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The map label for this gene is rmlA1 [C]

Identifier: 15899221

GI number: 15899221

Start: 2250305

End: 2251018

Strand: Reverse

Name: rmlA1 [C]

Synonym: SSO2479

Alternate gene names: 15899221

Gene position: 2251018-2250305 (Counterclockwise)

Preceding gene: 15899223

Following gene: 15899217

Centisome position: 75.23

GC content: 35.85

Gene sequence:

>714_bases
ATGTATGTTATGCACGCGGTTATTTTAGCGGGTGGGTATGGTAAGAGATTAAGACCACTTACAGATGATAGGCCTAAGCC
TTTGATTGAAGTGGCTGGGAGACCAATTATTGAATGGCAGATCTCTTGGCTTAAACAATTCGGTATTACATCCTTTGTAA
TATTAACAGGCTATAAATGGGAGGTTCTCATAAAGTGGTTAAGTGAAAACGAAAAGAGATTGGGAATTTCAACGTATTTT
TCTATAGAAGAGGAACCTTTAGGTACTGGAGGAGCACTCAGGAAGGTCGAGAGATTATTAAGTACGGAAAACACGTTTAT
AGTTCTCAACGGTGATATAATAACTAACCTAGATATAAGTAAGTTAAAAATATCTAATGAAAACGTAATGACAATGTCAC
TAGTTCCCTTGAAGAGCCCATACGGAATAGTCGAAACTAAGGATGACAAGATTATAGATTTTAAGGAGAAGCCAATCTTA
GAAAACTACTGGATAAATGCGGGAGTTTATCTAATGAGAAAGGAAATATTCAAATACTTACCAGAAAAGGGAGACATGGA
AAAACTCACTTTTCCTAAACTTGCAAAGGAATCGTTATTGATTGGCATAAAGTATTATGATGTCTACTGGAGATCAATAG
ATACAATAAAAGATATAGAGGAGGTCTCTGAAGATTTAATAAAGATGAAGAACGGGCTAAGCTCTGAAAGGTGA

Upstream 100 bases:

>100_bases
TAGAGCTGAAGAATTCGAAGGAAAGAACTTTCAAAATAGTCCTCTACGCTATGAGACTTTTAGGCTAGTATTGGAAAATG
TTTATTAAATTGGAAATAAT

Downstream 100 bases:

>100_bases
AGATCAAATCCGCGACTGATTTAATCAACTATGATAAGTTCCTCATCTTCCTCACCTAACCATTTTTTTATTGTCTCCTT
AACACCTAGTTCCTTAATAT

Product: sugar phosphate nucleotydyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MYVMHAVILAGGYGKRLRPLTDDRPKPLIEVAGRPIIEWQISWLKQFGITSFVILTGYKWEVLIKWLSENEKRLGISTYF
SIEEEPLGTGGALRKVERLLSTENTFIVLNGDIITNLDISKLKISNENVMTMSLVPLKSPYGIVETKDDKIIDFKEKPIL
ENYWINAGVYLMRKEIFKYLPEKGDMEKLTFPKLAKESLLIGIKYYDVYWRSIDTIKDIEEVSEDLIKMKNGLSSER

Sequences:

>Translated_237_residues
MYVMHAVILAGGYGKRLRPLTDDRPKPLIEVAGRPIIEWQISWLKQFGITSFVILTGYKWEVLIKWLSENEKRLGISTYF
SIEEEPLGTGGALRKVERLLSTENTFIVLNGDIITNLDISKLKISNENVMTMSLVPLKSPYGIVETKDDKIIDFKEKPIL
ENYWINAGVYLMRKEIFKYLPEKGDMEKLTFPKLAKESLLIGIKYYDVYWRSIDTIKDIEEVSEDLIKMKNGLSSER
>Mature_237_residues
MYVMHAVILAGGYGKRLRPLTDDRPKPLIEVAGRPIIEWQISWLKQFGITSFVILTGYKWEVLIKWLSENEKRLGISTYF
SIEEEPLGTGGALRKVERLLSTENTFIVLNGDIITNLDISKLKISNENVMTMSLVPLKSPYGIVETKDDKIIDFKEKPIL
ENYWINAGVYLMRKEIFKYLPEKGDMEKLTFPKLAKESLLIGIKYYDVYWRSIDTIKDIEEVSEDLIKMKNGLSSER

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=225, Percent_Identity=36, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI11761619, Length=225, Percent_Identity=36, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI31881779, Length=199, Percent_Identity=29.6482412060301, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI45447090, Length=199, Percent_Identity=29.6482412060301, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=203, Percent_Identity=37.9310344827586, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17509979, Length=234, Percent_Identity=27.3504273504274, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17509981, Length=207, Percent_Identity=27.0531400966184, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=226, Percent_Identity=36.283185840708, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21355443, Length=223, Percent_Identity=34.0807174887892, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24644084, Length=223, Percent_Identity=34.0807174887892, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24653912, Length=200, Percent_Identity=29, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 27388; Mature: 27388

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVMHAVILAGGYGKRLRPLTDDRPKPLIEVAGRPIIEWQISWLKQFGITSFVILTGYKW
CHHEEEEEEECCCCCCCCCCCCCCCCCHHHHCCCCEEEHHHHHHHHCCCEEEEEEECCHH
EVLIKWLSENEKRLGISTYFSIEEEPLGTGGALRKVERLLSTENTFIVLNGDIITNLDIS
HHHHHHHCCCCCEECEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCEEECCCCE
KLKISNENVMTMSLVPLKSPYGIVETKDDKIIDFKEKPILENYWINAGVYLMRKEIFKYL
EEEECCCCEEEEEEEECCCCCCCEECCCCCEEECCCCCCHHHHCCCCCHHHHHHHHHHHC
PEKGDMEKLTFPKLAKESLLIGIKYYDVYWRSIDTIKDIEEVSEDLIKMKNGLSSER
CCCCCCCCCCCHHHCCCCEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MYVMHAVILAGGYGKRLRPLTDDRPKPLIEVAGRPIIEWQISWLKQFGITSFVILTGYKW
CHHEEEEEEECCCCCCCCCCCCCCCCCHHHHCCCCEEEHHHHHHHHCCCEEEEEEECCHH
EVLIKWLSENEKRLGISTYFSIEEEPLGTGGALRKVERLLSTENTFIVLNGDIITNLDIS
HHHHHHHCCCCCEECEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEEECCEEECCCCE
KLKISNENVMTMSLVPLKSPYGIVETKDDKIIDFKEKPILENYWINAGVYLMRKEIFKYL
EEEECCCCEEEEEEEECCCCCCCEECCCCCEEECCCCCCHHHHCCCCCHHHHHHHHHHHC
PEKGDMEKLTFPKLAKESLLIGIKYYDVYWRSIDTIKDIEEVSEDLIKMKNGLSSER
CCCCCCCCCCCHHHCCCCEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA