFGSGTVSGCTGLDIGKSLKPNSSIE
CCEEEECCCCHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
LYVEKIGILKNIIVKNHQ
EHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]