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The map label for this gene is ntH-2 [C]

Identifier: 15899225

GI number: 15899225

Start: 2255473

End: 2256156

Strand: Reverse

Name: ntH-2 [C]

Synonym: SSO2484

Alternate gene names: 15899225

Gene position: 2256156-2255473 (Counterclockwise)

Preceding gene: 15899226

Following gene: 15899224

Centisome position: 75.4

GC content: 31.29

Gene sequence:

>684_bases
ATGGTTCGTAAAATACTTGACACATTGCTGAAAATATTTGAAAATAATAAAAGCATATTGAAGGAAAAAGGTTGGATAGT
TTCGTCCGAAACTTCTTATGAATGGTGGGACGGACTAAAAAGTGCAGAAGAAATAATTATTTCAGCAATATTGGTTCAAA
TGTCAAGATGGGAAATTGTAAAGAGCAAAGTAGAGGAGATGAGGAGTAAAGGTTTGACTGATTTTTATAAATTATGCAAT
ACTACTGAACAAGAATTATATGATGTATTGAAAGGAATTAACTTCTATAAGACTAAGGTTAAGAGGTTAATTAATTTATC
TAAAATCATAATAAATCTAGGTAGTGTTGAGAAATTTTATAATAGAAATTTACTTTTAAGCATTGATGGTATAGGCGAAG
AAACAGCTGACTCAATCTTGCTTTTCGCAGGTCACAAACCAAACTTTCCACCATCAGAGTACGGTAAGAGAGTATTATCT
AGAGTATTAGGAATTAGTATAAAGAAAAAGAATGAGGTTAAAAGACTAGTAGAGGAGAATTTAGAGCGAAACGTCTACGA
ATACAAATTACTACACGCTGGAATAGTCACTGTAGGTAGAGCATTTTGTTTCATTGAAAATCCCAAATGTGAAGACTGTA
TTTTGAAGAAAGTATGTAAATATTATAGAGAAAATTCCTCGTGA

Upstream 100 bases:

>100_bases
ATTATAACGTTTTATTAGAAGCTATAGAAAACGCTAATGAGCCTAACGTTTTTGATACAGGTACTCCAAATCTGGTTAAA
CATGTATTAAGTGAACTATA

Downstream 100 bases:

>100_bases
TACAAAATAGGCCTCTTTAAATACTTTTACTAAATTTAAGTAATGCATAGTAATGTTTAAATTTTTATGTGATAAGTATG
TGGTATGAAATTATATGAAT

Product: DNA endonuclease III (ntH-2)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MVRKILDTLLKIFENNKSILKEKGWIVSSETSYEWWDGLKSAEEIIISAILVQMSRWEIVKSKVEEMRSKGLTDFYKLCN
TTEQELYDVLKGINFYKTKVKRLINLSKIIINLGSVEKFYNRNLLLSIDGIGEETADSILLFAGHKPNFPPSEYGKRVLS
RVLGISIKKKNEVKRLVEENLERNVYEYKLLHAGIVTVGRAFCFIENPKCEDCILKKVCKYYRENSS

Sequences:

>Translated_227_residues
MVRKILDTLLKIFENNKSILKEKGWIVSSETSYEWWDGLKSAEEIIISAILVQMSRWEIVKSKVEEMRSKGLTDFYKLCN
TTEQELYDVLKGINFYKTKVKRLINLSKIIINLGSVEKFYNRNLLLSIDGIGEETADSILLFAGHKPNFPPSEYGKRVLS
RVLGISIKKKNEVKRLVEENLERNVYEYKLLHAGIVTVGRAFCFIENPKCEDCILKKVCKYYRENSS
>Mature_227_residues
MVRKILDTLLKIFENNKSILKEKGWIVSSETSYEWWDGLKSAEEIIISAILVQMSRWEIVKSKVEEMRSKGLTDFYKLCN
TTEQELYDVLKGINFYKTKVKRLINLSKIIINLGSVEKFYNRNLLLSIDGIGEETADSILLFAGHKPNFPPSEYGKRVLS
RVLGISIKKKNEVKRLVEENLERNVYEYKLLHAGIVTVGRAFCFIENPKCEDCILKKVCKYYRENSS

Specific function: Has Both An Apurinic And/Or Apyrimidinic Endonuclease Activity And A DNA N-Glycosylase Activity. Incises Damaged DNA At Cytosines, Thymines And Guanines. Acts On A Damaged Strand, 5' From The Damaged Site. Required For The Repair Of Both Oxidative DNA Da

COG id: COG2231

COG function: function code L; Uncharacterized protein related to Endonuclease III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 4.2.99.18

Molecular weight: Translated: 26344; Mature: 26344

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRKILDTLLKIFENNKSILKEKGWIVSSETSYEWWDGLKSAEEIIISAILVQMSRWEIV
CHHHHHHHHHHHHHCCHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSKVEEMRSKGLTDFYKLCNTTEQELYDVLKGINFYKTKVKRLINLSKIIINLGSVEKFY
HHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRNLLLSIDGIGEETADSILLFAGHKPNFPPSEYGKRVLSRVLGISIKKKNEVKRLVEEN
CCCEEEEECCCCCHHHCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LERNVYEYKLLHAGIVTVGRAFCFIENPKCEDCILKKVCKYYRENSS
HHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVRKILDTLLKIFENNKSILKEKGWIVSSETSYEWWDGLKSAEEIIISAILVQMSRWEIV
CHHHHHHHHHHHHHCCHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSKVEEMRSKGLTDFYKLCNTTEQELYDVLKGINFYKTKVKRLINLSKIIINLGSVEKFY
HHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
NRNLLLSIDGIGEETADSILLFAGHKPNFPPSEYGKRVLSRVLGISIKKKNEVKRLVEEN
CCCEEEEECCCCCHHHCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LERNVYEYKLLHAGIVTVGRAFCFIENPKCEDCILKKVCKYYRENSS
HHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Carbon-Oxygen Lyase [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]