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The map label for this gene is acaB-5 [H]

Identifier: 15899236

GI number: 15899236

Start: 2265544

End: 2266731

Strand: Reverse

Name: acaB-5 [H]

Synonym: SSO2496

Alternate gene names: 15899236

Gene position: 2266731-2265544 (Counterclockwise)

Preceding gene: 15899237

Following gene: 15899226

Centisome position: 75.75

GC content: 38.72

Gene sequence:

>1188_bases
ATGTTAGAGGATGTATATCTGGTAGATTATGCGAGAACGGCATTTACGAGGTTTTCACGCAAGGACTATCAAAAAGATCC
ATTTTACAATATAAGACCAGAGGAATTAGCTGGAATGGTAATAAATAGGTTAATAGAGAAAAACGGAATTAAGGCAGAAG
AAATAGACGAAATAATCACTGGATGTGCGCTCCAAGTAGGCGAACAATGGGCTTTCGGAGGTAGGCATGAAATTTTCGCA
GCGAGATTACCATATAACATACCAACTATGGCTGTGGATAGGCAATGCGCTTCATCATTAACTACAGTTTCTATAGGAGC
CATGGAAATATCAACTGGTATGGCTGATATAGTATTAGCGGGTGGAGTTGAAAAATTATCTAGAACGCCAATGTTTGATA
ATCCACATATTGAAGTTAACACTAAGTTTCTAACTGATAGTAAATATATTGAATACGATTTAACTACAGGATATGTTATG
GGATTAACTGCTGAGAAATTAGCTGAAGAAGCTAGAATAAAAAGGGAGGAAATGGATAGGTGGTCTTTAAGGAGTCATCA
ATTAGCATGGAAAGCTATACAAGAGGGGTATTTCAAAGACGAGATCCTACCTATTGAGGTAGAAGTTGAAGGGAAGAAAA
CTGTAGTGAATGTAGATCAATCGGTTAGACCAGACACTAGCATAGAAAAATTAGGCCAATTGCCTCCAGCCTTTAAACCT
AATGGTACAATAACTGCAGGAAATTCAGCACCTTTGAATTCTGGAGCTTCTTATGTACTTCTAATGTCAAAAAATGCATT
GAAGAAATATGGATTAACTCCAATGGCAAAAATAAGGAGTTTTGGGTTTGCTGGAGTACCTCCAGCAGTAATGGGGAAGG
GACCAGTACCGGCTTCCAAGAAGGCCTTAGAAAAGGCAAATTTAAGTACAAGAAAAATAGACTTATGGGAAATAAATGAG
GCATTTGCAGTTGTAGTATTATATGCTATAAAACAATTAGAATTGGATGAGAGCACAGTAAATAAGAAGGGAGGTGCTAT
TGCTATAGGGCATCCACTAGGAGCCACTGGGGCTAGACTAGTGGGTACCTTGGCTAGGCAATTAATAATAGAAGGAAAGG
ATTACGGTGTTGCAACGCTGTGTGTTGGTGGAGGTCAAGGTGGGGCAATAGTTCTAGAAAGAGTTTGA

Upstream 100 bases:

>100_bases
TTACATTAAGTAAGTTATACAATAGTAAAGTGAATATCTCTGAGTTCCTGCAACCTATATAATCTATCAAATAAAATAAT
ATAGTGGGTTAGATGATAAG

Downstream 100 bases:

>100_bases
GATCAATATTTTTCCGTACCTATTTTTACTGTCATTAAGCAAGTCAAGAGCTTTTCCAAAATTCTCTAAGCTAACCTCAC
TTCCAATAACAGGTTTTATT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MLEDVYLVDYARTAFTRFSRKDYQKDPFYNIRPEELAGMVINRLIEKNGIKAEEIDEIITGCALQVGEQWAFGGRHEIFA
ARLPYNIPTMAVDRQCASSLTTVSIGAMEISTGMADIVLAGGVEKLSRTPMFDNPHIEVNTKFLTDSKYIEYDLTTGYVM
GLTAEKLAEEARIKREEMDRWSLRSHQLAWKAIQEGYFKDEILPIEVEVEGKKTVVNVDQSVRPDTSIEKLGQLPPAFKP
NGTITAGNSAPLNSGASYVLLMSKNALKKYGLTPMAKIRSFGFAGVPPAVMGKGPVPASKKALEKANLSTRKIDLWEINE
AFAVVVLYAIKQLELDESTVNKKGGAIAIGHPLGATGARLVGTLARQLIIEGKDYGVATLCVGGGQGGAIVLERV

Sequences:

>Translated_395_residues
MLEDVYLVDYARTAFTRFSRKDYQKDPFYNIRPEELAGMVINRLIEKNGIKAEEIDEIITGCALQVGEQWAFGGRHEIFA
ARLPYNIPTMAVDRQCASSLTTVSIGAMEISTGMADIVLAGGVEKLSRTPMFDNPHIEVNTKFLTDSKYIEYDLTTGYVM
GLTAEKLAEEARIKREEMDRWSLRSHQLAWKAIQEGYFKDEILPIEVEVEGKKTVVNVDQSVRPDTSIEKLGQLPPAFKP
NGTITAGNSAPLNSGASYVLLMSKNALKKYGLTPMAKIRSFGFAGVPPAVMGKGPVPASKKALEKANLSTRKIDLWEINE
AFAVVVLYAIKQLELDESTVNKKGGAIAIGHPLGATGARLVGTLARQLIIEGKDYGVATLCVGGGQGGAIVLERV
>Mature_395_residues
MLEDVYLVDYARTAFTRFSRKDYQKDPFYNIRPEELAGMVINRLIEKNGIKAEEIDEIITGCALQVGEQWAFGGRHEIFA
ARLPYNIPTMAVDRQCASSLTTVSIGAMEISTGMADIVLAGGVEKLSRTPMFDNPHIEVNTKFLTDSKYIEYDLTTGYVM
GLTAEKLAEEARIKREEMDRWSLRSHQLAWKAIQEGYFKDEILPIEVEVEGKKTVVNVDQSVRPDTSIEKLGQLPPAFKP
NGTITAGNSAPLNSGASYVLLMSKNALKKYGLTPMAKIRSFGFAGVPPAVMGKGPVPASKKALEKANLSTRKIDLWEINE
AFAVVVLYAIKQLELDESTVNKKGGAIAIGHPLGATGARLVGTLARQLIIEGKDYGVATLCVGGGQGGAIVLERV

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=37.0646766169154, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=37.3737373737374, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI148539872, Length=399, Percent_Identity=35.0877192982456, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI4557237, Length=399, Percent_Identity=33.3333333333333, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4504327, Length=438, Percent_Identity=32.8767123287671, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI194353979, Length=396, Percent_Identity=29.5454545454545, Blast_Score=145, Evalue=5e-35,
Organism=Escherichia coli, GI48994986, Length=406, Percent_Identity=39.9014778325123, Blast_Score=267, Evalue=8e-73,
Organism=Escherichia coli, GI87082165, Length=403, Percent_Identity=36.7245657568238, Blast_Score=258, Evalue=6e-70,
Organism=Escherichia coli, GI1788554, Length=403, Percent_Identity=38.2133995037221, Blast_Score=249, Evalue=1e-67,
Organism=Escherichia coli, GI1787663, Length=421, Percent_Identity=36.104513064133, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1788683, Length=431, Percent_Identity=30.6264501160093, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=32.4189526184539, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=34.0909090909091, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI25147385, Length=401, Percent_Identity=30.4239401496259, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=432, Percent_Identity=30.3240740740741, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17535917, Length=404, Percent_Identity=27.4752475247525, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=36.9620253164557, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6325229, Length=408, Percent_Identity=36.2745098039216, Blast_Score=208, Evalue=9e-55,
Organism=Drosophila melanogaster, GI17648125, Length=402, Percent_Identity=38.3084577114428, Blast_Score=255, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24655093, Length=398, Percent_Identity=36.1809045226131, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24640423, Length=401, Percent_Identity=33.6658354114713, Blast_Score=221, Evalue=9e-58,
Organism=Drosophila melanogaster, GI17137578, Length=432, Percent_Identity=32.8703703703704, Blast_Score=194, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 43145; Mature: 43145

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEDVYLVDYARTAFTRFSRKDYQKDPFYNIRPEELAGMVINRLIEKNGIKAEEIDEIIT
CCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GCALQVGEQWAFGGRHEIFAARLPYNIPTMAVDRQCASSLTTVSIGAMEISTGMADIVLA
HHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEEEECCCHHHEEEE
GGVEKLSRTPMFDNPHIEVNTKFLTDSKYIEYDLTTGYVMGLTAEKLAEEARIKREEMDR
CCHHHHHCCCCCCCCEEEEEEEEEECCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHH
WSLRSHQLAWKAIQEGYFKDEILPIEVEVEGKKTVVNVDQSVRPDTSIEKLGQLPPAFKP
HHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEECCCCCCCCCHHHHHHCCCCCCCC
NGTITAGNSAPLNSGASYVLLMSKNALKKYGLTPMAKIRSFGFAGVPPAVMGKGPVPASK
CCCEECCCCCCCCCCCCEEEEEECHHHHHHCCCHHHHHHHCCCCCCCHHHCCCCCCCHHH
KALEKANLSTRKIDLWEINEAFAVVVLYAIKQLELDESTVNKKGGAIAIGHPLGATGARL
HHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEECCCCCCCHHHH
VGTLARQLIIEGKDYGVATLCVGGGQGGAIVLERV
HHHHHHHHEECCCCCCEEEEEEECCCCCEEEEEEC
>Mature Secondary Structure
MLEDVYLVDYARTAFTRFSRKDYQKDPFYNIRPEELAGMVINRLIEKNGIKAEEIDEIIT
CCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
GCALQVGEQWAFGGRHEIFAARLPYNIPTMAVDRQCASSLTTVSIGAMEISTGMADIVLA
HHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEEEECCCHHHEEEE
GGVEKLSRTPMFDNPHIEVNTKFLTDSKYIEYDLTTGYVMGLTAEKLAEEARIKREEMDR
CCHHHHHCCCCCCCCEEEEEEEEEECCCEEEEECCCCEEECCCHHHHHHHHHHHHHHHHH
WSLRSHQLAWKAIQEGYFKDEILPIEVEVEGKKTVVNVDQSVRPDTSIEKLGQLPPAFKP
HHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEECCCCCCCCCHHHHHHCCCCCCCC
NGTITAGNSAPLNSGASYVLLMSKNALKKYGLTPMAKIRSFGFAGVPPAVMGKGPVPASK
CCCEECCCCCCCCCCCCEEEEEECHHHHHHCCCHHHHHHHCCCCCCCHHHCCCCCCCHHH
KALEKANLSTRKIDLWEINEAFAVVVLYAIKQLELDESTVNKKGGAIAIGHPLGATGARL
HHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEECCCCCCCHHHH
VGTLARQLIIEGKDYGVATLCVGGGQGGAIVLERV
HHHHHHHHEECCCCCCEEEEEEECCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA